Researchers at Lund University discovered how E. coli bacteria target and degrade the MYC oncogene, a well-known contributor to many forms of cancer. This discovery has shown potent effects on tumor growth and increased survival in two different cancer models.
Professor Stephen M. Robertson at George Mason University is receiving $45,000 from the National Endowment for the Humanities to study the 1935 racial violence in Harlem. He will map the events and analyze how the press and legal system dealt with them.
A study published in Cell Death & Disease found that inhibiting the EZH2 protein can reduce cancer cell growth in multiple myeloma. The researchers discovered that certain metabolic pathways are altered in cells sensitive to EZH2 inhibition, providing potential markers for treatment response.
In rural Mexico, Indigenous people are coping with the pandemic by setting roadblocks to limit outsider access and promoting social distancing and mask use. They are also turning to traditional food sources like wild honey and chapulines, or grasshoppers.
Researchers have designed a new software called QuasiFlow to analyze the genetic variability of SARS-CoV-2 and identify its weak points. The goal is to develop a combination antiviral therapy that combines lethal mutagenesis with inhibitors to prevent the virus from evading the innate immune response.
New research reveals that deforestation in the U.S. does not always cause planetary warming; instead, in some places, it actually cools the planet due to the albedo effect. The study found that forest loss east of the Mississippi River and in Pacific Coast states causes planetary warming.
A UTEP professor's study discovered a specific area of the brain linked to recollection and desire for food, which could inhibit overeating. The research found that regulating this brain region reduced animal subjects' consumption of treats.
A new study comparing lemurs, distant primate cousins of humans, found few consistent differences between monogamous and promiscuous species. However, researchers discovered that the brain chemistry behind love in lemurs may involve a combination of multiple hormones and interactions rather than a single formula.
The article highlights four major challenges in the online world: manipulative choice architectures, personalized information, false and misleading information, and distracting environments. To address these challenges, researchers propose interventions such as boosting tools, self-nudging, and media literacy education.
Researchers at Monash University have discovered a biological process that prevents the human body from regenerating new cells or tissue after birth. By demethylating specific genes, they can reawaken progenitor cells to become insulin-producing beta cells, offering a potential breakthrough for treating Type 1 and Type 2 diabetes.
A new 'couple simulation' model developed by Dan Conroy-Beam simulates real-life couples to test different models of mate selection. The Resource Allocation Model proved most accurate, correctly matching 45% of the couples, and was found to have higher-quality relationships.
A UC Riverside-led study found that treatment with the medication risperidone leads to increased activity of astrocytes in persons who stutter. This increase in activity may help reduce stuttering by blocking dopamine receptors in the striatum.
Pediatric hospital admissions declined across various conditions in 2020, indicating potential gaps in pediatric care during the pandemic. The study's findings suggest a need for improved healthcare infrastructure and resource allocation.
This case series examines brain samples from COVID-19 patients with severe pulmonary pathology to understand the impact on brain capillaries. The study provides valuable information on the neurological consequences of COVID-19, shedding light on potential underlying mechanisms.
Research suggests that acne can leave lasting psychological scars, particularly for women and adolescents with darker skin, affecting self-esteem and mental health. A new study calls for a comprehensive approach to treating acne, integrating psychology and dermatology.
Researchers found that disrupting balance of gamma waves between hemispheres affects how brains integrate information from left and right ears. The study uses electric brain stimulation to manipulate interhemispheric connectivity, paving the way for new treatments for tinnitus and hearing loss.
Researchers found that non-metastatic cells can spread to distant organs through a new mechanism involving the fibrotic niche induced by malignant cells. This discovery suggests targeting the fibrotic niche as a promising strategy to control solid tumor progression.
The Mabee Foundation award will aid in the expansion of research and testing at Texas Biomedical Research Institute. The new facility will accommodate a growing need for animal models to test safety and efficacy of new treatments, including those for COVID-19.
A new study shows that liquid biopsies can detect lingering disease in patients with oligometastatic colorectal cancer, guiding treatment decisions. The biopsies identify patients who may benefit from immune therapies or targeted treatments based on mutations detected in blood samples.
The study reveals that next-generation climate models will provide valuable information on hourly precipitation, enabling better adaptation policies for infrastructure and economies. The research demonstrates the added value of high-resolution climate simulations, confirming their worth in areas with complex orography like the Alps.
Researchers at St. Jude Children's Research Hospital characterized genomic abnormalities of 84 therapy-related myeloid neoplasms in children, identifying notable mutations and increased expression of a transcription factor called MECOM. Early detection of these mutations could lead to early interventions and potentially benefit patients.
Researchers use NASA Infrared Telescope Facility's iSHELL spectrometer to confirm and measure exoplanet masses discovered by TESS mission orbiting bright K and M dwarf host stars. They aim to constrain bulk densities for a better understanding of the exoplanet mass-radius relation.
Scientists at TU Dresden have discovered that the dried flowers of St. John's Wort can catalyze photochemical reactions, showcasing a promising green and sustainable method for chemical synthesis. The discovery utilizes the plant compound hypericin as an active compound in chemical reactions without prior chemical processing.
A team of US engineers has received a $5.8 million NASA grant to create computational design tools for air taxi designs. The project aims to develop safe, quiet, and affordable eVTOL aircraft using advanced design optimization algorithms.
The study analyzed tweets of 186 users taking antidepressant medication, revealing increased activity and positive emotions during treatment. Users posted longer messages with more interactions and fewer messages at night.
Scientists have discovered genes involved in autoimmune Addison's disease, a life-threatening hormonal deficiency caused by immune system destruction. The discovery could lead to personalized treatment options and may determine the molecular repercussions of predisposing genetic variations.
For the first time, scientists have shown that positively charged iodine (iodonium) can favorably interact with a silver cation, breaking the strong electrostatic repulsion. This unexpected affinity is useful for various applications, including cloud seeding and artificial rain generation.
Hurricane maximum wind speeds in the subtropical Atlantic around Bermuda have more than doubled over the last 60 years due to rising ocean temperatures. This increase in energy extraction from warm oceans leads to more intense hurricanes, posing a significant threat to Bermuda.
Researchers have developed a strategy to amplify fluorescence signals using DNA probes and nano-antennas, enabling the detection of biomarkers in low concentrations. This technology has the potential to enable medical screening on patients without laboratory analysis.
A new study by a University at Buffalo researcher challenges the cultural transmission hypothesis suggesting that whales learn their songs from others. Humpback whales' songs are changing in a precise manner, similar to beat-matching in music, contradicting existing research on cultural transmission and social learning.
Researchers found that sounds can change brain circuits in newborn mice, even before the ear canal opens, and may eventually help detect and intervene in abnormal wiring. The study's findings suggest that sensory experience can alter cortical circuits at a very young age, potentially leading to neurodevelopmental problems.
Astronomers have found a concentration of smaller black holes at the center of the globular cluster NGC 6397, contradicting the long-held assumption of an intermediate-mass black hole. The discovery was made using Hubble data and Gaia space observatory measurements.
The rise of several significant SARS-CoV-2 variants has sparked concerns about vaccine efficacy and prompted calls for a global approach to combatting the virus. Experts from the National Institute of Allergy and Infectious Diseases emphasize the need for robust surveillance, tracking, and vaccine deployment worldwide.
A multi-disciplinary team at Harvard's Wyss Institute developed an electrochemical diagnostic sensor platform for multiplexed detection of clinically relevant biomarkers in whole blood. The device accurately detects three different sepsis biomarkers simultaneously and has the potential to revolutionize point-of-care diagnostics.
Researchers have made progress in understanding how heat shock proteins interact with faulty proteins in Huntington's disease, potentially leading to new treatments. The study suggests that these proteins can be activated to prevent protein aggregates from forming.
Researchers at George Mason University will provide access to and training on the Risk-Need-Responsivity (RNR) Simulation Tool for approximately 10 users through a $9,019 grant from Wood County Mental Health Services. The funding supports the RNR project until December 2021.
Researchers successfully manipulated magnets at the atomic level using ultrashort laser pulse excitation, reducing magnetic switching time by 1000 times. This breakthrough enables novel means to control magnetism, essential for efficient data processing technologies.
A new analysis of thousands of Michigan bees reveals that the most diverse bee communities have the lowest levels of three common viral pathogens. This study suggests that promoting diverse bee communities may be a win-win strategy to reduce viral infections in managed honeybee colonies while maintaining native bee biodiversity.
A meta-analysis of 31 studies found that certain brain regions, including the insula and inferior frontal gyrus, are consistently activated during stress regardless of the test method used. This suggests a common neural basis for stress perception across different stimuli.
Researchers at George Mason University are conducting a NASA-funded project to model telluric absorption features using iSHELL stellar spectra and line-spread functions. The goal is to improve EPRV measurements with high precision, enabling the detection of exoplanet atmospheres.
A new genomic test helps oncologists determine which patients with recurrent prostate cancer may benefit from hormone therapy, guiding precision medicine efforts. The Decipher test, measuring tumor gene activity, predicts risk of metastasis and death, even after adjusting for other factors.
Researchers investigated how high salt and nitrogen concentrations impact soil microbiome development in high tunnel systems. They found that these properties delayed the re-establishment of a diverse microbial community, with certain 'universal colonizers' surviving despite the stress.
A recent study found that biodiversity is vital at regional scales, not just local ones, to maintain stable ecosystems. This research can inform conservation planning and make human communities more sustainable by promoting biodiversity.
A University of Oregon postdoc has developed a new approach to reconstruct past ecosystem services by combining pollen records with key plant traits. The method provides confidence in the ability to understand how plants performed different benefits useful for humans over the past 21,000 years.
Researchers have identified a brain enzyme that activates dormant neural stem cells, enabling them to proliferate and generate new neurons. The study found that the enzyme Pr-set7 plays a crucial role in maintaining genome stability and regulating cell cycle, leading to reactivation of neural stem cells.
A study by the University of Kansas found that marching band members are at high risk of heat illness due to their heavy uniforms and performance in hot temperatures. The researchers recommend providing access to athletic trainers to prevent heat-related illnesses.
A recent study using Chicago Police Department data found Black officers used force less often than white counterparts, while women used force less than men. The findings provide insight into the impacts of diversification in policing and highlight the need for nuanced reforms.
A mathematician from RUDN University developed a stable difference scheme to solve inverse problems in elliptic-telegraph and differential equations. The scheme was tested both analytically and numerically, demonstrating absolute stability and independence from calculation step size.
Researchers found that a neuron in the snail's brain suppresses feeding circuit, reversing response to sugar after conditioning training. This mechanism may be similar to human brains, where negative associations with food can alter future eating habits.
A three-model approach was used to trace the spread of PEDV and analyze control strategies. The models showed varying levels of accuracy in predicting outbreaks, with PoPS being the most accurate overall.
Researchers have identified a previously unknown dual function of polymerase theta (pol theta) in DNA repair, which could lead to the development of new therapeutic options for breast and ovarian cancers. The finding shows pol theta can both extend DNA and trim it, making it a potential target for treatment development.
A team of researchers led by Alysson R. Muotri used stem cells to create 'mini-brains' modeled after extinct Neanderthals, discovering a single genetic alteration that could explain key differences in brain development and function between modern humans and our closest relatives
Researchers found that activating STING molecule reduced GVHD severity and mortality rates in a mouse model. The study suggests that a STING-activating drug might protect bone marrow transplant recipients from GVHD.
A study by scientists from Incheon National University reveals that microplastics in agricultural soil can affect soil quality, plant physiology, and even the environment. The researchers found that different shapes of MPs dominate various agricultural practices, highlighting the need for efficient management strategies to reduce the t...
A new algorithm detects hidden fingerprints in routine blood test results to identify people silently developing liver cirrhosis. The CIRRUS algorithm has an accuracy rate of 90% and can pick up over 70% of cases months or years before emergency admissions.
A new study found that introducing premium commercial food with high protein content from meat reduced the number of prey animals brought home by 36%, while five to ten minutes of daily play resulted in a 25% reduction. These non-invasive methods offer a solution for reducing hunting without restricting cat access.
Researchers developed a computer program to create geometric shapes from video sequences, comparing them to participants' recounted experiences. The study found that people tend to remember major plot points accurately, while finer-scale details are distorted or forgotten.
Scientists have challenged our current understanding of how galaxies form by unveiling pictures of a young galaxy with an unexpected appearance. ALESS 073.1 appears to have features expected of a mature galaxy, leading the team to question how it grew so fast.
A large-scale study found that early detection and treatment of rheumatic heart disease (RHD) through echocardiographic screening and antibiotic prophylaxis significantly reduced RHD prevalence by two-thirds in schools. This approach is an effective strategy to control RHD in endemic regions.
The report identifies eight categories of transition risk, including economic, financial, societal, environmental, technological, energy-related, geopolitical, and corporate. Policymakers and researchers need to grapple with the complex interconnections that tie these risks together.