A recent study published in the European Heart Journal has found a clear link between disrupted sleep and an increased risk of dying from diseases of the heart and blood vessels, as well as death from any cause. Women were found to have nearly double the risk of cardiovascular death compared to men.
Researchers at Ohio State University developed a new software tool called MagicDNA that can design more complex DNA robots and nanodevices in a fraction of the time. The software allows for 3D design and simulation, enabling fine control over individual component properties and increasing the complexity of overall geometry.
Researchers from TU Graz and FSU Jena discovered three opposing driving forces controlling the self-assembly of functionalized molecules at interfaces. A design principle using machine learning was established to predict structures and properties. This breakthrough enables the easy assembly of desired interfacial properties on demand.
A study by Indiana University School of Medicine researchers has found that B cell activating factor (BAFF) plays a role in the generation and maintenance of inhibitors in hemophilia A patients. Blocking BAFF with a combination therapy may induce tolerance in these patients, offering a potential solution to treatment failure.
Researchers from Aarhus University are conducting a treatment trial using faeces-microbiome transplantation to improve cirrhosis outcomes and lower mortality rates. The project replaces patients' sick intestinal bacteria with those from healthy donors, aiming to alleviate complications and disease progression.
Researchers have created a new catalyst that allows for more efficient and sustainable production of aromatic hydrocarbons using renewable sources like woody biomass. The catalyst reduces the need for high temperatures and pressures, minimizing energy costs and emissions.
A meta-analysis of 400+ clinical trials involving over 50,000 participants found that mindfulness, positive psychological interventions, and cognitive behavioural therapy can increase wellbeing across different groups. Consistent and prolonged practice is crucial for these interventions to be effective in improving wellbeing.
A shallow locked region south of Cartagena city suggests significant earthquake and tsunami hazard, with a magnitude 8.0 earthquake capable of occurring every 600 years. Researchers urge continued densification of the GPS network to better understand and evaluate this hazard potential.
A new study found that rock weathering and water storage follow similar patterns across hill slopes, improving wildfire and landslide risk predictions. The findings also suggest that computer models can use this scaling trend to model weathering in undulating terrain.
A study found that land use legacies, such as agriculture and forestry, can have lasting impacts on ecosystems, with only limited effects from restoration efforts. The researchers discovered that soil compaction, a common issue caused by agricultural use, was difficult to mitigate through restoration alone.
A recent study by North Carolina State University found that education alone cannot overcome social inequality, particularly among men. The research examined data from over 56,000 individuals and found that a parent's social status continues to provide an advantage to their children in terms of earnings.
Researchers at the University of Minnesota identified a new drug target for glioblastoma patients who defy conventional wisdom by surviving beyond expectations. Glioblastoma cells subvert immune system cells called microglia and macrophages, leading to tumor growth.
A recent study conducted at the University of Helsinki found that the risk of intellectual disability in younger siblings is low. The study utilized exome sequencing to determine the genetic background of developmental disorders and identified 9 new candidate genes, including 1 potentially novel gene enriched in the Finnish population.
A new study from the University of Gothenburg suggests that defective goblet cells may contribute to ulcerative colitis by damaging the mucus protection layer. The research team identified specific types of goblet cells and found that their premature rejection leads to inflammation and increased cancer risk.
A recent study found that it will take over 200 years for women to reach parity in orthopaedic surgery, highlighting the need for substantial changes across education and leadership levels. The research emphasizes the importance of increasing representation of women in medical schools, residency programs, and subspecialty societies.
Researchers from the Lundbeck Foundation GeoGenetics Centre have sequenced ancient DNA from soil for the first time, transforming the field of population genetics. The advance allows scientists to study the evolution of animals, plants, and microorganisms, with potential applications in climate change research.
Research reveals that pitviper species consuming more evolutionarily diverse prey produce more complex venom. The study found that the evolutionary distance between consumed prey species affects venom complexity, suggesting subtle differences in venom targets.
Two studies found that the bone microenvironment reduces ER expression in breast cancer cells, leading to resistance to endocrine therapy. The bone microenvironment also triggers reprogramming of cancer cells, promoting their ability to metastasize to other tissues and evade treatment.
Researchers summarize growing knowledge on light therapy's mechanism, effectiveness, and applications in treating neurodegenerative diseases like Alzheimer's and Parkinson's. Light stimulation has been shown to restore memory and cognition, improve sleep quality, and reduce symptoms in patients with these conditions.
Researchers discovered a new molecule, K162, that inhibits beta-amyloid toxicity and protects neurons from damage. The study provides hope for alternative therapeutic strategies against Alzheimer's disease.
A multi-disciplinary team has reconstructed ancient population and land use, showing that humans shaped much of the terrestrial biosphere by 12,000 years ago. The study found a close correlation between areas of high biodiversity and areas long occupied by Indigenous peoples.
A longitudinal study found that adherence to the Medicare Severe Sepsis and Septic Shock Early Management Bundle (SEP-1) had variable effects on sepsis treatment and patient outcomes. Researchers suggest that clinicians may have discretion in applying SEP-1 components to focus on aspects of care driving improvements in patient outcomes.
Researchers developed DANNCE, a 3D deep-neural network that can capture behavior and track movement in freely behaving animals from single video cameras. The tool has broad impact on animal behavioral studies, enabling standardized definitions of behaviors and tracing emergence of behavior over time.
Researchers have discovered an exotic new state of matter in the Kondo insulator ytterbium dodecaboride, which exhibits properties of both metals and insulators. The study used a newly developed 75-tesla duplex magnet to suppress insulating properties and measure quantum oscillations.
The astronomy industry has a long way to go before achieving gender parity, with women making up less than one-third of professional astronomers by 2080. Implementing 50:50 hiring ratios and retention initiatives, such as exit surveys and work-life balance improvements, can help reach the goal of 30% female representation in a decade.
A study found that human populations transformed wildlands into human biomes as early as 12,000 years ago, with 75% of the Earth's biosphere inhabited by humans. Anthropogenic land use reshaped more than 80% of the terrestrial biosphere by 2017 CE.
A new synthetic framework, TB-ResNet, combines discrete choice models and deep neural networks to improve individual decision-making analysis in travel behavior research. The framework has been proven to be highly predictive, interpretable, and robust.
A study analyzing 588 fossil land vertebrate specimens from the Karoo Basin, South Africa, found high extinction rates initially co-occurred with low origination rates. The ancient mammal relative Lystrosaurus experienced population peaks both before and after the end-Permian extinction event.
A recent study by Kanazawa University researchers found that leg muscle action can improve blood flow independently of age. The study used MRI imaging to measure changes in blood flow and pump action in the legs of healthy volunteers aged 24, 47, and 72 years.
Researchers found that high-dose omega-3 polyunsaturated fatty acids supplementation suppressed damage and boosted protection during and after stressful events. This led to sustained anti-inflammatory activity and preserved telomere length in healthy but sedentary, overweight, and middle-aged individuals.
A Hebrew University study found that ultra-processed foods negatively impact children's skeletal development, leading to reduced bone quality and growth. The research surveyed lab rodents who consumed junk food, showing growth retardation and impaired bone development.
A new study found that nearly one-third of patients prescribed a direct oral anticoagulant were also taking aspirin without a clear reason, leading to an increased risk of bleeding events. The researchers emphasize the importance of consulting with doctors to determine if combination therapy is necessary for individual patients.
A population-based study of Canadian children found no link between epidural pain relief during labor and an increased risk of autism spectrum disorders. The study analyzed multiple databases and concluded that epidural use did not increase the likelihood of autism.
A new Stanford University-led study uses AI and satellite imagery to locate and monitor hard-to-regulate industries, such as brick kilns in Bangladesh. The approach reveals that over three-fourths of kilns are illegally constructed near schools, and the government under-reports kilns with respect to regulations.
Researchers found a naturally occurring 'earthquake gate' on New Zealand's Alpine Fault that decides which earthquakes grow into magnitude 8 or greater. The study suggests this gate could change the stress and break larger earthquake chains.
Researchers at John Innes Centre discovered two genes, ATH1 and DELLA, controlling plant compactness and elongation. These findings may lead to more precise ways to modify crop shape and height in agriculture.
Researchers at VCU Massey Cancer Center have identified a protein called PLK3 that operates with mutated p53 genes to spur lung cancer growth. Inhibiting PLK3 has been shown to reduce tumor cell formation and proliferation in preclinical models of lung cancer.
Researchers have found that SARS-CoV-2 variants from minks can evade inhibition by COVID-19 antibodies, reducing immune control. The study showed that the Y453F mutation in the spike protein reduces the effectiveness of both therapeutic and human-made antibodies.
Researchers at the University of Copenhagen have discovered a better way to target and eliminate beetles using eco-friendly methods. The study found that beetles regulate their kidney function in a unique way, which can be exploited to disrupt their fluid balance without harming other insects.
The Herringbone Microfluidic Probe (HB-MFP) effectively isolates Circulating Tumor Cells from blood samples, providing insights into cancer metastasis. Researchers believe this technology has great promise for diagnosing and prognosticating prostate cancer using liquid biopsies.
A retrospective study suggests that MitraClip reduces death and heart failure hospitalizations by up to 50% for patients with secondary MR, even with slightly smaller mitral valve openings. The study also found improvements in quality of life measures in some patients with higher gradients.
A study found that wind patterns strongly affect genetic differentiation, gene flow, and genetic diversity in tree populations. Downwind populations tend to exhibit high genetic diversity.
Researchers found that applying fat grafts enriched with adipose-derived stem cells improved fat retention in LoS patients. The study suggested a safe and feasible alternative to conventional treatment methods for correcting facial atrophy.
A new once-a-week injectable insulin therapy has proven safe and as effective as daily insulin injections in two international clinical trials. The treatment may provide a convenient alternative to the burden of daily insulin shots for diabetes patients, improving long-term adherence and glucose control.
By integrating telemedicine, physicians at MUSC Health have shortened the time between stroke symptom onset and treatment by 15-20 minutes. This reduces complications from tPA and improves functional outcomes for patients.
The world's plant and animal diversity is declining, but the direction and pace of change in microbial life, including viruses, remain unknown. Microbial evolution can lead to greater or fewer species, with potential implications for the biosphere.
A new technique uses a laser to create colorful strokes on metal, offering a way to change or erase colors. The approach creates miniature art with complex meaning through shape and color, as well as microstructures on the surface.
A new AI tool analyzes COVID-19 conspiracy theories on Twitter, revealing how they evolve over time and incorporating details from unrelated theories. The study aims to help public health officials counter misinformation with factual campaigns.
A new study suggests that pandemic eviction bans reduced infection rates and protected not only evicted individuals but also entire communities from the spread of COVID-19. The researchers found that without eviction bans, people who experience eviction or live with evictees have a higher risk of being infected, increasing transmission...
A study found that addressing social determinants of health improved blood pressure control in patients with diabetes or hypertension in Kenya. The intervention combined community microfinance groups with group medical visits reduced systolic blood pressure by 44% compared to standard care.
Scientists identified depletion of liquid electrolyte as primary cause of failure in high-energy-density lithium-metal batteries. The study used high-energy x-rays to map performance variations and calculate cathode material state, enabling the discovery of dominant failure mechanism.
Researchers found that female mice with glioma lacking the POT1 gene survived less than males, leading to further investigation of human glioma cells. Low POT1 expression correlated with reduced survival in females, suggesting immune response and tumor cell proliferation played a role in tumor growth.
Researchers analyzed a database of over 3 million urban electric vehicles in China to understand energy consumption patterns. They found that energy consumption changes by up to 21% during winter-to-spring seasonal transitions.
A national registry is needed to capture all pharma/medical device industry payments and benefits made to doctors, healthcare organisations, and patient support groups in the UK. The UK government has been dragging its feet on setting up such a system despite recommendations from key reviews.
Postponing cardiovascular surgeries during the pandemic sparked anxiety and fear among patients, illustrating the profound impact of medical decisions on their emotional well-being. Many patients preferred to wait for surgery due to uncertainty about COVID-19's impact on their health.
A new framework connects metabolic principles to forest patterns, revealing regularities beneath apparent randomness. The model allows for generalization to diverse species and situations, providing insights into forest structure and biological complexity.
Researchers analyzed tool fragments, raw materials, and complete objects excavated from two sites in Ribe, Denmark, to understand the evolution of Viking metalwork. They found rapid technological advances in combining metals into mixes and refining their process over time.
Research on haematite, a widely known rust material, has been hindered by low photocurrent conversion efficiency compared to theoretical maximum values. A recent study reveals that the wavelength of absorbed light in hematite thin films affects its photoelectrochemical properties.
Researchers discovered that cells can migrate robustly on soft, viscoelastic substrates, using thin filopodia and molecular clutches to drive movement. This finding challenges traditional views of cell migration and highlights the importance of material properties in cellular behavior.
Researchers at Einstein College of Medicine developed a topical drug that regenerates and restores function of erectile nerves damaged by radical prostatectomy. The siRNA gel enhanced nerve regeneration and restored nerve function in rat models, restoring erectile function.