New research published in CMAJ found Indigenous peoples in Canada experience higher rates of complications after surgery, lower surgery rates, and longer wait times for life-saving procedures. The study highlights the need for better data collection methods and real-time outcome monitoring to address structural racism in healthcare.
Researchers found that finerenone reduced the risk of atrial fibrillation by 30% in patients with chronic kidney disease and Type 2 diabetes, regardless of their history with AFib. The study suggests that finerenone can delay the onset of heart rhythm disorder and protect the heart and kidneys from further damage.
A study published in Nature Genetics found 64 genome regions associated with an increased risk of bipolar disorder, providing new insights into the condition's underlying biology. The research also highlights potential therapeutic targets for future treatments.
An analysis of the Central-Western Greenland ice sheet reveals distinct marks of instability due to accelerated melting. The study suggests that this part of the ice sheet has reached a critical threshold, leading to severe consequences for global sea level and climate.
Researchers at Washington State University have developed a catalytic process to efficiently convert polyethylene to jet fuel and high-value lubricants. The process converts 90% of plastic to usable products within an hour, offering a promising approach to reducing waste plastics.
Scientists have identified two marine biodiversity refugia in the Eastern Bering Sea, where species richness and community stability are high. These regions, covering less than 10% of the study area, harbor 91% of analyzed species and support commercially important fish and crab populations.
Researchers from KIT and Wageningen University created new high-resolution maps called HILDA+ that reveal global land-use changes have affected nearly one-third of the land area in just six decades. The study found land-use changes are about four times as extensive as previously known.
Researchers evaluated the use of positive behavior supports to promote face covering compliance among school-aged children with autism spectrum disorders and/or ADHD. The study found that this approach was feasible and effective, leading to improved mask-wearing adherence.
Scientists launched a sounding rocket to investigate how the solar wind interacts with Earth's magnetosphere, producing the aurora. The experiment deployed barium thermite canisters that generated plasma clouds, which interacted with ionospheric plasma, creating electromagnetic fields and waves.
US patients with ischemic stroke experienced changes in hospital discharge rates and outcomes during the COVID-19 pandemic, according to a study published in JAMA Network Open. The study found that hospitalization rates for ischemic stroke decreased significantly before the pandemic, but increased again after vaccination efforts began.
A new study suggests that cardioprotective drugs during adjuvant breast cancer therapy may not be necessary for most patients, especially those at low risk of heart disease. The research found no significant differences in heart function between patients who received these medications and placebos.
Patients who underwent renal denervation experienced a median reduction of 8 mmHg in daytime ambulatory systolic blood pressure. The procedure was shown to be effective regardless of sex, ethnicity, age, or waist size.
Research shows that removing 'race correction' from pulmonary function test results reveals a higher prevalence and severity of lung disease among Black patients. The study found an increase in the percentage of patients with any pulmonary defect from 59.5% to 81.7%, indicating a significant difference.
Sperm deliver signals that increase the chances of conception by persuading female reproductive tissues to accept the male partner's genetic material. Factors like age, diet, and environmental exposures can affect sperm quality, impacting pregnancy health.
A weighted lottery system was implemented at 23 hospitals to increase equitable distribution of remdesivir during the 2020 COVID-19 surge. The system prioritized patients from disadvantaged neighborhoods and/or essential workers, allocating 61% of available medication to these groups.
Researchers found a highly effective treatment for high-risk neuroblastoma and other forms of aggressive childhood cancer. The combination of CBL0137 and panobinostat resulted in remarkable growth suppression and an immune response that targeted cancer cells.
A recent survey found that burnout rates doubled among cardiovascular clinicians during the COVID-19 pandemic, with half providing direct care to patients and reporting inadequate PPE. The study highlights the need for improved health system support and wellness initiatives to address burnout and its consequences.
Researchers at Pohang University of Science & Technology (POSTECH) have developed a revolutionary LiDAR device the size of a finger using nanophotonics-based technology. The device can be used in autonomous vehicles, intelligent robots, drones, and augmented reality platforms.
A new clinical trial found that a tailored, earlier heart failure rehabilitation program improved frailty, depression, and overall quality of life in hospitalized patients. The study showed significant gains in physical functioning and self-perception of health status.
A study published in the New England Journal of Medicine found that FFR-guided PCI had no significant benefits for STEMI patients with multi-vessel disease and was more expensive than angiography alone. The FLOWER-MI trial enrolled 1,171 patients who underwent a second stenting procedure after a STEMI heart attack.
Women in their early 40s with mildly elevated blood pressure face a doubled risk of acute coronary syndromes in their 50s. Regular monitoring and lifestyle changes can help mitigate this risk.
The HOST-EXAM trial found that patients who received clopidogrel experienced a 30% reduced risk of adverse events compared to those on aspirin. This study confirms the effectiveness of long-term maintenance therapy with clopidogrel as an alternative to aspirin for patients who have completed dual antiplatelet therapy.
Two research breakthroughs accelerate the development of synthetic diamond-based quantum technology by addressing cost and fabrication difficulties. A new hard masking method enables precise engineering of optical defects in diamond devices, while a novel growth process uses lower-cost polycrystalline substrate.
Research presented at the ATS 2021 International Conference found that patients with idiopathic pulmonary fibrosis (IPF) living in poor neighborhoods experience poorer outcomes, including increased mortality and reduced odds of receiving a lung transplant. The study highlights the impact of environmental factors on disease progression.
Patients taking daily omega-3 carboxylic acid had similar rates of major cardiovascular events as those taking corn oil placebo, according to a post-hoc analysis of the STRENGTH trial. Higher levels of achieved EPA and DHA did not affect outcomes.
Researchers developed a new multi-modal image fusion method based on supervised deep learning to enhance image clarity, reduce redundant features, and support batch processing. The method achieves state-of-the-art performance in visual quality and quantitative evaluation metrics, improving medical diagnosis accuracy.
In a phase 2 trial, evinacumab significantly reduced triglyceride levels in patients with severe hypertriglyceridemia, particularly those with specific genetic mutations. The study found that the magnitude of response was highly dependent on the participant's genetic profile.
The Lancet Commission report outlines 10 recommendations to improve health outcomes for millions of women worldwide and achieve the global targets set. The report aims to reduce the global burden of cardiovascular conditions in women, including heart disease and stroke, which account for 35% of deaths.
A novel rehabilitation program, REHAB-HF, improved physical function, balance, mobility, strength, and endurance in hospitalized older patients with acute heart failure. The program, tailored to individual needs and starting early in the hospital stay, showed significant gains regardless of ejection fraction.
A novel 12-week physical rehabilitation program tailored to address specific physical impairments in older heart failure patients improved physical functioning, quality of life, and depression. However, participation did not significantly reduce rehospitalizations during the six-month follow-up period.
A phase III trial found dapagliflozin did not significantly reduce organ failure or death, but showed favorable safety data and lower numbers of serious adverse events. The study suggests that SGLT2 inhibitors may offer organ protection in acutely ill patients hospitalized with COVID-19.
Dr. Morice's career spans over four decades, with a focus on pioneering the use of antiplatelet drugs in PCI and promoting education and training among young professionals. She has also been a key advocate for gender equality in medicine, co-founding Women as One to promote talent in cardiology.
Evinacumab reduces triglyceride levels by up to 82 percent in patients with severe hypertriglyceridemia and a history of hospitalizations for acute pancreatitis. The therapy also lowers the risk of recurrent acute pancreatitis, quality of life, and cardiovascular events.
A recent study found that using a rapid, high-sensitivity troponin T testing protocol did not improve patient outcomes after one year. In fact, patients who received this protocol were more likely to experience a heart attack or death compared to those in the standard-care group.
A global commission led by Mount Sinai cardiologist Roxana Mehran recommends expanding education and health programs, research on women's heart disease, and prioritizing sex-specific interventions. The report aims to improve women's heart health outcomes worldwide by 2030.
Switching from high-potency DAPT (ticagrelor) to less potent clopidogrel after 30 days reduced major cardiac events, including heart attacks and strokes. In a study of over 2,700 patients, de-escalation was shown to be safe and more effective than continuing on ticagrelor.
The study found that rivaroxaban significantly reduced the occurrence of total severe events in patients with symptomatic peripheral artery disease who underwent lower extremity revascularization. The treatment also showed a 12.5% absolute reduction in risk for adverse events in this high-risk population.
A new study found that ultrasound treatment, called renal denervation, significantly lowered blood pressure in patients with drug-resistant hypertension. The procedure, which uses brief pulses of ultrasound to disrupt nerve signals, resulted in a 8-point drop in daytime blood pressure and an average decrease of 8.3 points at night.
Regular gamblers were more than six times more likely to gamble online during lockdown, with usage growing six-fold. The study highlights the need for stricter regulation and awareness to protect vulnerable groups from addictive habits and online exploitation.
Researchers investigating the 'radius gap' in exoplanet sizes found that younger mini-Neptunes shrink drastically over billions of years, leaving behind solid cores and becoming super-Earths. As planets age, their gas is stripped away, shifting the radius gap between rocky super-Earths and larger, gas-shrouded planets.
Researchers at Newcastle University discovered that tiny pieces of genetic material, miR-424-5p, increase in early stages of heart disease in type 1 diabetes patients. This biomarker has the potential to define additional therapeutic options to help patients with type 1 diabetes.
Researchers found no significant differences in cardiovascular events or major bleeding between patients taking 81mg or 325mg daily doses of aspirin. Long-term adherence was better among those taking the lower dose.
The study analyzed over 36,000 LAAO procedures performed with the WATCHMAN device in older, higher-risk patients with atrial fibrillation. At one year, the estimated 1.53% ischemic stroke rate was lower than predicted by stroke risk scores, suggesting effective stroke prevention.
Researchers found that left atrial appendage occlusion significantly reduced stroke risk by 33% in patients with AFib or atrial flutter. The procedure, performed during heart surgery, added less than 10 minutes to the operation and demonstrated long-term safety.
A new study by Rutgers researchers found that COVID-19 can trigger a rare recurrence of upper extremity blood clots, requiring vigilant monitoring and treatment. Patients with a history of deep vein thrombosis or chronic medical conditions are at higher risk for recurrence.
A large international study led by McMaster University found that removing the left atrial appendage significantly cuts the risk of strokes by more than one-third in patients with atrial fibrillation. The procedure is simple, quick, and safe for the majority of heart surgery patients with this condition.
A study presented at ACC.21 found that low- and high-dose aspirin achieved similar health benefits for those with cardiovascular disease, including reduced death and hospitalization rates. However, the higher dose group was more likely to switch doses and discontinue use due to tolerability concerns.
Researchers found that apixaban reduced blood clot formation around implanted valves with no increased bleeding risk. However, a subset of patients showed higher rates of non-cardiovascular death without anticoagulation indication.
The PARADISE-MI trial found sacubitril/valsartan to be well-tolerated and associated with a trend toward improvement in secondary endpoints. However, it did not significantly reduce the rate of heart failure or cardiovascular death following a heart attack compared to ramipril.
New research by Aalto University warns that climate change could push a third of global food production out of safe climatic space if greenhouse gas emissions continue growing unchecked. The study assesses the impact of climate change on crop production and livestock, highlighting regions most vulnerable to changes.
A new analytical approach for detecting contaminants in Heparin has been developed, increasing sensitivity by over 100 times and reducing analysis time and material requirements. This technique has the potential to improve the quality and safety of the widely used anticoagulant drug.
Researchers at Hospital for Special Surgery found that oral tranexamic acid (TXA) is non-inferior to intravenous TXA in preventing blood loss during total knee and hip replacement surgeries. The study suggests that oral administration of TXA may be logistically easier, less costly, and equally effective as IV TXA.
Researchers at the University of Pittsburgh are working on new soft magnetic materials and manufacturing processes to enable ultra-high frequency power electronics switching devices. The four-year project aims to establish a foundation for ultra-wide bandgap semiconductor materials in novel power electronics switching devices.
A new study reveals that retinal scans can identify early signs of Alzheimer's disease by detecting changes in blood vessels associated with the APOE4 gene. The research provides a potential path forward for early detection and treatment of neurodegenerative diseases.
Rice University bioengineers have created electrospun scaffolds from decellularized skeletal muscle that mimic native tissue and direct the growth of myotubes. The tunable scaffolds promote muscle regeneration with minimal crosslinking agents, offering a promising solution for reconstructive surgeries.
Researchers investigate the limits of quantum theory in describing an observer's experience, leading to a 'no-go theorem' for the persistent reality of Wigner's friend perception. The study challenges traditional assumptions about the nature of reality and raises questions about the reliability of an observer's predictions.
A study found daily probiotic use was associated with a 27% lower incidence of upper respiratory tract symptoms in overweight and obese individuals. This suggests a potential role for probiotics in preventing respiratory infections in this vulnerable population.
Researchers have discovered a misinterpreted model of immature flavivirus particles, revealing an unexpected organisation that could lead to new and better vaccines. The study's findings define the exact wiring of the immature virus before it becomes infectious, providing a solid foundation for designing tomorrow's treatments.
A study published in JAMA Health Forum found that nonfatal opioid overdose visits have more than doubled during the pandemic, while few patients who overdosed on opioids had received a prescription for naloxone. The number of individuals filling naloxone prescriptions fell by over 25% throughout the pandemic.
A new study has confirmed that UK children with cystic fibrosis have poorer lung function than their US peers, suggesting differences in treatment patterns may be the cause. The research also found that children in the US received more aggressive mucolytic therapy earlier in life.