Scientists at UCL have identified a new immunotherapy that targets acyl-CoA:cholesterol acyltransferase (ACAT), an enzyme helping to manage cholesterol levels in cells. Boosting ACAT inhibition boosts specific immune cells fighting both the virus and cancerous tumours, demonstrating its effectiveness as an immunotherapy.
Researchers at UCSF have discovered that brain waves travel both up and down the hippocampus, integrating messages from different areas of the brain. The finding suggests that brain waves can predict direction and may be a biomarker for cognitive activity.
A Penn State-led study found that maternal stress during pregnancy can shorten the telomeres of male lizard offspring, leading to decreased lifespan. The researchers discovered a sex-specific effect, where stressed mothers give birth to sons with significantly shorter telomeres, highlighting potential implications for human longevity.
A new technology has made it possible to quickly sequence the entire genome of plant pathogens, enabling faster diagnosis and identification of emerging pathogens. This breakthrough has great implications for the plant pathology field, allowing for more accurate identification of difficult-to-diagnose pathogens.
Researchers at Ural Federal University found that yoga and breathing exercises can improve attention and reduce hyperactivity in children with ADHD. The studies involved 16 children aged six to seven years who received special classes, including diaphragmatic rhythmic deep breathing exercises.
Research identified specific genetic variants associated with COVID-19 risk, including the ABO gene and others like SLC6A20 and ERMP1. These variants can increase the chances of developing COVID-19, highlighting the importance of genetic factors in disease susceptibility.
University of Alberta scientists have identified Toll-like receptor 4 as a potential target for preventing permanent hearing loss caused by the chemotherapy drug cisplatin. By inhibiting this receptor, they may be able to eliminate toxic side effects from the drug that cause hearing loss in childhood cancer survivors.
A qualitative study evaluates a crowdsourcing open call to gather community input for university COVID-19 safety strategies. The platform aims to increase engagement and effectiveness of safety measures, ultimately improving overall health outcomes.
Researchers developed a unique pre-clinical model of long-term HIV infection using subset of human CD4 cells, excluding those prone to attacking mouse tissue. The model showed that memory CD4 cells can be infected and killed by HIV or protected by anti-HIV drugs, paving the way for T-cell based therapies
Only a few hundred climate scenarios avoid significantly overshooting the 1.5°C limit, according to a new study. All realistic scenarios require significant emission reductions and rely on multiple mitigation levers, including carbon removal and land use changes. The window for meeting the target is rapidly closing.
Researchers found that plant-eaters diversified quickly after mass extinctions and evolved specialized features like powerful jaws to digest tough plants. This enabled them to thrive in environments with drying conditions and expanded groups of herbivores took over roles by pushing competitors aside.
Scientists at Johns Hopkins Medicine counted brain cells in fruit flies and three mosquito species, revealing an average of 200,000 neurons. This estimate likely represents a baseline number of brain cells required for complex behaviors. The study provides insight into the intricate processing capabilities of these insects.
The study created a comprehensive catalog of healthy breast tissue cells, enabling scientists to pinpoint the origin of abnormal changes. By tracking gene activity in over 15,000 cells, the team redefined healthy breast tissue and identified subpopulations with different responses to therapies.
Researchers found that individuals with asthma living in historically redlined neighborhoods have lower lung function than those in non-redlined areas. This association was independent of race and co-occurring diseases, suggesting that environmental factors play a significant role in worsening asthma outcomes in these communities.
Researchers from Heidelberg University found solar noble gases in an iron meteorite, indicating that solar wind particles encased in the Earth's core over 4.5 billion years ago. The discovery suggests a new perspective on the Earth's mantle and its geochemical development.
Two studies published in Contraception found that telehealth abortion improves access to reproductive health services, particularly for low-income persons and those living in rural areas. The studies also showed that most patients prefer receiving abortion pills through the mail and interacting with healthcare providers via telehealth.
Researchers at the University of Michigan have determined the first steps in converting light into energy for a type of bacteria that uses photosynthesis. By studying heliobacteria's reaction centers, they identified which pigments initially donate and accept electrons during charge separation.
A research team at USTC reports a new class of axial superlattice nanowires (ASLNWs) that enable large lattice-mismatch tolerance and vast material combinations. They achieve this by designing an axial encoding methodology for predictable, high-precision synthesis.
A team of researchers has developed first-in-class small molecules to inhibit the SET domain of the ASH1L protein, preventing critical molecular interactions in leukemia development. The lead compound, AS-99, successfully reduced leukemia progression in mouse models.
A new study found that perceptions of teacher sexual misconduct vary according to the perpetrator's gender, sexuality, and age. Respondents perceived female teachers as less detrimental, students in heterosexual pairings as more mature, and relationships with younger teachers as more acceptable.
A groundbreaking study by University of Minnesota researchers shows how engineered immune cells can move faster and more effectively through tumors, improving cancer therapies for millions worldwide. The research uses advanced gene editing technologies to modify T cells, enabling them to recognize and destroy cancer cells.
Mouse and human lymphatic endothelial cells use primary cilia to direct lymphatic network growth during development and in response to inflammation and wound healing. The presence of functional cilia is necessary for healthy lymphatic vessel development and proper regulation of lymphangiogenesis.
Researchers discovered that fair treatment alone is insufficient to foster a sense of value in groups; instead, recognizing individual talents and qualities provides a sense of inclusion while promoting mental health. This approach complements the idea of 'fitting in' by allowing individuals to stand out and feel valuable.
Researchers used fibre-optic sensing to obtain highly detailed temperature measurements from the surface of the ice sheet to its base, revealing a heterogeneous temperature distribution. This finding contradicts previous theories and highlights limitations in current models, including those predicting global sea-level rise.
Researchers developed an AI algorithm that can accurately identify the tiger mosquito (Aedes albopictus) from photographs sent by Mosquito Alert users. The algorithm correctly classified 96% of images, providing near-real-time detection and enabling faster control of disease transmission.
Researchers at FAU have discovered a new class of magnesium complexes in which the metal has a zero-oxidation state, forming elemental Mg in complex compounds. This discovery represents a landmark in the chemistry of magnesium and opens up new avenues for research into its unusual reactivity.
Scientists from Osaka University used machine learning methods to enhance signal-to-noise ratio in nanopore data, enabling higher precision measurements. The 'Noise2Noise' technique improved resolution of noisy runs, revealing faint features hidden by random fluctuations.
Researchers have shown that injecting heart muscle cells derived from human induced pluripotent stem cells that overexpress cyclin D2 can aid heart attack recovery. The treatment stimulates proliferation of existing heart muscle cells and promotes angiogenesis, a development of new blood vessels.
A study by Hospital for Special Surgery found hip fracture patients during COVID-19 had longer hospital stays, higher complication rates and more nonsurgical treatments. In contrast, those without the virus were discharged earlier with less use of intensive care units.
Researchers at the Lundquist Institute have discovered an antibody that can protect against mucormycosis, a deadly fungal infection with a high mortality rate. The humanized monoclonal antibodies are being manufactured by Vitalex Biosciences and aim to improve treatment outcomes for patients with COVID-19.
Clinical trials for pancreatic ductal adenocarcinoma consistently exclude minority groups, who experience poorer health outcomes. The lack of diversity in these trials hinders the development of targeted treatments due to racial differences in tumor biology and therapeutic response.
Kakshine is a new DNA fluorescent dye with unprecedented versatility, enabling super-resolution imaging of mitochondrial DNA in living cells and deep tissue imaging. Its applications include electrophoresis, quantitative PCR, and flow cytometry, making it a promising tool for DNA analysis.
A new benefit has been implemented, allowing eligible Veterans to receive urgent care from community providers. The study found that most Veterans who used the service lived within 30 minutes of a VA primary care site and had no copays for urgent care visits.
A team of researchers has installed the first seaweed farm in Puerto Rico to explore how environmental conditions influence the biological properties of cultivated macroalgae. The farm will support year-round harvesting and test the scalability of tropical seaweed farming for biofuels production.
A study published in Spine Journal reveals that most pediatric spinal fractures occur in motor vehicle accidents where seatbelts are not used. The majority of these injuries (63%) occur in teenagers aged 15-17, who are at highest risk for MVA-related spinal fractures. Wearing a seatbelt significantly reduces the risk of death and spina...
Researchers at Beckman Institute develop new manufacturing process that shortens production time from two days to just minutes, enabling the creation of self-healing structural materials. The technology has potential applications in various fields, including aerospace and construction.
A simulation study examined the impact of frequent testing and immunity-based staffing on COVID-19 transmission in nursing homes. The results showed that these interventions can significantly reduce the risk of transmission, making them effective strategies for preventing outbreaks.
Research shows that imaginative product displays can increase customers' purchase intention and actual purchases, as well as product sales and ROI. The effects are attributed to dual mechanisms of affect-based arousal and cognition-based inferred benefits.
Researchers argue that companies must provide explanations for algorithmic decision-making processes, as this is an ethical obligation apart from performance impact. They propose that companies can achieve transparency while maintaining trade secrets by hiring data interpreters or implementing explainable AI.
Researchers have discovered a new species of cyanobacteria, Anthocerotibacter panamensis, which can help study the dawn of oxygenic photosynthesis. The species lacks thylakoids and has unique carotenoid biosynthesis pathways, providing insights into the evolution of photosynthesis.
Researchers used ancient zircons to reconstruct Earth's evolution and determine that modern plate tectonics emerged roughly 3.6 billion years ago. This finding suggests that the dynamic crust, which supports life on Earth, began to take shape during this time.
Glaciologists have created a new slip law to measure the relationship between forces and glacier speed. The study uses high-resolution measurements of glacier beds and digital models to estimate glacier speeds, which can be used to predict sea level rise.
A web-based survey found that e-cigarette users had a higher risk of asthma, wheezing, and shortness of breath compared to non-users. The study also showed that past 30-day e-cigarette use was associated with increased respiratory symptoms even after controlling for cigarette and cannabis use.
A new laboratory method called TaqMan Array Card (TAC) has been validated for detecting a diverse range of bacteria that cause diarrheal disease. The TAC is faster and cheaper than traditional methods while delivering comparable results, enabling comprehensive monitoring of enteropathogens in informal settlements.
Research presented at ATS 2021 International Conference found that e-cigarette users have a higher odds of developing asthma and having asthma attacks. Current smokers also had an increased risk, with former smokers facing the highest odds.
A new theory of dreaming proposes that our brains create strange dreamscapes to counteract overfitting by familiarizing themselves with everyday experiences. This 'overfitted brain hypothesis,' inspired by AI regularization techniques, suggests dreams serve a purpose in generalization and world understanding.
Researchers from Rijksmuseum Boerhaave Leiden and TU Delft used neutron tomography to examine a highly magnifying specimen without damaging it. The findings reveal that Van Leeuwenhoek's lenses were made using a common production method, contradicting long-held assumptions about his 'secret' technique.
A University of Stirling study found that COVID-19 lockdowns triggered feelings of loneliness in older adults but also encouraged them to engage with technology, reconnect with friends, and build new relationships with neighbors. The research highlights the importance of addressing loneliness and social support in older adults, particu...
A University of Seville group discovered the mechanism by which BRG1 inactivation leads to genetic instability and tumour formation. The study reveals that the SWI/SNF complex plays a crucial role in resolving chromosomal conflicts, and its mutation can cause DNA replication defects and chromosomal breaks.
Researchers evaluated hospital compliance with CMS ruling requiring public listing of charges in a machine-readable file, revealing inconsistent results. The study found that many US hospitals failed to comply with the rule, hindering transparency in healthcare pricing.
Researchers have identified the gene responsible for a male European corn borer moth's preference for its female counterpart's pheromone. The discovery provides insights into the evolution of mating signals and could help predict the spread of resistance to genetically modified insecticides, offering potential benefits for pest control.
During the COVID-19 pandemic, naloxone prescriptions decreased in the US, while overall prescriptions and opioid prescriptions remained relatively stable. Researchers analyzed changes in prescription trends to better understand the impact of the pandemic on opioid use.
Scientists successfully deliver oxygen through the lining of the intestine, a process called enteral ventilation or EVA, to alleviate respiratory failure. The method shows promise for reducing negative effects of oxygen deprivation and has potential as a less invasive alternative to traditional ventilators.
A study by Vanderbilt researchers found that maintaining a healthy lifestyle can reduce colorectal cancer risk by nearly 40% among those with a high genetic risk. Those at low genetic risk see only a 25% reduction, highlighting the importance of prevention strategies for high-risk individuals.
A multi-institutional team has identified a compound that prevents the lengthening of the heart's electrical event, preventing cardiac arrhythmia. The compound, C28, enhances the IKs potassium ion channel function without affecting normal action potentials.
Scientists at PNNL develop a novel material capable of capturing light energy, displaying high efficiency and programmability, with potential applications in photovoltaics, bioimaging, and beyond. The researchers' bio-inspired approach leverages natural hierarchical structures for exceptional properties.
The Acoustical Society of America will host its 180th meeting online June 8-10, offering new features to ensure an exciting experience for attendees. The meeting will include prerecorded talks, live discussion sessions, panel discussions, and lightning round sessions.
Researchers discovered that water can bond strongly with iron under extreme conditions, explaining the presence of significant amounts of hydrogen in the Earth's core. This finding suggests that much of the water that arrived on Earth during its formation might be stored in the core as hydrogen.
Ion transporters in chloroplasts play a crucial role in regulating gene expression, influencing the efficiency of photosynthesis. This discovery has significant implications for enhancing photosynthetic efficiency under unfavorable environmental conditions.
A novel screening strategy using cultured plant cells can identify microorganisms that stimulate plant immune mechanisms without harming plants. Eight bacterial strains were found to boost cryptogein-induced ROS production, inducing whole-plant resistance to bacterial pathogens.