Reconstruction of ancient oral microbiomes from the Upper Paleolithic to the Neolithic Periods in Southern Europe reveals a significant expansion of microbial species with the transition to agriculture. The studies sequenced ancient DNA from dental calculus, finding a dominant Anaerolineaceae species that diversified geographically.
A multi-hospital analysis of patients who experienced allergic reactions to their first mRNA COVID-19 vaccine dose found that all patients who received a second dose tolerated it without complications. The study suggests it's safe for most individuals to receive a second dose, despite initial concerns.
A study published in the British Journal of Ophthalmology found nerve fibre damage and an increase in dendritic cells on the eye surface may be identifying features of 'long COVID'. Patients with neurological symptoms showed greater corneal nerve fibre loss and higher dendritic cell density compared to those without symptoms.
Geophysicists use anisotropy of magnetic susceptibility (AMS) and geochemical analyses to map out magma pathways along over 100 km of the Oman spreading axis. This project aims to provide greater understanding of dynamic processes occurring at depth beneath the seafloor.
The study suggests that green habitat corridors connected eastern Africa to the Levant across the present-day Judean Desert, facilitating the dispersal of crested rats and humans. This correlation dates back to a brief period during the Last Interglacial.
Researchers at University of Pennsylvania School of Medicine developed a new technology for cellular immunotherapy that targets KRAS mutations in lung, colorectal, and pancreatic cancers. The therapy uses human cells to mobilize an immune system attack on mutated KRAS tumors and shrink them.
A new study suggests that emotional expression plays a significant role in leadership effectiveness. Women are seen as more effective leaders when they express calm and happy emotions, whereas men are viewed negatively when expressing negative emotions. The study's findings have implications for leaders to manage their emotions to maxi...
Researchers reprogrammed whale cells into neuronal cells to investigate the neurotoxic effects of an environmental pollutant. The study found that exposure to the pollutant led to apoptosis and disrupted cellular signaling pathways, ultimately causing neurodegeneration.
Researchers recreated damage seen in a widely studied form of frontotemporal dementia by growing special types of cerebral organoids. The study found that the mutated tau protein triggers the death of specific class of neurons, which can be prevented with an experimental drug.
Researchers found that individuals born in the mid-1990s were less likely to be classified as an offender compared to those born in the 1980s. Older cohorts were more likely than younger cohorts to have adolescent-limited or chronic arrest trajectories into adulthood.
A new study led by Iowa State University scientist Nicole Valenzuela sheds light on the function of sex chromosomes in turtles. The research found that temperature affects the dosage compensation mechanism in softshell turtles, leading to an imbalance in protein production.
Scientists from Tokyo Metropolitan University have created a technology that allows objects to be lifted off reflective surfaces without physical contact using sound waves. They employed a hemispherical array of ultrasound transducers to generate a 3D acoustic field, stably trapping and lifting a small polystyrene ball.
Researchers at Ruhr-University Bochum have developed a new reverse optogenetic tool that can be controlled by light, suitable for studying changes in the brain responsible for epilepsy.
A high school student presented an observational study on the distribution of Oral-Health Impact Profile (OHIP5) scores in a general adult population at a private dental clinic. The study found no significant difference between male and female populations in OHIP5 score distributions.
Researchers found that green pigments had impurities that produced porous, poor quality concrete, while red and blue pigments had little effect. The study discovered that the morphology of hydration products and kinetics was related to compressive strength.
Researchers found a strong association between higher net worth and lower mortality risk among adults in the US. Even within sibling pairs, those with greater wealth tended to live longer, suggesting that wealth accumulation may have a causal impact on longevity.
Researchers have created an 'atlas' charting how antibodies attack the spike protein of SARS-CoV-2, identifying broadly responsive neutralizers and regions resistant to attack. The study highlights the importance of studying antibody responses for developing effective COVID-19 booster vaccines.
A new study reveals that increased lobbying spending leads to decreased customer satisfaction, which in turn reduces the effect of lobbying on firm value. Firms can mitigate this loss by adopting marketing-focused efforts, such as having a marketing CEO or spending more on R&D and advertising.
Researchers studied how adolescent experiences of racial, ethnic, national origin, and other marginalized identities are associated with negative health, mental health, and violence outcomes. The study found a significant link between these experiences and poorer outcomes among adolescents.
Researchers at UC San Diego found that mice can manipulate unpredictable dopamine pulses, which occur approximately once per minute, and learn to anticipate and act upon them. This new understanding opens a dimension in the study of dopamine and brain dynamics.
The American Dental Association (ADA) created a centralized hub to disseminate COVID-19 evidence, policy, and guidance to dental professionals. The initial guidance focused on urgent and emergency care, with subsequent tools developed to address patient screening, operatory disinfection, and return-to-work protocols.
A new machine learning-based model predicts ICU patients' mortality risk based on characteristics such as demographics, comorbidities, and APACHE II score. The model overcomes traditional approaches' weak points, offering a better alternative for personalized medical predictions.
A recent study found that meeting the Paris Agreement's 2°C target will increase net energy sector jobs globally by about 8 million by 2050. The majority of these new jobs will be in the solar and wind industries, while fossil fuel extraction jobs are expected to decline rapidly.
Scientists at Washington State University identified a DNA region known as VNTR2-1 that drives telomerase gene activity, which helps prevent aging in certain cells. The study suggests that this 'junk DNA' sequence contributes to genetic diversity of aging and cancer development.
A new study finds that delayed hospital floor transfers and ED arrivals on Sundays are associated with a higher short-term risk of delirium in older patients. Delirium is a serious cognitive disorder that can be prevented in up to 40% of cases, and improved processes between the ED and hospital can help reduce its occurrence.
A new study found that quality-of-life policing restricts access to free Wi-Fi, especially for Black and other people of color. Wealthier neighborhoods experienced a 5% increase in quality-of-life complaints after internet access was introduced, while other areas did not.
Researchers investigated the association between net worth at midlife and subsequent longevity. The study found a significant positive correlation between wealth and longevity among individuals, as well as their siblings and twins.
Researchers found that patients who developed severe COVID-19 had a muted antiviral response in cells collected from nasal swabs at the time of diagnosis. This early response may determine the course of disease, opening up new avenues for interventions to prevent severe disease.
A new radiotracer, 18F-TRX, has been developed to measure iron concentration in tumors, predicting treatment response. The agent successfully distinguished between tumor types and identified those likely to respond to iron-targeted therapies.
A new study from Simon Fraser University found that only 44.2% of children with mental health disorders receive services, highlighting unacceptable service shortfalls in high-income countries. The study's authors call for increased investment and protection of children's mental health budgets to address growing needs.
A phase 2 trial of Loncastuximab tesirine demonstrates efficacy in treating relapsed or refractory Diffuse Large B-Cell Lymphoma (DLBCL), with a response rate of 48% among patients. The drug, an antibody-drug complex targeting CD19, provides a novel mechanism of action for this patient population.
Ashfaq Adnan's team uses 3D printing to create multilayered materials for smart helmets, absorbing impact energy and deflecting directed energy attacks. The resulting helmets will be lightweight and resistant to blast impacts, alerting soldiers to potential dangers.
The research found dramatically different quantum state population distributions of OH and OD fragments from HOD photodissociation. The branching ratios display large wavelength-dependent isotopic fractionation, influencing D/H isotope heterogeneity in the solar system.
Researchers found that Fgr binds to Numb, activating the signalosome and promoting cell differentiation and G1/0 arrest. The study provides insights into RA resistance and suggests potential therapeutic targets.
Researchers identified four key themes contributing to diseases of despair in Pennsylvania: financial instability driving self-harming behavior, lack of infrastructure exacerbating distress, deteriorating sense of community leading to loneliness and isolation, and family fragmentation. These findings have significant implications for u...
Researchers identified molecular markers to purify unstable regulatory T cells, which can switch from protective to damaging function. Exposing these cells to a destabilizing environment also removes the unstable cells, leaving behind stable regulatory T cells for therapeutic use.
The AZ HEROES study, led by the University of Arizona Health Sciences, has received a $15 million award from the CDC to continue its research on COVID-19 vaccine effectiveness. The study will expand to include children aged 4 months to 17 years and focus on underserved populations.
The project digitized over three million specimens collected by botanists and naturalists across the southeastern US over 200 years. The resulting database is now freely accessible online, providing valuable insights into ecosystems, species distribution, and the effects of climate change.
A strategic toolkit has been developed to help manage the nexus between water, energy, food and ecosystems, reducing disputes in catchment areas. The DAFNE methodology uses state-of-the-art modeling techniques to enable participatory planning and engage stakeholders, finding compromises and synergies that benefit everyone.
Researchers developed a new index to track tropical forest vulnerability using satellite data, revealing regions at risk due to climate change and land use pressures. The Tropical Forest Vulnerability Index (TFVI) provides early warnings for conservation efforts.
Biochemical processes exhibit topological protection, ensuring robustness to changes in system shape or disorder. Edge currents emerge from futile cycles, driven by energy consumption, and are linked to out-of-equilibrium nature.
The ASCCP Task Force supports the ACS's 2020 cervical cancer screening guidelines, which recommend primary HPV testing. During the transition to primary HPV screening, the Task Force endorses any cervical cancer screening approach, including co-testing and cervical cytology alone.
The article highlights the advantages of intranasal vaccination against SARS-CoV-2, including needle-free administration and elicitation of mucosal immunity in the respiratory tract. Researchers argue that this approach may be more effective than traditional intramuscular vaccinations, offering a broader range of protection.
A new study published in PLOS ONE warns that Kenya's Tana River Basin species will be unable to survive if global temperatures continue to rise. However, remaining within the goals of the Paris Agreement could save many species by protecting refugia from climate change.
Researchers at Aalto University have developed a bio-based coating for wood using lignin, a natural polymer abundant in wood and other plant sources. The coating retains the natural structure of wood, making it more water repellent and resistant to stains and sunlight.
A novel therapeutic agent, MS21, has been developed to disrupt a biological pathway that helps cancer survive. The therapy shows high effectiveness in vitro by causing the degradation of AKT, an enzyme overly active in many cancers.
Flinders University researchers have successfully manipulated Beta-lactoglobulin, a major whey protein in cow's, sheep's, and other mammal's milk, using an Australian-made thin film microfluidic device. The device combines with a new form of biosensor to control and monitor protein denaturation and renaturation.
Researchers used beetroot pigments to visually track soil fungi colonizing plant roots in real-time. The technique enables selection of fungi that provide the biggest benefits in agricultural scenarios, enhancing crop production while reducing artificial fertiliser needs.
Researchers from the University of Otago debunked a long-held belief about Paranthropus' eating habits, finding no evidence to support regular consumption of hard foods. Instead, they found similar tooth fracture patterns in fossil humans and living primates that eat soft fruits or leaves.
A Yale study found that US methadone clinics were slower to accept new patients and longer in providing treatment compared to Canadian clinics during the pandemic. Clinics with open access models provided timelier treatment access, but only a fraction of US clinics offered this option.
Researchers found that Pseudomonas bacteria use a network of proteins to regulate twitching and respond to mechanical forces, allowing them to navigate based on what they feel in front of them. This 'sense of touch' helps the microbes move forward in the same direction when moving as a group.
A study published in Frontiers in Human Neuroscience found that brain activity associated with aesthetically appealing natural landscapes is not limited to the reward system, but also involves early visual areas. This suggests an early form of beauty perception that can be triggered by surprise and unexpected stimuli
Researchers at Texas A&M University have developed an organ-on-a-chip that models the interaction between platelets and ovarian cancer tumors, revealing a crucial genetic signaling pathway. This breakthrough technology has potential applications in observing how cancer cells interact with blood vessels and testing novel treatments.
A Chinese satellite has reported a global carbon net of six gigatons, indicating an increase in carbon emissions that contributes to climate change. The TanSat satellite's data will be used to independently verify national emission inventories and help ensure transparency across the globe.
A study by St. Jude Children's Research Hospital demonstrates the power of comprehensive whole genome, whole exome and RNA sequencing to better understand and treat each patient's unique cancer. The research found that 86% of patients had at least one clinically significant variation in tumor or germline DNA.
Researchers developed a general framework for dynamic control of THz wavefronts using cascaded metasurfaces. By varying the polarization of a light beam with rotating multilayer metasurfaces, they demonstrated efficient redirection and manipulation of THz beams, overcoming limitations in local tuning.
Scientists have developed a novel indicator to monitor danger to the world's rainforests, which are losing their capacity to cycle carbon and water. The unique tropical rainforest index (TFVI) provides a snapshot of long-term observations, revealing that rainforests are more vulnerable than previously predicted.
Researchers found that severe COVID-19 patients have muted interferon responses, leading to a failed early immune response. The study suggests that building on type I interferon may be key to developing treatments for severe COVID-19.
University of Virginia researchers identified a potential avenue for treating seizure-related brain injuries by harnessing the brain's natural immune response. Microglia cells were found to form pouches that tend to swollen dendrites, suggesting a 'healing' process.
Studies investigate how ideological differences impact attitudes towards diverse community features and what 'diversity' means to conservatives and liberals. Researchers find that demographics, viewpoints, and consumer features are perceived as relevant aspects of diversity.