Researchers estimated the extent of Medicare Part B medical services subject to private insurer prior authorization under coverage policies. The study found that these restrictions would have resulted in significant spending savings, affecting healthcare delivery and policy.
A study of 512 patients with rheumatoid arthritis or systemic lupus erythematosus found that irregular hydroxychloroquine supply was linked to muscle pain and rash, while irregular methotrexate intake was associated with joint pains.
A study in the Peruvian Amazon reveals that declining fish biodiversity poses a significant risk to human nutrition, particularly for iron and essential fatty acids. The researchers predict that a tipping point will be reached when 40 of 60 food species become scarce or extinct, leading to a nosedive in nutritional value.
Researchers are investigating CAV1's dual role in tumor metastasis and suppression using machine learning-based analyses of super-resolution microscopy. They leverage computer vision and AI to automatically analyze data, capturing three-dimensional coordinates with nanometer resolution.
A new R-Gene Atlas would help identify genetic solutions to disease resistance in commercial wheat varieties, reducing global food security risks. The proposed platform would enable breeders to design gene stacks using computer modeling before starting breeding in the field, with a potential cost of £41 million.
The Jebel Sahaba cemetery, 13 millennia old, was initially thought to be a testament to prehistoric warfare. However, recent analysis reveals a succession of violent episodes, likely exacerbated by climate change. The study found that individuals bore injuries from projectiles and repeated episodes of violence over their lifetimes.
The American Gastroenterological Association (AGA) recommends early introduction of biologics for patients with moderate-to-severe luminal and fistulizing Crohn's disease. Biologics are the most effective treatment option, which should be used early rather than delaying their use until other treatments fail.
Researchers developed a neuromorphic chip that can detect high-frequency oscillations and recognize complex biosignals in real time. The technology has the potential to improve neurosurgical interventions and monitor epilepsy outside of hospitals.
Ant workers infected with a tapeworm live significantly longer than uninfected nest-mates, resembling the lifespan of ant queens. The parasites alter expression of ant genes and release antioxidants, contributing to their extended lifespan.
A new study finds that plastic surgeons' apparent gender and ethnicity can influence patient perceptions of their competence. However, the findings suggest more favorable perceptions of surgeons of the same racial/ethnic group, which may be crucial for cosmetic surgery patients in the US.
Researchers have developed a new technique called diffuse optical localization imaging (DOLI) that enables noninvasive imaging of the brain's microvasculature and neural activity at depths of up to 4 millimeters. This method uses the NIR-II window and is poised to bring new insight into how the brain works in health and disease.
A new panorama of the Galactic Center builds on previous surveys, expanding Chandra's high-energy view. The image features X-ray and radio emission intertwined threads, bound by magnetic fields that may have formed through magnetic reconnection. This process drives galactic-scale outflows and affects cosmic rays and interstellar medium.
A research team led by the University of Houston will examine external review letters and tenure clock extensions to uncover ways to reduce bias and increase representation of faculty from diverse backgrounds. The project aims to create training programs to promote transparency and fairness in promotion and tenure processes.
CSU researchers have observed early RNA transcription dynamics by recording where, when, and how RNA polymerase enzymes kick off transcription. The breakthrough technology has far-reaching potential, including sharpening understanding of basic biological processes and unveiling genetic underpinnings of certain diseases.
Researchers analyzed ancient DNA from 25 humans, revealing that the population dynamics between 40,000-9.5 ka were influenced by Ice Age climatic fluctuations. The study provides evidence for an Asian-specific variant associated with anthropogenic traits.
A new computational method estimated that mass gatherings during the Malaysian election directly caused 70% of COVID-19 cases in Sabah and 64.4% elsewhere in Malaysia. The study used a synthetic control method to compare the aftermath of the election with what might have happened without the gatherings.
The researchers developed a biomaterial made from discarded bullfrog skin and fish scales that acts as a scaffold for bone-forming cells to multiply, leading to the formation of new bone. The biomaterial has shown low risk of triggering an inflammatory response and could be used to assist with bone growth around surgical implants.
A national database analysis reveals a cumulative incidence of 2.75% for autism spectrum disorders among children born between 2009 and 2014. The study found regional differences and an increasing trend over the years, with the proportion of diagnosed individuals showing a significant increase globally.
A DNA-led framework is needed to reunite separated migrant families, prioritizing scientific rigor and rights protection. The proposed framework addresses trauma-informed protocols and existing standards for DNA technology, aiming to establish a global protocol for living family reunification.
A study found that mindfulness-based intervention (MBI) improved mindful parenting, self-compassion, and mental health in parents of children with ADHD. The training also showed small effects on ADHD symptoms and anxiety in children, but a subgroup benefited from improved self-control.
A University of Córdoba study found that mixing two herbicides in laboratories results in a more effective and environmentally friendly method for controlling difficult-to-control weeds. The commercial mixture was shown to have a lower environmental impact than manual mixing, reducing risks and boosting effectiveness by 10-20%.
Francisella tularensis can persist in a dormant state for over six months in cold water without nutrients, remaining fully virulent. This discovery changes the understanding of the bacterium's ecology, suggesting it spends most of its time outside a host and amplifies disease events in mammals.
Researchers found that widely used SRU Consensus Criteria overestimated ICA stenosis severity. New criteria propose increasing peak systolic velocity thresholds and requiring higher PSV ratios for accurate diagnosis.
University of Guelph researchers have discovered how entangled proteins in brain cells enable Parkinson's disease to spread. Misfolded alpha-synuclein aggregates spread to other parts of the brain, impairing areas responsible for motor function and cognition.
A Flinders University study found participants with an automatic bias towards soft drinks were more responsive to TV ads than those without these tendencies. The researchers suggest targeting people who show cognitive vulnerabilities to reduce consumption of sugary drinks.
A clinical trial found that nearly half of patients treated with nivolumab and ipilimumab were alive six-and-a-half years after treatment, outperforming those who received either drug alone. The combination therapy demonstrated a durable benefit for advanced melanoma patients.
A digital tool developed by UK University of Bath predicts protein stability with speed and accuracy, cutting down on time and cost of drug development. The tool, called Quantitative Understanding of Bio-molecular Edge-Shift (QUBES), uses fluorescence and mathematical algorithms to analyze protein structure and predict stability.
Researchers at Columbia Engineering have developed a new autonomous robot called EVA, which uses artificial intelligence to teach itself how to make appropriate reactive human facial expressions. This technology has the potential to improve interactions between humans and robots in various settings, such as nursing homes and factories.
A collaborative research group successfully controlled the magnetization of a ferromagnetic thin film using circular vibrations of surface acoustic waves. The discovery opens up new possibilities for combining and developing acoustic and magnetic devices.
A new article analyzes seven books that discuss health inequalities in Latin America and the Caribbean, highlighting regional disparities in healthcare access. The author calls for a universal approach to health care based on equity and inclusion to address these inequalities.
A new study suggests that managing local environmental conditions can help coral reefs persevere in the face of climate change. Local factors like macroalgae presence and nutrient pollution exacerbate coral loss, but also offer opportunities for management to boost reef resilience.
Researchers identify immunosuppressive cells as key link between obesity and cancer risk, progression, and metastasis. Altered metabolic factors in obesity activate these cells, leading to poor survival and resistance to immunotherapy in cancer patients.
A team of biologists has developed a new classification system for cell nuclei, revealing how species can switch between different nuclear types. The researchers discovered that mutations in a protein called condensin II can convert human cells into fly-like nuclei, and created a computer program to simulate the effects.
Researchers from Hefei Institutes of Physical Science created three manganese oxides with different Mn valences for high-capacity capacitive desalination. The results showed that these electrodes displayed high salt adsorption capacity and corresponding high salt adsorption rates surpassing other carbon materials.
Researchers found clear reflected seismic phases between 410-km and 660-km, indicating subducted oceanic plates are trapped at the bottom of the mantle transition zone. This discovery sheds light on mantle dynamics and circulation of deep materials.
A new study reveals that valuing fair contribution to public good and self-control are key factors in practicing health-protective behavior during the COVID-19 pandemic. People who prioritize cooperation with others and expect them to do their part are more supportive of government regulations.
Researchers at CU Boulder discovered that a sudden change in slushy iceberg aggregates can trigger calving events up to an hour before they occur. The findings may help scientists predict future sea-level rise scenarios and understand the forces determining how much ice discharges into the ocean.
Researchers developed a portable saliva screening test that detects SARS-CoV-2 using infrared light technology, offering faster and more efficient testing than current gold standard RT-PCR. The new approach has significant advantages, including speed, ease of use, affordability, and reduced risk to patients and healthcare workers.
An online survey capturing COVID-19 symptoms received over 87,000 responses, providing important insight into the spread of disease. The survey revealed patterns of symptoms and correlations with testing rates in U.S. states.
Researchers analyzed YouTube comments on exotic animal videos and found overwhelmingly positive reactions to human-animal interactions. The study highlights concerns about the normalization of exotic pets and the exotic pet trade due to platform portrayals.
Researchers from Simon Fraser University and Canadian Space Agency will develop a new system to capture detailed seismic and gravimetric models of the lunar subsurface. This project aims to advance our understanding of the moon's geophysical properties and inform future exploration, potentially enabling human settlement.
Researchers at Johns Hopkins Medicine found long-term exposure to PM2.5 increases the risk of losing one's smell by nearly twice, potentially due to airborne pollutants reaching the olfactory nerve. The study also highlights the need for better air pollution management, especially in vulnerable populations.
A study published in the Journal of Sleep Research found that disrupted slumber can be associated with cognitive dysfunction in middle-aged and older men. The research suggests that optimal attention and cognitive speed may be affected by poor sleep, particularly in day-to-day activities such as driving and physical activities.
Researchers found that disturbances in cholesterol catabolism are associated with increased risk of Alzheimer's disease and vascular dementia. The study also suggests that bile acid synthesis may impact brain signaling pathways, leading to sex-specific effects on dementia progression. Further studies are needed to confirm these findings.
A new study found that delaying lung cancer surgery for more than 12 weeks after diagnosis is associated with a higher risk of recurrence and death. Patients who underwent surgery within this time frame lived 7.5 months longer than those who delayed treatment.
A team of researchers studied how the brain recovers from general anesthesia, finding that recovery unfolds over time and higher cognition recovers first. After anesthetizing 30 healthy adults for three hours, they discovered that abstract problem-solving abilities return before reaction time and attention.
Researchers developed a novel immunosensor called BRET Q-body, which works on the bioluminescence resonance energy transfer principle. The sensor detects antigens by inducing fluorescence through an enzyme-luminescent substrate reaction, allowing for simple and accurate immunoassay tests.
Patients undergoing total hip arthroplasty (THA) show significant improvements in pain, function, and quality of life, as well as improved walking gait biomechanics. However, daily physical activity levels remain largely unchanged, with most patients engaging in only light physical activity.
Scientists from Scripps Research have discovered a cross-reactive coronavirus antibody that neutralizes SARS-CoV-1 and other coronaviruses, including those causing the common cold. The finding is a promising development for the eventual development of a pan-coronavirus vaccine.
A study published in Nature Metabolism found that specific proteins in the blood can predict an individual's trainability and response to exercise. The researchers identified 147 proteins related to cardiorespiratory fitness, which improved their ability to predict an individual's change in VO2max.
A new study by NUI Galway confirms that Noble False Widow spider bites can cause severe envenomations, ranging from mild pain to debilitating symptoms and even hospitalization. The research team established a DNA database to identify the species, revealing that most bites occur in homes and around sleep sites.
A global study has discovered over 10,000 previously unknown bacteria and viruses in public transit systems and hospitals worldwide. The researchers mapped urban antimicrobial resistance and identified potential city-specific signatures for some genes.
Scientists have discovered a way to synthesize highly active single-atom catalysts using iron-breathing bacteria, promising a cheap and reliable method for hydrogen production. The innovation utilizes the bacterium's metal-reducing ability to conduct electrons and produce single atoms of catalytically active metals.
New research identifies persistent Gαs associated signaling changes in lipid rafts following drug withdrawal as the cause of antidepressant withdrawal syndrome. This finding has significant implications for developing personalized treatment for depression.
A global study reveals that physical activity levels dropped by 41% and mental well-being declined by 26% during pandemic-related restrictions. Exercise is known to boost immune function and reduce mortality risk, but too little exercise may contribute to premature deaths.
A Penn State scientist has developed a new mathematical formula that may solve the decades-old problem of spacetime in Einstein's theories of relativity. By placing space and time on an equal footing, Gopalan's approach removes the negative sign problem, allowing for traditional Euclidean geometry to be applied.
Researchers have discovered that naturally occurring variants in yeast can suppress harmful mutations, potentially contributing to genetic diseases like cancer. The study found that 26% of harmful mutations were suppressed by a single 'rescue mutation' in wild yeast strains.
The 58th ERA-EDTA Congress features presentations on groundbreaking studies for C3 glomerulopathy, primary IGA nephropathy, focal segmental glomerosclerosis, and end-stage kidney disease. Expert insights into treatment strategies will be shared during the virtual press conference.
Scientists have created a new instrument that can sort and sequence the genome of individual soil bacteria while identifying their functions. The RACS-Seq technique uses laser tweezers and gravity to analyze each bacterium one by one.
Researchers from UOC's PSINET group found that trust enables parents to confront the role of parent/caregiver without high levels of stress. A long process of overcoming fear and finding meaning leads to a reparative effect on existential unease, resulting in well-being.