Researchers developed a novel nanobody-based detection method for recombinant human interferon α2b (rhIFNα2b), which has a lower detection limit than existing methods. The assay's operation time was shortened from two days to a few minutes, making it suitable for rapid market counterfeit detection and early diagnosis of hepatitis.
Archaeologists confirm early humans made backed artefacts in the same shape across southern Africa, indicating strong social connections and communication. The findings suggest that these social networks allowed early populations to prosper and eventually migrate out of Africa.
Researchers used bacteriophage therapy to treat 20 complex, antibiotic-resistant lung infections in a clinical trial, resulting in no adverse reactions. More than half of treated patients experienced symptom improvement or reduced bacterial presence. The study's findings advance the promise of phage therapy as an alternative to traditi...
Researchers developed an algorithm to improve matching efficiency, considering user preferences and behavior. The new algorithm shows improved results in field experiments, with at least 27% more matches than the current one.
Scientists have identified a new pathway for peroxisome division, independent of Mitochondrial Fission Factor (MFF). The study, led by Professor Michael Schrader, reveals that PEX11β and FIS1 cooperate to divide peroxisomes, restoring normal morphology. This discovery offers potential therapeutic options for diseases caused by defects ...
Researchers discovered over 1,200 RNA viruses linked to carbon absorption on the ocean floor. The study suggests engineered viruses could be used as 'knobs' to control carbon storage, potentially slowing climate change.
The German Research Foundation has granted funding to Johannes Gutenberg University Mainz (JGU) and its strategic alliance partners for four years. Researchers in materials sciences, biophysics, and medicine are working on three collaborative projects with a total funding volume of EUR 35 million. The focus is on developing multiscale ...
A study from the University of Tsukuba found that home oxygen therapy, care level need 4-5, and cancer are key predictors of frequent emergency house calls among elderly patients. This prediction can help allocate medical resources effectively.
The Department of Energy has awarded Early Career Research Program funding to three Oak Ridge National Laboratory scientists. The awardees will receive $500,000 annually for five years to support their research in fusion energy, advanced scientific computing, and biogeochemical controls on phosphorus cycling.
A recent study published in Cell Reports Medicine reveals that a gene family is involved in immunotherapy resistance, allowing tumor cells to evade immune detection. Inhibiting this gene family, including RNF31, makes tumor cells more susceptible to immune cell destruction.
Researchers found that infants can punish antisocial behavior exhibited by a third party, indicating an intrinsic motivation for morality. The study's findings suggest that humans may have acquired behavioral tendencies toward moral behavior during evolution.
The researchers successfully demonstrated attosecond-pump attosecond-probe spectroscopy to study non-linear multi-photon ionization of atoms. The experiment showed that the absorption of four photons from two attosecond pulse trains led to three electrons being removed from an argon atom.
Researchers have identified the remains of Europe's largest ever land-based hunter, a 10m long spinosaurid dinosaur that lived around 125 million years ago. The 'White Rock spinosaurid' was a predator of immense size and likely supported a range of scavengers after death.
A novel BRAF inhibitor, C1a, has been developed to cross the blood-brain barrier and treat melanoma brain metastasis. The study found that C1a triggered robust responses in patient-derived models and outperformed approved BRAF inhibitors, achieving significant increases in survival rates.
Researchers at the Kosinski Group used a combination of cryo-electron tomography, single particle cryo-EM, and integrative modelling to create the most complete model of the human NPC to date, covering over 90% of its core. This breakthrough enables scientists to understand the NPC's structure and function in greater detail.
A Galapagos giant tortoise species previously believed to be extinct has been confirmed to still exist, thanks to genetic research that sequenced the genome of a single specimen and compared it with living individuals. The study's findings offer hope for the recovery of this species.
Researchers developed a hot-melt tissue adhesive that can heal operative wounds without causing adhesions. The adhesive, made from biopolymers, transforms into a stable gel at body temperature and eventually decomposes, preventing postoperative complications.
A new study led by Cedars-Sinai research suggests that androgen hormones interfere with the body's ability to fight bladder cancer, explaining why males experience higher cancer rates. Androgen deprivation therapy may improve treatment outcomes for male patients.
Researchers at the University of California San Diego have developed a tiny, flexible neural probe that can record and stimulate neural activity while minimizing injury to surrounding tissue. The probe is ideal for studying peripheral nerves or the spinal cord, where traditional probes may not fit due to its small size and flexibility.
Researchers from Japan and the US share new technologies and blood biomarkers to detect pancreatic cancer and identify high-risk individuals. The findings aim to decrease cancer mortality rates by developing attractive new methods for early diagnosis.
A UVA researcher has earned a prestigious NSF CAREER award to develop new models and data compression algorithms that will make the storage and analysis of large data sequences more efficient and accurate. The goal is to tackle the challenges of data storage capacity, particularly for genomic data.
Scientists employed artificial intelligence to determine the 3D structure of the VP8* B domain in group B rotavirus, a crucial step towards understanding its interaction with host cells and developing new treatments. The newly described structure reveals unique sugar recognition capabilities, distinct from other rotaviruses.
Researchers found that certain characteristics of refugia led to more tree regeneration, with taller trees and mountain hemlock species showing higher seed dispersal. The study suggests that natural regeneration is possible in some areas, making replanting efforts unnecessary and potentially harmful.
Researchers at Northwestern University have developed a photosynthesis-inspired process to convert acetylene into ethylene, a key ingredient in plastics. The new method uses visible light and water instead of high temperatures, flammable hydrogen, and expensive metals, achieving nearly 100% selectivity for ethylene.
Researchers analyzed 16 ancient genomes from Wallacea, revealing striking differences between regions and a previously unknown ancestry contribution from Mainland Southeast Asia. The findings suggest multiple human dispersals into Wallacea and major implications for the understanding of Neolithic dispersals into Island Southeast Asia.
A giant tortoise from the Fernandina Island species, believed extinct for over a century, has been confirmed alive through genetic sequencing. The discovery opens up new questions about its evolutionary relationship to other Galápagos tortoises and provides hope for conservation efforts.
A new study reconstructs streamflow data for the Colorado River up to 800 years into the past, revealing an unmatched second-century drought. Compared to current drought levels, this 22-year period had only 68% of average water flow.
Researchers at McMaster University found that older adults with Type 1 diabetes are at a higher risk of reduced muscle strength and cardiovascular complications. They discovered abnormally low diastolic blood pressure in these patients, which may indicate early increased cardiovascular disease risk.
A study published in PNAS reveals that about 15.4% of rhinos in Kruger National Park have been infected with M. bovis, the pathogen causing bovine tuberculosis. The finding highlights the need for a one health approach to support global conservation efforts and prevent potential spread to human health.
A study by Australian National University researchers found genetic evidence of ancient migration and intermingling between Austronesian peoples and local populations in Wallacea. The findings suggest a significant maritime migration occurred between 3,000 to 3,500 years ago.
Research reveals Paradise, California's water contained VOCs at levels exceeding EPA standards due to degraded plastic pipes near or above ground. To protect communities, experts recommend burying service lines deeper, using isolation valves, and monitoring temperature thresholds.
A new study has found a temperature-dependent latitudinal gradient in nearshore fish predation, with greater predation intensity and stronger impacts in warm equatorial waters. This research could help inform patterns of biodiversity, ecosystem function, and resilience to climate warming.
Alexander Austregesilo, a staff scientist at Jefferson Lab, has been awarded a $2.5 million grant to study novel forms of nuclear matter within the spectrum of hadrons. He aims to develop new tools and resources to analyze large datasets generated by the GlueX experiment in search of exotic particles or hints of their existence.
Researchers identify fast-fashion waste as a result of low environmental awareness and desire for varied clothing options. The study proposes policy solutions to reduce waste, including sustainable disposal and production tax incentives.
A genetic variant in nearly 30% of Greenlanders is linked to high cholesterol and an increased risk of cardiovascular disease. The variant, p.G137S, has a marked population-level impact, increasing the risk of high cholesterol and cardiovascular disease for up to 30% of the Greenlandic population.
A NJIT-led team has created an injectable hydrogel designed to recruit dental pulp stem cells and promote tissue growth in teeth after a root canal. The therapy mimics the body's natural growth factor signaling, promoting healing and regeneration of lost tooth pulp.
Airports in colder climates accumulate more pollutants like PM2.5 during fall and winter months, posing a significant threat to human health and the climate. Researchers recommend targeted reduction of PM2.5 emissions, particularly in cold climate regions.
The samples returned from the Hayabusa2 mission provide valuable insights into the formation and evolution of our solar system. The study found that Ryugu contains hydrated minerals and evidence of freeze-thawing, indicating that it experienced both liquid and frozen water in its past.
The American College of Chest Physicians' flagship journal CHEST published its June issue featuring 58 articles on various chest medicine topics, including asthma and COPD. The journal is set to expand with two new open-access journals, CHEST Pulmonary and CHEST Critical Care.
Researchers evaluated the history of hydrothermal explosions at Yellowstone Lake, discovering at least 16 deposits in sediment cores. The Mary Bay and Elliott's Craters were found to have larger extent of deposits than previously thought, with the lake level likely lower during the explosions.
Researchers discovered that each neuron performs complex calculations within its branches, enabling precise movements. This understanding may lead to new treatments for neurodegenerative disorders like Parkinson's disease and autism.
Using Perturb-seq, researchers created a comprehensive functional map of genes expressed in human cells, tying each gene to its job in the cell. This dataset enables discovery-based research and can help decode cellular effects of genetic changes, with potential applications in understanding gene functions and phenotypes.
A recent study identified Pdyn-expressing neurons in the ventromedial hypothalamus as a novel nucleus controlling homeostatic thermogenesis and social interaction-associated hyperthermia. These neurons respond to cold temperatures, promoting thermogenesis, and also modulate social interactions, leading to increased body temperature.
Scientists have refined the use of magnetic fields to improve tokamak performance by suppressing instabilities called ELMs. The new technique allows plasma to operate in H-mode for longer periods, increasing efficiency and reducing the risk of damage to internal parts.
Infants born to mothers with positive SARS-CoV-2 tests during pregnancy were more likely to receive neurodevelopmental diagnoses by 12 months, even after accounting for preterm delivery. Longer studies are needed to confirm these associations and understand the long-term effects of in utero COVID-19 exposure.
Gliomas, a common brain and spinal cord tumor, undergo genetic evolution that alters their behavior at recurrence, leading to increased invasiveness and poorer prognosis. The study identified distinct phenotypes and cellular features associated with treatment resistance.
A Rice University study found that parents accustomed to home schooling felt more resilient during the COVID-19 pandemic due to increased physical activity. In contrast, parents whose public-school children were suddenly housebound experienced increased stress and lower resilience. The study highlights the importance of physical activi...
Researchers found that increasing the influencer marketing budget increases consumer engagement, but firms are allocating budgets sub-optimally. Selecting influencers who post original content and have more followers leads to greater effectiveness.
Monkeypox is a viral disease caused by the monkeypox virus, typically spread through contact with infected animals or humans. Symptoms include a rash and fever, and treatment involves antiviral medications.
A new study explains how leukemia cells can transform into harmless immune cells through epigenetic changes, potentially leading to novel therapies for blood malignancies. The METTL3 gene is identified as a key controller of this process.
Researchers at the Center for Genomic Regulation (CRG) found that chromatin, a genetic architecture that protects DNA and regulates gene expression, originated in ancient microbes between 1-2 billion years ago. This eukaryotic innovation has been essential for life since its emergence.
A KAUST-led team developed organic semiconductor-based photocatalysts to store solar energy as clean hydrogen fuel. These catalysts can absorb visible light and generate long-lived charges, improving efficiency for hydrogen evolution.
Researchers from the University of Tokyo have created a controllable robotic finger covered with living skin tissue that can heal itself. The development could lead to new possibilities in advanced manufacturing industries, such as automation and cosmetics, reducing costs, time, and complexity of research.
Non-Hispanic Black and Hispanic decedents with dementia used less hospice but more emergency department and inpatient services. They incurred higher Medicare inpatient expenditures, with a 60% increase compared to white decedents.
Samples from asteroid Ryugu are chemically similar to Ivuna-type (CI) carbonaceous meteorites, offering insights into the Solar System's formation. The findings suggest that Ryugu samples represent the most primitive and pristine Solar System materials analyzed in a laboratory.
A new study found climate change is altering how large whales, including the critically endangered North Atlantic right whale, use habitats in the warming Gulf of Maine. The research team analyzed over 20 years of data and found that peak use of Cape Cod Bay had shifted almost three weeks later for right whales and humpback whales.
A new platform mimics live cellular environment to guide stem cell differentiation outside the body. Researchers from Chung-Ang University developed a novel platform based on metal-organic frameworks, which offers advantages over conventional methods for in vitro stem cell differentiation.
A new study published in Nutrients found that individuals with higher red blood cell DHA levels have a 49% lower risk of developing Alzheimer's disease. The study, conducted on 1,490 participants aged 65 and older, suggests that increasing dietary omega-3 DHA levels may slow the development of the disease.
The University of Illinois Chicago has joined the Co-design Center for Quantum Advantage, a US Department of Energy-funded center focused on building scalable quantum computer systems. The partnership will open new opportunities for UIC students in quantum engineering and collaboration with researchers.
A study by UFZ researchers used satellite data and artificial intelligence to determine the land-use intensity of meadows and pastures in Germany. The results show that grassland was used less intensively in 2018 due to drought, with 64% not mowed compared to 36% in 2017.