Researchers have developed an antibody conjugate called BonTarg that delivers drugs to bone tumors and inhibits metastasis. The combination of a breast cancer drug with a bone-targeting antibody was found to significantly enhance the concentration of the antibody at tumor sites, and inhibit secondary metastasis from infected organs.
A new analysis identifies neighborhoods in England where dietary habits deviate significantly from recommendations, prioritizing urban areas in northern England and inner-city London. Targeted strategies such as vouchers for fruits and vegetables may ultimately reduce health inequalities in these areas.
A $200,000 grant will help promote vaccine confidence and uptake among farmworkers and other marginalized populations in 8 New York counties. The project aims to address health disparities and build equity through effective vaccination partnerships.
A new study by University of Sydney researchers found that the Anglo-Saxons were a mix of continental European and local ancestry, with 50-70% of Middle Anglo-Saxon individuals being of local ancestry. The findings suggest that being Anglo-Saxon was more likely a matter of language and culture, not genetics
A 120-million-year-old fossil of a tiny bird found in China shares structural and functional features with the massive Tyrannosaurus rex. The discovery sheds light on the evolution of birds from dinosaurian ancestors.
Researchers develop a two-step encryption technique that improves complexity and energy efficiency, and has been proven safe for various attacks. The new algorithm simulates genetic coding processes to generate a complex key.
A study of 805,992 Japanese individuals found that systolic blood pressure (SBP) above 120 mmHg increases the rate of cardiovascular disease. SBP levels were also associated with an increased risk of coronary artery disease and cerebrovascular disease, even in individuals with normal glucose status.
Researchers from the Center for BrainHealth developed a virtual platform, Charisma™, to enhance social skills in middle school students. The study found that participation in virtual training sessions led to improvements in students' confidence, participation in the classroom, and ability to communicate with peers and teachers.
A Korean research team has developed a nanofilm-based 'cell caging' technology to prevent immune rejection and facilitate smooth insulin secretion in type 1 diabetic patients. The technology, announced by Seoul National University, uses enzymatic crosslinking to create ultra-thin nanofilms that can regulate blood glucose levels.
A new review suggests chronic psychosocial stress contributes to Alzheimer's development by impacting the hypothalamic-pituitary-adrenal axis, leading to neurodegeneration and dementia. Genetic factors influencing this axis may also affect inflammation, further increasing disease risk.
A new study by Iowa State University found that small Iowa towns have significantly higher environmental exposures than state averages, including diesel, air toxins, and lead paint. These risks disproportionately affect vulnerable populations such as minority status, low-income, and linguistic isolation.
Researchers used genome-wide association studies (GWAS) to analyze whole-genome sequencing data of SARS-CoV-2 mutations and COVID-19 mortality data. They identified a mutation in the spike protein linked to increased mortality, which was later found to be part of the P.1 variant.
A new study shows that climate change is increasing ozone depletion over the Arctic, contrary to previous assumptions. The researchers found record-low polar vortex temperatures and highest ozone losses on record in 2020, driven by greenhouse gas emissions.
Researchers from Tokyo Medical and Dental University have developed an AI system called DeepACT that quickly identifies healthy stem cells with the same accuracy as humans. This technology speeds up the process of evaluating stem cell quality, which is crucial for skin grafts and other applications.
Researchers at Columbia and Northwestern universities have developed a method to induce oscillations in micro-particles using DC electric fields. This motion could be used to develop microrobots with capabilities rivaling those of living organisms.
Researchers at Harvard University have created a comprehensive molecular atlas of the developing somatosensory cortex, providing insights into how gene activity and regulation change over time. The study sheds light on the complex process of cortical development, including when different neuron populations are established.
A study by NYU Rory Meyers College of Nursing highlights the importance of respect, agency, and consent in clinical interactions surrounding childbirth. Researchers found that dismissive behavior by providers can hurt self-efficacy, mental health, and willingness to engage with healthcare.
A new study found that one in ten veterinary workers in the Netherlands carries strains of antibiotic-resistant bacteria, including ESBL-producing bacteria. The study suggests that occupational contact with animals may be a key factor in transmitting these resistant bacteria to humans.
Researchers used data from SOFIA to create a 3D view of an expanding stellar-wind bubble surrounding Westerlund 2, disproving earlier studies suggesting two bubbles. The team identified the source of the bubble and energy driving its expansion.
The use of additional Metop-C and Fengyun-3 C/D data has been shown to improve regional weather forecasts by filling existing data gaps. By incorporating more PMW satellite radiances, scientists can enhance the quality of forecast models, leading to better short-range predictions.
A new study by Carnegie Mellon University researchers suggests that storing both oil and gas on-site at power plants can reduce dependence on gas grids and mitigate fuel shortages. This could reduce costs for electric customers in New England, where gas supply constraints have led to frequent power plant outages.
Researchers at Heidelberg University successfully introduced a rare genetic mutation into a fish model to study the causes of complex metabolic diseases. The study found that supplying fully functional ALG2 mRNA could reverse the genetic defect, allowing analysis of individual function areas of the enzyme.
The 2021 ESMO World Congress on Gastrointestinal Cancer presented new concepts in clinical trials, advances in surgery and transplant, and novel immuno-oncology mechanisms. Researchers shared findings on the effects of drug interactions in GI oncology and strategies to improve outcomes for patients with metastatic pancreatic cancer.
Researchers have identified a light-sensitive protein in birds' eyes that is also sensitive to magnetic fields. The discovery sheds light on how migratory birds navigate using the Earth's magnetic field.
The study analyzed 114 COVID-19 guidelines from leading organizations in the UK, France, Germany, and the US, finding significant variations in respiratory protection recommendations. The variations were attributed to differences in national and international guidelines, as well as shortages of equipment.
A recent study by Portland State University researchers detected low levels of pharmaceuticals and personal care product chemicals in oysters along the Oregon and Washington coast. The concentrations were higher near wastewater sites, indicating a need to address the sources of these pollutants.
The Barcelona Institute for Global Health has identified 10 key principles for integrating health components into urban design, aiming to reduce premature mortality. The study provides a checklist for urban planners to incorporate public health into their work, promoting active and public transport, green spaces, and mixed land use.
The use of tobacco pipes by Native groups provides valuable insights into their cultural practices and exchange networks. Researchers uncovered evidence of diverse pipe-making techniques, materials, and symbolism across different regions, highlighting the complexities of pre-Columbian American cultures.
Researchers found that the symbiotic relationship between ambrosia fungi and beetles originated more than 100 million years ago, during the early Cretaceous period. This discovery sheds light on the evolutionary history of insect farming, a strategy similar to human agriculture.
A new online database, TOPOGRAPH, has been developed to streamline the process of recommending therapeutic treatments in precision cancer medicine for Australian patients. The platform catalogues oncology research and provides personalized treatment recommendations based on genomic variations and biomarkers.
Researchers applied compost to apple orchards, finding it increased the number of beneficial bacteria that recycle nutrients. This leads to more nutrients available for apple trees, reducing the need for fertilizers and promoting sustainable agriculture practices.
A study of UK junior doctors highlights a lack of access to clinical and emotional support, leading to chronic stress and mental health issues. Researchers are calling for a cultural shift towards more supportive leadership and work environments.
Research by Universidad Complutense de Madrid found that consuming 2.5g of pure cocoa powder enhances photopic visual acuity in healthy adults during daylight conditions. The flavanols and theobromine in cocoa stimulate the central nervous system, improving attention.
A study conducted by researchers in Paris identified the natural gas distribution network as a major source of methane emissions, accounting for 63% of total emissions. The study also found that sewage networks were another significant source of methane, with 33% of total emissions attributed to these systems.
A new study published in Nature Communications finds that sand grains are in constant motion, challenging prevailing theories. Researchers used optical interference data to observe individual sand particles at rest and found they behave like glass, with creeping soil rates controlled by disturbances such as heat or tapping.
The study confirms that childhood cancers originate from specific developmental cells and exhibit unique 'cellular signals' that can be used to classify them. This method holds promise as a tool for diagnosing patients with rare cancers, including one patient's cryptic kidney cancer identified through cellular signal analysis.
A special report highlights the controversy surrounding the treatment of chronic fatigue syndrome and long COVID, with clinicians weighing in on the role of exercise in rehabilitation. While some advocates reject research on exercise, others argue that careful screening and individualized treatments are key to helping patients manage t...
A new study by Columbia University's Mailman School of Public Health found that public toilets in Manhattan do not meet the needs of women experiencing homelessness, with limited access to resources and safety issues. The research highlights the need for improved menstrual hygiene management and accessibility in public facilities.
A study developed a genetic risk score to predict adolescent idiopathic scoliosis (AIS) onset and severity. The score may help identify children at risk who could benefit from preventive treatments.
Researchers detected changes in fractal motor activity regulation (FMAR) patterns in cognitively healthy adults, particularly among women, which were associated with preclinical Alzheimer's disease pathology. FMAR may serve as a non-invasive biomarker for testing and screening AD.
Researchers found that extreme caloric restriction diets alter the gut microbiome, leading to weight loss in participants. The study suggests that a decrease in gut bacteria and an increase in Clostridiodes difficile may be responsible for the observed weight loss effects.
Research from the University of Colorado Boulder reveals that Toxoplasma-infected hyena cubs are more bold and approach lions from closer distances, leading to a higher risk of death. The parasite has a direct and detrimental impact on hyena fitness.
A new study from Ohio State University found that Americans consistently overestimate the chances of Black Americans moving up the economic ladder, with a 16% difference compared to actual likelihood. Recognizing racial disparities helps people calibrate their beliefs.
A study by Florida Atlantic University finds that minority language exposure does not hinder English acquisition in US-born children. In fact, bilingualism is associated with greater total language knowledge. By age 5, balanced bilinguals show stronger English skills than some English-dominant peers.
A new study published in Neurology found that trying more than one time to remove blood clots during endovascular treatments for ischemic strokes was associated with increased disability and brain damage. Researchers suggest aiming for a single attempt at removal with new devices, highlighting the need for further development.
Research shows that surgical face masks can filter out up to 98% of particles and provide low resistance to breathing. In contrast, plastic face shields have little to no protective effect.
Researchers at Cornell University have developed a method of magneto-thermal imaging that provides nanoscale and picosecond resolution, previously available only in synchrotron facilities. This innovation enables the study of magnetic properties of materials at unprecedented scales.
Researchers at ETH Zurich developed a technology to harvest water 24/7 with no energy input, using specially coated glass and a radiation shield. The device can produce up to twice as much water as current passive technologies, with potential for large-scale integration.
A novel lncRNA, Caren, has been identified as a potential therapeutic target for heart failure. It enhances energy production in cardiomyocytes and inhibits the activation of the ATM protein, which accelerates heart failure severity. Increasing Caren expression may inhibit heart failure progression.
States have inconsistent regulations, making it difficult to control invasive plants. Prohibited plant lists can prevent intentional introductions, but states are not creating these lists proactively. Communication is key to success.
The study reveals a dominant network of neutrophils and tissue-resident T cells in the bile ducts of patients with primary sclerosing cholangitis (PSC), a severe inflammatory disease. This discovery may pave the way for new treatment strategies against PSC and other biliary disorders.
A study by researchers at the University of Kansas found that counties with state mask mandates in Kansas experienced lower rates of COVID-19 cases, hospitalizations, and deaths. The association between mask mandates and COVID-19 outcomes was observed across various age groups and populations.
A comprehensive review of 315 clinical trials found that most weight-loss supplements and therapies did not produce significant weight loss. Only 16 studies demonstrated significant results, with weight loss ranging from 0.3 to 4.93 kg.
A genomic study of 51 high-quality samples reveals the Chinese mountain cat is a wildcat subspecies (Felis silvestris bieti) and was not directly involved in feline domestication in China. This finding supports the theory that housecats originated solely from African wildcat domestication, but raises conservation concerns for the species.
K-12 schools should focus on improving students' food literacy to bridge health gaps between lower-income and higher-income families. A conceptual model offers guidance for schools to enhance health and food literacy through practice opportunities, research, policy, or interventions.
A comprehensive study by Artyom Gusarov found that soil erosion and river sediment load decreased significantly in European Russia. Climate change and warming of near-soil air led to reduced frosting and decreased erosion-inducing sediment from tillage in the steppes.
A group of patients with neurological disease have been found to lack a critical cell process called autophagy. This discovery challenges the understanding that humans cannot survive if their cells completely fail to carry out autophagy, and may have important implications for research and therapies in neurodegeneration and cancer.
A new algorithm developed at Caltech allows autonomous systems to recognize their location by analyzing the terrain around them, even in seasonal changes. The system uses self-supervised learning to identify patterns in images, resulting in more accurate localization, with 92% success rate compared to 50% with traditional techniques.
Life expectancy in the US decreased by nearly two years between 2018 and 2020, widening the gap with other high-income countries, especially among Hispanic and Black Americans. The largest declines were observed in these groups, with life expectancy falling by 15-18 times more than in peer countries.
Researchers discover that cryptochrome 4, found in birds' retinas, is sensitive to magnetic fields and could be the long-sought magnetic sensor. The team deciphered the mechanism behind this sensitivity, which arises from electrons moving within the molecule after blue-light activation.