Researchers created a comprehensive map of how individual mutations alter the energy landscape of amyloid beta aggregation, a process central to Alzheimer's disease. They found that preventing interactions in the C-terminal region could pave the way for new therapeutic strategies.
A study of 7,944 ADHD patients found that telehealth-based relationships did not increase the risk of substance use disorder. However, patients aged 26 and above who received initial stimulant prescriptions during telehealth appointments were at higher risk.
A novel immuno-PET/CT imaging technique has identified a potent biomarker for nasopharyngeal cancer (NPC), CD70, which is highly expressed in NPCs. The technique showed 100% detection rate of primary tumors and 93% detection rate of local lymph node metastasis in patients with early-stage disease.
A Rutgers University study found lamotrigine to be safe in older adults with epilepsy, contradicting an FDA safety warning. The research analyzed data from over 158,000 adults and found no increased risk of heart rhythm problems or sudden cardiac arrest.
A recent survey by Ateneo de Manila University researchers highlights the challenges faced by young Filipino nursing and medicine graduates in finding stable employment and meaningful roles. Many new graduates feel lost and unsupported, with restricted hiring rules and budget ceilings forcing them to take on multiple roles without addi...
A clinical trial led by London Health Sciences Centre Research Institute has improved the detection of hidden blood clots responsible for strokes by extending imaging to include the heart. This approach has increased detection rates by 500% and can help determine an effective treatment plan.
The UT Health San Antonio Multispecialty and Research Hospital is the first in Texas to approve use of suzetrigine, a new non-opioid medication for post-surgical pain. This medication targets the peripheral nervous system, avoiding opioid-related side effects.
A study of 34 children found significant differences in basal ganglia volume between those exposed to prenatal Superstorm Sandy and those not exposed. The findings suggest that extreme heat may have amplified the risk of having a differently-sized basal ganglia.
Researchers review how geometry engineering improves c-Si's mechanical properties, allowing for high-performance soft electronics. Silicon nanowires with enhanced flexibility, superior mechanical properties, and excellent electrical performance are poised to transform the landscape of flexible electronics.
A new study by NYU and the Natural History Museum of Los Angeles County found that 90% of bird species' names are derived from biological characteristics, while 11% are named after people. The database reveals specialized terminology used to name birds, which may not be accessible to native English speakers.
The teXirc project aims to create novel, scalable textile materials that are easily recyclable and biodegradable. The researchers will incorporate low-density functional groups into polyethylene-like crystallinity to enable efficient breakdown during recycling processes.
A new study by researchers at The Hebrew University of Jerusalem finds that people with higher levels of depressive symptoms are more susceptible to the emotional influence of negative surrounding images. This effect was not mitigated by positive imagery, highlighting an asymmetry in how depression affects emotional processing.
A new study found that remotely supervised exercise programs can significantly improve cognitive function in older adults with MCI. The research highlights the potential of home-based exercise interventions in preventing cognitive decline.
Researchers investigated In2O3 catalyst evolution during CO2 hydrogenation induction, revealing sintering and oxygen vacancy creation. This activation stage enhances reaction rate but reduces methanol selectivity.
Scientists have developed a holistic understanding of light-driven hydrogen gas production using a nanocrystal-enzyme complex as catalyst. This breakthrough framework can be applied to optimize future light-driven chemical reactions.
Researchers found that environmental educators improved their teaching and leadership skills after learning from students in an environmental education program. The study revealed the impact of youth-to-adult intergenerational learning on educator attitudes and behaviors.
A proof-of-concept study shows that chimeric antigen receptors (CARs) can distinguish between tau tangles and various forms of toxic amyloid plaques, two key contributors to Alzheimer's disease pathology. The technology has the potential to deliver therapeutic drugs directly to affected areas of the brain with reduced side effects.
Researchers using the James Webb Telescope have discovered silicate clouds in the atmosphere of exoplanet YSES-1-c, which is thought to be linked to the planet's relative youth. The findings offer new insights into planetary formation and atmospheric processes, shedding light on how our own solar system may have formed.
Researchers developed an intelligent biosensing platform based on luminescent nanoparticles and a microfluidic biochip with machine vision algorithm analysis for efficient tumor marker detection. The platform offers high sensitivity, noninvasive sampling, and portable design for early cancer screening and monitoring.
The PUNCH mission has successfully imaged a huge solar eruption, providing unprecedented views of coronal mass ejections and the solar wind. The spacecraft constellation is enabling scientists to better understand and predict space weather events that can disrupt communications and endanger satellites.
Dr. John Oldham's contributions have fundamentally reshaped personality disorder classification, moving from rigid categories to a more nuanced dimensional system. His Alternative DSM-5 Model for Personality Disorders (AMPD) has marked the most significant epistemological shift in psychiatric diagnosis for decades.
A team of researchers from the University of Adelaide and other institutions has discovered a new sex-determination mechanism in monotremes, which include echidnas and platypuses. The AMHY gene plays a crucial role in determining sex in these animals, differing from the SRY gene found in all other mammals.
A new study published in JRSM Open found that healthcare workers born overseas, particularly those from Asian and Black backgrounds, are less likely to reach higher pay bands under the NHS Agenda for Change framework. This is despite education and job role being adjusted for.
Researchers found that COPD patients have a larger accumulation of carbon deposits in their alveolar macrophage cells, which grow abnormally large and cause inflammation. This buildup is associated with worsened lung function.
Scientists from University of Leicester collaborate with traditional Amazonian communities to monitor biodiversity using artificial intelligence, enabling them to maintain control over their resources and territories. The project aims to reshape conservation approaches in the world's largest tropical rainforest.
Researchers at IGTP reveal a clear separation between lesional and non-lesional tissue, with high expression of pro-inflammatory genes in lesions. The study identifies 17 differential transcriptomic modules and associates molecular profiles with clinical indicators from the same patients.
The AMA has passed a resolution calling for easier access to anti-obesity medications, which have been shown to help adults lose an average of 15-20% of their weight. Improved access could benefit millions nationwide, reducing obesity-related medical costs estimated at $173 billion annually.
A new dual-laser strategy revolutionizes breast cancer photothermal therapy by minimizing damage to surrounding tissues while effectively ablating tumors. The approach uses near-infrared photothermal agents with aggregation-induced emission properties and achieves precise targeting through second NIR-II fluorescence imaging technology.
Researchers developed AI-driven platform IDentif.AI to uncover sex-specific drug combinations for aortic valve stenosis, a serious heart condition. The study found that female-biased combinations were more effective in addressing the disease in female cells, while male-biased combinations were more effective in male cells.
Researchers at Edith Cowan University have developed a new method to detect the coffee berry borer pathogen using colour and shape separation via L-systems software. This technology could save farmers around $1 billion annually by identifying infected berries quickly, allowing for swift action to be taken.
A new study from Karolinska Institutet found that infants who survive serious health problems in the first few weeks of life have a higher risk of dying during childhood and adolescence. Children with neurological health problems had almost six times the risk of death compared to healthy children.
Researchers from Ben-Gurion University of the Negev have found coral-derived molecules that can disrupt bacterial communication and reduce the virulence of pathogenic bacteria. The combination of these molecules with antibiotics increases effective killing of bacteria, even when they form biofilms.
Researchers developed AI-Mg@PVDF and AI-Si@PVDF composites with enhanced combustion efficiency, demonstrating superior performance compared to pure metal particles. The study explores the effect of different metal fuel systems on aluminum alloy-PVDF MICs, revealing two distinct pathways for modulating combustion properties.
A recent study suggests that supernovae may have caused abrupt climate shifts in Earth's history by interacting with the atmosphere and degrading greenhouse gases. The research matches known supernovae to climate shifts preserved in tree ring records and predicts potential effects on human society.
A non-DNA based test using a nanopore device and AI model can identify live viruses in patients within minutes. The system showed 100% sensitivity and 71.4% specificity for detecting herpesvirus, with improved accuracy when conditions were adjusted.
PDX models accurately mimic human tumors, offering a powerful preclinical platform for testing novel therapies. These models have demonstrated significant promise in various types of cancer research.
Researchers developed a self-folding origami-based sensor that harnesses the triboelectric effect to generate electricity and eliminate the need for batteries. The device can identify dropped objects with high accuracy, making it suitable for logistics, medical devices, and wearable applications.
Research reveals shared genetic associations between type 2 diabetes mellitus and subcortical brain volumes, including hippocampus and amygdala. The study identifies 229 loci associated with T2DM and 220 loci with subcortical brain structures, providing critical genetic evidence for risk prediction and early intervention strategies.
High aflatoxin levels in Ghana's maize and peanuts contribute to the country's high liver cancer rates. Experts call for research to quantify the impact of fungal toxins on the disease.
A week-long web-based wellbeing intervention boosted participants' happiness through daily micro-acts, including sharing inspiring moments and performing kind acts. The Big Joy Project tested the effectiveness of a simple yet impactful approach to improving well-being.
Researchers found that an AI app improved efficiency for low-skilled taxi drivers by 7%, while high-skilled drivers saw little benefit. The study suggests AI can help close skills gaps in various professions.
A recent study found that parental firearm storage methods, such as locking and unloading guns, may not be effective in preventing teens from accessing household firearms. Storing additional firearms securely does not necessarily negate the perceived risk of access if at least one gun remains unlocked.
Researchers discover iguratimod, a rheumatoid arthritis drug, effectively treats excessive COVID-19 inflammation in mice by maintaining antiviral immune responses. The study provides hope for patients with severe COVID-19-related cytokine storms.
Experts from the National Comprehensive Cancer Network (NCCN) and African Cancer Coalition gathered in Nairobi, Kenya to update NCCN Clinical Practice Guidelines in Oncology for Sub-Saharan Africa. The meeting aimed to improve cancer care in the region by sharing evidence-based recommendations.
Researchers have developed a once-a-week pill that can be taken orally to deliver medication to patients with schizophrenia. The treatment maintains consistent levels of the drug in the body and controls symptoms, making it easier for patients to adhere to their medication regimen.
Bulgaria's membership in GBIF will enable the country to integrate genetic data on species diversity into the global scientific community, increasing scientific visibility and relevance. This will support initiatives such as the Bulgarian Barcode of Life and contribute to global knowledge on biodiversity and conservation.
Nach01, a large language model-based foundation model, leverages structural and spatial data for diverse chemical tasks. The model is now available on AWS Marketplace, streamlining access for researchers and pharma companies to build and apply large-scale generative models.
A Chinese research team developed a magnetic microrobot capable of manipulating small droplets in the presence of magnetic fields. The robot achieved speeds 20 times faster than previous models and could interact with highly corrosive compounds without damage.
A study analyzing data from nearly one million people found that socioeconomic status is linked to brain health, with a common genetic signal across measures of occupation, income, education, and social deprivation. The study suggests that this factor may explain differences in cognitive skills and dementia risk.
A novel observation of enhanced neutron-rich particle emission from out-of-fission-plane has been made in Fermi energy heavy ion reactions. This study uses advanced detection system CSHINE to measure charged particles and fission fragments, providing a vivid view of isospin migration dynamics.
A study on long-lived bats found that they possess robust tumor-suppressor mechanisms that protect against cancer. The researchers discovered that increased activity of the p53 gene is a key defense against cancer, and that safely increasing telomerase enzyme activity could be a way to apply their findings to humans.
Researchers at the Hebrew University of Jerusalem have developed a highly effective dual-layer coating that protects iron from rust with 99.6% efficiency. The breakthrough combines an ultra-thin molecular primer with a durable polymer layer, creating a strong and long-lasting barrier against corrosion.
The study reviews international trends in regulating stem cell-based embryo model (SCBEM) research, highlighting areas for improvement such as citizen participation, coordination, and informed consent. The authors propose a framework to alleviate complexities, treating fertilized embryos distinctly from SCBEMs and relying on committees...
Researchers at Osaka Metropolitan University discovered a new way to block cancer cell energy production by suppressing de novo fatty acid synthesis with ethyl p-methoxycinnamate. This natural substance inhibits ATP production, leading to increased glycolysis as a possible survival mechanism in tumor cells.
A new Stanford University report examines how US power utilities are confronting the escalating threat of wildfires. The research team found that while progress has been made in some Western states, utilities in high-risk areas remain underprepared.
A survey of 1408 doctors from 8 jurisdictions found that most would consider assisted dying if faced with advanced cancer or Alzheimer's disease. They predominantly prefer symptom relief over life-sustaining treatments, and their preferences are influenced by local legislation on euthanasia.
Researchers at Nagoya University have created CAR-T cells that recognize and target the Eva1 protein on cancer cells, effectively eliminating tumors in lab mice. The treatment is designed to be safer by ignoring healthy cells with low amounts of Eva1.
The Brief Emotional Experience Scale (BEES) is a simple, short questionnaire designed to assess emotional health. It has been validated in a large-scale study involving over 7,000 participants and shows high accuracy and low stress for users.
A new study by University of British Columbia researchers suggests the summer solstice is an optimal day for plant growth and reproduction. However, in a changing climate, relying on this fixed signal may no longer help plants to survive or thrive.
A new study found that most Americans overrate the climate impact of actions like recycling and underrate high-impact choices like skipping long flights or eating less meat. Active learning interventions boost climate literacy and commitment to impactful lifestyle changes, but must be paired with strategies supporting collective action.