A new preclinical study shows that combining HER3-DXd with olaparib significantly improves treatment responses in lung cancer models. The combination therapy induces irreparable DNA damage in cancer cells and stimulates the immune system to combat the disease.
Researchers developed a versatile hydrogel platform that enables the design of customised biomaterials for tissue engineering, disease modelling, and regenerative medicine. The platform preserves the functionality of incorporated biomolecules and supports high cell viability, enabling the creation of tissue-specific environments.
A new study at Tampere University found that simple risk factors like body mass index, waist-to-hip ratio, and smoking habits are better predictors of chronic disease than epigenetic clocks. This challenges the marketing claims of biological age tests, which can cost hundreds of euros.
Scientists at Tampere University identified a new chemical process that can influence the formation of air pollution particles in urban environments. Nitric oxide is found to promote the conversion of certain volatile compounds into aerosol precursors, challenging existing assumptions.
A recent international study identified 26 genetic regions associated with intrahepatic cholestasis of pregnancy (ICP), including ten previously unknown regions. The study found a strong link between genetic susceptibility to ICP and bile acid metabolism, offering new avenues for research into maternal health and pregnancy-related live...
A new study by Tampere University researchers found that maternal pre-pregnancy hypertension and child body composition may contribute to the development of fatty liver disease. The study also identified dietary factors, such as high protein intake and low fruit consumption, as risk factors for elevated liver enzyme levels in children.
Scientists at Tampere University created a 3D printed ceramic implant material that closely mimics real human bone. The findings advance personalized bone regeneration and may lead to more effective treatments for bone defects.
Researchers at Tampere University have developed light responsive hydrogel thin films that enable programmable surfaces with high sensitivity, rapid response, precise spatial control and reversibility. The technology opens new possibilities for tunable devices in photonics, sensing and biomedicine.
A Finnish study found that adolescents and young adults who underwent gender identity assessments had higher rates of severe mental health problems, with a fourfold increase compared to controls. Medical gender reassignment interventions were particularly associated with worsening mental health outcomes.
A new study introduces CoPISA, a high-throughput proteomics workflow that uncovers how drug combinations reshape the soluble proteome. The research team applied CoPISA to two AML drug combinations, revealing conjunctional targeting and vulnerabilities in critical proteins.
A new study shows that valved holding chambers used to deliver medication to children with acute respiratory diseases differ markedly in their performance. The choice of device can affect treatment outcomes, with higher delivery devices resulting in lower hospital admissions and better physiological recovery.
Researchers at Tampere University found that humanoid robots perceived as having eyes exhibit greater agency and experience, evoking emotional responses and increasing empathy. This suggests that the presence of eyes shapes human perception of a robot's mind, with implications for design and ethics.
The study found that people's everyday experiences with technology play a crucial role in shaping trust around the world. Human-centred approaches to AI design and governance are essential for building trust, as simply improving technical performance is insufficient if people feel disconnected or powerless.
A new €4.4 million EU-funded doctoral network, HiPOVor, aims to establish optical vortex beams as a key technology for advanced light-matter interaction. The project will train 15 doctoral researchers in generating and applying high-power optical vortex beams.
The European Randomized Study of Screening for Prostate Cancer found that PSA screening can substantially reduce deaths from prostate cancer, with a 13% relative reduction in prostate cancer mortality after 23 years. However, the study also highlights the issue of overdiagnosis associated with PSA screening.
Researchers at Tampere University discovered that quantum scars enhance electron transport in open quantum dots, enabling electrical conduction in nanoscale components. This breakthrough paves the way for developing efficient microchips and potentially new types of qubits for quantum computing.
Researchers discovered that atherosclerotic plaques contain gelatinous biofilms formed by bacteria, which can trigger inflammation and rupture of the plaque leading to myocardial infarction. The study also validated an antibody targeting these bacteria, suggesting new diagnostic and therapeutic strategies for myocardial infarction.
Recent research reveals that adipose-derived stem cells from obese individuals do not fully recover their anti-inflammatory capacity even two to three years after significant weight loss. The study, published in Stem Cells International, used bariatric surgery as a model to investigate the impact of weight loss on these stem cells.
Researchers at Tampere University have experimentally confirmed the conservation of angular momentum in a single photon converted into a pair, validating a key principle of physics. This breakthrough opens up new possibilities for creating complex quantum states useful in computing, communication, and sensing.
A research team from Tampere University and Université Marie et Louis Pasteur has demonstrated a novel way to process information using light and optical fibers. The study used femtosecond laser pulses and an optical fiber to mimic the processing of artificial intelligence, achieving accuracy of over 91% in under one picosecond.
A recent psychological study found that high levels of toxic metals in mothers and newborns are associated with early childhood development problems. Breastfeeding during the first six months is generally considered favourable to an infant’s health, but exposure to toxic metals reduces its intensity and duration.
A study by Tampere University found that childhood brain injuries, including mild concussions, can lead to lower educational attainment in adulthood. Researchers compared individuals with brain injuries to those with limb fractures and found significant differences in educational outcomes over a 20-year period.
A new drug screening method developed by Tampere University has found biologically active molecules that target specific tissues, potentially solving delivery issues in cancer and brain diseases. The method uses phage display and microdialysis to identify peptides with tissue-homing and penetration capabilities.
Researchers at Tampere University and Kastler-Brossel Laboratory have demonstrated self-imaging of light in cylindrical systems, facilitating unprecedented control of light's structure. They also explore a new type of space-time duality, bridging different fields of optics.
Tampere University has licensed a drug molecule intended for treating Epidermolysis Bullosa, a group of rare and severe skin disorders. The licensing agreement includes collaboration with Theravia to develop, register and commercialise the drug.
Researchers at Tampere University developed a new method to detect congestive heart failure using inter-beat intervals measured by smartwatches and heart rate monitors. The accuracy of the method was found to be 90% in distinguishing patients with congestive heart failure from healthy control subjects.
Researchers found that immunosuppression in prostate cancer is associated with a specialised epithelial subtype. This interaction between the immune system and club-like epithelial cells can lead to treatment resistance in patients with advanced, treatment-resistant prostate cancer.
Researchers at Tampere University have developed a non-electric touchpad that can sense force, area, and location of contact without electricity. The device is made of soft silicone and contains 32 channels, enabling precise detection of handwritten letters and multiple simultaneous touches.
Researchers develop physiologically relevant model to investigate breast cancer bone metastasis, holding promise for predicting risk and developing new treatments.
Researchers have developed a cell culture platform to form two distinct, interconnected vascular networks, replicating human physiology and reducing animal testing costs. This breakthrough enables the study of cellular interactions in vascularized tissues.
Researchers developed a light-driven, toroidal micro-robot that can navigate complex environments like medicine and environmental monitoring. The innovation uses liquid crystalline elastomer to overcome viscous forces and enables autonomous movement in low Reynolds number regimes.
Researchers at Tampere University have observed hidden deformations in complex light fields for the first time. These deformations carry significant information about the object, such as its material properties. The study has implications for measuring material properties with structured waves and will inspire new optical technologies.
A new study mapped genes linked to schizophrenia and uncovered a mechanism disrupting synaptic plasticity in affected individuals. The researchers identified three proteins mediating impairments of plasticity, holding promise for new treatments.
A recent study proposes a multi-dimensional approach to map disease relationships using genomic, chemical, and clinical data. The research reveals significant distinctions from the classical International Classification of Diseases system and highlights potential links between previously separate conditions.
Researchers developed artificial maple seeds that can be controlled using light to monitor environmental conditions, such as pH levels and heavy metal concentrations. The technology has potential applications in search-and-rescue, endangered species studies, and infrastructure monitoring.
Researchers at Tampere University analyzed the molecular activity of over 10,000 genes to investigate the efficacy of ZED1227, a transglutaminase 2 inhibitor. The study found that ZED1227 effectively prevented gluten-induced intestinal mucosal damage and inflammation in celiac patients.
Researchers developed a computational method to estimate sudden cardiac death risk using one-minute heart rate measurements at rest. The new method provides a significantly better estimate than previous analyses, identifying differences in heart rate intervals between high-risk and healthy patients.
The study reveals sulfur trioxide can form acid sulfuric anhydride products with organic and inorganic acids, contributing to atmospheric new particle formation. These findings improve aerosol formation prediction models, aiding in managing air pollution and mitigating climate change impacts.
Research at Tampere University aims to develop adaptable safety systems for autonomous off-road mobile machinery. The framework focuses on ensuring public safety without compromising technological advancements, incorporating a human-in-the-loop safety option.
Researchers at Tampere University and Hospital discovered that aberrant DNA methylation contributes to the development of aggressive AT/RT brain tumors in young children. This finding paves the way for a deeper understanding of the disease and potential new treatments.
A new three-step prostate cancer screening method can detect aggressive cancers while minimizing the detection of insignificant ones. The study found that this approach reduces unnecessary diagnoses and may lead to improved mortality rates.
A recent study on the Tor network found that one in five onion domains shared child sexual abuse material. The researchers also discovered that users sought CSAM through popular search engines and found that viewing violent material correlates with addiction, while seeking help is often hindered by lack of resources.
Researchers used single-molecule microscopy and X-ray crystallography to discover that pathogenic JAK2 mutations utilize pseudokinase domain-mediated dimerization as a mechanism for activation. The study provides new insights into the molecular basis of JAK2 activation and its role in blood cancers.
A study published in Nature Communications reports the discovery of a wound-homing molecule called CAR peptide, which accelerates tissue repair by activating natural healing pathways. The treatment shows promise for treating various injuries, including muscle ruptures and bone fractures, without forming less functional scar tissue.
Researchers studied how epithelial cells sense small changes in their environment using ion channels. They found that even small movements can trigger rapid intracellular calcium changes via mechanosensitive cation channels, which play a key role in touch sensation and other physiological functions.
A new method allows for the estimation of exercise thresholds based on dynamical correlation properties of heart rate variability, optimizing athlete training and injury prevention. This method utilizes heartbeat interval measurements from sports watches and heart rate monitors, providing a reliable alternative to current methods.
Researchers from Tampere University discovered that marine organisms can form new atmospheric particles in the South Pacific Ocean, which could help explain climate change predictions. The study found that these particles were formed at night and were accompanied by signs of nitrogenous compounds.
Scientists created a supramolecular machine that efficiently converts azobenzenes to their metastable conformation using visible light. The approach, inspired by the deep-sea fish vision system, overcomes limitations of traditional photoswitchable molecules.
A team of researchers at Tampere University and Eastern Washington University used weather records to validate the effectiveness of musical characteristics in enhancing data interpretation. The study found that musical sounds can be a powerful complement to traditional data visualization methods.
Researchers developed an accelerating wave equation to solve daily phenomena, revealing a well-defined direction of time. The framework also predicts energy conservation in certain situations, including exotic materials.