Researchers found that WNTinib significantly delayed tumour growth and extended survival in mice with hepatoblastoma cells harboring CTNNB1 mutations. The treatment also showed promise in shrinking tumors in patients' tumor tissue models, with some tumors disappearing completely.
Research from the UC San Diego School of Global Policy and Strategy warns of democratic backsliding globally. The US is not immune to such threats, with Americans worrying about election fraud. Scholars investigate how illiberal regimes use international organizations to erode democracy.
A low-carbohydrate diet may improve beta-cell function in people with type 2 diabetes, allowing them to better manage their disease and possibly discontinue medication. The study found that participants on a low-carb diet showed significant improvements in acute and maximal beta-cell responses compared to those on a high-carb diet.
A new study suggests that MRI can predict patient outcomes and the risk of tumor reccurrence or spread for patients with rectal cancer who have undergone chemotherapy and radiation. This information could help doctors determine the best course of treatment, including whether to spare patients from invasive surgery.
Research highlights cerebellum's essential role in refining motor movements and improving social task performance in individuals with autism. Non-invasive brain stimulation techniques like magnetic stimulation have shown promise in enhancing cognitive tasks.
Dr. Fyodor Urnav proposes a set of initiatives to address the crisis, including pooling patients by syndrome and permitting multiple gene editors in a single Investigational New Drug application. This approach aims to accelerate the development of CRISPR therapies for rare genetic diseases.
Researchers investigated the role of hydrous mineral phase D in seismic anisotropy. Phase D's deformation under high pressure and temperature conditions explains mid-mantle anisotropy observed near cold subduction zones.
A new study by Florida Atlantic University explores the experiences of harm in the metaverse among US youth, finding that 33% of teens own a VR device and 13% use it weekly. The study reveals significant percentages of youth reporting hate speech, bullying, harassment, and grooming behaviors.
A new study found that exposure to higher levels of air pollution as a baby is associated with increased odds of developing a peanut allergy and having it persist throughout childhood. Policies aimed at tackling poor air quality could potentially reduce the development and persistence of peanut allergies, according to researchers.
A systematic review of 12 studies found that urban green spaces are associated with lower rates of heat-related ill health and death, particularly among vulnerable groups. Additionally, urban greenery is linked to better mental health and wellbeing, potentially mitigating the negative effects of high temperatures.
Chemists at Brookhaven Lab develop new theoretical framework to accurately predict catalyst behavior, revealing how conditions like temperature and pressure can change a catalyst's structure, efficiency, and products. The study highlights the significant impact of reaction environment on catalytic performance.
Researchers found that verified users with entrenched opinions can trigger echo chambers, while centrist ideologues may actually facilitate consensus. The study used a computational model to simulate how people post and receive messages on social media platforms.
The ASHG 2024 Annual Meeting will showcase the latest research in human genetics and genomics. The event will feature a Presidential Symposium on Mendelian traits and a Distinguished Speakers Symposium on the promise of human genetics and genomics, among other sessions.
Researchers found that physically fitter patients with metastatic lung cancer live longer and respond better to chemotherapy. The study identified biomarkers in blood plasma that can indicate which patients are most likely to respond to treatment.
A Yale University team developed a method to assess the impact of biodegradable microplastics on the environment. The study found that while biodegradable plastics may be more sustainable, they can still release greenhouse gases and have toxic effects.
Researchers from Osaka University discovered that the GPR31 receptor in gut surveillance cells detects bacterial metabolites and triggers immune responses, which could lead to new drug developments and probiotic treatments. The study also found that these receptors play a key role in the immune response to gut infections in humans.
A clinical study published in Clinical Cancer Research confirmed that tissue stiffening in HER2-negative breast cancer can directly cause disease progression and metastasis. The use of the MeCo Score diagnostic tool was found to predict the likelihood of relapse or recurrence among patients with early-stage breast cancer.
A new report highlights the need for clearer policies to address unpaid meal charges, which can lead to practices like lunch shaming. The study found significant disparities and gaps in communication across US school districts, with notable similarities in North Carolina's policies.
Researchers at Caltech have developed a new technique called 'fingerprint nanoelectromechanical mass spectrometry' that allows for the accurate measurement of individual protein masses. This breakthrough could pave the way to determining the complete proteome, providing insights into an organism's health and potential disease treatments.
Researchers are combining large datasets to understand the impact of environmental factors on mental health and develop new ways to reduce the burden. A 4-step approach is being used to integrate complex data across many studies, resulting in a detailed perspective of individuals within their environment.
Researchers at Durham University have developed a novel drug compound, Ellorarxine, which demonstrates significant potential in improving neuronal health and nervous system regeneration in MND sufferers. The study's findings suggest that Ellorarxine addresses the '3Ns' - neuroprotection, neuroplasticity, and neurorepair, offering a com...
A recent study by the University of New Hampshire found that political affiliation plays a significant role in gift-giving decisions, with participants favoring politically aligned items for others over themselves. This suggests that individuals often consider how their target's politics may affect them when making purchasing choices.
Research suggests that cognitive effort enhances the perceived reward of unhealthy choices, such as overeating potato chips or seeking cocaine. This link may be adaptive in certain contexts and has significant implications for understanding addiction and other unhealthy behaviors.
A UK study found that menopausal hormone therapy may have moderate effects on brain health, but these depend on past surgical history, treatment duration, and age at last use. The research revealed no significant differences in brain health between women who used MHT and those who did not, but those on MHT had higher grey and white-mat...
A randomized controlled trial found that removing toddler screen time in the hour before bed leads to better sleep quality and more efficient nighttime sleep. The study suggests that limiting screen time before bed may be a useful strategy for improving toddler sleep.
Researchers developed an advanced system integrating GNSS, IMU, and LiDAR Odometry to overcome urban navigation challenges. The new approach improves positioning accuracy by 35.9% and boosts 3D positioning by 50%, enabling smarter transport solutions.
GeniPhys secures $500k NSF grant to support regulatory and commercial readiness of Collymer SAS for soft tissue restoration in advanced wound care. The technology promotes regenerative remodeling without inflammatory response, facilitating faster healing and tissue repair.
The international project will analyze temperature-sensitive proteins in animals adapted to different thermal environments to understand how they perceive temperature changes. The study aims to uncover the molecular mechanisms underlying cold perception in animals, enabling them to initiate physiological responses crucial for survival.
Researchers found that the presence of a fungus increases the pH of the soil, promoting growth of beneficial bacteria. This interaction could lead to sustainable agricultural practices by harnessing microbial interactions to combat plant diseases.
A new study finds that happy intimate partners are associated with lower stress hormone levels, particularly in older adults. Positive emotions with a partner can act as a social resource, buffering cortisol production and promoting healthy aging.
A team from UNIGE analyzed the formation of grooves in dog noses using 3D imaging and computer simulations. They found that differential growth of skin tissue layers leads to the formation of domes, supported by blood vessels.
Researchers at Tohoku University have developed a novel catalyst to control the atomic arrangement of carbon nanotubes, achieving ultra-high purity and precise chirality. The breakthrough could lead to significant advancements in semiconductor device manufacturing.
Researchers found that active genes contribute to the stirring motion of the genome, with compaction affecting gene motion. The study reveals unexpected connections among gene activity, genome packing, and genome-wide motions.
Researchers have developed dielectric metamaterials exhibiting effective self-duality and full-polarization omnidirectional Brewster effect. These materials enable impedance matching with free space, eliminating birefringence despite significant anisotropy in dispersion.
The Appalachian Region's mortality rate from diseases of despair decreased by 4% between 2021 and 2022, while remaining virtually unchanged outside of Appalachia. However, the region still experiences higher rates of mortality from these diseases across all age groups, particularly among those in their prime working years.
A recent breakthrough in ultra-broadband diffractive imaging has enabled the handling of unknown probe spectra, overcoming constraints on non-dispersive specimens. This innovation provides a nearly fourfold improvement in bandwidth over current mono CDI methods.
A new study predicts that climate change will threaten the survival of up to 2,000 resident bird species in the Neotropics by 2100. However, a more optimistic future scenario suggests that only 90 bird species will be exposed to longer dry seasons.
A new study by Monash University researchers highlights essential factors for adapting Generative AI (GenAI) to support human learning in all levels of education and workplaces. The key considerations include understanding how to use GenAI to enhance human learning while fostering critical thinking and self-reflection skills.
A new Concordia study reveals that bilingualism is associated with larger and healthier hippocampi in patients with Alzheimer’s disease. The research found no evidence of hippocampal atrophy in bilinguals across the continuum of Alzheimer’s development.
KAIST researchers developed a new electrochemical impedance spectroscopy (EIS) technology using small currents to diagnose electric vehicle batteries with high precision. This low-current EIS system minimizes thermal effects and safety issues during measurement, making it suitable for integration into vehicles.
Researchers demonstrate the first cross-chiral exponential amplification of an RNA enzyme, potentially leading to the development of cross-chiral therapeutics and biotechnologies. The discovery suggests that a bioengineer can create a new form of biochemical evolution by using both left- and right-handed molecules.
Artificial intelligence is creating a new way of thinking with System 0, an external cognitive process that enhances human abilities. This system relies on AI's capabilities to process information and provide suggestions, but humans must interpret and assign meaning to the results.
Researchers used a mouse model to assess the impact of senolytic agents dasatinib and quercetin on pelvic organ prolapse. The study found that D+Q injections did not result in significant differences in prolapse development but reduced cellular senescence markers.
Twenty-two new species of gall wasps have been identified and named for the first time, thanks to new research led by a Penn State graduate student. The tiny wasps were named after famous thieves and tricksters in history, mythology and pop culture.
A new study finds that AI-powered models exhibit similar levels of accuracy as ophthalmologists in identifying infectious keratitis, a leading cause of corneal blindness worldwide. The AI models displayed a sensitivity and specificity of 89.2% and 93.2%, respectively, matching the diagnostic accuracy of human experts.
Researchers at Politecnico di Milano discovered that the ratio of CO2 to methane present in the reaction determines carbon build-up on catalysts. This finding paves the way for more efficient technologies and longer-lasting catalysts.
A study found plastic mulch contaminates soil with up to 25 kg of macroplastic debris per hectare, affecting critical soil functions even under best management practices. Microplastics were also detected, with concentrations positively correlated with macroplastic levels.
Researchers found lacerations, hair loss, and skin ulcerations affecting polar bears' feet, as well as other parts of their body. The study suggests climate warming is causing ice buildup and injuries due to freeze-thaw cycles, wet snow, and thin sea ice.
Researchers developed a new type of electrode material using MXene and organic molecules, achieving high capacitance and energy density in an asymmetric supercapacitor. The findings suggest potential applications for MXene-based composites as alternative electrode materials for sustainable energy storage devices.
Researchers discovered that tuberculosis alters liver metabolism and can push patients towards metabolic disease like diabetes. The study suggests undiagnosed TB could be a significant contributor to metabolic health issues.
Researchers developed a novel, homogeneous customizable OpenGUS immunoassay that detects target analytes quickly and effectively. The platform provides a hassle-free approach for biomarker detection in point-of-care diagnostics, high-throughput testing, and environmental monitoring.
A phase Ib clinical trial has shown that the MVA-MERS-S vaccine candidate is safe and effective in healthy individuals previously infected with SARS-CoV-2. The vaccine was tested in a placebo-controlled study with no serious vaccine-related side effects, indicating promising results.
A novel data-driven joint model enhances infrastructure planning and smart charging of shared electric vehicles by optimizing charging strategies and predicting user behavior. The model aims to reduce charging costs and improve grid integration, with potential savings of up to 34.97%.
Researchers humanize the lupus-derived autoantibody 3E10, preserving its therapeutic efficacy, to create novel cell-penetrating antibodies targeting tumors and RAD51. Humanized variants exhibit faster cell uptake and superior in vivo tumor targeting.
A team of scientists developed a method to increase the light collection efficiency in multicore optical fibers by thermally modifying them. This results in more than five times higher signal-to-noise ratio and significant gain in image contrast, making it suitable for minimally invasive medical procedures.
A magnitude 4.8 earthquake in New Jersey triggered widespread alarm, but surprisingly, the epicenter showed minimal damage, while distant areas like NYC and Virginia experienced stronger shaking. An analysis of Lg waves revealed a previously unmapped fault with complex strike-slip motion and thrust, affecting regional hazard assessments.
A research team led by Prof. ZHOU Rongbin found that GPR34 promotes tumor growth by suppressing ILC1-mediated anti-tumor activity. Blocking GPR34 with inhibitors can inhibit tumor growth in various models, providing a new immunotherapy strategy for liver and colorectal cancers.
A new study from Georgetown University Medical Center and MedStar Health researchers found that cognitive difficulties, lack of social participation, and self-perceived poor recovery are key drivers of depression after a stroke. Contrary to previous studies, physical disability was not a significant predictor of depression in this study.
A new study found that transcranial direct current stimulation (tDCS) is a safe and effective treatment for depression when administered at home. Researchers reported significant improvements in depression severity and remission rates compared to a placebo control group.
A new special issue of JCOM explores the challenges and opportunities of communicating basic science, highlighting its relevance in everyday life. The issue emphasizes the importance of curiosity and the need to convey the impact of scientific discoveries on individuals.