Researchers found that movement-evoked pain activates the brain's Default Mode Network (DMN), which is associated with self-reflection and identity. This suggests that treatments like mindfulness and psilocybin may be more effective than traditional symptom-based approaches in managing chronic low back pain.
Researchers will create coast-to-coast infrastructure to study biological systems in three dimensions. The observatory will integrate advanced imaging capabilities, artificial intelligence, and powerful data networks to enable new discoveries in neuroscience and life sciences.
UC San Diego Health has adopted new coil technology and FDA-approved liquid-based treatment for chronic subdural hematoma, expanding minimally invasive treatment options. These advances provide more options for customizing treatment based on a patient's anatomy and clinical needs.
The new center will bring together researchers from various disciplines to study the biological factors contributing to addiction across multiple substances. Researchers will examine biological systems, brain networks, and gene activity to understand individual differences in addiction risk.
A 12-month exercise intervention improved attention and memory in breast cancer survivors, while a companion study found exercise slowed epigenetic aging. These findings suggest exercise may help buffer against cognitive effects associated with accelerated epigenetic aging.
Liangfang Zhang's invention uses human cell membranes to cloak nanoparticles, making them deliver drugs and remove toxins more effectively. The approach has shown promise against bacterial toxins, including MRSA, and may potentially treat diseases without conventional drugs.
A study from the University of California San Diego School of Medicine found that 11.4% of older adults who used cannabis in the past year met the criteria for cannabis use disorder (CUD). This condition is characterized by a pattern of cannabis use that causes problems or interferes with daily life. The study highlights the importance...
Researchers at the University of California San Diego have developed a new approach to switch magnetic states using light, which could lead to faster and more efficient data storage. By shaping and shrinking light, they were able to overcome limitations of previous methods and achieve optical switching in thicker magnetic materials.
Researchers developed a method to test cosmic uncertainty in the universe's oldest light, which could provide evidence for physics beyond the Standard Model. The team compared maps from different detectors to establish the calibration pattern, finding consistency with existing analysis.
Scientists tracked brain activity of schooling glassfish to uncover how animals detect social partners' actions, allowing groups to escape danger. The study found that social behavior is crucial for coordinated escape, with groups responding more effectively to threats than individual fish.
Researchers at UC San Diego identified a naturally occurring peptide called catestatin (CST) that reduces toxic protein accumulation, neuroinflammation, and improves cognitive function in mouse models. CST may provide a new peptide-based therapeutic strategy for Alzheimer's disease and related neurodegenerative disorders.
By creating virtual cells from 4D AI models and digital twins, researchers can predict how mitochondria respond to drug treatment, grouping cells that respond similarly together. This technology has the potential to speed up drug discovery and accelerate research for diseases such as cancer, diabetes, and Alzheimer's.
Researchers identified a distinct risk profile for young adults with early-onset fatty liver disease, associated with genetic factors and metabolic conditions like type 2 diabetes. The study highlights the need for more accurate liver screening and assessment for individuals at greatest risk.
Researchers identified a natural antibody, anti-NMDAR1, that may protect the brain after traumatic brain injury, reducing the risk of depression and PTSD. The study found that Marines with higher levels of the antibody had lower depression and PTSD symptoms after a TBI.
Researchers at University of California San Diego have demonstrated that one of biology's most essential enzymes can accurately read and transcribe an expanded, eight-letter genetic alphabet. This breakthrough advances synthetic biology and could allow scientists to create new biological systems and diagnostic tools.
Researchers developed a method to distinguish authentic ancient clay artifacts from fakes by analyzing the magnetic properties of the clay. By measuring the temperature needed to erase magnetism acquired over time, the method can determine the age and authenticity of the artifact.
A new study from the University of California San Diego reveals that the brain tracks subtle variations in breathing to decode neural activity patterns. Researchers found a precise connection between breathing patterns and brain activity, offering new avenues for understanding disorders like SUDEP and SIDS.
Researchers at UC San Diego will develop optimized red blood cells to temporarily boost human performance and health through enhanced oxygen delivery. The project has the potential to improve athletic performance and treat conditions involving oxygen delivery to tissues.
Researchers at the University of California San Diego used computational models and virtual reality to study the social interaction rules of schooling fish. They found that individual fish 'copy' the movement direction of a randomly-chosen nearby neighbor, leading to highly dynamic behavior in groups.
A UC San Diego study links certain agricultural and natural landscapes to Valley fever rates, suggesting land management decisions can impact public health. Research analyzed 65,657 confirmed cases and found higher disease rates in areas with dry, sparsely vegetated landscapes and certain types of farmland.
Scientists in the University of California San Diego laboratory used AI to decipher the 'initiator' DNA sequence, which is responsible for gene activation. The researchers found that about 60% of human genes contain the initiator, enabling the prediction of DNA mutations that can lead to various disorders.
Scientists discovered a previously missed DNA mutation pattern in colorectal cancer, found in 3 independent datasets of 2616 tumors, suggesting a new mechanism of DNA damage accumulation. The pattern appears relatively late in tumor development and is associated with small insertions and deletions in DNA.
Researchers at the University of California, San Diego, have developed an inexpensive solution to the path-obstruction problem in millimeter wave wireless communications. Their passive reflective tiles, called FlowForm, can nearly double average data rates indoors and double wireless coverage area in challenging environments, matching ...
The five-year Brain-FRAMe program aims to improve clinical care and brain health for people with HIV and active methamphetamine use disorder through innovative, multidisciplinary treatment approaches. The program investigates the combined efficacy of long-acting injectable ART and medication for addiction treatment.
A team of computer scientists at the University of California San Diego developed a device that can take over communications between two key flight computers on a Boeing 737 by plugging into an unused maintenance port. This attack can be carried out in under 60 seconds, posing a significant risk to aviation security.
The West Health Accelerator will expand UC San Diego Health's ability to ensure every patient gets the right care at the right time in the right setting. The six-year initiative aims to raise the standard for health systems across the country, leveraging advanced technologies and data analytics.
High-frequency brain waves called ripples facilitate long-range neural communication during working memory tasks, suggesting a mechanism for integrating information. The study's findings may also help differentiate healthy cognitive signals from abnormal activity associated with neurological diseases like Alzheimer's or ADHD.
The University of California San Diego and San Diego County have developed a tool to track the New World screwworm, a parasitic fly whose larvae feed on living tissue. The dashboard combines reports of confirmed detections, environmental suitability, and media coverage to estimate risk nationwide.
Researchers at UC San Diego identified a key cellular pathway that drives brain degeneration in both Sanfilippo syndrome type A and Alzheimer's disease. The study reveals how the brain's immune cells respond to waste buildup, providing a novel target for drug development.
The Stein Institute at UC San Diego will serve as the Central Laboratory and Biorepository for the XPRIZE Healthspan Competition. The 10 finalist teams will conduct coordinated clinical trials worldwide to test their treatment approaches, aiming for a decade-long extension of human healthspan.
Engineers have created a bacterium that can consume all three major sugars present in corn stalks, opening up possibilities for more efficient biomanufacturing processes. The new strain of Pseudomonas putida was developed using an automated culturing platform and can potentially be used to produce valuable molecules like indigoidine.
A new study suggests that doctors' reassuring language can have the opposite effect on patients, making them less likely to seek treatment. The researchers found that normalizing symptoms can be misinterpreted as acceptable or not worth treating.
A new study reveals that Mindfulness-Oriented Recovery Enhancement (MORE) is highly effective in reducing opioid misuse and costs. The therapy, which combines mindfulness skills to regulate craving and pain, has been shown to provide $12 in cost savings for every dollar spent, with potential economic benefits of over $324,000 per patient.
A vegan diet for one month shifts epigenetic patterns associated with reduced inflammation, immune function, and biological aging. The study found changes in DNA methylation linked to lower proportions of inflammatory immune cells and increased proportions of CD4 T cells.
UC San Diego Health has been ranked as the top care facility in California and among the top 20 in the nation for eight medical specialties. The institution achieved this distinction through its patient-dedicated, collaborative spirit and commitment to delivering outstanding care.
A soft, wearable fingertip patch continuously monitors levodopa levels in patients' sweat, comparable to standard laboratory blood tests. This technology enables precise customization of daily medication schedules for patients at home, potentially improving treatment outcomes.
Physicists at the University of California San Diego discovered that substrates are not inert when subjected to electrical stimulus, instead coupling with thin film. This finding has implications for building brain-inspired computer chips needed for energy-efficient computing.
UC San Diego engineers created a smart ring that continuously monitors up to four different chemical biomarkers from finger sweat. The ring provides real-time health insights into individuals with diabetes management and nutrition tracking, closely matching commercial glucose and ketone readings.
Researchers created the most detailed map of gene regulation in human heart failure, revealing how genes are controlled in specific cell types. The study identified key shifts in cell composition, gene expression, and regulatory networks, pointing to new precision medicine therapies.
A recent national study analyzing over 11,800 adolescents found that substance use increases steadily with age, with 38% reporting use by age 16. The study highlights notable differences between boys and girls, particularly in polysubstance use patterns.
Researchers have determined the cryo-electron microscopy (cryo-EM) structure of E. coli TGT, overturning a prevailing model for bacterial TGT function. The study reveals the enzyme binds to two tRNAs, providing a more complete picture of protein modification and potential antivirulence targets.
A study by UC San Diego researchers found that at least 2.2 million cars in the US and worldwide are vulnerable to theft due to a Bluetooth-based anti-theft system installed by dealers since 2017. The device, which can be controlled remotely via a smartphone app, has been fixed by the manufacturer with a firmware update.
Researchers developed a personalized gene therapy that dramatically reduced seizures and sparked developmental gains in two children with SCN2A-related DEE, allowing one to walk independently. The therapy targets the root genetic cause of the condition, producing measurable improvement.
The partnership aims to develop genomic tools addressing large-scale problems in health and the environment, combining research strengths across UC San Diego's departments. The collaboration will accelerate discovery and drive real-world impact, leveraging CRISPR technology and microbiome-editing tools.
A new study found that faculty women in academia earn 23% less than men, narrowing to 4.3% when accounting for field and academic rank. The research suggests that transparency alone is not enough to eliminate pay gaps, and representation does not guarantee equal pay.
Researchers at UC San Diego have found a dramatic increase in e-bike injuries across California, particularly among children. The study highlights the urgent need for safety education, infrastructure improvements, and policy changes to prevent preventable injuries and deaths.
A clinical trial showed semaglutide improved liver scarring in patients with advanced fatty liver disease and early-stage cirrhosis. Non-invasive blood tests reflected treatment-related improvements more clearly than liver biopsies, which could reduce reliance on invasive procedures.
Researchers have developed a new drug candidate, SB-0110, that boosts L-dopa's benefits while reducing dyskinetic side effects in animal models of Parkinson’s disease. The compound preserves the gene-activity patterns tied to L-dopa’s benefits while counteracting biological changes associated with dyskinesia.
A team of researchers at the University of California San Diego developed a genome-scale reference map detailing how individual genes control human stem cells' functions and identities. This open-access resource enables scientists to build virtual cell models for complex diseases and design patient-specific treatments.
A new report from Scripps Oceanography suggests that in-ground sensors can provide reliable warnings of impending cliff collapses. The study detected movement in cliffs several hours to days prior to collapse, with one event leading to a 0.015-inch-per-day crack widening due to rain events.