Researchers discovered NGR1's neuroprotective effects are mediated by microglia-mural interactions and a FOXO1-associated program involving ABCA9. This study provides single-cell resolved insights into NGR1's mechanism and identifies potential therapeutic targets for cerebral blood flow regulation.
Researchers at the University of Tokyo used a new radiocarbon analysis technique to study ocean sediment cores, revealing previously undetected history of geophysical disasters in Japan. The study found multiple 'hidden' traces of earthquakes in the Nankai Trough, which could help predict future geophysical events and prepare for poten...
Researchers found that H3mm15, a histone variant differing from H3.3 by three amino acids, contributes to normal sperm development in mice by regulating gene expression. The study found that H3mm15 forms less stable nucleosomes, leading to changes in chromatin behavior and gene regulation.
The CT scans of Jeremy Bentham's head have provided valuable insights into his life and after-life, showing that he suffered from chronic toothache and a jaw riddled with arthritis. The scans also reveal further physiological factors, such as tissue structure and preservation choices, which were previously unknown.
Phase 3 clinical trials involving over 1,000 participants found that those taking retatrutide, a new experimental weight-loss injectable drug, lost about a quarter of their body weight on average and experienced significant pain relief. The drug also showed benefits in reducing blood pressure, lipid levels, and systemic inflammation.
A new study found that using portable air filters with high-efficiency particulate air (HEPA) filters can reduce daily blood sugar swings and morning sugar surges in people with prediabetes. By cutting levels of tiny air particles by 36%, cleaner air was linked to a nearly 8% drop in blood sugar swings and smaller morning surges.
A randomized trial found that intravenous iron repletion led to functional benefits after 12 weeks for patients with HFpEF and iron deficiency. Peak oxygen uptake improved by approximately 10% in the intervention group.