A vegan diet for one month shifts epigenetic patterns associated with reduced inflammation, immune function, and biological aging. The study found changes in DNA methylation linked to lower proportions of inflammatory immune cells and increased proportions of CD4 T cells.
UC San Diego Health has been ranked as the top care facility in California and among the top 20 in the nation for eight medical specialties. The institution achieved this distinction through its patient-dedicated, collaborative spirit and commitment to delivering outstanding care.
A soft, wearable fingertip patch continuously monitors levodopa levels in patients' sweat, comparable to standard laboratory blood tests. This technology enables precise customization of daily medication schedules for patients at home, potentially improving treatment outcomes.
Physicists at the University of California San Diego discovered that substrates are not inert when subjected to electrical stimulus, instead coupling with thin film. This finding has implications for building brain-inspired computer chips needed for energy-efficient computing.
UC San Diego engineers created a smart ring that continuously monitors up to four different chemical biomarkers from finger sweat. The ring provides real-time health insights into individuals with diabetes management and nutrition tracking, closely matching commercial glucose and ketone readings.
Researchers created the most detailed map of gene regulation in human heart failure, revealing how genes are controlled in specific cell types. The study identified key shifts in cell composition, gene expression, and regulatory networks, pointing to new precision medicine therapies.
A recent national study analyzing over 11,800 adolescents found that substance use increases steadily with age, with 38% reporting use by age 16. The study highlights notable differences between boys and girls, particularly in polysubstance use patterns.
Researchers have determined the cryo-electron microscopy (cryo-EM) structure of E. coli TGT, overturning a prevailing model for bacterial TGT function. The study reveals the enzyme binds to two tRNAs, providing a more complete picture of protein modification and potential antivirulence targets.
A study by UC San Diego researchers found that at least 2.2 million cars in the US and worldwide are vulnerable to theft due to a Bluetooth-based anti-theft system installed by dealers since 2017. The device, which can be controlled remotely via a smartphone app, has been fixed by the manufacturer with a firmware update.
Researchers developed a personalized gene therapy that dramatically reduced seizures and sparked developmental gains in two children with SCN2A-related DEE, allowing one to walk independently. The therapy targets the root genetic cause of the condition, producing measurable improvement.
The partnership aims to develop genomic tools addressing large-scale problems in health and the environment, combining research strengths across UC San Diego's departments. The collaboration will accelerate discovery and drive real-world impact, leveraging CRISPR technology and microbiome-editing tools.
A new study found that faculty women in academia earn 23% less than men, narrowing to 4.3% when accounting for field and academic rank. The research suggests that transparency alone is not enough to eliminate pay gaps, and representation does not guarantee equal pay.
Researchers at UC San Diego have found a dramatic increase in e-bike injuries across California, particularly among children. The study highlights the urgent need for safety education, infrastructure improvements, and policy changes to prevent preventable injuries and deaths.
A clinical trial showed semaglutide improved liver scarring in patients with advanced fatty liver disease and early-stage cirrhosis. Non-invasive blood tests reflected treatment-related improvements more clearly than liver biopsies, which could reduce reliance on invasive procedures.
Researchers have developed a new drug candidate, SB-0110, that boosts L-dopa's benefits while reducing dyskinetic side effects in animal models of Parkinson’s disease. The compound preserves the gene-activity patterns tied to L-dopa’s benefits while counteracting biological changes associated with dyskinesia.
A team of researchers at the University of California San Diego developed a genome-scale reference map detailing how individual genes control human stem cells' functions and identities. This open-access resource enables scientists to build virtual cell models for complex diseases and design patient-specific treatments.
A new report from Scripps Oceanography suggests that in-ground sensors can provide reliable warnings of impending cliff collapses. The study detected movement in cliffs several hours to days prior to collapse, with one event leading to a 0.015-inch-per-day crack widening due to rain events.
Researchers developed antifungal nanoparticles from human immune cells that target Candida albicans, reducing fungal growth and improving survival rates in mice. The nanodiscs physically damage fungal cells and boost the body's natural immune defenses.
A study suggests geoengineering methods like marine cloud brightening could reduce the impact of extreme weather events during a super El Niño. By targeting natural variability, geoengineering could provide shorter-term benefits with less sociotechnical risk.
Researchers at UC San Diego successfully performed two surgeries using teleoperated humanoid robots, called Surgie, which have real potential for amplifying access to critical surgeries. The compact robots can be deployed in remote areas and are easier to use than specialized robotic systems.
Researchers found bacteria can forcefully eject cells from communities as a survival mechanism, utilizing self-generated hydrogels. This ability allows biofilms to disperse and colonize new areas, potentially aiding in the elimination of harmful bacterial communities without antibiotics.
The new institute aims to accelerate data-driven health care with partnerships between six schools, UC San Diego Health, and specialized centers. By integrating digital technology and rigorous research, the institute seeks to achieve scalable, reliable health outcomes for all.
Researchers discovered Bacillus subtilis employs a slower growth strategy for better survival under antibiotic stress, decoupling ribosome production from amino acid supply. This trade-off makes B. subtilis more tolerant of stress and challenges the assumption that bacteria are wired to grow as fast as possible.
The new health system combines the strengths of a community-based and academic health system, offering advanced specialty care and increased access to UC San Diego Health specialists. The JPA oversees joint operations of hospitals and clinics, improving care for nearly one million people in North San Diego County.
Researchers identified disrupted neural circuits behind Huntington's disease and used optogenetics to selectively activate key neurons, restoring function and improving motor skills. The study provides hope for future therapies targeting specific brain circuit imbalances.
The study reveals how genetic mutations disrupt muscle signaling in CMS, a family of genetic disorders that weaken communication between nerves and muscles. Researchers identified promising new therapeutic opportunities, including a potential use for an existing antidepressant.
Researchers at University of California San Diego have developed a large-scale screening approach that identifies proteins controlling alternative polyadenylation (APA), a fundamental step in gene expression. The study reveals 63 high-confidence activators of poly(A) site usage, including seven new regulators previously unknown.
Researchers analyzed 11.6 million marketplace interactions and experiments involving job candidates and service providers to find that faster responders were viewed more positively than delayed responders. Employers preferred speed as a signal of future responsiveness, but authenticity also mattered.
Researchers found AI can accurately assess complex quality measures in seconds, providing near real-time feedback to physicians. This results in improved compliance with national sepsis quality measures and lower administrative costs.
Researchers at UC San Diego discovered a previously unknown mechanism that contributes to high blood cholesterol by depleting LDL receptors. A CTSA inhibitor has already shown safety in humans and may be effective in treating high cholesterol, offering a new treatment option for patients.
A new project aims to create realistic AI-powered digital twins of people who use drugs to improve public health responses to HIV, hepatitis C and overdose. The 'AMPLIFY' project will combine community perspectives with cutting-edge AI tools to help health departments allocate resources more effectively and save lives.
A new WTRS scale captures how strongly people believe smoking should be restricted in public settings, with support increasing steadily over time, particularly in indoor spaces. The study supports the long-standing public health strategy of reducing smoking by shifting social norms around secondhand smoke exposure.
Researchers at UC San Diego have received major grants to investigate the relationship between menopause and hormone therapy on dementia risk in women. The studies aim to develop a clinical tool for earlier dementia detection and improve prevention and treatment strategies.
A recent study published in Cell has revealed that senescent cells, often associated with aging and disease, play a previously unrecognized role in building the brain's protective barriers. These cells contribute to the formation of two critical barrier systems: the blood-brain and blood-CSF barriers.
A recent study has identified a specific group of genes, known as Ces1, which are responsible for creating the enzyme that metabolizes cocaine. Variations in these genes are closely linked to how frequently and compulsively rats self-administered the drug, suggesting a potential new target for treatment.
A new telescope technology, featuring a metasurface component, can collect scientifically meaningful data from the Sun in a single snapshot. This technology solves problems in space missions by stabilizing telescopes and reducing costs.
Researchers develop a gene therapy approach to restore normal nerve signaling and reduce muscle spasticity in spinal cord injury patients. The treatment targets GABA signaling and has shown significant improvements in reducing spasticity and restoring reflex function.
UC San Diego Health has received multiple awards from Practice Greenhealth for its achievement and innovation in health care sustainability, including the Greenhealth Leader Award and Circle of Excellence Award. The institution's commitment to operations supporting healthier patients, staff, and communities is recognized nationally.
A major security vulnerability was discovered, allowing attackers to fake their identity in smartphone text conversations by exploiting the difference between email and text message formats. The issue was patched in Android and Apple smartphones as well as all major wireless carriers, including Verizon and T-Mobile.
Researchers created a way to spot and correct distortions in light using artificial intelligence and a tiny optical element. The approach can improve the quality of images in fields like biology, astronomy, and precision manufacturing by making advanced optical systems faster, smaller, and easier to use.
Researchers have developed molecular cages that encase tetrazine, allowing for specific targeting of cancer cells for imaging and drug delivery. This technology enables precise spatial control over chemical reactions in living systems, promising improved outcomes for patients with limited side effects.
A recent study found that semaglutide, a widely used GLP-1 drug, slows down the accumulation of biological aging markers in adults with HIV. The treatment reduced chronic immune activation, visceral and ectopic fat, and reprogrammed certain cells, which may help explain its effects on multiple aging clocks.
The US overdose death rate declined by 24.4% in 2024, primarily driven by falling fentanyl-related deaths. However, deaths involving only stimulants continued to rise, and racial disparities remain severe. The study highlights the need for targeted public health interventions to address persistent inequities.
Researchers identified microRNA-25 as a key player in creating an immune-suppressive tumor environment that resists cancer immunotherapy. Removing miR-25 reshaped the environment and activated anti-tumor immune responses, suggesting a potential target for converting 'cold' tumors into responsive 'hot' tumors.
Engineers at UC San Diego developed an optical device that reveals hidden images and changes colors in response to different levels of humidity. The technology has potential applications in anti-counterfeiting labels, secure data storage, interactive displays, and environmental sensors.
Researchers at UC San Diego have identified a naturally occurring peptide that significantly slows melanoma growth, reduces tumor spread, and restores sensitivity in drug-resistant cells. The findings suggest CST could serve as the foundation for a new class of peptide-based therapies against advanced and therapy-resistant melanoma.
Researchers developed an experimental gene therapy that protects brain cells from toxic protein damage caused by TDP-43, which is linked to neurodegenerative diseases such as frontotemporal dementia and Alzheimer's disease. The approach strengthens the neuron's resilience and helps preserve brain function.
A new AI model, MutationProjector, analyzes tumor DNA to predict immunotherapy and chemotherapy outcomes in various cancers. The model identifies biomarkers associated with treatment responses and provides insights into why predictions are made.
Researchers developed a soft, wearable ultrasound patch that continuously monitors a fetus for hours, enabling early detection of complications in high-risk pregnancies. The technology has the potential to expand access to prenatal care in low-resource settings and improve pregnancy outcomes.
A machine-learning guided lifestyle coaching program based on data collected via personal devices reduced depressive symptoms by six weeks. Participants who implemented the program experienced significant reductions in depressive symptoms and the treatment effect persisted during three months after the intervention ended.