A comprehensive compendium of patient-derived models paired with their original human tumors has been developed, providing powerful tools for understanding tumor biology and predicting treatment response. The resource includes rich molecular profiles that help researchers identify and understand the biological mechanisms driving indivi...
Researchers developed a multiscale framework to understand liquid transport in fibrous membranes. At the single fiber scale, fiber diameter and curvature regulate droplet nucleation, adhesion, and migration. The study also explores droplet transport mechanisms at 2D fiber network and 3D multilayer scales.
A global review found that high temperatures and heatwaves are associated with poorer mental health outcomes in children, with a 25% increase in risk during heatwaves. The study suggests targeted interventions for children and young people to mitigate the effects of climate change on their mental wellbeing.
Researchers find molybdenum carbide formation on metal oxide supports enhances reverse water gas shift activity. The study identifies ionic potential as a key descriptor for support selection, providing a practical framework for designing high-performance Mo-based RWGS catalysts.
A novel framework, CA-Mamba2, uses state-space modeling enhanced by coordinate attention to capture long-term temporal dependencies and nonlinear degradation characteristics in lithium-ion batteries. It achieves superior performance on public datasets, demonstrating strong generalization capabilities.
Researchers have developed a novel perovskite photodetector structure, combining two materials with different bandgaps to enhance current flow. The 'chocolate-chip-cookie' design allows for efficient charge transfer and photocarrier generation, enabling fast photoresponse and linear dynamic response.
Researchers at Stanford University discovered that aging brings a large influx of immune cells into the brain, upending previous assumptions about the brain's immune system. The study suggests that these immune cells may interact with the brain and contribute to its resilience against Alzheimer's disease.
Researchers have developed a 'double-punch' approach to treating brain cancer using light-activated nanoparticles that enable precise imaging during surgery and targeted phototherapy after surgery. The platform has shown promising results in mouse models, achieving 100% survival rate at 60 days.
Researchers develop a physics-data co-driven deep neural network that captures underlying physical characteristics of coupled resonant systems using coupled mode theory-generated datasets. This approach enables accurate retrieval of intrinsic resonant frequency, coupling strength, and transmission phase in complex systems.
ISM9077 boasts potent inhibition across species, excellent exposure and permeability traits, and a favorable safety profile in preclinical studies. It modulates pathological inflammation, supporting broad indication expansion into therapeutic areas like aging and neurodegenerative diseases.
A new study by UCLA researchers found that most deaths in the LA County Jail occur after a person has been in jail for several weeks. Chronic conditions such as heart disease are also a significant cause of mortality, with effective interventions available to prevent death.
A Northwestern University study found that areas with shrinking tree canopy cover experience higher mortality rates, particularly in hot neighborhoods. Protecting mature trees alongside planting new ones is crucial for reducing health risks and strengthening climate resilience.
The Barrow Neurological Institute is conducting a Phase 1/2 clinical trial investigating ibogaine as a therapeutic agent for treating traumatic brain injury (TBI). Researchers aim to enroll 40 participants and determine how effectively ibogaine addresses TBI symptoms and quality of life.
Researchers discovered that depression is associated with a specific area of the hippocampus, independent of Alzheimer's disease risk factors. The study found participants with depression had smaller volumes in the CA23DG region, which plays a crucial role in retrieving memories and distinguishing between similar experiences.
The BESIII Collaboration identified the dominant constituent of the X(2370) as a pseudoscalar glueball with spin-parity quantum numbers of 0⁻⁺. This discovery provides decisive validation of quantum chromodynamics at low energies and represents an entirely new form of matter.
Researchers found that feeding whole carcasses increased lion feeding time by almost three times and led to activity patterns mirroring those in the wild. The study also showed no increase in aggression or social instability around carcass feeding events.
Jiaqi Ma's $660,307 grant aims to develop tools for understanding how individual components of training data affect large AI systems. This project will improve the performance and reliability of widely used technologies like language models and recommendation systems.
A new Cochrane review analyzed 11 studies involving 2,524 women undergoing embryo transfer, finding no reliable evidence that preparatory techniques improve IVF success rates. The techniques examined included straightening the utero-cervical angle and removing cervical mucus before transfer.
Researchers found that people with well-controlled HIV have more fibrosis in their fat tissues, leading to insulin resistance and type 2 diabetes. The study also identified a blood marker of scarred fat, which may help predict metabolic future for individuals with HIV.
A field study in northeastern China shows that combining no-tillage management with microbial organic fertilizer can significantly increase soil organic carbon across both surface and deeper soil layers. The treatment increased soil organic carbon by up to 93.2% and maintained larger macroaggregates, which can physically enclose organi...
Researchers developed a simple visual method for tracking vapor movement inside a fixed-bed reactor, finding that internal structures can redirect vapors and improve tar production and gas quality. The design increased total tar yield and raised the light tar fraction to as much as 74.42 percent.
Adding tirzepatide to standard care reduces the risk of major cardiovascular events, such as heart attack or stroke, by 32% compared to sitagliptin. The study found significant benefits on individual MACE components and mortality from any cause.
A KAIST research team has developed a technology that reconstructs the shape, optical thickness, and position of a transparent object from a single shot. The technique uses an optical model and AI framework to analyze light intensity and overcome challenges in conventional phase imaging.
A new study warns that ambitious climate pledges may lead to a 12.8% reduction in global cropland by 2100, compromising food security. The impact could be unevenly distributed, with countries in the Global South and South America facing significant losses.
A large cohort study found that the National Early Warning Score (NEWS2) can identify patients most likely to benefit from immediate antibiotics, allowing clinicians greater confidence in treating lower-risk patients. The study analyzed nearly 100,000 adults treated for suspected infection and suggests NEWS2 may provide a more comprehe...
Researchers developed GridFusionX, an AI tool that improves forecasts of electricity demand and renewable energy generation. The system reduces uncertainty in predictions, allowing grid operators to plan reserves more efficiently and respond proactively to sudden changes.
Researchers have gained a deeper understanding of how autophagy and ferroptosis interact to disrupt cellular balance and contribute to the development of complications. This knowledge positions these processes as central components in the evolving landscape of diabetes care, offering a more integrated view of disease and recovery.
The enzyme HMGCR plays a central role in cholesterol biosynthesis, supporting tumor growth by enhancing cell proliferation and enabling metastasis. Inhibiting its activity can disrupt the supply of cholesterol and related molecules that tumors rely on, leading to reduced tumor growth and increased sensitivity to treatment.
Researchers at UCLA Health Jonsson Comprehensive Cancer Center are developing drug-based strategies to enhance cancer immunotherapy for melanoma and potentially other cancers. They identified two promising compounds that could strengthen T cell interaction with cancer cells or make tumor cells more susceptible to destruction by T cells.
A new study by NYU researchers found that firearm carrying is strongly linked to an increased risk of suicide among high school students. The study revealed that adolescents who carried a firearm were nearly four times as likely to have attempted suicide within the prior 12 months.
The ALARA+ Coalition has released a suite of resources to help hospital leadership and decisionmakers implement enhanced radiation and occupational safety guidelines for clinicians and staff working in fluoroscopy laboratories. The new toolkits provide practical steps to protect cath lab team members from both occupational radiation ex...
A study found that pumas change deer behavior, reducing the likelihood of deer-vehicle collisions by 67%. Deer alter their use of space and time where pumas are present, overlapping less with roads.
Researchers have made a groundbreaking discovery in solar physics by visualizing tiny plasma vortices on the Sun's surface. These vortices are changing our understanding of the Sun and its magnetic field, providing new perspectives on energy storage and release.
A new wearable electric-field device has been shown to slow the growth and spread of aggressive breast cancer in preclinical models. The technology uses low-intensity electric fields that interact with cancer cells in a controlled way, reducing tumor growth and increasing immune responses.
Researchers engineered a novel electrode via boron reduction, exhibiting ultra-low overpotentials and exceptional long-term stability. The Co-B bond stabilizes the electrode, suppressing metal leaching and enabling efficient water splitting.
Researchers from Memorial Sloan Kettering Cancer Center discovered ZFP36L2, a protein that regulates stem cell renewal and repair in the gut. Colorectal cancer cells exploit this process to spread to new organs through metastasis. Disrupting ZFP36L2 may compromise cancer cells' ability to form new tumors.
Scientists at Gladstone Institutes have developed a regenerative treatment using stem cell-derived spinal interneurons to repair damaged neural networks in rats. The new cells not only survived and formed connections with the animals' own neural circuits but also improved breathing-related motor function after transplantation.
A recent study published in PLOS One found that American black bears sleep twice as much during hibernation periods compared to summer months, with only 1/3 of the time spent awake. The researchers used machine-learning analysis of data from captive bears recorded over a period of five years.
Researchers have discovered a new species of extinct amphibian, the spadefoot toad Spea labreae, from La Brea Tar Pits. The discovery highlights the impact of climate change on species distribution and provides insights into ancient environmental conditions.
Researchers found that disease prevention has reduced the incidence of heart attacks, strokes, and hip fractures, while cancer cases have increased. Improved diagnosis and treatment for cancer have led to better survival rates.
A recent study found that rewetting severely burned peatlands can dramatically reduce methane emissions, making these areas prime candidates for accelerated restoration. Severe fires alter the peat's chemical composition, reducing methane production and increasing carbon storage.
The KU-Fermilab team designs and builds two cutting-edge particle detectors for the Compact Muon Solenoid experiment at the Large Hadron Collider. The project strengthens collaboration with Fermi National Accelerator Laboratory and creates hands-on research opportunities for Kansas students.
Researchers discovered how cancer cells exploit palmitate to suppress neutrophils' anti-tumor activity, allowing tumors to survive and grow. By disrupting this process, the researchers restored neutrophil function and reduced metastatic growth in liver metastases.
Researchers have discovered novel quantum phenomena in twisted graphene, including orbital magnetism, quantum anomalous Hall effect, and unconventional superconductivity. The review highlights the flatband electronic structure of magic-angle bilayer graphene, driving complex behaviors like correlated insulators and topological states.
A cross-sectional study found that US physicians with a rural background and training experience in rural settings are more likely to practice in rural locations. The study assessed the interdependence of these factors on rural practice among US physicians.
A new open resource of cancer models has enabled researchers to create the first large-scale map of the genes that cancers rely on to survive. The biobank, developed by the Wellcome Sanger Institute and collaborators, reveals potential weak points that could be targeted with future treatments.
Researchers at Virginia Tech develop process to strip chlorine from PVC and produce synthetic lubricant-based oils. The new method converts discarded PVC into a key lubricant ingredient, offering a potential solution to two environmental challenges: recycling difficult-to-process plastics and producing valuable industrial materials.
The dynamic relationship between nerves and tumors reveals a complex tumor microenvironment that includes neural networks. Signals from the peripheral nervous system can directly influence cancer cell proliferation, metastasis, and treatment resistance.
Researchers have unveiled a transformative intrinsic enhancement strategy that redefines the performance ceiling of electrochemical deionization. The F-Cu3Pv-2 electrode leverages heteroatom doping to trigger self-adaptive dual defect formation, enhancing electron transfer, ion adsorption, and diffusion kinetics.
Researchers investigated how individuals interpret nonordinary experiences, finding that most people view them as neutral or positive. The study's findings suggest that how a person interprets an unusual experience matters more than the experience itself in determining its impact on wellbeing.
Research at AIST, Institute of Science Tokyo, and Ritsumeikan University uncovers the impact of histone acetylation site location on liquid–liquid phase separation in gene regulation. This study provides new perspectives for therapeutic development targeting aberrant gene expression.
Researchers discovered that immunosuppressed patients with non-melanoma skin cancer have macrophages that fail to communicate effectively, leading to tumor progression. The study's findings suggest that boosting the functionality of these immune cells may lead to new treatment opportunities for these patients.
Researchers at St. Jude Children's Research Hospital have found a way to reactivate the frataxin gene in Friedreich's ataxia, a neurodegenerative disease, by using a specially designed chemical adaptor. The study challenges a longstanding assumption about histone modifications and offers new insights into gene regulation.
Researchers developed a dual-enzyme cascade system for one-pot biosynthesis of salidroside, increasing efficiency and reducing costs. The optimized system achieved high titer and space-time yield, demonstrating strong commercial potential.
A research team has created a silicon-carbide-based maser that operates continuously above room temperature, enabling new applications in communication and sensing. The maser amplifies microwave radiation and has high frequency stability, making it suitable for precise magnetic field measurements.
People with eczema face a higher risk of developing shingles due to an altered skin immune response. Researchers analyzed UK database data and found that eczema severity was directly linked to increased shingles risk.
The Neandertal growth hormone receptor has been found to increase muscle mass in people today, with carriers having around 270 grams more muscle mass on average. This effect is most pronounced in individuals of South and East Asian descent.
A study of over-50s in Brazil and Europe found aging-related decline begins a decade earlier in Brazil due to social disparities. The findings highlight the impact of socioeconomic factors on healthy aging.
A new study reveals that Mindfulness-Oriented Recovery Enhancement (MORE) is highly effective in reducing opioid misuse and costs. The therapy, which combines mindfulness skills to regulate craving and pain, has been shown to provide $12 in cost savings for every dollar spent, with potential economic benefits of over $324,000 per patient.
The U.S. Disease Tracker tracks cases of measles, meningitis, and pertussis at state/substate levels with detailed visualizations, providing reliable data for public health professionals, policymakers, and researchers.
Researchers have developed a transformative silicon nanocomposite anode that overcomes longstanding barriers to practical deployment, achieving simultaneous optimization of electronic conduction, mechanical robustness, and elastic stress recovery. The anode delivers exceptional high-rate performance and outstanding cycling stability, m...
Researchers at Johns Hopkins Medicine have discovered that inhibiting sensory neurons with a nerve blocker can reduce abnormal bone growth in cartilage after childhood bone injuries, potentially improving recovery. The study found that the treatment reduced unwanted bone growth by up to 60% in mice.
A team of physicists from Boston College created a quantum nanocorral that can trap and control charged excitons, enabling precise electrical control of tiny light sources. The discovery opens up new ways to control hybrid charge, photon, and spin quantum states.
Researchers developed a universal strategy to repair quantum dot surfaces, boosting photoluminescence quantum yield and suppressing exciton quenching. Optimized QLEDs achieved record-breaking external quantum efficiency of 34.3% with nearly four times longer operational lifetime.
Researchers engineered a biochemical halo of interleukin 10 to suppress immune rejection of pancreatic beta cells, enabling implanted insulin-producing cells to control blood sugar for over 100 days. The approach could lead to a cure for Type 1 diabetes and improve outcomes for implantable therapies.
A new study challenges long-held assumptions about autism by showing that autistic people can understand others' emotions just as well as non-autistic people. Researchers found that autistic participants were similarly accurate at tracking emotional experiences and may have been slightly more accurate when understanding other autistic ...
The University of Illinois Oat Breeding Program has achieved significant gains in yield and test weight over 18 years, despite environmental challenges. The program's success highlights the importance of public breeding programs in sustaining crop improvements.
Scientists have discovered a new process that forms cloud-forming particles in the Arctic atmosphere when melting sea ice meets open ocean. This combination of marine life and sunlight releases a chemical mixture that seeds the sky with particles, increasing cloud cover and affecting global climate.
The review highlights how long non-coding RNAs (lncRNAs) may help bridge the critical gap in diagnosing and treating liver cancer linked to hepatitis B. LncRNAs, once overlooked molecules, are now recognized as powerful regulators of cellular activity influencing gene expression and immune responses.
A new treatment for periodontitis uses an MXene-based hydrogel that disrupts bacterial biofilms and reprograms immune cell metabolism, reversing bone resorption. The hydrogel combines electrostatic sterilization with photothermal stimulation to target periodontal bacteria.
A global analysis of butterfly range shifts found that 80% had expanded their range and 79% linked to climate change and extreme weather events. However, severe data gaps persisted in critical biodiversity hotspots like Central Africa and the Amazon Basin.
Researchers used the NSF Inouye Solar Telescope to capture high-resolution images of swirling vortices in the sun's photosphere, which are believed to be the 'engine' driving twisting magnetic field lines. This discovery could fundamentally change our understanding of solar dynamics and evolution.
Researchers discovered that newborn German cockroaches use pheromones in feces to recognize their own colony and form a kind of social bond. This behavior was found to be mediated by both innate attraction to conspecific fecal odor and learned preferences for specific odorants encountered during coprophagy soon after they hatch.
A five-year panel study in Japan found that vaccine-related conspiracy beliefs are associated with media skepticism and distrust of institutions. Common forms of conspiracy thinking involve persistent distrust of social institutions and mainstream media.
The study introduces a high-performance NIR photodetector that optimizes interfacial energy alignment and suppresses leakage current. The optimized device achieves an ultra-low dark current density of 6.1×10−8 A cm−2, the lowest value reported for AgBiS2 CQD photodetectors so far.
A new study found that the meningococcal B (MenB) vaccine was associated with a 38% lower risk of gonorrhoea notifications in young people aged 14 to 22 years in the Northern Territory. The researchers believe the vaccine triggers an immune response to help prevent both infections.
Advances in CRISPR-Cas9 gene editing and epigenetic modification are revolutionizing disease prevention by enabling earlier detection of risk and more precise intervention at the genetic level. These technologies hold promise for preventing inherited conditions and chronic illnesses, and may ultimately lead to personalized medicine.
Individuals in psychotherapy for trauma from killing in war experienced improvements in psychosocial functioning. IOK participants showed greater improvements in work, social, and family life compared to PCT group at posttreatment.
Researchers developed an innovative vaccine strategy that uses genetically modified viruses to protect against Chikungunya and other diseases. The new approach generates antibodies without causing disease, paving the way for a robust vaccine platform with broad protective potential.
A nationwide study in Australia found that financial status impacts access to modern anti-nausea medications, driving off-label prescribing and structural health inequities. The study suggests updating medication funding structures to expand pregnancy-relevant medication approvals and subsidies.
Researchers reveal that spacecraft observations can conceal the true movement of particles in near-Earth space, challenging traditional assumptions about radiation belt dynamics. The study highlights a fundamental challenge for space scientists: different physical processes can produce similar observational evidence.
Researchers found that natural sounds, specifically biophonic ones, are associated with the highest levels of place attachment. Biophonic sounds were also perceived as more pleasant and linked to a strong sense of place attachment. The study highlights the importance of managing soundscapes near residential areas.
The Human Cancer Model Initiative released a compendium of more than 150 organoid models of 25 types of cancer, which are now available to scientists worldwide. These patient-derived organoids provide state-of-the-art research tools for accelerating discovery and developing personalized treatment strategies.
Selenoproteins, tiny proteins built with selenocysteine, play a significant role in protecting cells from damage, regulating metabolism, and guiding life-and-death decisions. They manage oxidative stress, supporting antioxidant defense systems and maintaining redox balance.
A Brazilian study found a bidirectional relationship between hypothyroidism and sleep apnea, with participants experiencing more frequent and severe OSA when diagnosed with hypothyroidism. Hormone replacement therapy improved sleep quality by an average of 49 minutes per night.
A recent study compared the clinical validity of a proposed consensus ACLF framework with an outcome-calibrated A-TANGO classification. The findings show that the consensus definition captures a smaller, liver-centered phenotype, while A-TANGO identifies a broader population with clinically meaningful mortality.
A new AI model developed by Japan Advanced Institute of Science and Technology identifies the most relevant information in videos, significantly reducing analysis time. The model achieved state-of-the-art performance while using only 15.42% of available visual features and reduced processing time per video by approximately 65%.
Researchers developed a 'beehive inspired' nano carrier that solves the recyclability issue of single-chain nano-catalysts. The system uses a dynamic Diels Alder covalent bond to anchor copper-loaded SCNP onto a glass surface, releasing catalysts into the reaction medium and then re-grafting them for recovery.
A new study published in Science Advances reveals that neuronal precursor cells divide into two independent lineages, producing distinct types of projection neurons. This challenges previous assumptions about the development of neural stem cells and sheds light on how the cerebral cortex arises.
A growing body of scientific insight is transforming how cancer treatment resistance is understood, highlighting lactylation as a key regulatory mechanism. This emerging perspective points to new opportunities for more precise and effective interventions.
Research investigates how bioactive molecules in human milk shape infant metabolism and informs formula development.
FOXO2 is a key transcription factor that coordinates pancreatic development, maintains islet cell identity, and regulates glucose homeostasis. It drives pancreatic organogenesis, guiding the formation and specialization of endocrine cells within the pancreas.
Two subspecies of wild boar in Japan, Japanese Wild Boar (JWB) and Ryukyu Wild Boar (RWB), have been found to share a common ancestral population. Genetic analysis reveals they diverged from Eastern Russian/Northern Chinese wild boars around 25,000-10,000 years ago.
A new study led by Brown University researchers found that pupil dilation signals a spike in arousal, enabling the brain to adapt to new situations and learn from unexpected information. This 'refresh' mechanism helps to reduce bias and improve learning by replacing mental context with new information.
Tumors harbor complex communities of bacteria, fungi, and viruses that influence disease progression and immune responses. These microbial populations can either promote or suppress cancer growth, underscoring their dual role in oncology.
Researchers develop a bio-inspired nanonetwork strategy to improve the mechanical performance of carbon nanotube composite films. The approach results in ultra-high dynamic toughness and enhances strength, toughness, and damage tolerance.
Researchers found the nucleocapsid protein amplifies inflammatory pathways in macrophages, fueling tissue-damaging immune responses. The study suggests a possible mechanism for cardiac injury seen in severe COVID-19 cases and points to targeted treatments
Researchers discover that early biochemical evolution was a hybrid of enzymatic and metal catalysts, with pioneer bacteria and archaea emerging independently from the environment. The team found that enzymes catalyzed only half of metabolic reactions in the last universal ancestor of all cells, while metals replaced them in other cases.
SwRI successfully developed an optimized spark-ignited hydrogen engine for medium-duty commercial vehicles, demonstrating diesel-like torque characteristics while producing near-zero tailpipe CO2 emissions. The engine was designed, constructed, and rigorously tested to ensure efficiency and performance.
A new study found that women with type 2 diabetes are at higher risk of experiencing severe menopause symptoms. The study, published in Menopause journal, analyzed data from nearly 300 women and discovered a significant association between diabetes and increased prevalence and severity of menopause symptoms across all stages.
Researchers digitally reconstructed a dodo brain cavity to understand its sensory abilities, finding it may have had a flexible daily activity pattern and enhanced sense of smell. The study provides new clues on how the dodo foraged and interacted with its environment before disappearing in the late 17th century.
A new study published in the Journal of the American Heart Association suggests that even low levels of physical activity can increase life expectancy for adults with or without atrial fibrillation. The research tracked over 87,000 adults in Norway for 15 years and found a positive association between physical activity and reduced stro...
Researchers have identified a protein called integrin alpha-5 as the cargo in tumor-derived extracellular vesicles that promotes lung blood vessel leakiness and lung metastasis in several types of cancer. The discovery could lead to new ways of monitoring and reducing lung metastasis risk in cancer patients.
A new study from Pusan National University reveals that climate-driven changes in vegetation can significantly impact ozone and aerosol pollution in East Asia. The researchers used satellite observations to update vegetation data, finding substantial changes in biogenic emissions and air quality, particularly in suburban areas.
A new USDA listing provides standardized nutrition data for watermelon rind, complementing the nutrient-rich flesh and offering a simple way to reduce food waste. The data reveals that 1/3-cup serving of diced raw watermelon rind contains just 10 calories and provides 1 gram of dietary fiber.
Researchers developed a phase-field model to understand how charged defects affect grain boundaries in oxide ceramics. The simulations revealed that solute drag can drive abnormal grain growth and that grain-boundary potentials vary throughout the microstructure.
A new MRI metric, PSMD, detects early white matter abnormalities in Alzheimer's disease, including in individuals with Down syndrome. This study provides insights into the early stages of Alzheimer's disease and its progression.
The study reveals a sharp increase in biomass losses due to climate change-related events, with Central European forests being particularly impacted. The findings raise concerns about the European Union's ability to meet its climate goals, highlighting the need for adapted forest management practices.
Researchers found that IVMT-Rx-4 selectively blocks the function of the MDA-9/Syntenin protein, limiting tumor growth and eliminating therapy resistance in preclinical cancer models. The study suggests a new targeted treatment option for head and neck squamous cell carcinoma.
This viewpoint discusses how inflammation can coexist with hyperpigmentation, particularly in individuals with darker skin tones. The authors propose an approach where hyperpigmentation prompts continued assessment for persistent inflammation, addressing the potential underrecognition of this condition.
The MYH9 gene encodes non-muscle myosin IIA, essential for cell movement, division, and signal transmission. Emerging therapeutic strategies target MYH9, potentially improving treatment outcomes in various malignancies.
Researchers from Kyushu University found that low-density gas contributes to hub growth through direct inflow and by replenishing nearby dense filaments, substantially underestimating the material available for massive star formation. The study's combined analysis of dense and diffuse gas increased estimated material flowing onto hubs ...
Teaching children emotional regulation and healthy friendships can provide a crucial buffer against social media's risks to mental health and self-worth. Strong childhood friendships are better equipped to navigate digital spaces, reducing the likelihood of online validation-based identity and self-worth issues.
Researchers at SKKU create a novel electrode material that suppresses water-splitting reactions and improves energy storage performance. The SA-Pb/NC electrode achieves twice the specific capacitance of conventional electrodes, delivering high power and energy density.
Researchers at Charité – Universitätsmedizin Berlin investigated the use of THC to alleviate PTSD-related nightmares. The study found that more than half of participants responded to treatment, with over a third experiencing complete disappearance of nightmares. The medication was also well-tolerated, with moderate side effects reported.
Professor Röthlisberger's work has pioneered ab initio molecular dynamics and QM/MM multiscale simulation methods, providing rigorous frameworks for investigating complex molecular processes. Her research has guided scientific discovery in areas like quantum chemistry, materials science, and sustainable energy.
Emerging knowledge highlights FOXK2's versatile transcription factor function in shaping cancer behavior, with varying expression levels observed across cancers. Its dynamic activity positions FOXK2 as a critical factor in understanding tumors' growth, adaptation, and response to treatment.
A multidisciplinary team of researchers converts polyvinyl chloride waste into high-performance lubricants with exceptional energy-saving potential. The discovery could address growing plastic waste challenges while advancing lubrication technologies.
The American College of Chest Physicians has appointed Julie Captain as its new Director of Philanthropy, building on the organization's $1.9 million in donations and 530 engaged donors in 2025. With her expertise in legacy and charitable gift planning, Captain aims to grow CHEST philanthropy and expand its impact.
Megalain plays a central role in maintaining cellular balance, organ function, and human health through nutrient transport, neuroprotection, and receptor-mediated endocytosis. Its involvement in drug interactions and toxic responses highlights the need for precise therapeutic strategies.
Vertically resisted plyometric training ranked highest among 10 training modalities for improving change-of-direction speed in trained individuals. The analysis found that this type of training optimizes reactive strength and muscle's ability to switch from eccentric to concentric contraction.
Researchers have developed an experimental drug that tricks cancer cells into consuming more sugar than usual, then blocks their backup fuel source – fat. This approach puts cancer cells under so much stress that many die, demonstrating effectiveness in treating aggressive melanoma in mice.
A study published in Neurology found that between 70% and 85% of people with atypical Alzheimer's disease would not meet eligibility criteria for anti-amyloid treatments. The main reason for exclusion was poor performance on cognitive screening tests, particularly those assessing visual-spatial abilities or executive functioning.
Researchers at NIST successfully transmitted entangled photons through a commercial fiber-optic network, a crucial step towards building quantum networks. The study demonstrates the feasibility of using existing infrastructure to connect distant users and could enable ultra-secure communications and boost quantum computing power.
Researchers found that dietitians recommend fish oil and creatine to support concussion recovery. The study also highlights the importance of a food-first approach, focusing on energy intake, hydration, and healthy eating patterns. More clinical research is needed to inform safe and consistent nutrition advice for athletes.
Scientists at North Carolina State University have created a highly-porous, superadhesive mesh that can capture both large and small microplastic particles, including those as small as tens of nanometers. The mesh is made from sustainable biopolymers and can clean microplastics from both saltwater and freshwater.
A Norwegian nationwide study found that women with pregnancy complications face different long-term cardiovascular risks. Women who had a complication in their first pregnancy and later pregnancies faced the highest risk, while those with no further pregnancies had the lowest risk.
A new study by UBC researchers found that watersheds with greater variation in elevation are less prone to flooding after tree harvesting, while flatter landscapes are more vulnerable. The study also highlights the role of fog in influencing flood behavior and suggests a targeted approach to forest management.
A NIH-funded research project has generated a comprehensive collection of patient-derived tumor models, covering 25 types of cancer from thousands of donor tissues. These models closely match their parental tumors in terms of genetic alterations and gene expression signatures, enabling researchers to explore tumor evolution and diversity.
Previous research found that overconfidence might aid learning, but a new study replicates findings using different methods to find no effect on performance changes between the two groups.
Researchers propose a new analytical approach to determine the limiting velocity of an avalanche crack, revealing that it may propagate at supersonic speeds in certain situations. The findings reconcile conflicting interpretations and provide insights into designing structures impacted by snow masses.
Researchers have identified a unique case of a massive star's demise, marked by an exceptionally faint X-ray burst and the absence of high-velocity jets. This discovery challenges current supernova theories, which typically associate such events with gamma-ray bursts.
Scientists create a two-step anion-exchange strategy to synthesize metastable quasi-1D van der Waals material W6Te6 on a wafer scale. The method utilizes a WS2 template and overcomes the thermodynamic limitation of conventional tellurization, allowing for uniform growth of the material.
Research highlights cellular senescence as a key driver of intervertebral disc degeneration and chronic low back pain. Senescent cells release inflammatory signals that accelerate tissue breakdown and impair repair processes.
Researchers tracked nearly 80,000 adults with type 2 diabetes over ten years, finding those who consistently took their prescribed medication stayed free of serious heart and circulatory complications for over seven extra months. Low adherence was linked to a higher risk of cardiovascular disease, especially in younger adults.
A new AI triage agent will be embedded in Vanderbilt Health's EHR to quickly evaluate patients with Alzheimer's disease. The system will analyze chart information, flag missing details, and recommend referrals for priority or standard evaluation, aiming to reduce wait times from weeks to days.
Researchers developed an experimental drug using AI to target a 'undruggable' protein in pancreatic cancer, slowing tumor growth and improving survival rates. The study demonstrates the potential for AI-assisted discovery of new cancer treatments.
A new study found that six leading AI models exhibit a strong masculine bias in generating stories about animal characters, with only 2% being female. The models use neutral pronouns or avoid them altogether to reduce gender bias, but ultimately erase non-masculine identities.
Researchers developed a new design strategy to overcome limitations in metasurface-based approaches, creating a response that enables strong, fast modulation across a wider range of colours. This advance provides a pathway for compact, high-speed optical devices with potential applications in faster data transmission and future light-b...
A new synthesis paper examines how ecological structures and processes help ecosystems withstand disturbances while providing benefits. The study highlights the importance of 'portfolio effects' in maintaining ecosystem resilience.
A Virginia Tech team analyzed over 1,000 storm surge events to identify distinct patterns that depend on both storm characteristics and coastal geography. The findings could help engineers design infrastructure to withstand unique flood timelines and support better planning and decision making for coastal communities.
A new study suggests that even the smallest non-bird dinosaurs were unusually large due to ecological pressures, such as competition with early mammals. The findings also reveal that powered flight played a crucial role in allowing birds to evolve into tiny species, which is not seen in their dinosaur ancestors.
Researchers at Boston Children's Hospital found that fecal transplants from healthy donors reduced peanut allergy symptoms in some patients. The study suggests that the right bacteria can help restore tolerance to food through bile acid metabolites. Increased levels of immune regulatory cells also protected against allergic reactions.
A new SwRI study provides the first evidence of recent liquid flows to Pluto's surface, suggesting that liquid nitrogen is rising from beneath the Sputnik Planitia glacier. This finding, based on data from NASA's New Horizons spacecraft, indicates a new kind of time-variable feature on Pluto.
Research team led by University of Zurich found Arctic fires occurred 2.5 times more often in lit areas associated with human activity than in climatically similar unlit areas. Effective fire prevention and response can help reduce risks extending far beyond the Arctic.
Researchers developed a conductive e-skin patch that enables real-time wireless monitoring of physiological signals, accelerates wound healing, and promotes smart wound dressing. The patch demonstrates exceptional 99% wound healing rate within 14 days in rat full-thickness wound models.
A U-shaped association exists between LVEDD and mortality in HF, suggesting high risk for both abnormally small and large ventricles. The findings support integrating LV size assessment into routine risk stratification to guide personalized management.
The researchers successfully switched the chirality of phonons within a ferroelectric crystal using an electric field, enabling active control of spin. This breakthrough could lead to the creation of faster and more energy-efficient spintronic devices.
New research suggests that collecting and spraying rainwater on rooftops during hot weather can significantly reduce energy demand for air conditioning and lower urban temperatures. The study found that this approach could cut the number of heatwave days overall and lessen the intensity of extreme heat events.
Researchers used real human brain tissue samples to test the underlying mechanisms of deep brain stimulation. They found that brain cells became more synchronized in communicating, similar to memory formation, while altering gene expression across different types of brain cells.
Researchers have developed a novel solution for dynamic terahertz wavefront control using stretchable single-walled carbon nanotube-based metasurfaces. The devices enable focal-length-tunable and beam-steering capabilities through simple mechanical deformation, opening up new avenues for smart and wearable THz components.
The collaboration aims to turn thousands of data points into actionable insights, helping coaches identify trends and evaluate strategies. By organizing play-level data from football games, the team creates a searchable platform for analysts to quickly test ideas and compare trends across seasons and opponents.
The article highlights Lgr6 as a central regulator of tissue repair and disease development, with its presence linked to stem cell markers and influential signaling pathways. Abnormal expression of Lgr6 is observed in various diseases, including cancer, and is associated with disease severity and treatment response.
A study of comatose survivors treated with therapeutic hypothermia found that longer cooling durations did not improve neurological outcomes. Increasing cooling duration was ineffective in improving patient recovery after out-of-hospital cardiac arrest, suggesting alternative treatments may be more effective.
A new study by Cornell University researchers has found that biofortified millet provides essential nutrients to toddlers without causing adverse side effects. The study showed increased activity in microbial pathways associated with fighting pathogens and improved antioxidant metabolism in children who consumed the fortified millet.
Researchers at Tohoku University identified a new class of small molecules that improves drought tolerance in plants without causing unwanted side effects. The compounds, NS5806 and UA49, inhibit stomatal opening and enhance plant survivability during water scarcity.
Dendritic cell vaccines are engineered to carry tumor-associated antigens, stimulating cytotoxic T lymphocytes to attack malignant cells while sparing healthy tissue. These vaccines have the potential to amplify immune activation and overcome tumor-induced immunosuppression when paired with other therapies.
A new portable blood testing device connects via Bluetooth and uses AI to analyze blood samples, providing real-time health insights. This technology allows for regular monitoring of patients undergoing chemotherapy or taking medications with potential side effects.
The Boston University-Quantitative Population Science and Healthy Cognitive Aging Research Program (BU-SHARP) aims to better understand how and why Alzheimer's disease manifests among certain populations. The center will fund pilot studies, provide technical assistance, and facilitate access to underutilized datasets.
Researchers found that GSTM3 knockdown promotes liver fibrosis reversal through the inhibition of hepatic stellate cell activation via PPARγ signaling. GSTM3 levels were negatively correlated with reversal, suggesting its potential as a diagnostic biomarker.
Researchers developed a new drug called CS18 that targets TopBP1, a biological switchboard controlling multiple cancer-driving pathways. CS18 reduces defenses helping cancer cells survive therapy and increases genes stopping uncontrolled growth.
A study by King's College London has identified an immune pathway that prevents a normally harmless fungus from developing into a fatal infection. The IL-1 family signalling plays a critical role in containing the fungus, suggesting it may be a broader defence mechanism against other fungal species.
According to the study, people with none of these risk factors lived nearly 13 years longer without dementia than those with all three. Women and white participants also had longer survival times without developing dementia. The study highlights the importance of preventing these vascular risk factors in midlife.
A new paper proposes a framework to support more women entrepreneurs, focusing on digital workplace innovation and flexible ways of working. The researchers argue that technology alone is not enough and requires investment in digital skills and inclusive workplace design.
Research found that social media influences travel plans across all age groups, but millennials were the most impacted. Younger generations, especially Gen Z, gravitated toward posts about less common locales.
A study published in Annals of the Rheumatic Diseases found a strong association between air pollution, particularly PM2.5, and increased disease activity and flare risk in RA patients. The study suggests that avoiding prolonged exposure to poor air quality may help reduce disease activity.
The Cancer Dependency Map now includes nearly 150 3D cancer models, expanding its resource to include organoids and spheroids across 10 cancer types. These next-generation models reveal new genetic dependencies and disease-driving mechanisms, particularly in brain and gastrointestinal cancers.
Researchers have developed a numerical model that explains how increasing ultrasonic power reduces chemical reaction rates in sonochemistry. The model shows that oscillating bubbles emit their own sound waves, generating unwanted noise that distorts the ultrasonic field and limits reaction efficiency.
The Osiris 41 volume examines the interrelation between childhood and science, highlighting children's influence and contributions to historical change. Articles challenge traditional norms and assumptions in the field, proposing a more dynamic understanding of this relationship.
Researchers at the University of São Paulo have developed an algorithm for optimal pruning using LiDAR technology, which creates a detailed 3D model of tree architecture. By simulating wind forces on these models, they can identify vulnerable branches and recommend precise cuts to improve tree stability.
A new MUSC study found that patients with college experience and those without health insurance are more likely to decline participation, while younger adults and those who feel unwell or disinterested also opt out. However, many who declined still want help, suggesting it's not the peer support itself that's unappealing.
CircRNAs are emerging as powerful regulators of cellular processes, influencing mechanisms such as oxidative stress, apoptosis, and DNA damage. They interact with key biological pathways to shape outcomes in cardiotoxicity, nephrotoxicity, neurotoxicity, and gastrointestinal injury.
The KUNIST platform cultivates globally competitive physician-scientists with five core competencies, including clinical problem-solving, convergent research, and commercialization. The collaboration aims to develop joint educational programs, establish collaborative research laboratories, and build a commercialization support platform.
Recent advances in machine learning enable data-driven design of carbon dots, enhancing their luminescent properties. The technology facilitates rational design and controllable preparation, paving the way for various applications such as sensing, biomedicine, and optoelectronics.
CXorf67, a protein regulating gene activity and DNA repair processes, has been linked to several cancer types including brain tumors, osteosarcoma, and lung cancer. Therapeutic strategies targeting CXorf67-related vulnerabilities, such as PARP inhibitors and EZH2 inhibitors, are being explored.
A recent study found that severe COVID-19 reactivates certain dormant viruses in hospitalized patients, which may contribute to autoimmune disease and chronic conditions. Notably, reactivation of Anelloviridae viruses was associated with long-term physical disability and long COVID.
A study in Arequipa, Peru, found that a decentralized, immune-inspired surveillance model detected 23 infested households compared to just one through the conventional strategy. The new approach allowed local public health staff to accept reports of infestations and expand outreach to nearby areas.
A study found that telemedicine is commonly used for problem-based primary care, particularly for children with endocrine or behavioral health issues. The availability of telemedicine may help increase appointment volume, making more patients accessible to care.
The Gerontological Society of America has announced its newest elected officers, consisting of Vice President Edward Alan Miller and Secretary Sherry A. Greenberg. The organization, founded in 1945, aims to foster excellence, innovation, and collaboration in aging research, education, practice, and policy.
A new study reveals that patients with metabolic dysfunction-associated steatotic liver disease (MASLD) have elevated lipocalin-2 levels and exhibit early signs of cardiovascular and cognitive impairment. The findings highlight the importance of considering MASLD as a systemic condition affecting multiple organ systems.
Ancient human genomes showed differing functional PSPH gene variants, with modern-day phosphoserine phosphatase having the greatest function. The study highlights potential in combining evolution-guided variant prioritization for uncovering functional differences.
Researchers developed a compact antenna-in-package wireless module that achieves 144 Gbps data transmission in the 150 GHz sub-terahertz band, paving the way for future 6G devices. The technology uses phased-array transceivers and dual-polarized MIMO to increase communication efficiency and capacity.
A study found that coating developing raven eggs with non-toxic mineral oil helps protect sensitive prey populations. Raven nests treated with egg oil showed more than doubled sage-grouse nest survival and a 44% increase in relative abundances of sage-grouse.
Researchers at the University of Exeter discovered that a 19th-century estate agent, Brooks & Green, created an early version of Rightmove using cosmorama technology. The discovery reveals how this innovative approach to property marketing paved the way for modern virtual tours and online property previews.
A new platform enables high-performance single photons with exceptional purity and indistinguishability, key resources for quantum communication, networks & computing. The technology addresses scalability challenges in wafer-scale arrays of deterministic emitters.
The Office of Naval Research will host an Innovation Industry Days event from Sept. 21-25, 2026, in Arlington, Virginia. The multi-day event aims to identify and fill future technology gaps across 11 key Focus Areas, fostering collaboration with industry and discussing Navy's pressing research needs.
In a new study, researchers found that wild capuchin monkeys prioritize stones with proven track records of cracking nuts, even if they're not the mechanically optimal choice. This demonstrates that primates rely on durable physical traces to guide their tool selection.
A study by Goethe University found that zoo education programs can genuinely strengthen people's sense of connection to nature, especially among those with low or moderate connections. Programs with direct animal encounters and longer durations showed the strongest effects.
Researchers developed a cost-effective and sustainable approach to produce freshwater by capturing water vapor from the air using specialized materials. The wind-driven strategy utilizes hygroscopic polymer sponges integrated with wind-powered eddy current heating, generating up to 9.9 liters of water per day.
Researchers engineered Cupriavidus necator H16 to convert CO2 into p-coumaric acid, producing a 1,593.3% increase in yield under autotrophic conditions. The breakthrough establishes a framework for CO2-based biomanufacturing and paves the way for producing phenylpropanoids from industrial CO2 emissions.
Researchers created nearly 700 new cancer models derived from patient tumors to aid in drug development. The models, representing 25 types of cancer, are now available for global use, providing a resource for identifying new drug targets and testing potential treatments.
Butterflies worldwide are experiencing extensive climate-induced range shifts, impacting ecosystems globally. As temperatures rise, butterfly populations are adapting to new habitats, altering species interactions and community dynamics.
The Lifestyle Medicine Evidence Repository brings together systematic reviews, meta-analyses, and intervention studies to support clinicians in translating whole-person care evidence into practice. The repository includes studies focusing on lifestyle medicine's six pillars: optimal nutrition, physical activity, restorative sleep, stre...
A collaborative team led by Dana-Farber Cancer Institute has developed 665 next-generation patient-derived cancer models across 27 common and rare forms of cancer. The models are available as a resource to researchers worldwide, accelerating cancer advances with reliable and faithful replicas of original samples.
Researchers found that patients with inflammatory bowel disease (IBD) are at a significantly higher risk of developing psychiatric disorders, particularly depression and anxiety. The study highlights the importance of early screening and integration of psychological care into routine IBD management to improve quality of life.
The KCNE gene family acts as key regulators of voltage-gated potassium channels, controlling their activation and ion flow. These subtle disruptions can have widespread consequences on cellular communication and physiological demands.
A new study found that avoiding three risk factors in middle age is linked to nearly 13 more years without dementia. Participants who had no risk factors lived without developing dementia an average of 30 years, compared to 17 years for those with the three risk factors.
A cohort study evaluates histotripsy's short-term outcomes for liver tumors, highlighting its potential as a treatment option. The study also examines national practice patterns and adult patient results.
Researchers have successfully generated atomic quantum gas mixtures with unprecedented particle flux using a highly sophisticated and compact optical system. The miniaturized laser system developed by Mainz physicists enables precise control of atoms under microgravity conditions, opening doors for future space missions.
A new study found that older adults living in homes with electrical or plumbing problems, insufficient space, or poor lighting are more likely to experience a fall. The study analyzed data from over 5,500 adults aged 65 and over, revealing a significant association between housing conditions and fall risk.
Researchers found that lithocholic acid, a secondary bile acid, can alleviate fatty liver in mice and non-human primates when administered at CR-mimetic doses. The study identified two safe regimens, 0.25 mg/kg and 0.5 mg/kg twice daily, without detectable toxicity.