Researchers developed multivalent mRNA-exosome vaccines that induce local inflammation, recruiting immune cells and triggering epigenetic regulation, turning 'cold' tumors into 'hot' niches. These vaccines drive tumor cell death and sensitize tumors to immune checkpoint inhibitors.
Researchers have found that Astragalus polysaccharide protects against ischemic stroke by modulating the gut-brain axis, a two-way communication network between gut microbes and the brain. The compound also reduces inflammation and preserves neurons, suggesting a new route for treating the world's leading cause of long-term disability.
Researchers discovered a natural compound, hederagenin, that slows kidney aging in diabetes by reversing epigenetic silencing of the anti-aging gene Klotho. Hederagenin reduces Klotho promoter methylation, restoring Klotho protein levels and curbing cellular senescence.
Researchers created a self-stratified stretchable passive cooling interface that reduces temperature in wearable electronics. The interface, composed of aluminum-oxide-rich and liquid-metal-rich layers, combines external-blocking and internal-dissipation functions, improving cooling performance.
Pinoresinol diglucoside (PDG) attenuates diabetic cardiomyopathy by suppressing store-operated calcium entry and downregulating STIM1/Orai1/NFAT3 signaling pathway, ultimately inhibiting the progression of diabetic cardiomyopathy.
Quzhou Fructus Aurantii ethyl acetate extract (QFAEE) significantly ameliorates liver enlargement, lipid accumulation, and liver injury in MASH models. It activates the PPARalpha signaling pathway, upregulating CPT1A and downregulating lipogenic markers.
Researchers found that using the loose side of thin wood sheets as the tension surface reduces stress concentration and improves bending performance. This technique resulted in significant cost savings and waste reduction, making it an attractive alternative to traditional reinforcement methods.
Researchers developed a method to enrich EVs from whole blood, capturing complementary biological information lost in plasma or serum analysis. This approach may support deeper investigation of disease mechanisms and discovery of circulating biomarkers.
NeuroSyn decodes movement intentions and tracks nerve recovery in real-time, capturing continuous recovery dynamics. The device achieves high signal-to-noise ratio and accurate motor intention decoding, making it a potential tool for exoskeleton-based rehabilitation.
Researchers used directed evolution to boost bacterial tolerance to industrial spray-drying, improving survival by 1000-fold. The genetic basis of this newfound toughness was linked to a mutation in the pepC gene, which truncates the protein and likely abolishes its enzymatic activity.
Researchers developed a dual-enzyme cascade system for one-pot biosynthesis of salidroside, increasing efficiency and reducing costs. The optimized system achieved high titer and space-time yield, demonstrating strong commercial potential.
Researchers developed a phase-field model to understand how charged defects affect grain boundaries in oxide ceramics. The simulations revealed that solute drag can drive abnormal grain growth and that grain-boundary potentials vary throughout the microstructure.
Recent advances in machine learning enable data-driven design of carbon dots, enhancing their luminescent properties. The technology facilitates rational design and controllable preparation, paving the way for various applications such as sensing, biomedicine, and optoelectronics.
This study demonstrates the efficacy of Fufang Huangbo Formula in alleviating myeloproliferative neoplasms by inducing cell senescence, inhibiting proliferation, and reducing inflammation. Key components like forsythiaside A and chlorogenic acid are identified as active molecules targeting STAT3 and NF-κB pathways.
Researchers developed a novel film by incorporating tannic acid into deacidified chitin nanofibers, achieving remarkable tensile strength, UV shielding, and antioxidant properties. The film demonstrated exceptional performance in preserving fruits, such as strawberries, for extended periods.
A new AI framework reduces operational costs by 6% and improves grid reliability through coordinated energy source management. The approach uses distributed reinforcement learning to optimize hydrogen storage and minimize coal consumption.
Researchers found that intestinal mucus provides a niche for Klebsiella pneumoniae colonization and supports bacterial growth. Mucus exposure also increases sensitivity to certain antibiotics, suggesting a new target for improving therapy.
Research compares three hemp fiber preparation methods, finding TEMPO-oxidized nanocellulose ideal for high-stability applications and hydrolysed SCNC suitable for composites and packaging. The study demonstrates sustainable production of high-performance bio-based materials from abundant agricultural resources.
Researchers elucidate Yangxinshi Tablet's cardioprotective effects in post-MI heart failure rat models and in vitro hypoxic cardiomyocytes. The formula restores energy homeostasis by targeting the FOXO1/PDK4 axis, promoting the TCA cycle, and increasing ATP levels.
Silibinin meglumine reduces neuroinflammation and oxidative stress by downregulating UCP2 expression, restoring mitochondrial homeostasis. It alleviates liver function in a thioacetamide-induced HE mouse model.
Researchers discover Murraya exotica L. extract inhibits fibroblast-like synoviocyte proliferation, reduces inflammatory cytokine release, and mitigates oxidative stress by targeting NF-κB/AP-1 axis in rheumatoid arthritis models. The primary active constituent murrayone shows promise as a therapeutic agent.
The mbLFIA platform overcomes the sensitivity bottleneck in traditional enzyme-free isothermal amplification approaches by using dual-mechanism multisite bridging and gold-platinum nanoparticles. It achieved a visual limit of detection as low as 2 pmol·L⁻¹ for CHIKV, demonstrating perfect clinical sensitivity and specificity.
Researchers discover celastrol's dual mechanism to ameliorate cholestatic liver injury by inhibiting CTSS and restoring autophagy, shifting iNKT cell balance from pro-inflammatory to protective phenotype.
A lightweight genetic toolkit has been developed for streamlined gene expression regulation in industrial streptococci, featuring short constitutive promoters and a compact IPTG-inducible promoter system. The toolkit was successfully applied to two production-relevant scenarios, revealing new targets for improving exopolysaccharide yie...
A research team identified crocin II as a potent natural ANGPTL8 degrader, which drives selective autophagic degradation of ANGPTL8. This reduces hepatic lipid accumulation and inflammation, improving metabolic dysfunctions associated with MASLD.
Researchers engineered a Bacillus subtilis strain to increase intracellular guanine levels, alleviating feedback inhibition and enhancing the de novo purine biosynthesis pathway. This led to a 15.3% increase in riboflavin production without affecting cell growth or energy charge levels.
Researchers propose a new strategy combining nobiletin with the HDAC inhibitor SAHA to enhance anti-tumor efficacy in non-small cell lung cancer. The study reveals the critical role of TRKC in NSCLC and demonstrates synergistic inhibition of tumor growth through regulating BH3-only protein expression.
A recent study published in Life Metabolism found that exercise reduces inflammation, promotes pro-inflammatory gene expression, and improves glucose-stimulated insulin secretion in human and mouse islets.
Researchers have successfully incorporated sulfur into Fe–N–C catalysts to enhance oxygen reduction reaction kinetics and mitigate 'site blocking' effects. This results in a 3.2-fold increase in turnover frequency compared to traditional FeNC catalysts, leading to improved fuel cell performance.
Comparative study evaluates membrane affinity binding, ultracentrifugation, and size-exclusion chromatography methods for isolating extracellular vesicles from bronchoalveolar lavage fluid. SEC method yields significant EV populations with reliable results and preservation of structure and function.
A collaborative team developed an AI-assisted pipeline to identify promising gp130 inhibitors from a library of natural products. Evodiamine was identified as a starting scaffold, and Compound 8a was selected as the optimal candidate with high affinity for the gp130 D1 domain.
Researchers discovered acteoside alleviates hepatic ischemia-reperfusion injury through two mechanisms: inhibiting IRF1 nuclear translocation and promoting CMPK2 degradation. Acteoside reduces liver injury, serum ALT/AST, inflammatory infiltration, oxidative stress, and mtDNA release.
Researchers developed HerbSyner_Finder to identify synergistic herb pairs for cough variant asthma. The model showed strong synergy between berberine and luteolin, reducing symptoms and inflammation in rat models.
Researchers identify Sanguinarine as a potent agent that synchronously induces apoptosis and ferroptosis in lung squamous cell carcinoma by hijacking the ER chaperone protein BiP. This 'switch' triggers Endoplasmic Reticulum Stress, leading to catastrophic cell death.
Research explores the impact of donor-acceptor ratio on buried interface optimization in perovskite solar cells. The study reveals that an EDG-rich modification leads to efficient defect passivation and high-quality film growth, resulting in improved stability and performance.
Researchers identify MARK2 as a unique upregulator of mutant p53 in triple-negative breast cancer, linked to poor survival. Disrupting the MARK2-mutp53 interaction through dominant-negative mutants may restore mutp53 degradation and inhibit TNBC growth.
Researchers identified chipericumin D as a potent inhibitor of human aortic valve interstitial cell calcification, halting the disease progression by silencing the EGFR/PI3K/AKT signaling pathway. This natural compound offers a new therapeutic strategy for calcific aortic valve disease.
A hybrid Ti3C2Tx/Bi2Se3 material exhibits high-efficiency photothermal conversion and gradually conceals targets in environmental simulations. This work constructs a thermal protection strategy via enhanced photothermal conversion, providing a promising approach for developing advanced stealth technologies.
A new study identifies distinct gut microbiome 'cluster types' associated with disease severity and progression risk in IBD. These clusters reflect higher-order microbial community organization, suggesting a more integrated view of host-microbe interactions in IBD.
A multi-stage coupled refining process converts high-acid-value waste cooking oil into high-performance natural ester insulating oil with improved physical, chemical and electrical properties. The process increases the oil's dielectric dissipation factor and power frequency breakdown voltage.
A novel paper-based device has been developed to detect cancer biomarker miRNA-21 with high sensitivity and specificity. The device utilizes nanozyme-catalytic colorimetric detection, demonstrating a wide linear detection range and remarkable detection limit.
Researchers developed a method to produce nylon precursor cadaverine continuously using immobilized cells entrapped in carrageenan gel and crosslinked with polyethylenimine. This approach enhances enzyme stability, allowing for a titer of 112 g/L and productivity of 44.8 g/g DCW/h, surpassing previous batch processes.
Researchers used molecular docking and computational modeling to identify a superior mutant of L-amino acid deaminase, overcoming substrate inhibition at high concentrations. The mutant showed significantly enhanced catalytic efficiency and high-substrate tolerance, demonstrating a powerful approach for optimizing industrial biocatalysts.
This study evaluates provincial expressway PV potential using a multi-scenario and credibility interval model, revealing that slopes exceed service areas in generating power. The research provides a standardized tool for assessing expressway PV potential worldwide, supporting the construction of zero-carbon green power corridors.
A study assesses carbon unlocking levels in China's transportation infrastructure across 30 provinces. The results show a clear regional pattern, with eastern provinces leading and western provinces lagging behind. Key driving factors include green patents, R&D investment, and low-carbon regulation.
A new method generates physically synthesized data for defect segmentation, outperforming data-driven methods due to its ability to capture geometric variations. Adding only a few real images significantly improves performance.
The study reveals that the structural transition of SnTe originates from atomic-level mismatches between S/Se and Sn. SnTe retains a cubic structure due to its similar physicochemical properties with Sn, enabling it to exhibit remarkable advantages in conductivity, tap density, and lithium-ion diffusivity.
Spatial proteomics enables precise mapping of protein distribution in native tissue contexts, addressing critical limitations of conventional bulk proteomics. This transformative solution has far-reaching implications for disease stratification, therapeutic target discovery, and personalized treatment strategies.
Researchers employed PCT-assisted sample preparation with DIA mass spectrometry to compare the proteomic profiles of MGA and non-neoplastic kidney tissues. They identified 1,338 differentially expressed protein groups, including 190 downregulated and 1,148 upregulated proteins.
A new study introduces NARA, a computational framework that combines firefly algorithm with uncertainty-aware machine learning to make atomic structure prediction more robust. The method achieves higher efficiency than the widely used basin-hopping algorithm and recovers competing structures in a single run.