Researchers developed an integrated bioprocess to produce antifungal bioproducts from winery waste, reducing mycelial growth of grapevine pathogens by 45-75% and symptoms of wood discoloration by 47-52%. The process uses fermentation design, ultrasound-assisted autolysis, and enzymatic hydrolysis to yield active peptide mixtures.
Researchers developed a biomimetic mineralization-immobilized whole-cell biocatalyst for efficient nicotinic acid production. The biocatalyst achieved 14 reuse cycles, producing 603.56 g/L nicotinic acid with a total molar conversion of 90.2%, significantly outperforming free cells.
The strain accelerates wheat straw decomposition, reduces fungal proliferation, and decreases aflatoxin content, promoting peanut seedling growth and supporting sustainable agriculture. SQ1 functions as a dual-purpose biocatalyst, breaking down cellulose and inhibiting fungal growth.
A high-entropy alloy introduces a distorted interface to magnesium hydride, weakening interfacial Mg–H bonds and reducing activation energy by 30%. This boosts dehydrogenation kinetics, lowering the dehydrogenation temperature by 74°C. The alloy also enables rapid hydrogenation and sustained cycling stability.
Researchers developed an asymmetric polarization strategy to improve photocatalytic H2O2 production in covalent triazine frameworks. The resulting CTF-P1 exhibits enhanced polarization, internal electric field, and efficient charge separation and transport, achieving high H2O2 production rates.
Researchers developed a stretchable dry electrode inspired by spider silk, achieving stable resistance during stretching and high-fidelity electrophysiological interfaces. The 'bead-on-string' structure enabled long-term use of wearable devices, tolerating up to 400% strain without significant impedance changes.
Researchers developed an interpenetrated RuO2/Co3O4 heterostructure to overcome the scaling relationship of OER, enabling low-energy O–O coupling and accelerating deprotonation. The catalyst achieved high mass activity and stability, surpassing commercial RuO2, with improved antioxidant capacity and long-term operation.
Researchers develop bioplastic composite by using small L-lactide molecules to reinforce spongy wood, resulting in 1,333% mass gain and 35.40 MPa compressive strength, limiting water uptake to 20%. This strategy offers strong, dimensionally stable, and biodegradable wood-plastic composites for construction and engineered materials.
Rapeseed straw extract reduces steel corrosion by 91.72% in methanesulfonic acid by forming a compact protective film. The extract's mechanism involves adsorption of molecules onto the steel surface, sealing the surface and reducing corrosive ion consumption.
This study compares three flow cytometers for characterizing nanoparticles and extracellular vesicles. The results show that sensitivity varies between instruments and that sample concentration affects particle discrimination. The study provides practical guidance for selecting detection strategies and sample concentrations.
Researchers designed a dynamic covalent assembly strategy to co-deliver multiple hydrophobic drugs to inflamed joints. The system efficiently loads two complementary drugs and exhibits accelerated drug release under acidic pH, reducing serum levels of inflammatory markers and restoring cartilage architecture.
In vivo immune cell engineering allows for direct genetic modification of immune cells in the body, enabling more efficient and accessible CAR-T-cell therapy. The approach overcomes the limitations of traditional ex vivo cell manufacturing, such as long manufacturing times and high costs.
Researchers developed a dynamic covalent assembly strategy to overcome drug delivery hurdles in osteoarthritis. The system efficiently loads two complementary drugs into hyaluronic acid carriers, achieving high encapsulation efficiencies and accelerated drug release under acidic pH.
Researchers developed multivalent mRNA-exosome vaccines that induce local inflammation, recruiting immune cells and triggering epigenetic regulation, turning 'cold' tumors into 'hot' niches. These vaccines drive tumor cell death and sensitize tumors to immune checkpoint inhibitors.
Researchers have found that Astragalus polysaccharide protects against ischemic stroke by modulating the gut-brain axis, a two-way communication network between gut microbes and the brain. The compound also reduces inflammation and preserves neurons, suggesting a new route for treating the world's leading cause of long-term disability.
Researchers discovered a natural compound, hederagenin, that slows kidney aging in diabetes by reversing epigenetic silencing of the anti-aging gene Klotho. Hederagenin reduces Klotho promoter methylation, restoring Klotho protein levels and curbing cellular senescence.
Researchers created a self-stratified stretchable passive cooling interface that reduces temperature in wearable electronics. The interface, composed of aluminum-oxide-rich and liquid-metal-rich layers, combines external-blocking and internal-dissipation functions, improving cooling performance.
Pinoresinol diglucoside (PDG) attenuates diabetic cardiomyopathy by suppressing store-operated calcium entry and downregulating STIM1/Orai1/NFAT3 signaling pathway, ultimately inhibiting the progression of diabetic cardiomyopathy.
Quzhou Fructus Aurantii ethyl acetate extract (QFAEE) significantly ameliorates liver enlargement, lipid accumulation, and liver injury in MASH models. It activates the PPARalpha signaling pathway, upregulating CPT1A and downregulating lipogenic markers.
Researchers found that using the loose side of thin wood sheets as the tension surface reduces stress concentration and improves bending performance. This technique resulted in significant cost savings and waste reduction, making it an attractive alternative to traditional reinforcement methods.
Researchers developed a method to enrich EVs from whole blood, capturing complementary biological information lost in plasma or serum analysis. This approach may support deeper investigation of disease mechanisms and discovery of circulating biomarkers.
NeuroSyn decodes movement intentions and tracks nerve recovery in real-time, capturing continuous recovery dynamics. The device achieves high signal-to-noise ratio and accurate motor intention decoding, making it a potential tool for exoskeleton-based rehabilitation.
Researchers used directed evolution to boost bacterial tolerance to industrial spray-drying, improving survival by 1000-fold. The genetic basis of this newfound toughness was linked to a mutation in the pepC gene, which truncates the protein and likely abolishes its enzymatic activity.
Researchers developed a dual-enzyme cascade system for one-pot biosynthesis of salidroside, increasing efficiency and reducing costs. The optimized system achieved high titer and space-time yield, demonstrating strong commercial potential.
Researchers developed a phase-field model to understand how charged defects affect grain boundaries in oxide ceramics. The simulations revealed that solute drag can drive abnormal grain growth and that grain-boundary potentials vary throughout the microstructure.
Recent advances in machine learning enable data-driven design of carbon dots, enhancing their luminescent properties. The technology facilitates rational design and controllable preparation, paving the way for various applications such as sensing, biomedicine, and optoelectronics.
This study demonstrates the efficacy of Fufang Huangbo Formula in alleviating myeloproliferative neoplasms by inducing cell senescence, inhibiting proliferation, and reducing inflammation. Key components like forsythiaside A and chlorogenic acid are identified as active molecules targeting STAT3 and NF-κB pathways.
Researchers developed a novel film by incorporating tannic acid into deacidified chitin nanofibers, achieving remarkable tensile strength, UV shielding, and antioxidant properties. The film demonstrated exceptional performance in preserving fruits, such as strawberries, for extended periods.
A new AI framework reduces operational costs by 6% and improves grid reliability through coordinated energy source management. The approach uses distributed reinforcement learning to optimize hydrogen storage and minimize coal consumption.
Researchers found that intestinal mucus provides a niche for Klebsiella pneumoniae colonization and supports bacterial growth. Mucus exposure also increases sensitivity to certain antibiotics, suggesting a new target for improving therapy.
Research compares three hemp fiber preparation methods, finding TEMPO-oxidized nanocellulose ideal for high-stability applications and hydrolysed SCNC suitable for composites and packaging. The study demonstrates sustainable production of high-performance bio-based materials from abundant agricultural resources.
Researchers elucidate Yangxinshi Tablet's cardioprotective effects in post-MI heart failure rat models and in vitro hypoxic cardiomyocytes. The formula restores energy homeostasis by targeting the FOXO1/PDK4 axis, promoting the TCA cycle, and increasing ATP levels.
Silibinin meglumine reduces neuroinflammation and oxidative stress by downregulating UCP2 expression, restoring mitochondrial homeostasis. It alleviates liver function in a thioacetamide-induced HE mouse model.
Researchers discover Murraya exotica L. extract inhibits fibroblast-like synoviocyte proliferation, reduces inflammatory cytokine release, and mitigates oxidative stress by targeting NF-κB/AP-1 axis in rheumatoid arthritis models. The primary active constituent murrayone shows promise as a therapeutic agent.
The mbLFIA platform overcomes the sensitivity bottleneck in traditional enzyme-free isothermal amplification approaches by using dual-mechanism multisite bridging and gold-platinum nanoparticles. It achieved a visual limit of detection as low as 2 pmol·L⁻¹ for CHIKV, demonstrating perfect clinical sensitivity and specificity.
Researchers discover celastrol's dual mechanism to ameliorate cholestatic liver injury by inhibiting CTSS and restoring autophagy, shifting iNKT cell balance from pro-inflammatory to protective phenotype.
A lightweight genetic toolkit has been developed for streamlined gene expression regulation in industrial streptococci, featuring short constitutive promoters and a compact IPTG-inducible promoter system. The toolkit was successfully applied to two production-relevant scenarios, revealing new targets for improving exopolysaccharide yie...
A research team identified crocin II as a potent natural ANGPTL8 degrader, which drives selective autophagic degradation of ANGPTL8. This reduces hepatic lipid accumulation and inflammation, improving metabolic dysfunctions associated with MASLD.
Researchers engineered a Bacillus subtilis strain to increase intracellular guanine levels, alleviating feedback inhibition and enhancing the de novo purine biosynthesis pathway. This led to a 15.3% increase in riboflavin production without affecting cell growth or energy charge levels.
Researchers propose a new strategy combining nobiletin with the HDAC inhibitor SAHA to enhance anti-tumor efficacy in non-small cell lung cancer. The study reveals the critical role of TRKC in NSCLC and demonstrates synergistic inhibition of tumor growth through regulating BH3-only protein expression.
A recent study published in Life Metabolism found that exercise reduces inflammation, promotes pro-inflammatory gene expression, and improves glucose-stimulated insulin secretion in human and mouse islets.
Researchers have successfully incorporated sulfur into Fe–N–C catalysts to enhance oxygen reduction reaction kinetics and mitigate 'site blocking' effects. This results in a 3.2-fold increase in turnover frequency compared to traditional FeNC catalysts, leading to improved fuel cell performance.
Comparative study evaluates membrane affinity binding, ultracentrifugation, and size-exclusion chromatography methods for isolating extracellular vesicles from bronchoalveolar lavage fluid. SEC method yields significant EV populations with reliable results and preservation of structure and function.
A collaborative team developed an AI-assisted pipeline to identify promising gp130 inhibitors from a library of natural products. Evodiamine was identified as a starting scaffold, and Compound 8a was selected as the optimal candidate with high affinity for the gp130 D1 domain.
Researchers discovered acteoside alleviates hepatic ischemia-reperfusion injury through two mechanisms: inhibiting IRF1 nuclear translocation and promoting CMPK2 degradation. Acteoside reduces liver injury, serum ALT/AST, inflammatory infiltration, oxidative stress, and mtDNA release.
Researchers developed HerbSyner_Finder to identify synergistic herb pairs for cough variant asthma. The model showed strong synergy between berberine and luteolin, reducing symptoms and inflammation in rat models.
Researchers identify Sanguinarine as a potent agent that synchronously induces apoptosis and ferroptosis in lung squamous cell carcinoma by hijacking the ER chaperone protein BiP. This 'switch' triggers Endoplasmic Reticulum Stress, leading to catastrophic cell death.
Research explores the impact of donor-acceptor ratio on buried interface optimization in perovskite solar cells. The study reveals that an EDG-rich modification leads to efficient defect passivation and high-quality film growth, resulting in improved stability and performance.
Researchers identify MARK2 as a unique upregulator of mutant p53 in triple-negative breast cancer, linked to poor survival. Disrupting the MARK2-mutp53 interaction through dominant-negative mutants may restore mutp53 degradation and inhibit TNBC growth.
Researchers identified chipericumin D as a potent inhibitor of human aortic valve interstitial cell calcification, halting the disease progression by silencing the EGFR/PI3K/AKT signaling pathway. This natural compound offers a new therapeutic strategy for calcific aortic valve disease.