Advanced Brain is an open access journal dedicated to publishing cutting-edge research across the brain-mind continuum. The journal aims to foster dialogue across life, medical, and behavioral sciences to accelerate fundamental and applied understanding of the human brain.
Teachers tend to accept overly harsh AI grades more than human grades, resulting in a 22% larger gap between their score and the fair score. Teachers are more likely to accept strict AI grades if they view the system as competent and accountable.
Researchers found that extreme heat impacts daily life, access to care, and treatment-related decisions among people with cancer. Participants adapted by limiting outdoor activity, but these compromises affected health, independence, and quality of life.
In a groundbreaking study, ordinary pet dogs and their owners excelled at finding spotted lanternfly egg masses, with teams outperforming trained human searchers by over 2:1 in dense vegetation. The research demonstrates the potential of community dog-handler teams as an early detection force to combat the invasive pest's spread.
A new study published in Menopause journal found that brain activity differs significantly across menopause stages, linked to hormonal changes particularly estrogen fluctuations. This research contributes to understanding the neurological effects of hormone changes at midlife.
A study from Tokyo University of Science found that public preferences for immigrants shift towards high-income individuals when their participation in the welfare system is highlighted. The researchers also discovered a joint interaction between concerns about welfare systems and job security on attitudes toward immigration.
A major new analysis of over 3000 scientific papers on climate change mitigation found that policy recommendations are often non-existent, disconnected from the study's findings, or 'wish lists'. The researchers created a tool to assess the quality of policy recommendations and identified key challenges, including unclear uncertainty a...
A large-scale genome-wide association study (GWAS) has identified 74 genetic loci associated with anxiety symptoms, providing new insight into the biological pathways involved. The study found that common genetic variation explains around 6% of differences in anxiety symptom severity.
FireANTs, an open-source algorithm, combines AI optimization and geometry to quickly match complex medical images. The new method can accomplish what took weeks in minutes, detecting subtle changes that signal disease or cognitive decline, making it practical for clinical practice.
In a phase 1 clinical trial, researchers found the LASSARAB vaccine to be safe and well-tolerated, inducing strong immune responses against Lassa fever and rabies. The vaccine demonstrated robust neutralizing antibody levels against the rabies virus, exceeding WHO's established threshold for protection.
A new dual vaccine against Lassa fever and rabies has been shown to be safe and induce immune responses against both viruses. The vaccine could potentially streamline delivery in settings where access is limited, reducing the need for separate vaccination efforts.
Researchers at Penn State developed photomemristors that adjust sensitivity based on light levels, like the human eye. These devices can process light data faster and more accurately than traditional systems in mixed lighting environments.
A large retrospective analysis found a significant association between glucosamine supplementation and increased likelihood of progressing from mild cognitive impairment to Alzheimer's disease. The study also revealed elevated sugar attachment in Alzheimer's brain specimens, suggesting metabolic dysfunction as a contributing driver.
Researchers found that temperature and calcium levels inside cells can dramatically impact how drugs interact with their targets. This discovery could lead to smarter medicine design and more effective treatments.
A new design for microscopes and microscope lenses, called HySIL, addresses both problems by pairing a simple solid lens with a precisely matched immersion liquid. This enables inexpensive air lenses to deliver high-resolution images across centimeter-scale tissues.
Researchers found that asexual reproduction slowed the pace of evolution due to limited competition between groups. However, as life spread to shallower waters, stress and increased competition led to the development of sexual reproduction, accelerating evolutionary diversification.
Researchers used remote sensing technology to capture camera trap images of the short-eared dog, revealing its unique physical profile and activity patterns. The study found that this Amazonian predator is more abundant than previously thought, with a preference for intact forests and protected areas.
Scientists at VUB mapped healthy pancreas cells down to the cellular level, discovering rare cells with properties similar to aggressive tumour cells. This fundamental discovery may offer opportunities for early detection of pancreatic cancer, currently one of the most difficult diseases to treat.
The UCDP reported a record high number of armed conflicts between states in 2025, including eight interstate conflicts. The year saw the highest figure since World War II, with 65 conflicts resulting in over 244,000 fatalities, including a sharp increase in violence targeting civilians.
A study by Royal Netherlands Institute for Sea Research found that Lesser Black-backed Gulls rarely visit wind farms off the Zeeland coast, except for some male birds. Despite being attracted to fishing boats outside the wind farm, the gulls' behavior suggests they avoid entering the wind farm due to unknown reasons.
A new EPI-SLEEP study will investigate the impact of personalized in-ear sleep technology on sleep disturbances and circadian health in adults with epilepsy. The study aims to generate robust evidence for a low-risk approach to improving sleep without adding medication burden.
A study of 4,967 community-dwelling adults aged 60+ found that being female, polypharmacy, and unintentional weight loss are associated with fragility fractures. Physical activity was not significantly linked to either fractures or falls, contradicting previous debate.
A new study links even low levels of alcohol consumption to increased risks of death, disability, and chronic diseases like cancer and heart disease. Drinking up to 7 drinks per week is associated with only minimally elevated risks for most conditions, while 14 drinks per week increases mortality risk by 1 in 25.
A new study links even moderate drinking to elevated risks of chronic diseases and premature death. The research provides a much-needed benchmark with findings that one drink per day above the daily limit increases the risk of death, disability, and chronic diseases.
A genomic study reveals koalas' population decline began around 100,000 years ago, coinciding with intense glacial environmental shifts. This finding corrects previous estimates and provides a precise timeline for the species' demographic changes.
Researchers have developed a new method that can detect cancer with low levels of DNA in the blood, providing more detailed information about tumour composition. This could lead to better care for cancer patients, enabling closer monitoring of treatment progress and more informed decision-making.
Researchers develop a gene therapy approach to restore normal nerve signaling and reduce muscle spasticity in spinal cord injury patients. The treatment targets GABA signaling and has shown significant improvements in reducing spasticity and restoring reflex function.
A genomic study reveals koalas experienced a severe population decline around 100,000 years ago due to climate change and habitat loss. This finding overturns earlier studies that suggest human arrival led to the decline.
A new study from Northwestern University developed a customized video game to help chronic stroke survivors regain lost arm function. After six weeks of therapy, participants showed significant improvement in arm function and daily activities, with scores improving up to 7.8 times that of the control group.
Researchers have identified a key mechanism underlying 5-FU resistance in colorectal cancer and proposed a new therapeutic strategy. The study reveals that EHMT2 functions as a critical regulator of chemotherapy resistance and that targeting this protein can potentially return resistant cancer cells to a treatment-responsive state.
Researchers at Shinshu University discovered a unique surface architecture in the petals of the hardy ice plant that produces glossy appearance. The parabolic ridge structures reflect and concentrate light, creating gloss across a broad range of viewing angles.
A study proposes a new mechanism, the 'delayed seismic champagne effect,' where earthquakes can trigger fires by releasing methane from soft sediment layers beneath cities. The research found intense shaking that drove methane into a supersaturated state, leading to localized ruptures and rapid gas releases.
A new study from Edith Cowan University identifies a smarter approach to protecting fragile marine ecosystems from invasive species. The researchers developed a biosecurity system that focuses on reducing risk at critical points, allowing for the balance between environmental protection and tourism to be maintained.
A comprehensive study of the protein repair system reveals changes in post-translational modifications, or PTMs, that disrupt the system's ability to respond to misfolded protein stress signals. The findings suggest that IDCM can be viewed as a protein misfolding disease, with potential treatments being explored in cancer research.
A KAIST research team has developed a technology that leverages natural ingredients to increase the strength of seaweed-based hydrogel by more than fivefold, while controlling its adhesiveness and degradation rate. The new material design strategy utilizes tannic acid to enhance mechanical strength and adhesiveness.
The University of New Hampshire will lead a national effort to grow and strengthen America's seafood supply through aquaculture research, with a focus on sustainability and environmental friendliness. The $13.5 million initiative aims to expand domestic seafood production and improve food security.
Researchers highlight five contexts – duration, time of day, purpose of use, interactivity, and content structure – to determine whether screen time is healthy or harmful. By examining these factors, individuals can protect themselves and their children from unhealthy screen behavior and create healthier digital environments.
As we age, the body adopts a safety-first walking style that sacrifices efficiency for stability, leading to slower speeds and increased fatigue. Researchers identified subtle changes in ankle and surrounding muscles controlling each step.
A team of NUS researchers has developed a self-testing quantum chip that generates certified random numbers while verifying its own measurement hardware's functionality. The chip, published in PRX Quantum, removes the trust assumption in traditional random number generators.
A neural network-based machine learning model accelerates diffuse optical tomography by over a million-fold, enabling real-time diagnosis. The model accurately reproduces signals even for unseen parameter combinations, with each inference taking approximately 2 milliseconds.
Researchers discovered consistent shifts in immune cell behavior before symptoms develop, suggesting underlying genetic risk factors. The study found that CD4 helper T cells from people with coeliac disease showed weaker responses, contradicting expectations of overactivity.
A new analysis tracks global sugar-sweetened beverage tax adoption across 183 countries, revealing South Asia's significant lead in tax implementation. The study found that countries with higher burdens of type 2 diabetes and obesity are more likely to adopt taxes, but not necessarily those with high rates of sugary drink consumption.
A new scoreboard reveals the nations facing climate penalties, ranking countries on six climate indicators, including emissions and heat stress. The top-ranked nations include Paraguay, England, and Scotland, while those with severe projected warming and high fossil fuel dependency struggle.
Researchers found a unique protein called YAF9B that helps plants protect their stem cells from DNA damage. This discovery sheds light on how plants coordinate DNA repair processes, which could improve future crops by guiding more precise genome editing.
A new oral GLP-1 medication, elecoglipron, has been shown to significantly reduce blood glucose levels and bodyweight in adults with type 2 diabetes. The study found that up to 89.6% of participants achieved an HbA1c level of 7%, while 72.3% experienced at least 5% weight reduction.
Researchers developed a framework to analyze high-frequency satellite data and measure the vital signs of global cities. The Urban Pulse can identify areas of unsustainable sprawl and provide an early warning system for policymakers and citizens. This tool has the potential to revolutionize how people interact with their cities.
A study by Kyoto University researchers found that hospital admissions for persons with dementia result in higher healthcare spending, with a $2,500 increase in 30-day costs after an emergency room visit. However, there was no conclusive evidence linking hospital admission to 30 or 90-day mortality rates.
A study analyzing insurance claims data found similar risks between continued and non-continued GLP-1RA medication use during early pregnancy. The authors conclude that further research is needed to better understand the safety of GLP-1RAs in pregnancy due to imprecise estimates for rare outcomes.
Two studies from the University of Pennsylvania School of Medicine have identified a key signaling pathway, ERK, that regulates heart cell growth and restructuring. Stabilized microtubules promote lateral growth, increasing cell width, while destabilized microtubules favor longitudinal growth, lengthening cells.
Researchers found that asking people to take multiple looks at unfamiliar faces improved identification accuracy by around 8%. This simple approach, which combines decisions made by the same person, outperforms gains from specialist training programs.
Researchers implemented behavioral nudges to increase prescription of naltrexone, a medication for alcohol use disorder. The study resulted in a 15-fold increase in patients leaving with a prescription, offering an effective treatment to those who struggle with alcohol.
A study by Rice University researchers found that hitting with a slower swing speed can lead to more contact, but also sacrifices power. The study analyzed MLB swing-tracking data and found that batters who adjust their approach with two strikes do not necessarily get better results.
Researchers have discovered a key protein, Mylpf, essential for fast-twitch muscle fibers to form and contract. The study found that even partial reduction in Mylpf function can hinder muscle formation, leading to diseases like muscular dystrophy.
Researchers identified key factors, including diet, exercise, stress, and social engagement, that contribute to the long lives of Cilento residents. The CIAO Study aims to inform clinical solutions by providing actionable answers on aging and longevity.
A global study of over 8,000 participants found that changes in physical activity are closely linked to changes in mood throughout the day. Participants who engaged in light activities like walking or doing chores reported feeling happier and more energized.
The HUG-CELL project aims to identify couples at risk of transmitting recessive genetic disorders and Fragile X syndrome. The initiative will create a large genetic database for Brazil to determine the prevalence of hereditary genetic diseases and develop 'risk calculators' based on the diversity of the Brazilian population.
Researchers from UMass Amherst have developed a new AI architecture called ANT that enables continuous learning and reduces energy consumption by orders of magnitude. Unlike human brains, which operate asynchronously, modern deep neural networks rely on synchronized computations, leading to high energy demands.
Researchers from Florida Atlantic University have identified a key immune pathway that appears to drive damaging inflammation in Huntington disease. Blocking this pathway reduced brain inflammation, protected neurons, and improved movement in a humanized mouse model of the disease.
A University of Minnesota Medical School research team led by Dr. Monica Campo is studying early immune responses in lung cells and their impact on tuberculosis infection outcomes.
UC San Diego Health has received multiple awards from Practice Greenhealth for its achievement and innovation in health care sustainability, including the Greenhealth Leader Award and Circle of Excellence Award. The institution's commitment to operations supporting healthier patients, staff, and communities is recognized nationally.