A team at Scripps Research has discovered that erucamide, a naturally occurring molecule, plays a key role in how the retina copes with disease. Restoring erucamide levels activates cellular responses that support retinal stability, slowing aspects of degeneration by preserving structure and function.
The Centre for Applied English Studies (CAES) at HKU hosted a two-day conference that brought together over 300 participants from eight UGC-funded universities and around the world. The event featured keynote addresses, paper presentations, and workshops on contemporary issues in language education.
This study describes ten new species of Inocybe and a new record for China from the Gaoligong Mountains. The research team conducted detailed taxonomic and phylogenetic investigations using extensive field collections, morphological examinations, and molecular analyses.
A team of researchers has solved the long-standing structural puzzle of γ-N2 using a combination of high-pressure experiments and first-principles calculations. The study reveals that γ-N2 adopts a monoclinic P21/c structure containing two nitrogen molecules per unit cell.
Researchers integrated social determinants of health with genetic information to predict disease risk. Social, behavioral, and environmental factors contributed as much as genetics to disease risk for four out of six studied conditions.
A study found that younger generations are aging faster biologically, increasing their risk of early-onset cancers. The study linked accelerated aging in immune systems and fat tissue to higher risks of lung and colorectal cancer.
A unique regulatory protein called VadK has been identified as a key player in Mycobacterium tuberculosis survival. The enzyme acts as a molecular control switch, enabling the bacterium to access essential energy sources and cause disease.
Scientists have identified a unique chimeric RNA called UBA1-CDK16 that plays important roles in women's blood cell development and disease severity. The findings suggest the chimeric RNA may serve as a natural brake to protect women from excessive autoimmune activity.
Researchers at UMass Amherst have discovered a way to make thermally insulative plastics by limiting heat-carrying vibrational channels, reducing thermal conductivity by 17% while maintaining flame-retardant behavior. This new design framework has promising applications in lightweight insulation materials and advanced building materials.
New research found that human body size increased in two stages: initially with early hominins like Australopithecus and later with Homo species, which coincided with changes in diet, movement, and environment. The study analyzed 386 fossils across 21 species of hominins.
European researchers warn that EU Commission's draft legislation on pesticides weakens key safeguards, increasing risks to biodiversity and human health. The proposed reforms could lead to indefinite approval of active substances without periodic reassessment.
Researchers developed a new gel-based material that filters PFAS 'forever chemicals' from water using 'molecular Velcro', improving filtration capacity and reducing the need for fluorinated materials. The material can be reused by flushing out contaminants, offering a potential solution to removing PFAS from water.
Amy Arnsten, a Yale University researcher, received the prestigious Peter Seeburg Integrative Neuroscience Prize for her groundbreaking work on executive brain functions. Her research has transformed our understanding of how prefrontal cortical circuits support working memory and goal-directed behavior.
Igor F. Palacios, MD, is honored for his groundbreaking work in structural heart disease interventions, including mitral balloon valvuloplasty and the percutaneous pericardial window technique. He has mentored hundreds of physician leaders worldwide through his kindness, generosity, and passion for patient-centered care.
The article explores ways clinicians can deliver care tailored to each patient's unique needs, priorities, and identities. Research highlights the importance of considering life transitions in supporting adolescents and young adults with cancer.
A target trial emulation study found that delaying treatment of moderate pre-cancerous cervical cells (CIN 2) does not increase three-year cancer risk and reduces unnecessary excisions. The study suggests it may be safe to delay treatment, especially for lower-risk CIN 2, by adopting careful follow-up strategies.
Raman microscopy generates molecular fingerprints from biological samples without stains, revealing cellular composition and real-time changes. The technology has advanced significantly, with applications in precision medicine, single-molecule analysis, and multidimensional analysis.
Transition-age youth experiencing suicidal thoughts and behaviors face substantial mental health care access disparities, with Asian, Black, and Latine youths receiving significantly lower treatment rates than white peers. Structural barriers are believed to drive these inequities rather than clinical or patient-related factors.
A new review suggests that immune checkpoint inhibitors can help selected patients with hepatocellular carcinoma (HCC) shrink or stabilize tumors before transplantation, increasing transplant eligibility. However, the therapy also carries a risk of rejection, highlighting the need for precise timing and patient selection.
The RMIT Food Innovation Hub will bring together food technology and nutrition expertise to address industry challenges and support sustainable innovation. The Hub aims to create knowledge, build future workforce skills, and translate research into practical applications for the Australian food system.
HKU ranks 11th globally for the second year, solidifying its position as a premier institution with academic excellence and global impact. The university's success is driven by attracting top talent, fostering innovation, and supporting national education strategies.
Researchers found that forest fires now burn ten times more acreage annually than in 1985, with severe fires causing widespread tree death. The study attributed the changes to an increasingly warm and arid environment, as well as high fuel density in forests.
Scientists predict that New Horizons will encounter the termination shock as early as 2029 or as late as 2040, helping improve understanding of heliosphere interactions with interstellar space. The research aims to prepare for future missions exploring solar system boundaries.
A new review of interspecies cooperation reveals that animals use cues and signals to work together for mutual benefit. The study found commonalities in these interactions across various species, including fish, dolphins, birds, and butterflies. Researchers highlight the importance of communication in these unique team-based behaviors.
Researchers elucidate Yangxinshi Tablet's cardioprotective effects in post-MI heart failure rat models and in vitro hypoxic cardiomyocytes. The formula restores energy homeostasis by targeting the FOXO1/PDK4 axis, promoting the TCA cycle, and increasing ATP levels.
A new study reveals that the shape of poo is determined by the stiffness of the material and direction of gravity compared to extrusion. This explains why animals defecate downward, creating a pointy mound like the poo emoji, but lugworms defy gravity with uniform spirals.
A long-term study published in Circulation found that consuming sugary drinks and fruit juice in childhood may increase the risk of developing high blood pressure later in life. The study suggests that substituting these beverages with whole fruits, milk, and water may be associated with a lower risk of developing high blood pressure.
Researchers at the Flatiron Institute used mathematical models to understand how fruit fly sperm swim and interact in a small space. They found that individual sperm use a collective push to propel themselves forward, resulting in orderly flows.
Scientists at Tampere University identified a new chemical process that can influence the formation of air pollution particles in urban environments. Nitric oxide is found to promote the conversion of certain volatile compounds into aerosol precursors, challenging existing assumptions.
Researchers developed DUET, a motion-robust dual-color microscope that overcomes challenges in neuroscience imaging. The system achieves stable dual-color imaging with minimal crosstalk, enabling cell-type-specific activity patterns to be studied during natural behaviors.
Insilico and SK Biopharmaceuticals collaborate on AI-powered drug discovery for neuroimmune disorders, aiming to accelerate discovery timelines and advance next-generation therapies. The partnership could be worth up to $2.5 billion, with Insilico receiving upfront and milestone payments.
Researchers have uncovered the molecular 'gate' for bulky cargo in bacteria, allowing it to safely transport large proteins across cell membranes. The Tat system, essential for metabolism and virulence, may serve as a potential target for antimicrobial interventions.
Researchers found that higher hydrothermal temperatures promote melanoidin formation, inhibiting methane production and disrupting methanogenic microbial communities. Melanoidins accumulated at increasing levels with hydrothermal severity, reducing digestion efficiency and methane quality.
Montana State researchers aim to eliminate harmful bacteria from hydroponic farming systems using electrochemical sensors and biodegradable nanoparticles. The system can automatically detect pathogen concentrations and trigger removal, protecting harvests from damage.
A new study assesses six climate mitigation strategies in buildings, transport, and industry, finding that demand-side options scored higher across a wider set of dimensions. Improvements in building efficiency emerged as the most robust performer, benefiting both higher- and lower-income countries.
A new study suggests that wearable monitoring can detect cytokine release syndrome (CRS) hours before standard hospital monitoring, potentially reducing complications and improving patient outcomes. The findings support the use of wearable technology to expand access to CAR-T therapy and reduce reliance on prolonged hospital stays.
Dr. Nowicki's research aims to develop a next-generation CAR-T cell therapy targeting GD2, a protein found on osteosarcoma cells, with enhanced immune-signaling molecule TNF-alpha. The grant will support preclinical studies to evaluate safety and effectiveness in laboratory and animal models.
A qualitative study found that abortion bans disrupt clinical care beyond traditional abortion services, leading to treatment delays, patient autonomy erosion, and compromised trust between physicians and patients. The restrictions also create new gatekeeping roles for physicians, potentially exacerbating healthcare inequities.
The American Society of Anesthesiologists is calling for stronger safeguards to address the growing problem of home delivery of ketamine and the lack of physician oversight in ketamine clinics. The risks are not theoretical, with a recent case resulting in death after at-home ketamine prescription.
Researchers developed a groundbreaking approach to prioritize schizophrenia-associated genes by analyzing genetic data from over 102,000 individuals. This study uncovered 641 previously unrecognized genes associated with schizophrenia, shedding light on the complex interactions between distant genetic variants.
Researchers developed an AI-powered platform to track drug responses across thousands of patient-derived organoids, enabling real-time monitoring and analysis of tumor heterogeneity. The platform successfully measured how tumor organoids responded to drug treatment, providing a detailed view of treatment responses at the level of indiv...
A Stanford Medicine study found that pregnant women with severe hyperemesis gravidarum face higher risks for preterm birth, anemia, smaller babies, preeclampsia, and placental abruption. The study also showed that hospitalization for HG can flag a pregnancy as being at higher risk for serious complications.
Researchers discovered Paneth cell metaplasia can act as a protective response in ulcerative colitis by promoting healing and regeneration of the intestinal lining through REG3A. However, persistent changes may still carry risks, including increased cancer risk.
Researchers have identified several groups of metabolites involved in embryo implantation, including glucose, lactate, lipid-derived molecules, amino acids, and neurotransmitters. These metabolites help create a local environment that supports embryo invasion into the uterine lining and promotes tissue remodeling and immune tolerance.
The new report identifies six principles shaping trust in AI: reliability and competence, contextual awareness, transparency and accountability, fairness and integrity, resilience, and relational dynamics. The paper argues that trust must be grounded in demonstrated system performance, governance, and institutional responsibility.
A recent study challenges the widely accepted argument that the universe's expansion rate is accelerating, driven by 'dark energy' from the quantum vacuum. The research finds that cosmic expansion may be slowing down rather than speeding up.
Researchers found that GATA6 expression is reduced in liver metastases, correlating with poorer clinical outcomes. Losing GATA6 allows cancer cells to change their identity and become more adaptable, leading to metastasis.
Forming habits can make complex tasks automatic, reducing mental effort required for animals to find food efficiently. Breaking habits may also be essential if a habit is no longer beneficial, suggesting evolutionary benefits for creatures of habit.
The NFL PLAY 60 initiative encourages children to get at least 60 minutes of physical activity each day to support both immediate and long-term physical and mental health. The program is rooted in the American Heart Association's physical activity guidelines, which recommend at least 60 minutes of moderate-to-vigorous activity daily fo...
Researchers studied dark matter's potential additional attractive force and found it suppresses structure growth, contrary to expectations. The extra clustering effect is counterbalanced by a decrease in dark matter particles' mass over time, reducing the overall impact on cosmic microwave background observations.
A new case report highlights the danger of Marjolin ulcer after decades, a rare but aggressive skin cancer arising in long-standing burn scars or chronic wounds. The patient underwent successful surgical removal and remained cancer-free after one year of follow-up.
Silibinin meglumine reduces neuroinflammation and oxidative stress by downregulating UCP2 expression, restoring mitochondrial homeostasis. It alleviates liver function in a thioacetamide-induced HE mouse model.
Researchers at Edith Cowan University discovered a link between genetics and sleep habits influencing early brain changes associated with Alzheimer's Disease. Individuals carrying certain AQP4 gene variants showed faster grey matter loss when reporting shorter sleep.
A landmark international competition has revealed that AI systems designed to spot fake faces perform unevenly across demographic groups, with lighter-skinned individuals enjoying higher accuracy while darker-skinned faces are more frequently misclassified. The top-ranked solution combined data curation, mixture-of-experts architecture...
A new study reveals that US hospitals and clinics are adopting digital health tools, supplementing in-person care with secure online patient portals and health apps. The study found a significant increase in patient-provider interactions via these channels, but in-person visits have rebounded since the pandemic.
A Hiroshima University study finds that practical digital skills, positive financial attitudes, and self-protection are more consistently associated with lower old-age anxiety than traditional financial knowledge alone. The study suggests that financial education may need to move beyond knowledge alone in the digital age.
A research team has created a comprehensive map of how the anti-aging protein Klotho operates in distinct regions of the kidney, resolving long-standing scientific uncertainties. The study reveals that different kidney tubule segments carry out fundamentally different aspects of Klotho biology.
Researchers discover Murraya exotica L. extract inhibits fibroblast-like synoviocyte proliferation, reduces inflammatory cytokine release, and mitigates oxidative stress by targeting NF-κB/AP-1 axis in rheumatoid arthritis models. The primary active constituent murrayone shows promise as a therapeutic agent.
The 'Hess Evolution' expedition aims to uncover the origin and age of Hess Rise, a vast volcanic plateau. Researchers will analyze rock samples collected from depths of up to 6,000 meters to determine if they reveal systematic age patterns across the plateau.
The exhibition at The Fringe Club features artworks created by emerging artists using local materials and plant-based pigments, while others draw inspiration from traditional cooking utensils and ambient recordings. The programme aimed to translate intangible rural wisdoms into compelling contemporary art.
Researchers found that patients often wait an average of four weeks for biomarker test results, with the first step taking up to 23 days to order testing. This delay can lead to mismatched therapies, toxic side effects, and reduced treatment options, emphasizing the need for improved testing turnaround times.
The American Heart Association and International Federation for Emergency Medicine collaborate to strengthen training, research, and systems of care for emergency cardiovascular and resuscitative care. The three-year agreement aims to improve access to training, education, and emergency care resources in low- and middle-income countries.
Researchers at Salk Institute uncover an unexpected role for HDAC enzymes in controlling critical genes involved in DNA repair, making pancreatic cells more vulnerable to therapies that induce DNA damage. This finding paves the way for new treatment strategies combining entinostat with DNA-damaging therapies.
A team of researchers has conducted the first comprehensive exploration of Inútil Bay's underwater ecosystems, documenting 72 distinct macroalgal taxa. The survey revealed a diverse assortment of green, brown, and red algae, including rare and highly unusual specimens.
Pre-retrieval imaging is revolutionizing liver transplantation by improving graft selection, reducing uncertainty, and supporting better surgical planning. Imaging modalities like ultrasound, CT, and MRI offer distinct strengths and limitations in evaluating liver graft quality, vascular anatomy, and biliary variants.
A PSO-based optimization strategy improves economic and environmental performance of hybrid residential microgrids by optimizing distributed energy resources. The approach reduced system cost, diesel dependence, and carbon dioxide emissions by up to 50% compared to the HOMER simulation platform.
Researchers discovered that the brain uses both sharpening and refining strategies to process expected and unexpected events. Expected events lead to rapid responses but poor memory recall, while unexpected events receive sensory priority and are better remembered.
A new positioning framework combines satellite navigation with asynchronous ground-based transmitters, enabling faster convergence and improved accuracy. The findings suggest that existing terrestrial communication infrastructure can be repurposed to enhance next-generation navigation services.
Researchers have developed an AI-generated photonic framework that maps optical properties to subwavelength structures directly via a diffusion model. The system achieves high-precision mapping, flexible design constraints, and fuzzy search capability, transforming the field of photonic innovation.
Primary and secondary schools in Shanghai are using an AI-based classroom analysis system to support instructional improvement. The platform automatically processes video data and provides theory-informed analytic reports, enabling teachers to track student agency and professional growth over time.
A research team from the University of Liège uncovered a previously unrecognized mechanism that promotes cancer cell survival under therapeutic pressure. Cancer cells reprogram their lipid metabolism to sustain proliferation, with key enzyme SCD1 cooperating with epigenetic regulator HDAC2 to support tumor growth.
A new study from the University of Nebraska-Lincoln reveals that cumulative exposure to parental smoking over time significantly increases the likelihood that adolescents will view smoking and vaping more favorably and engage in those behaviors. Most surprisingly, a father's smoking habits were found to be more significantly linked to ...
A new paper reports a record-breaking optical vortex array with 3,070 phase-coherent vortices at a peak power of 58 megawatts. The system uses a novel three-mode representation and multibeam interference geometry to achieve scalability.
A study by Edith Cowan University found that re-engaging in new goals is linked to higher mental wellbeing for people living with chronic pain. However, letting go of old goals did not improve wellbeing overall, especially for those with high pain interference.
Researchers at Johns Hopkins University have identified a region in the brainstem that controls attention by suppressing distractions and directing focus. This discovery could lead to more targeted treatments for attention disorders like ADHD.
A study by researchers at the University of Cincinnati found that insects respond to cycles of humidity in a predictable manner, similar to temperature and daylight. This suggests that organisms may be able to anticipate optimal conditions for survival, such as hydration or energy expenditure, based on humidity cues.
The mbLFIA platform overcomes the sensitivity bottleneck in traditional enzyme-free isothermal amplification approaches by using dual-mechanism multisite bridging and gold-platinum nanoparticles. It achieved a visual limit of detection as low as 2 pmol·L⁻¹ for CHIKV, demonstrating perfect clinical sensitivity and specificity.
A modular nanorobot with a magnetic propulsion module and payload capsule has been developed by researchers at the University of Basel. The system can be adapted to different applications and has shown promise in delivering therapeutic agents to cancer cells, reducing viability by 16% within 72 hours.
A study found that teacher feedback is positively related to student social and emotional skills, with feedback about strengths and strategies improving these skills. The study also identified factors such as age, immigrant status, and reading grades influencing student perceptions of teacher feedback.
Research from Edith Cowan University suggests that people who excuse harmful behavior are more likely to create deepfake pornography than those with dark personality traits. The study found a significant link between attitudes and the willingness to create deepfake content.
A systematic review and network meta-analysis found that combining lifestyle treatment with obesity medications resulted in significant short-term weight loss and improved body composition in adolescents. Health behavior remained crucial to effective weight management.
Researchers optimized four critical stainings for hyperphosphorylated Tau, β-amyloid, α-synuclein, and phosphorylated TDP-43 using comparative testing of antigen retrieval conditions. The optimized protocols yielded consistent results with the Netherlands Brain Bank, confirming reliability, repeatability, and international compatibility.
A new study finds that counterfeit luxury goods are purchased by both lower- and higher-income consumers, with social and status-related motivations playing a significant role. The research reveals important differences in purchasing habits between the two groups, including a preference for ultra-luxury brands among wealthier consumers.
Researchers developed an injectable hydrogel combining silk proteins and a kudzu plant compound, achieving complete wound closure within 72 hours. The material's mechanical stability and cell viability exceeded expectations.
Most adults in Singapore living with anxiety or depression are open to receiving support from peers, even if they haven't sought professional help. Peer support is identified as a potentially important complement to existing healthcare infrastructure, offering a community-based pathway to encourage more people to seek help earlier.
A new study found that conversations about prostate cancer screening are uncommon in primary care visits but lead to higher screening rates when they do occur. The study suggests a gap between national guidelines and clinical practice, highlighting the importance of shared decision-making for individualized care.
A new interfacial modification layer composed of a chlorinated conjugated polymer is introduced to address device performance limitations in tandem solar cells. This strategy leads to significant improvements in charge extraction and non-radiative recombination, resulting in record power conversion rates.
The 2026 Chinese Guidelines for the Diagnosis and Treatment of Alopecia Areata introduce a new therapeutic ladder, prioritizing JAK inhibitors for severe chronic cases and routine screening for autoimmune comorbidities. The guidelines also emphasize long-term follow-up to prevent relapse.
Researchers developed a protein-tracing platform that maps fat and liver cell communication, tracing proteins back to their cells of origin. The platform linked 65 signals to human conditions, including type 2 diabetes and cardiovascular disease.
Researchers discover celastrol's dual mechanism to ameliorate cholestatic liver injury by inhibiting CTSS and restoring autophagy, shifting iNKT cell balance from pro-inflammatory to protective phenotype.
Researchers discovered that lithium doping of a 12-benzene-ring molecule creates a material with strong optical responses due to synergistic effects between aromaticity and charge transfer. This finding establishes fundamental design principles for high-performance carbon-based photonic devices.
A Bar-Ilan University study finds that artificial light spilling into coastal waters disrupts sleep in coral reef fish, causing increased aggression and DNA damage. Chronic exposure may have lasting biological consequences.
Researchers developed biohybrid magnetic microbots from natural microalgae to overcome drug penetration limitations in bladder cancer treatment. The technology increased drug delivery by over ten times compared to standard treatment methods, reducing tumour burden and improving treatment effectiveness.
A recent study reveals that mosquitoes harbor viruses without killing them due to translational repression, allowing for efficient transmission. The virus takes a moderate approach in mosquito cells, limiting protein production to avoid overloading the host cell.
A longitudinal study found that higher screen viewing time during infancy and school-entry age was associated with poorer academic performance and weaker working memory. The study suggests that the timing of screen exposure may be as important as the amount of screen time itself.
A study of Canadian physicians reveals that the hiring process for resource-intensive jobs is often opaque and biased, favoring those with connections over those from diverse backgrounds. The research highlights the need for transparency and equitable access to employment opportunities among physicians.
Scientists have developed a new supramolecular hydrogel inspired by natural articular cartilage, boasting a friction coefficient close to that of human joints. The material maintains stable lubrication under various loads and sliding frequencies, making it suitable for joint applications and potential biomedical implants.
The University of Hong Kong hosted a Super Angel and Going Global Innovation Forum in Qianhai, Shenzhen, to foster collaboration and drive global expansion for high-potential ventures. The event highlighted the growing importance of internationalization amid a rapidly evolving global innovation landscape.
The report reveals cutting-edge technologies affecting physical systems, from energy to medicine and manufacturing. These innovations have the potential to make a meaningful impact on pressing challenges like climate change and food insecurity.
Scientists at the University of Colorado Boulder discovered a seaweed-based ingredient that can bind earthen materials like clay and sand, making them 3D-printable. The biopolymer, sodium alginate, produces materials that are strong and printable, reducing environmental impact.
A lightweight genetic toolkit has been developed for streamlined gene expression regulation in industrial streptococci, featuring short constitutive promoters and a compact IPTG-inducible promoter system. The toolkit was successfully applied to two production-relevant scenarios, revealing new targets for improving exopolysaccharide yie...
Scientists have discovered four new species of Sylvan Chameleons in Mozambique's isolated granite mountains, showcasing unique adaptations and emphasizing the importance of conservation. The research highlights that local community involvement can make a significant difference in protecting these vulnerable habitats.
Hantavirus and Ebola virus disease are two deadly infectious diseases that require rigorous infection and prevention control (IPAC) practices. Both diseases present with similar early symptoms and can be treated effectively with proper precautions.
Researchers develop AI framework using principles of superposition and entanglement to tailor cancer treatment to patients' entire molecular background. The technique predicts health outcomes and suggests genes to target, outperforming standard biomarkers in clinical trials.
A new study identifies proteins potentially involved in the emergence of thylakoids, internal membranes where oxygen-producing photosynthesis takes place. The researchers compared hundreds of cyanobacterial genomes and found that these proteins may have played a crucial role in their formation.
Researchers identified protective human monoclonal antibodies against West Nile virus and related orthoflaviviruses. These antibodies recognize specific sites on the virus envelope domain III, providing a promising lead for vaccine development and therapeutic interventions.
Researchers developed a novel fluorescent-based method to analyze upstream open reading frames (uORFs) in plant genomes, enabling rapid analysis of gene regulation. The technique simplifies current methods by using intact leaf tissue and fluorescent proteins, reducing sample preparation and consumable materials.
A study by UC Santa Barbara researchers found that California has lost more than 60% of its coastal dune systems, primarily due to human activity. The assessment highlights the importance of preserving these ecosystems for biodiversity and coastal resilience.
A genomic study reveals Hong Kong's introduced population of Yellow-crested Cockatoos retains surprisingly high genetic diversity, potentially aiding global conservation efforts. Researchers installed artificial nest boxes to monitor breeding behavior and provide safe havens for the urban population.
Researchers developed a drone-mounted IRS system with virtual bounce paths to bypass blockages and jamming, reducing outage probability by an order of magnitude. The optimized system provides real-time optimization for critical scenarios and cost-effectiveness for civilian networks.
Researchers will examine the impact of 'partygoing' behaviors on young people's health, as well as the use of nicotine pouches. The projects aim to provide practical evidence for prevention, policy, and health promotion in Western Australia.
A new study reveals that reheating in two-stage Rankine cycles can generate up to 9.2 MW of net power with 24.1% thermal efficiency, representing a 22% improvement over optimal single-fluid designs. This technology offers LNG terminals a practical pathway to recover wasted cryogenic energy and reduce energy losses during regasification.
Researchers discovered blood RNA biomarkers that could support earlier diagnosis of Alzheimer's disease, potentially reducing the need for invasive tests. They identified brain-specific markers in circulating blood nanoparticles, which may offer a minimally invasive approach for diagnosing the progressive neurodegenerative disease.
A new study reanalyzes the Gaza Mortality Survey, identifying interviewer-level anomalies and inconsistencies with external demographic data. This raises concerns about the survey's representativeness and validity of its estimates of conflict-related deaths in Gaza.
A new study by Cornell University finds that women achieve similar economic outcomes in negotiations as men, but foster stronger interpersonal relationships, which lead to greater satisfaction. Women are preferred partners in negotiations due to their likability, fairness, and ability to build trust.
Researchers from the Dalian Institute of Chemical Physics have discovered the molecular mechanism behind V(II) precipitation in vanadium electrolytes. By introducing acetonitrile and HCl as co-additives, they created a dual-site solvation engineering strategy that boosts electrolyte stability at low temperatures.
The study found that during surprising events, the brain allocates more energy to sensory information, leading to better memory recall. In contrast, predictable situations stimulate faster responses but less detailed encoding.
A team at the University of Illinois has developed a method to produce jet-grade fuel from food waste, contributing to a circular bioeconomy. The researchers' approach uses hydrothermal liquefaction and distillation, producing a biodiesel blend that can be used with regular jet fuel.
Researchers at the University of Electro-Communications have developed a new, cost-effective catalyst using nitrogen-doped graphene that outperforms traditional platinum. This breakthrough enables the creation of high-performance, low-cost fuel cells, bringing mainstream sustainable energy closer to reality.
The Robert A. Winn Clinical Investigator Pathway Program is launching its fifth cohort, welcoming 80 medical students from across the US and Puerto Rico for a six-week immersion in clinical research, community engagement, and improving clinical trial participation. Students will gain hands-on experience at leading institutions nationwide.
A new study shows that liquid biochar mineral complex fertilizers can substantially improve pasture yield, nutrient balance and farm-level economic returns. The nitrogen-enriched formulation delivered the strongest performance, increasing pasture yield by 42.20 t ha⁻¹.
A recent study found associations between early-onset colorectal cancer and male sex, Hispanic ethnicity, high birthweight, maternal birthplace, and paternal age. The study suggests that these factors may contribute to the rising incidence of early-onset colorectal cancer.
Research explores role of short-chain fatty acids in regulating dendritic cell development and differentiation via epigenetic regulation. Study reveals butyrate increases expression of surface molecules, influencing immune-cell trafficking and localization.
Eight EU-funded research consortia warn that Europe's food security and societal functions are at stake due to failing pollinators. The report advocates making Pollinator Stewardship an explicit priority across policies, promoting ecoliteracy in education, and addressing short-term production goals.
Researchers at the University of Texas MD Anderson Cancer Center discovered a new approach to help overcome immunotherapy resistance. Copper-induced cell death, known as cuproptosis, activates the immune system and can be combined with anti-PD-L1 immunotherapy to slow tumor growth.
Researchers found cytoskeletal proteins in cell nuclei of neural stem cells, influencing developmental programs. MAP1B protein helps maintain stem cell state for longer, contributing to abnormal brain development.
A University of Zurich study found that positive, everyday life events like school, friendships, and travel have a greater impact on young people than crises. The research used open-ended written responses from 1,442 participants to show that 83% of mentioned events were positive.
A new AI paradigm, Dermatology AI 2.0, enhances rare skin disease diagnosis by up to 32.9% through causal algorithms, while predicting eczema flares with over 90% accuracy. This technology frees dermatologists to focus on complex cases and patient care, potentially cutting diagnosis delays.
Hydrothermal carbonization byproduct water may support crop production and nutrient recovery, with potential for circular bioeconomy systems. Proper characterization and application can unlock benefits, but safety and management challenges must be addressed.
A new study by Meike van der Heijden challenges the long-held assumption that activity in easily measured cerebellar cells like Purkinje cells can reliably predict signals in deeper brain regions linked to dystonia, ataxia, and tremor. The research found no significant correlation between Purkinje cell and deep nuclei cell activity.
In the 2026 Journal Citation Reports (JCR), MDPI journals demonstrate continued growth in visibility and influence of OA research. A total of 33 journals achieved a JIF of 5.0 or higher, with Machine Learning and Knowledge Extraction rising to 8.4.
A comprehensive review of recent research reveals neuroimmune alterations in the central nervous system may contribute to fibromyalgia's development and progression. This study suggests that factors such as sleep, stress, and lifestyle habits are central aspects of its management.
A research team identified crocin II as a potent natural ANGPTL8 degrader, which drives selective autophagic degradation of ANGPTL8. This reduces hepatic lipid accumulation and inflammation, improving metabolic dysfunctions associated with MASLD.
Engineered NIR-II-responsive plasmonic nanozymes degrade extracellular DNA and induce hyperthermia, destabilizing biofilm integrity. Biocompatible surface functionalization ensures seamless integration with bone implants.
Researchers developed a data standardization pipeline to transform heterogeneous clinical records into analyzable research resources for psoriasis. The approach enables the creation of integrated specialty databases and AI-assisted clinical decision support tools.
Scientists created a shape-changing flying robot named Floaty that can fly efficiently while staying stable in the air. By adjusting its flaps to control air resistance, Floaty balances itself and recovers from disturbances.
Researchers have identified IL1RAP as a key player in the tumor-driven inflammatory network that helps pancreatic cancer resist treatment. Blocking this receptor may help break down tumors and improve response to combination therapy.
A new study by University of Michigan researchers found that smaller tree swallows reproduce less due to declining insect populations. The decline in insects affects the timing of breeding and reproduction, leading to a phenological mismatch, which has significant consequences for bird biology.
Researchers developed engineered CAR-T cells that specifically degrade soluble TNF, preventing and treating all stages of RA in human TNF-transgenic mice. A single infusion provided sustained benefit without redosing or ADA risk, offering a promising alternative to chronic disease management.
Researchers found that the new galaxy has the mass of 100 million suns and no dark matter, suggesting it formed through a violent event without dark matter 'halos'. This discovery provides strong evidence for an extreme process of galaxy formation and offers insight into the nature of dark matter.
A Drosophila study shows that macrophages detect nutritional stress caused by high-sugar diets and send a signal to the endocrine system to delay development. This delay helps buffer the impact of the diet on growth, allowing organisms to reach adulthood in better condition.
Researchers developed biodegradable tissue-carriers from natural biopolymers for effective delivery of anti-aging compounds. These carriers mimic the skin's extracellular matrix, offering controlled release and reducing skin irritants.
Researchers engineered a Bacillus subtilis strain to increase intracellular guanine levels, alleviating feedback inhibition and enhancing the de novo purine biosynthesis pathway. This led to a 15.3% increase in riboflavin production without affecting cell growth or energy charge levels.
Researchers develop cellular model to reproduce NF1-associated tumour progression, identifying new therapeutic opportunities. The combination of olaparib and selumetinib shows promise in reducing tumour growth.
Researchers developed a two-part vaccination method that prevented genital herpes infection in mice, with 80% of treated mice showing no signs of disease. The 'prime and pull' approach uses nanoparticles to stimulate local immunity, establishing strong immune cell and antibody responses against the virus.
BL18U1 supports the determination of numerous high-quality crystal structures, with most structures in the 1.5–2.5 Å range. The beamline has consistently delivered excellent results in lysozyme experiments and demonstrated long-wavelength anomalous diffraction capability.
Transcranial ultrasound stimulation (TUS) has been shown to improve gait and restore communication between cortical brain networks in mice with ischemic stroke. This treatment targets neural mechanisms that may lead to improved motor function, according to the study.
Natural biomass hydrogels can be turned into responsive sensing platforms due to their softness, water-rich structures, tunable networks, and abundant functional groups. By adjusting crosslinking density and network architecture, researchers can tune the sensor's response to various stimuli.
Researchers propose a new strategy combining nobiletin with the HDAC inhibitor SAHA to enhance anti-tumor efficacy in non-small cell lung cancer. The study reveals the critical role of TRKC in NSCLC and demonstrates synergistic inhibition of tumor growth through regulating BH3-only protein expression.
JMIR Publications' journals have achieved strong rankings, with 12 in the first quartile and 6 in the 90th percentile or higher. The journal of Medical Internet Research has an all-time high Journal Impact Factor of 8.2.
Researchers identify cholesterol ester buildup as biomarker predicting progestin therapy response in young women with endometrioid endometrial carcinoma. Combination treatment with progestin and a statin doubles six-month remission rate and helps patients become mothers.
Researchers have developed a polymer-based microring resonator array with over 40 elements, demonstrating broadband acoustic detection and fine spatial resolution. The system achieved strong correspondence with biological structures, including blood vessel regions, in imaging mouse prostate tissue.
Researchers have designed a clay material that can absorb and retain ethylene gas, slowing down the ripening process of fruits and vegetables. This innovation has the potential to reduce food waste and improve fruit flavor by allowing for later harvesting in the ripening process.
The US retains its scientific edge but is losing the race to translate discoveries into cures, warns a new report from Cure Innovation Index. Without immediate renewed investment and policy changes, the US scientific edge will not hold.
Researchers at Georgia Tech found that sulfoxaflor disrupts bee reproduction and gene expression, leading to reduced reproductive output. The study sheds light on the molecular effects of pesticides on bees and highlights a pressing challenge in agriculture.
A newly discovered Australian ballista spider uses a silk-powered snare to target and capture the highly aggressive green tree ant Oecophylla smaragdina, launching its prey into the air with incredible power and speed. The snare is triggered by the prey's reaction and stores elastic energy in the silk to release it rapidly.
Global review of kelp conservation found strongest restoration programs built on unlikely partnerships. Communities have a direct stake in outcome for kelp forests to thrive.
Researchers have found that cats show comparable patterns of brain deterioration as they age, similar to humans. This study, part of the Translating Time project, aims to unlock new insights into human ageing and disease by comparing cat and human brain development.
A new process-based model predicts how biochar affects crop yields, soil carbon, and greenhouse gas emissions. The DLEM-Ag-Biochar model performed well against field observations, capturing patterns in agricultural systems across different environmental and management conditions.
Andrei Khodak, a principal engineering analyst at PPPL, has been awarded the ANS Outstanding Achievement Award for his work on virtual prototyping of liquid-metal plasma-facing components. He has made significant contributions to the design and engineering of major fusion systems, including ITER and DIII-D.