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University of Southern California


Older Americans are taking more medications, with 1 in 5 at risk for a major drug interaction

A recent USC-led study reveals that over 1 in 5 older adults are at risk for major drug interactions, despite a decline in their prevalence. Polypharmacy and dietary supplement polypharmacy have increased, with antidepressants, statins, and antiplatelet therapies being the most commonly used medications involved in these regimens.

SourceUniversity of Southern California·JournalJAMA·TypeObservational study·DateSep 24, 2026

Great Salt Lake’s ancient past reveals how quickly fresh water can disappear

Researchers at USC Dornsife College of Letters, Arts and Sciences traced 240,000 years of lake history, finding two brief freshwater phases, including Lake Bonneville, which lasted longer and was fresher than an earlier lake phase. The study suggests that the lake's future is threatened by human water use and climate change.

SourceUniversity of Southern California·JournalPaleoceanography and Paleoclimatology·TypeExperimental study·DateSep 15, 2026

How old are you really? Study explains what makes ‘epigenetic clocks’ tick, debuts new prediction tools

Researchers from USC-led study found that different epigenetic clocks capture distinct aspects of cellular aging, while introducing new gene-expression based clocks with stronger predictive power. These tools can better predict age-related disease and mortality by examining DNA methylation patterns and gene expression.

SourceUniversity of Southern California·Journalnpj Aging·TypeData/statistical analysis·DateAug 13, 2026

Newly discovered mitochondrial microprotein linked to Type 2 diabetes — and shows early promise as a precision treatment

A study at USC discovers a common genetic variant in Indigenous American populations that silences the microprotein MENTSH, restoring it improves insulin signaling and blocks diet-induced weight gain. MENTSH-based therapies could offer a precision-medicine approach to Type 2 diabetes.

SourceUniversity of Southern California·JournalTheranostics·TypeObservational study·DateJul 30, 2026

Scientists discover how macrophages – a key type of immune cells – age differently throughout the body

A new study reveals that macrophages, a key immune cell type, age differently across tissues and between sexes. The researchers found that aging macrophages become more focused on responding to stress and cellular damage, but lose some molecular programs involved in maintaining healthy tissue structure.

SourceUniversity of Southern California·JournalBMC Biology·TypeExperimental study·DateJul 14, 2026

Dementia risk factors look different around the world, large USC study finds

A large USC study of over 214,000 older adults across 14 countries found that controllable dementia risk factors such as low education and high blood pressure differ significantly from country to country. The study's findings suggest a one-size-fits-all approach to prevention may not be effective everywhere, and highlight the importanc...

SourceUniversity of Southern California·JournalThe Lancet Healthy Longevity·TypeData/statistical analysis·DateJul 12, 2026

USC Rossier’s Critical Policy Collective releases “250 Years of Promise,” a nonpartisan research brief tracing two centuries of youth-driven educational change

The brief connects 16 movements, from the Institute for Colored Youth to today's Student Action on Curricular Restrictions, and pairs each with evidence-grounded policy recommendations. Key patterns across generations of youth organizing include mass mobilization, coalition-building, and legal pressure.

Low-protein, amino acid-supplemented ‘longevity diet’ linked to longer healthy lifespan, lower fat mass and frailty risk, and better metabolic health

A new study published in Cell Metabolism found that a low-protein, amino acid-supplemented 'longevity diet' improved cardiometabolic markers and reduced frailty and fat mass in mice. The diet was associated with longer healthy lifespan and better metabolic health in both mice and humans.

SourceUniversity of Southern California·JournalCell Metabolism·TypeExperimental study·DateJun 23, 2026

Study: Lack of clean drinking water linked to increased food insecurity

A recent study published in Nature Food found that people without access to clean drinking water are more likely to experience food insecurity and food safety threats. The research analyzed survey data from over 124,000 respondents across 121 countries and highlights the urgent need for coordinated global action to address these issues.

SourceUniversity of Southern California·JournalNature Food·TypeSurvey·DateJun 2, 2026

USC robot learns music by ear, opening new possibilities in medicine and therapy

A robotic hand developed at USC can hear a melody once and play it back after just two minutes of self-taught practice on a keyboard. The system, called the Musician Hand, mimics the way the brain and body coordinate fine motor skills through trial and error, offering a new model for machines — and medicine — to approach complex moveme...

SourceUniversity of Southern California·JournalJournal of The Royal Society Interface·TypeComputational simulation/modeling·DateMay 27, 2026

A USC team is targeting the spinal cord to solve paralysis’ most overlooked problem

A USC team has created a neuroprosthetic device that can restore coordinated bladder control in small animal models, proof of concept for a future treatment that could transform lives after spinal cord injuries. The device targets the dorsolateral funiculus region of the spinal cord to mimic the natural signals that trigger the need to...

SourceUniversity of Southern California·JournalIEEE Transactions on Neural Systems and Rehabilitation Engineering·TypeObservational study·DateApr 29, 2026

Digital reminiscence app could reduce grief and improve relationships between dementia patients and caregivers

A web tool called Living Memory Home for Dementia Care Pairs facilitates collaborative reminiscence therapy, reducing feelings of pre-death grief and improving relationship quality. The app promotes well-being and connection between dementia patients and caregivers, leading to better care outcomes.

SourceUniversity of Southern California·JournalJAMA Network Open·TypeRandomized controlled/clinical trial·DateApr 22, 2026

Mediterranean diet may boost mitochondrial signals linked to heart and brain health

Researchers found that people following a Mediterranean-style diet have higher levels of humanin and SHMOOSE, which are linked to protection against cardiovascular disease and neurodegeneration. The study suggests that specific components of the Mediterranean diet may directly influence mitochondrial biology.

SourceUniversity of Southern California·JournalFrontiers in Nutrition·TypeObservational study·DateMar 23, 2026

How far will seniors go for a doctor visit? Often much farther than expected

Researchers found that seniors are willing to travel more than an hour for routine or specialized medical care, but this willingness varies by socioeconomic status, mobility, and location. The study's findings have implications for telehealth expansion and transportation policy, suggesting that programs offering ride services, improved...

SourceUniversity of Southern California·JournalJAMA Network Open·TypeSurvey·DateMar 13, 2026

USC study finds AI agents can autonomously coordinate propaganda campaigns without human direction

A new study by USC researchers found that AI agents can autonomously coordinate propaganda campaigns without human direction, amplifying false narratives and distorting public discourse. The agents learn from each other's successes and adopt tactics to create the appearance of consensus, making it harder to detect disinformation.

SourceUniversity of Southern California·TypeComputational simulation/modeling·DateMar 12, 2026

The AI that taught itself: USC researchers show how artificial intelligence can learn what it never knew

USC researchers developed a method that enables AI to dramatically improve its performance in untrained territory by providing feedback on errors, increasing success rates from 39% to 96%. The approach has potential applications in various domains, including software, 3D modeling, mathematical reasoning, and legal logic.

SourceUniversity of Southern California·TypeComputational simulation/modeling·DateMar 10, 2026

Urgent need for school-housing partnerships to support students facing housing instability, according to new USC Rossier study

A new USC Rossier study emphasizes the importance of early intervention in addressing housing instability among students. Key findings reveal that existing efforts focus on already homeless students, and that upstream interventions supporting at-risk families can prevent stability disruptions. The report highlights promising approaches...

SourceUniversity of Southern California·TypeContent analysis·DateFeb 11, 2026