Scientists create new two-step annulative p-extension method for synthesizing structurally diverse nanographenes, including curved and non-planar structures. The research expands the toolbox for chemists to access rare molecular fragments with unique properties.
A new fluorescence microscopy technique, SPIFFI, harnesses polarization of fluorescent light to generate super-resolution images of dynamic structures and processes inside living cells from a single camera exposure. The method allows researchers to visualize nanometer-scale structures in real-time, revealing details such as mitochondri...
Researchers at Cedars-Sinai Medical Center tested a novel drug called TY1, which targets an immune system pathway, and found it reduced inflammation and DNA damage in immune cells. The drug also improved heart function and physical activity in laboratory mice with a condition mimicking systemic sclerosis, suggesting a potential future ...
Researchers have developed an eggshell-inspired aluminum material that offers significant protection from space debris. The material, which consists of water-filled aluminum eggshells arranged in an array, can withstand high loads and reduce the velocity of an impact projectile by nearly 65%. The design, which is inspired by the natura...
A US study of 20 years of health data found that hormone therapy initiated during peri- or early postmenopause reduces cardiovascular disease risk by 22% compared to those who did not use hormone therapy. The protective effect was strongest among Black women and those who initiated therapy within 10 years of menopause onset.
Researchers will develop a molecular diagnostic test that quantifies small RNA species to detect fetal oxygen deprivation during labor. The technology aims to provide clinically relevant values for stratifying the risk of babies during labor.
A Phase 3 clinical trial showed tozorakimab reduced moderate-to-severe COPD exacerbations by 29-34% compared to placebo, impacting a broad COPD population. The therapy's safety profile was generally comparable to placebo, with injection-site reactions being more frequent.
A high-dose flu vaccine has been shown to reduce hospitalizations for older people with lung disease, including COPD and asthma. The vaccine reduced hospital admissions for flu or pneumonia by 8.8% compared to the standard-dose vaccine.
A study by Binghamton University found that 8-10% of children can carry strep bacteria even after antibiotic treatment, despite no symptoms. Researchers hope to understand this phenomenon through genome analysis and throat microbiota studies.
A study found that 95% of patients who used virtual reality during cardiac imaging completed the procedure, with 80% wearing the headset for the entire duration. The VR program also demonstrated significant financial impact, with estimated cost savings of $3,000 per aborted imaging study.
Researchers found changes in brain structure, including white matter organization and region size, in people with severe asthma compared to those with well-controlled mild or moderate asthma. Inflammation levels were also linked to white matter changes, suggesting a possible connection between inflammation and brain changes.
The authors propose norms for AI use in research, distinguishing between non-generative tasks and generative AI, which should not replace human interpretation and judgement. Science requires diversity of inputs and ideas, and serendipity counts, making generative AI training on existing data limiting breakthroughs.
Researchers found ancient methane in every river sampled from Svalbard glaciers, indicating a natural feedback loop that may worsen as the Arctic warms. The study suggests that the physical state of the glacier bed and geological sources of methane are key factors in methane release.
Researchers found that most larval cells in acorn worms were reprogrammed to take on new roles in the adult organism, including neurons and skin cells. This challenges the long-held assumption that cells become increasingly restricted in their function as they develop.
Research at Kyushu University found that using Igusa mats increases brain activity related to concentration and engagement. Participants reported reduced tension and anxiety after using Igusa mats, indicating potential benefits for stress resilience.
A new study reveals that cohesin, a protein complex, prevents local mixing of compact active genome domains in living human cells. This domain organization helps maintain proper gene regulation. The study challenges the simple textbook view of chromatin and provides a revised view of euchromatin.
Researchers identified a distinct 40 kHz inverted-U USV associated with palatable chocolate consumption, suggesting rats vocally express enjoyment of eating. The vocalization was linked to the endogenous opioid system and was more frequent with palatable food, suggesting a measurable signal for positive emotional states.
Researchers discovered that β1 integrin and DDR2 form a cooperative collagen-sensing system in skeletal progenitor cells, regulating their migration, proliferation, and differentiation during bone regeneration. Targeting both receptors may provide a more effective strategy for enhancing bone repair in degenerative or injury-related ske...
Researchers have discovered that each signaling pathway leaves behind a unique fingerprint of gene activity, allowing them to reconstruct signaling histories across different cell types. This AI-driven approach, called IRIS, enables scientists to comprehensively map signaling histories at an unprecedented scale, accelerating stem cell ...
Virginia Tech researchers have developed degradable polymers with a new molecular architecture that combines strength, toughness, flexibility, and oxygen-blocking properties. The findings have implications for food packaging, which could lead to more sustainable and durable materials.
The Kobe University team demonstrates glossy, non-iridescent, and protection-coated structural color coatings for 3D objects, reducing diffuse reflectance and increasing color brightness. The coatings are lightweight, making them ideal for aircraft and other applications where weight reduction is crucial.
Researchers developed a new treatment for acute myeloid leukemia (AML) by using AcTor, a molecule that inhibits a signalling protein, in combination with ixazomib. The treatment successfully eliminated cancer cells and leukemic stem cells, showing promising results in mice studies.