Women with a history of gestational diabetes in pregnancy are at a substantially increased risk of developing type 2 diabetes later in life, with a median onset age 13 years earlier than those without prior gestational diabetes. They also experience more severe disease, requiring insulin treatment more frequently.
A 10-fold increase in new case rate of type 2 diabetes in young people under 20 years old since the turn of century has led to a significant shift in the disease's demographics. The study found an accelerating trend in type 2 diabetes incidence, with a 3.8% annual increase between 2002 and 2023.
Researchers have designed a novel quintuple agonist combining GLP-1R, GIPR, and PPAR agonism to treat obesity and type 2 diabetes. The molecule, lanifibranor, shows potent effects in reducing body weight and improving hyperglycaemia in mice with obesity and insulin resistance.
A new trial has shown that a lower dose of the immunomodulatory drug ATG is safe and effective in preventing the progression of type 1 diabetes in young people. The study found that the drug was able to arrest or delay the progression of T1D at a dose as low as 0.5mg/kg, with a good safety profile.
The Ver-A-T1D trial suggests that verapamil could preserve beta-cell function in adults with newly diagnosed type 1 diabetes. The study demonstrated encouraging trends towards beta-cell preservation and well-established safety profile, but narrowly missed statistical significance.
The SURPASS-PEDS trial shows that tirzepatide significantly improves HbA1c levels, BMI, and fasting glucose in children aged 10-17 years with type 2 diabetes. The study demonstrates sustained improvements over a year-long period, making it a potential safe and efficacious treatment option for youth-onset type 2 diabetes.
A daily pill of baricitinib, a Janus kinase inhibitor, preserves insulin-producing beta cell function and slows type 1 diabetes progression in people recently diagnosed with the condition. The treatment's therapeutic effect is lost when it's stopped, justifying its testing in earlier stages to prevent or delay clinical diagnosis.
The study predicts that 513,000 new cases of T1D will be diagnosed worldwide in 2025, with the greatest increases expected in Africa and the Middle East/North Africa. The analysis reveals substantial global inequities in diabetes care and outcomes.
A new RNA-based drug, RES-010, is designed to block an RNA molecule called miR-22, which plays a key role in obesity. The treatment has shown promising results in preclinical studies, inducing significant weight loss without regaining weight after treatment stops.
A UK Biobank study suggests that people with type 2 diabetes progress to additional chronic conditions at a faster rate than those without the condition. The study found that individuals with T2D experience a 60% higher risk of new disease diagnosis compared to those without T2D.
A new study published in Pharmaceutics found that semaglutide provides powerful protection against diabetic retinopathy, a condition that can lead to sight loss. The study suggests that GLP-1 receptor agonists enhance retinal cells' defences against damage in diabetes-like conditions.
A phase 3 trial of once-daily orforglipron found substantial weight loss in people with obesity but not type 2 diabetes. The medication improved cardiometabolic levels and was associated with significant reductions in body weight, waist circumference, systolic blood pressure, triglyceride levels, and non-HDL cholesterol.
The European Association for the Study of Diabetes (EASD) has finalized its first evidence-based clinical practice guideline, which prioritizes assessing and managing diabetes distress among adults with type 1 and type 2 diabetes. Key recommendations include routine assessment and management of emotional burden.
A randomised trial found that regular exercise reduced inflammation and improved endothelial function, leading to lower risk of heart attack and strokes. Exercise maintained weight loss without GLP-1 receptor agonist liraglutide.
A large community-based study has found that individuals with type 2 diabetes are at a doubled risk of developing sepsis, particularly among younger adults and men. The study identified several modifiable risk factors, including smoking, high blood sugar, and complications of diabetes.
Research suggests that semaglutide, a weight loss medication, decreases intrusive thoughts about food and improves mental health in individuals with obesity. The study found that 81% of participants experienced less food noise after taking semaglutide for at least four months.
A study of individuals taking Ozempic, Wegovy, or Mounjaro found that 21.3% reported food tasting sweeter, while 22.6% said it tasted saltier than before. These changes were linked to reduced appetite and weight loss in all groups, with participants who experienced increased sweetness being twice as likely to report increased satiety.
A systematic review of over 9 million pregnancies found that gestational diabetes is associated with cognitive decline in mothers and an increased risk of neurodevelopmental disorders in children. Children born to mothers with gestational diabetes have a 36% higher risk of ADHD and a 56% higher risk of autism spectrum disorders compare...
A Danish study found that individuals with a normal weight range (22.5-25 kg/m2) had the lowest mortality rate, followed by those in the overweight category. However, being underweight was associated with a significantly higher risk of death, while severe obesity was linked to a slightly increased risk. The study suggests that BMI may ...
Women with type 2 diabetes taking oral hormone replacement therapy are at a higher risk of developing pulmonary embolism and heart disease. Transdermal HRT, on the other hand, appears safer, reducing cardiovascular risk by up to 25%.
A new study analyzing real-world data from over 4 million adults found that cannabis users face almost four times the risk of developing type 2 diabetes within five years compared to non-users. The study suggests that long-term metabolic effects of cannabis use may be linked to insulin resistance and unhealthy dietary behaviors.
A new European study of over 45,000 individuals aged 50-plus found a significant association between diabetes and depression, with individuals having diabetes increasing their risk of developing severe depressive symptoms by 48%, regardless of country. Conversely, those with high depressive symptoms had a 15% higher odds of developing ...
Research from Sweden, Norway, and Finland shows smoking significantly raises type 2 diabetes risk across all subtypes, with severe insulin-resistant diabetes (SIRD) being the most affected. Heavy smokers face greater risks, especially those with genetic predispositions.
A national study found that half of adults without diabetes who started taking semaglutide for weight loss discontinued treatment within a year. The most common factors influencing discontinuation were age, with younger users more likely to stop, as well as high costs and higher predisposition to adverse effects.
A 14-year study highlights the importance of diagnosing and treating obstructive sleep apnea in people with type 2 diabetes. The research suggests that continuous positive airway pressure (CPAP) treatment can reduce mortality risk by up to 26%.
People with hepatitis B immunity induced by vaccination have a lower risk of developing diabetes of any kind. The study found that higher HBsAb levels were associated with greater reductions in diabetes risk.
A new study found that younger men with type 2 diabetes are more likely to experience worse cardiovascular disease and mortality outcomes compared to those with type 1 diabetes. In contrast, women with type 1 diabetes face poorer health outcomes across all ages, particularly due to longer exposure to high blood sugar levels and less ag...
A study found that almost 50,000 adults with prediabetes and 30,000 with type 2 diabetes lived in the same households as index cases. The researchers analyzed electronic health records to identify household members with diabetes risk factors, including obesity and abnormal blood fats.
A new study found that self-reported physical activity is associated with reduced risk of all-cause mortality and major adverse cardiac events in individuals recently diagnosed with type 2 diabetes. Higher levels of physical activity were linked to lower risks of cardiovascular disease and death, even after adjusting for other risk fac...
A new study finds that living in rural areas in the first five years of life may be a risk factor for developing type 1 diabetes, whereas urban environments are associated with lower risk. The research identified significant high-risk clusters in rural areas and low-risk clusters in cities.
A large meta-analysis of over 800,000 participants shows that high adherence to the Mediterranean Diet, Alternative Healthy Eating Index, and Dietary Approaches to Stop Hypertension reduces type 2 diabetes risk across diverse ethnic groups. These three diets have been recommended for general health and their potential benefits were fou...