The Synoptic Ferry Observation Network (SYNFONY) project monitored marine megafauna in the Mediterranean, recording 707 sightings of 10 species, including fin whales and sperm whales. Distribution patterns changed in just a few weeks, with fin whales showing considerable changes and sea turtles experiencing variability.
Sara Zapico, NJIT's forensic scientist, has been awarded the National Higher Education Forensic Science Educator of the Year award for her contributions to forensic science education. She is recognized for her innovative approaches to teaching and mentoring students in forensic science, who go on to work in various fields, including la...
A new study reveals metabolic-associated kidney disease among young girls and women, and those without heat exposure in Nicaragua. The research found a greater prevalence of poor kidney health among young girls and women than previously known, and risk factors for kidney disease are present at younger ages.
Researchers have identified genetic regions associated with environmental conditions like temperature and precipitation in wild crabapples. The study's findings could help breeders develop apple varieties more resilient to climate change.
A new AI platform, Precision AI for Survivorship and Supportive Care, aims to personalize evidence-based support for cancer survivors navigating persistent side effects and other challenges after treatment. The platform uses machine-learning models to identify patterns associated with symptom burden and unplanned healthcare utilization...
A new study found that personalized support and navigation services significantly increased genetic testing of hereditary cancers among immediate family members, with 73% uptake among at-risk relatives. The study revealed that with navigation support, genetic testing uptake for BRCA increased from 51% to 73% among family members in six...
The OS10 programme aims to develop open science infrastructure in accordance with UNESCO's Recommendation on Open Science. The collaboration between National Science Library, Chinese Academy of Sciences, and PLOS will explore cooperation in sharing scientific research and open science resources.
Researchers have identified a promising new therapeutic target, MAP4K4, and developed an experimental compound, GPPD, that reduces fat buildup, inflammation, and scarring in preclinical models. The therapy has shown encouraging safety and efficacy in preclinical testing, offering a potential new treatment option for patients with metab...
A University of Washington study suggests the north pole of Mars contains less dust than previously estimated, with layers of cleaner ice stacked between dustier ice. This discovery could provide key details about Mars' climate thousands of years ago, and potentially shed light on the planet's habitability.
Researchers aim to identify biological mechanisms behind insulin resistance and develop therapeutic strategies. The study focuses on skeletal muscle tissue from lean and obese individuals, exploring protein modifications that distinguish insulin-sensitive from insulin-resistant muscle.
A study by McGill researchers found that certain diets associated with obesity improve cancer treatment responses, suggesting a complex relationship between diet, gut microbiome, and the immune system. The findings aim to improve cancer treatment success by understanding the synergistic effect of diet and gut bacteria.
The NRG-HN009 trial found that weekly cisplatin induced a similar overall burden of serious acute treatment-related toxicity compared to the standard every-three-week schedule in patients with p16-negative locally advanced head and neck cancer. The two treatment approaches resulted in different profiles of side effects.
A study published in the journal Psychedelics found that 18 of 19 tips from an obscure 1967 guide for LSD use were agreed upon by survey participants, emphasizing the importance of interpersonal trust, personal responsibility, and psychological preparation for safe and meaningful psychedelic experiences. The study highlights the releva...
Physicists at University of Toronto have identified 'octupolar' magnetism, a complex form of magnetism with eight poles, using light to probe atomic vibrations. This discovery opens up new avenues for quantum technology development, including controllable memory elements and computing devices.
Researchers developed a mathematical model to understand how the tumor microenvironment affects cancer therapy. The model suggests strategies to
A $3 million gift from Randy Kendrick establishes the Kelly Tarantello Chair in Pediatric Cardiac Surgery at USC, supporting research into genetically engineered pig hearts as a potential bridge to heart transplant. The gift aims to save the lives and improve the health of infants with severe congenital heart disease.
A study of 100,000 young adults found that those using generative AI for health questions are more likely to screen positive for anxiety and depression, with odds increasing by 52% for anxiety and 46% for depression. The study suggests an association between AI use and mental health but does not establish causation.
Researchers at Rice University have designed a softer porous material that selectively transports lithium ions and can help improve contact with battery electrodes. The material, ZnBTCA, combines efficient ion movement with better mechanical adaptability, offering a new approach to porous solid electrolytes.
The SETI Institute has welcomed three new postdoctoral fellows to study the evolution of viruses and cells, habitability on Mars, and the formation of planetary systems. Their research covers three distinct areas, from the origins of genomic complexity to the conditions that constrain the potential for life.
A new study found that children of mothers with depression have a higher risk of neurodevelopmental disorders, regardless of antidepressant exposure. The study followed over 167,000 children and found a significant association between maternal depression and special educational needs in children.
A new paper-thin robot powered by muscle cells can swim through a watery maze, offering a way to design small, efficient biohybrid robots. The robot uses a layer of live muscle cells that twitch in response to light, allowing it to control its direction and speed.
Professor John Bower joins the University of Bath as the new Raymond Schinazi and Family Chair of Science, bringing expertise in synthetic and medicinal chemistry to enhance the university's research capabilities. He aims to translate fundamental research into real-world impact, supporting the development of new sustainable processes f...
A Concordia study found that media outlets increasingly linked wildfires to climate change, with 40% of stories mentioning the topic and 30% explicitly connecting it to climate change. The shift in coverage may signal a long-term realignment in the discussion around climate change in the media ecosystem.
A new study published in the Journal of Vascular and Interventional Radiology found that kidney-sparing embolization is associated with lower rates of acute kidney injury and in-hospital mortality compared to nephrectomy in patients with high-grade kidney injuries. The study analyzed 849 cases and found that embolization reduced in-hos...
A survey of 561 NYC delivery workers found that over half were injured on the job, with 40% experiencing severe psychological distress. Workers reported long hours, bad weather, and violence, highlighting the need for improved labor protections and worker safety.
A new study by the Boyce Thompson Institute has created a detailed map of the genetic controls behind tomato flavor and traits, allowing breeders to target specific genes for developing tastier and more nutritious tomatoes. The research used hybrid plants to compare gene activity in cultivated tomatoes and three wild relatives, pinpoin...
Scientists at ETH Zurich develop method to disentangle X-ray diffraction patterns from two snapshots captured by a single detector exposure, enabling ultrafast structural changes in nanoscale objects to be observed. This breakthrough opens the door to studying rapid changes in nanoparticles.
A $7.6 million NIH grant will advance understanding of polyaminopathies, a group of rare genetic disorders affecting neurodevelopmental presentations. The grant will help identify new approaches to molecular diagnosis and care, as well as train the next generation of rare disease researchers.
A new textile fabric, Plant Armor, has been developed to cover strawberry plants, increasing yields by up to 3.56 times without negatively impacting plant health. The fabric provides a consistent warming effect, enhances growing degree-days, and reduces insect feeding, leading to significant increases in fruit production.
Researchers will sequence genomes of 250 Antarctic species and 600 ecosystem samples to understand life's resilience to extreme conditions. The project aims to uncover genetic principles governing adaptation and inform biotechnology innovations.
A Baylor College of Medicine-led team developed an AI-powered strategy to discover small molecules called 'molecular glues' to treat disease. They found a new class of molecular glues that can potentially neutralize harmful proteins linked to blood cancers and autoimmune diseases.
A new clinical trial aims to test personalized brain stimulation targeting two pain-related brain networks for patients with severe, treatment-resistant central neuropathic pain. Researchers will use functional MRI to map each participant's brain and adjust stimulation settings based on individual responses.
A study examines how urban heat impacts everyday life, health, and social interactions in Mexico City, revealing a clear threshold beyond which heat becomes a public concern. The research combines satellite observations, social media data, and geographic analysis to understand the human dimension of urban heat.
Researchers at the University of São Paulo found that anti-cancer molecules effective against malaria parasites, eliminating them at both the asexual and gametocyte stages of development. This discovery paves the way for the development of new effective drugs.
Researchers have identified three subclusters of cells driving pancreatic cancer-induced cachexia, a muscle-wasting and fat-loss condition that affects pancreatic cancer patients. The subclusters form a triangular regulatory network that drives the initiation and progression of cachexia.
A new study reveals that adding lunar satellites to China's BeiDou-3 navigation constellation can eliminate navigation constellations' drift. The team achieved stable orientation for 60 days and low user range error, demonstrating the effectiveness of lunar satellites as an anchor for the network.
APIC and SHEA express concern over CDC's erosion of capacity, citing impact on infection prevention and patient safety. The loss of experienced scientists and guidance has left healthcare facilities vulnerable to emerging infectious diseases.
Cing-Dao Kan, Director of the Center for Collision Safety and Analysis, is leading a project to develop anti-ram barriers to protect against vehicular bomb threats. The funding, provided by the Federal Highway Administration, will be used for barrier development and testing from July 2026 to July 2028.
Researchers Arafin and Khasawneh are designing microarchitectural attacks that exploit power oversubscription to destabilize multi-tenant GPU servers. They are also developing defense mechanisms using hardware-software monitoring and load-balancing services.
CHARGE syndrome is a rare developmental disorder that may be linked to developmental senescence, a tightly controlled cellular program involved in embryonic tissue remodeling. Disruption of this program may contribute to the characteristic abnormalities associated with the disorder.
Researchers at ISTA develop a light-driven nickel catalyst for efficient chemical synthesis, overcoming limitations of traditional palladium-based methods. The new catalyst requires less nickel and can activate with visible light, making it a promising alternative for sustainable chemical production.
A new study found that while nutritional screening and dietitian involvement have increased, early oral feeding remains low, and total parenteral nutrition use is still high in China. This suggests that continued education and guideline promotion are needed to improve patient outcomes.
European researchers recommend changes to EU funding and support systems to create a stronger path from discovery to impact. The proposals aim to simplify funding procedures, recognize entrepreneurship, and strengthen support for high-risk innovation.
New research by Nurlan Musazade reveals that AI is primarily a support tool, requiring human oversight and analytical thinking to achieve better outcomes. The study highlights the importance of combining AI capabilities with human judgment to stay ahead in the job market.
Fraunhofer IAF presents research activities in AI tools for chip design and III-V semiconductor manufacturing for pilot lines. The institute highlights its expertise in connecting artificial intelligence and chip design, as well as its access to powerful and sovereign III-V pilot lines.
A major review of 63 studies involving over 265,000 people found that cannabis use is associated with a higher risk of committing violent acts and experiencing violence. Women were more likely to be victims of violence than men.
Researchers from the University of Southern Denmark have found evidence of a previously overlooked process in which bone can renew its spongy inner structure (trabecular bone) from within. The finding provides new insight into how the skeleton is maintained, suggesting a potential new mode of bone remodelling.
A study published in Nature Communications reveals that ancient ocean chemistry created a self-sustaining cycle that kept oxygen levels high after they first rose. This cycle, fueled by phosphorus recycling, allowed for biological productivity and maintained oxygen in the atmosphere.
A comprehensive review of seagrass restoration activities in Africa highlights the need for urgent protection and restoration of these critical ecosystems. The review found that many countries lack data on seagrass meadows, and that climate change and human pressures threaten the very existence of these habitats.
A pilot study found that daily blueberry consumption reduced depressive symptoms in older adults, with minor changes in gut microbiome markers. Fiber and anthocyanins in blueberries have potential to modify the gut microbiome and metabolites relevant to depression.
Binghamton University researchers have developed a new type of wallpaper that absorbs moisture from the air and turns it into small amounts of electric current. The technology has potential applications in powering small devices and regulating indoor humidity levels.
Scientists at Monash University have discovered a new gene that gives Clostridioides difficile bacteria the ability to survive even hospital-grade disinfectants. The research highlights the growing threat of antimicrobial resistance, which is estimated to contribute to millions of deaths worldwide.
A BU-led team has been awarded a $3.4M NIH grant to develop a method for early lung cancer detection. The team will use a multimodal approach combining advanced robotic biopsies, artificial intelligence, and molecular mapping to predict cancer presence and growth. The goal is to improve clinical management of lung ground glass nodules ...
Researchers discovered that moderate-intensity exercise significantly improved cartilage health and tissue resilience in aging-related osteoarthritis. The molecular cargo of extracellular vesicles was found to be enriched with microRNA-29, which restored youthful characteristics in cartilage cells and reduced joint degeneration features.
Liangfang Zhang's invention uses human cell membranes to cloak nanoparticles, making them deliver drugs and remove toxins more effectively. The approach has shown promise against bacterial toxins, including MRSA, and may potentially treat diseases without conventional drugs.
A study found that methanotrophic bacteria in African lakes break down methane, reducing its impact on global warming. The greener the water, the more these bacteria thrive, mitigating the effects of lake pollution.
A new clinical practice guideline aims to standardize the identification and management of infants at increased risk for cerebral visual impairment (CVI). The guideline recommends comprehensive ophthalmologic evaluation and referral to developmental services within the first six months of life to access interventions as early as possible.
Two new studies suggest that smiling and positive interactions with caregivers help babies develop emotion regulation skills and physiological foundations of emotional well-being. Researchers found increases in heart-rate variability when both the baby and caregiver were positively engaged, indicating a unique effect of mutual positive...
Weiw Wen Jiang is building a reusable and scalable training program that combines rigorous instruction, hands-on practice, and health care-relevant applications, positioning participants to contribute to the national quantum workforce.
The study reveals MED14's crucial role in regulating fetal organogenesis, highlighting its importance in transcriptional programs governing later stages of organ development. MED14 disruption affects cell-fate specification and organogenesis, leading to VACTERL-like congenital defects.
Researchers identified circLPAR3 as a key mediator of docetaxel resistance in prostate cancer, promoting tumor growth under chemotherapy by suppressing ferroptosis. The study highlights circLPAR3 as a promising biomarker for treatment response and suggests targeting its regulatory network could help overcome chemotherapy resistance.
Researchers at Bielefeld University propose a precise and unambiguous way to define chemotypes within a plant species, highlighting genetic and environmental factors influencing chemical composition. This systematic approach aims to improve understanding and practical applications of chemotypes in medicinal plants and agriculture.
Researchers conducted a genetic audit to verify the variability of the GLU-B1 gene in wheat, finding that most alleles were duplicated or triplicated. They developed a master set of wheats covering the gene's variability, providing a tool for breeders to improve wheat quality and quantity.
A study by IRCCS Fondazione Istituto Neurologico Carlo Besta and Politecnico di Milano demonstrates that innovative materials can coat mitochondria without compromising their function. The coating method retains the mitochondria's ability to produce energy.
JGU welcomes evolutionary neurobiologist Max Farnworth with EUR 1.8M Emmy Noether funding, focusing on neural circuit & systems evolution. Farnworth's team investigates brain evolution by comparing four insect species, revealing contrasting developmental programs in mushroom bodies and central complex.
DHHC13 controls lysosomal cholesterol egress through palmitoylating NPC1, a key enzyme in cholesterol transport. The modification of NPC1 by DHHC13 enables lysosomal localization and protein stability, maintaining cholesterol homeostasis.
Researchers develop a new technique called Light-Induced Spindle Activation (LISA) to study centrosomes and spindle assembly in greater detail. LISA reversibly activates Aurora A kinase, a key centrosomal enzyme critical for spindle assembly, and can be applied directly in living cells.
A new study published in Advances in Atmospheric Sciences uses balloon-borne instruments to track the journey of desert dust to the tropopause layer over the northern Tibetan Plateau. The research provides valuable observational data for evaluating dust-transport models and highlights the importance of sustained balloon observations.
Researchers from UNIST, Ewha Womans University, TUM, and ILL report a significant increase in liquid hydrogen storage time using metal-organic frameworks. The study found that IRMOF-20 can retain about 97% of liquid hydrogen's theoretical volumetric capacity for over 221 days, more than three times as long as neat liquid hydrogen.
Researchers have identified the molecular signaling pathway that links mechanical stimulation to changes in plant genes and growth. A chain of three specific proteins becomes activated within a minute, sending signals that affect hundreds of genes and contribute to changes in plant growth.
The study examines how the Odyssey has been systematically reinterpreted in light of historical and cultural dilemmas, showcasing its impact on modern human experience and characterization of scientific concepts. Female figures like Circe and Penelope are reimagined as symbols of autonomy and resistance in contemporary literature and t...
Researchers found that microplastics clog liver phagocytes, disrupting metabolism and leading to fatty liver disease. In contrast, smaller particles activated brown adipose tissue, stimulating heat production.
A retrospective case series of 5 patients with severe COPD-associated pulmonary hypertension found modest improvements in pulmonary hemodynamics and exercise capacity after 6 months of nebulized ensifentrine, without exacerbations or worsening oxygenation. The study suggests a potential therapeutic role for ensifentrine in this under-t...
Researchers have identified DLL3 as a key player in neuroendocrine cervical cancer, driving immune evasion and tumor progression. Targeted DLL3 inhibition shows promise in improving treatment outcomes for this aggressive subtype of cervical cancer.
CCT2 stabilizes c-Myc to promote HNSCC progression and cisplatin chemoresistance. CCT2 also regulates cell-cycle programs and facilitates the transfer of chemoresistance between tumor cells through apoptotic vesicles.
Extracellular vesicles (EVs) are key players in the pathogenesis of chronic lung diseases, modulating cellular senescence and immune-inflammatory responses. EVs facilitate aberrant intercellular communication, deliver pathogenic miRNAs and proteins, and promote chronic inflammation.
Researchers developed a method to extract scintillation amplitude errors from amplitude streaks and retrieve ionospheric parameters using L-band SAR. The study reveals high-resolution observations of ionospheric scintillation and its relationship with ionospheric anomalies.
A recent study published in eGastroenterology reveals that intestinal neutral ceramidase plays a crucial role in metabolic steatohepatitis (MASH) progression by altering gut microbial composition and metabolite profiles. The study suggests that targeting this enzyme and its downstream effects may lead to novel therapeutic strategies fo...
A recent survey found that 31% of Americans believe RFK Jr. recommends measles vaccination for children, while 29% believe he does not. The public is evenly divided on the issue, with 40% unsure. The survey also found that most adults reject the link between vaccines and autism.
KRAS-driven cancer is a complex disease with multiple layers of post-translational control, including membrane localization, stability, activity, and signaling output. Post-translational modifications of KRAS offer new therapeutic opportunities by targeting PTM enzymes and modification-dependent regulatory networks.
Researchers at North Carolina State University have identified two neuroproteins, BDNF and S100B, as potential biomarkers for diagnosing Neonatal Maladjustment Syndrome (NMS) in foals. The study found that levels of these proteins and neurosteroids in blood serum were associated with NMS, suggesting a link to the disease's pathophysiol...
Researchers at the University of Vienna developed a new method to automatically detect anomalies in large scientific datasets. The method, called Simulation-Based Benfordness Estimation, uses Benford's Law to identify irregularities and improve data quality, leading to more reliable research and AI applications.
Researchers have developed an open, low-cost imaging-based ST platform called OpenFISH, which integrates spatial transcriptomics and MALDI-MSI on the same slide. This platform addresses two major ST challenges, reducing the cost by 95% compared to commercial platforms.
Researchers found distinct gut microbiome patterns in adults 50 or younger with colorectal and breast cancers compared to those diagnosed later in life. The study identified broad microbiome differences between cancer patients and healthy individuals, and pinpointed specific bacterial species associated with five cancer groups.
New research suggests that neck lymph node removal may interfere with cerebrospinal fluid drainage, contributing to cognitive impairment. Patients undergoing cervical lymphadenectomy had a higher rate of cognitive impairment than the general population.
Researchers found that anti-flooding infrastructure can sometimes make floods worse, especially during lighter rain. The study used computer simulations to analyze the impact of modern terrain modifications on flood hazards and exposure.
A closed-loop modeling and assessment framework for aerospace engineering managers' AI competency is proposed, capturing governance priorities and multi-attribute interdependencies. The framework, comprising five dimensions and twenty attributes, provides a traceable decision-support tool for selection, performance management, and care...
Researchers developed a new method to manipulate objects on solid surfaces using specially structured vibrations. The approach uses a passive subwavelength-encoded platform to generate flexural-wave vortices, allowing for confinement, transportation, and rotation of objects across multiple scales.
A new paper has questioned the effectiveness of the Gaza Humanitarian Foundation's aid distribution model, citing inhumane treatment and potential violations of international law. The model, which relied on private security contractors, led to crowding, stampedes, and shootings at aid distribution sites, causing thousands of civilian c...
Rising rates of ocular syphilis and ocular toxoplasmosis are putting people at risk of preventable vision loss. Early diagnosis and treatment can significantly reduce the risk of permanent sight loss. Regular eye examinations and timely reporting of vision changes are crucial in protecting sight.
This special issue explores the formation, evolution, and maintenance of biological diversity across all branches of the tree of life. Researchers can submit papers on topics such as speciation, adaptive evolution, and eco-evolutionary feedbacks, with a focus on developing a unified evolutionary framework for understanding biodiversity.
This special issue investigates biodiversity loss, ecosystem stability, and resilience in the face of climate disruption and global change. It welcomes contributions on ecological restoration, nature-based solutions, and adaptive management to address biodiversity conservation and ecosystem function.
Researchers are exploring quantum RF sensing, sensemaking, and related technologies through a three-year MOU. The collaboration combines superconducting quantum technology and advanced signals expertise to address congested electromagnetic environments and complex operational scenarios.
The American College of Lifestyle Medicine has released a new position statement asserting the interconnected threats of climate change, biodiversity loss, and chronic disease. Lifestyle medicine's six pillars can benefit both individual and environmental health, improving health outcomes while reducing greenhouse gas emissions and pol...
The first-ever EU Screening Week aims to detect risk factors earlier and prevent serious cardiometabolic diseases. Key health indicators like blood pressure, blood sugar, and cholesterol will be checked to take preventive action sooner.
A new study led by the University of Michigan rules out planets with the mass of Jupiter or larger in the 70 Oph AB binary system, but finds that smaller worlds may still exist within the habitable zone. The research achieved record-setting sensitivity for the system and opens the door for future studies of smaller planets.
Bile genome sequencing detected tumour DNA in 73% of patients with initial pathological diagnosis of malignancy, including 82% of cholangiocarcinomas and 56% of pancreatic ductal adenocarcinomas. The test showed high specificity, identifying 96% of benign cases and 51% of initially indeterminate cases, outperforming serum CA19-9.
A novel biomass-based aerogel combines two natural salt-management strategies to maintain high performance in highly concentrated brine, outperforming conventional evaporators. The material, inspired by marine fish gills, regulates ions and water transport efficiently, enabling continuous desalination even in extreme conditions.
Biologists from UMass Amherst discovered two of the world's loudest birds, the bare-throated bellbird and red-legged seriema, with volumes exceeding 120 decibels. A new study measured the amplitude of 123 bird calls, resulting in a 58-decibel variability, with the hummingbird's call being the quietest at 64 decibels. The study found a ...
A new study published in British Journal of Nutrition found that no-sugar sweetened soft drinks are equivalent to water for long-term weight management. The 104-week trial showed that diet beverages do not disrupt appetite regulation or cause metabolic harm, providing evidence to inform global guidelines.
The German B8 nuclear project, led by Werner Heisenberg, aimed to produce fissile material before Nazi Germany completed its own reactor. The project's failure was attributed to material shortages, including a lack of heavy water and uranium, making a working bomb highly unlikely.
The study found substantial international variability in laboratory testing for bone and mineral metabolism, limiting data sharing and clinical impact. The survey highlights the need for greater consistency in BSI testing to improve clinical utility and patient care.
The FAU/NCHA Community Health Center, operating nurse-led clinics in West Palm Beach, has earned a federally funded FQHC designation, allowing it to strengthen services and reach more patients. The center provides care regardless of ability to pay and serves nearly 1 million people nationwide.
New research published in ACS Chemical Neuroscience found that male rats exposed to menthol-containing e-cigarette aerosols experienced nicotine's effects more strongly and for longer than rats exposed to nicotine alone. The study suggests that menthol modifies nicotine's effects when delivered together in an e-cigarette aerosol.
Love Your Lungs Day draws attention to the critical importance of respiratory health in Phoenix residents, with over 410,000 cases of adult asthma and 187,000 cases of COPD in Maricopa County. The event aims to promote education, research, prevention, and access to quality respiratory care.
Large language models (LLMs) evaluate humans based on cooperation and social norms, with most models favoring cooperation and punishing bad behavior. The LLMs' judgements often depend on the recipient's gender and cultural background, and may be influenced by prompting interventions.
A behavioral economics study of nearly 15,000 South Koreans over six years found that people are more likely to report suicidal ideation when their life is perceived to be getting worse relative to their recent past. The study's key findings suggest that loss aversion is a stronger predictor of suicide risk than life circumstances.
Researchers at HKUST developed a biomimetic nanocoating inspired by human cartilage to suppress battery degradation and extend lifespan. The coating enables batteries to retain high capacity after thousands of charge-discharge cycles, opening a pathway toward next-generation nickel-rich lithium-ion batteries.
A novel molecular mechanism regulating TMEM63B lipid scrambling has been discovered, with the C-terminal tail acting as a brake to keep the protein inactive under resting conditions. Disrupting this region, particularly the Leu776 residue, releases the brake and triggers constitutive lipid scrambling.
A study led by UCalgary researchers found that both recreation and roads impact wolverine populations in western Alberta and eastern British Columbia. The study shows that recreation is linked to lower population density in a carnivore, and road density affects females the most.
Researchers discovered that declining cardiolipin levels in aging muscle mitochondria trigger a defense mechanism to protect cells from ROS damage. By mimicking this decline in young mice, they found that restoring cardiolipin levels can reverse muscle wasting and prevent early deaths.
Researchers from Shibaura Institute of Technology used molecular simulations to investigate how an enzyme's shape affects molecular recognition and ligand retention. They found that enzyme shape influences ligand retention, with 75.6% of trajectories in the closed group retaining ligands compared to 55.1% in the open group.
BD2 is seeking additional clinical sites to join its Integrated Network, aiming to advance understanding of bipolar disorder. The network, spanning 11 institutions, combines longitudinal cohort study and learning health network to improve care outcomes.
Dr. Constanze Schelhorn takes on the role of Chief Publishing Officer, bringing 10 years of experience to strengthen MDPI's publishing practices and navigate the evolving scholarly publishing landscape. Her expertise and perspective will be valuable in developing publishing practices and serving researchers and academic communities.
A new AI tool, Tessera, has been developed to map smallholder crops in Senegal with high accuracy, providing essential data for food security planning. The technology, trained on satellite images, outperformed existing methods and can be used to guide support decisions, helping vulnerable populations.
A research team found that slow freezing and fragmentation can separate salts and organics in ejected material from Enceladus' ocean. This process creates chemically diverse ice grains, with each grain enriched in different salts and compounds.
Researchers developed a blood-based approach to identify cancer-specific proteins, which may enable personalized immunotherapy. The study found that circulating tumor DNA analysis identified 63.25-97.4% of neoantigens found in tumor tissue, and T cells isolated from blood samples recognized and reacted to these neoantigens.