A $7.6 million NIH grant will advance understanding of polyaminopathies, a group of rare genetic disorders affecting neurodevelopmental presentations. The grant will help identify new approaches to molecular diagnosis and care, as well as train the next generation of rare disease researchers.
Researchers developed a tool to observe complex molecular choreography in real-time, shedding light on how a key protein locates the correct regions of the genome to initiate an adaptive response. The study proposes that transcription produces a 'dynamic RNA hub' that recruits the DNA mutator protein AID.
A team of researchers at MSU used machine learning to predict how chemicals will influence gene expression, leading to the discovery of promising compounds for the treatment of liver cancer and a chronic lung disease. The study results from years of interdisciplinary work across multiple disciplines and institutes.