Researchers at the University of Oklahoma will conduct clinical trials to evaluate the effectiveness of combining CAR T-cell therapy with opaganib for ultra-high-risk multiple myeloma. The trials aim to improve treatment outcomes for patients with poor responses to standard treatments.
The Center for Grassland Ecosystem Forecasting (CGEF) will use in-situ observatories and advanced models to predict grassland ecosystem dynamics. The team will work with ranchers and land managers to develop actionable forecasts and tools, supporting regenerative practices and strengthening the STEM workforce.
The University of Oklahoma will continue its life-saving weather research with a $220M 5-year renewal from NOAA, marking its fifth decade of partnership. Researchers will focus on severe weather phenomena, forecast improvements, and societal impacts, providing innovative forecasts that reduce extreme weather impacts.
The OU-led project, Shale 2.0, recovers critical minerals from existing oil and gas wells, reducing reliance on imports and boosting American independence and competitiveness. The project will engineer reactive fluids to extract minerals, using flexible, modular technologies to separate them at the surface.
Researchers have identified three subclusters of cells driving pancreatic cancer-induced cachexia, a muscle-wasting and fat-loss condition that affects pancreatic cancer patients. The subclusters form a triangular regulatory network that drives the initiation and progression of cachexia.
A new study by OU researcher Sam Moore found that heavier training loads can lead to worse sleep recovery, lower wellness scores, and slower speed performance. The research highlights the importance of considering each athlete's individual needs to maximize success in sports.
Research identifies MLKL as a protein that helps drive liver cancer associated with obesity-related fatty liver disease by reducing mitochondrial function, promoting tumor development. Removing MLKL reduces liver tumors but not fatty liver or liver inflammation, suggesting a new therapeutic target for liver cancer treatment
A new study at the University of Oklahoma is testing an interactive app called Connect2Care to increase prostate cancer screening among Black men in Oklahoma. The app provides culturally tailored education, guides users through at-home PSA testing, and connects them with medical professionals.
A new University of Oklahoma study examines whether targeted social media messages can increase parents' knowledge and help them take action to prevent teen vaping. The research aims to give parents the information and tools they need to recognize vaping and help prevent its use with their children.
Two OU-led research teams have been awarded nearly $1.4 million in funding under the DOE's Genesis Mission to develop AI for enhanced geothermal systems and quantum computing. OU's projects align with the university's impact-centers research priorities and address the Genesis Mission's pillars of Energy Dominance and Discovery Science.
A University of Oklahoma researcher is receiving a five-year, $2 million NCI grant to investigate how pancreatic cancer uses cholesterol to survive chemotherapy. The research aims to identify new ways to treat this deadliest form of cancer by uncovering the biological processes that help tumors thrive.
Researchers discovered how breast tumors recruit immune cells to attract nerves that support tumor growth and treatment resistance. Blocking nerve growth may boost the immune response to fight cancer.
Researchers are developing a new platform for obesity drug discovery using human-induced pluripotent stem cell-derived brain organoid models. They will test thousands of potential drug compounds on specialized brain cells to identify those that activate the protein adenylate cyclase 3 (ADCY3), a key regulator of appetite and body weight.
A new study reveals that photoreceptors possess an internal recycling system that removes damaged proteins and maintains cellular health. This discovery has important implications for inherited retinal diseases and raises questions about the safety of certain drugs in clinical testing.
The OU College of Medicine has received a $10.7 million NIH grant to study how cells sense their environment and respond to diseases that occur when this process malfunctions.
A six-year study on drought's impact on soil microbial communities found decreased biodiversity and shifted ecological configurations. This decline affects nutrient cycling processes and broader ecosystem health.
Andean leaf-eared mice have evolved to survive extreme elevations with low oxygen and freezing temperatures. They can generate higher heat through shivering and process plant-derived dietary toxins.
A team of University of Oklahoma researchers has developed a noninvasive imaging approach using polarization-sensitive optical coherence tomography (PS-OCT) to evaluate donor livers more comprehensively. This technology could help transplant teams make faster, more informed decisions about liver suitability for transplantation.
Researchers identified a previously unrecognized immune system pathway that connects cigarette smoking to cardiovascular disease. Cigarette smoke activates immune cells, triggering widespread inflammation throughout the body and accelerating plaque buildup in arteries.
A study from the University of Oklahoma reveals that microplastic exposure can exacerbate fatty liver disease, especially in high-fat dietary conditions. Researchers used advanced mapping technology to pinpoint specific regions of liver damage caused by polyethylene exposure.
The University of Oklahoma is establishing the Oklahoma Center of ImmunoEngineering with an $11.5 million NIH award. The center will integrate wet lab science and data science to accelerate disease research. Four early-career faculty members are selected as research project leaders, and the center offers training workshops, seminars an...
Researchers found that obesity alters the biological changes in breast cancer cells, enabling them to survive and thrive. The study's findings could improve prediction and treatment of invasive breast cancer, reducing overtreatment and unnecessary treatments.
University of Oklahoma economist Georgia Kosmopoulou will study the environmental and economic impacts of industries like agriculture and mining in Peru. Her research aims to strengthen interdisciplinary collaboration and bring economics into existing partnerships.
Researchers from OU's Gallogly College of Engineering are developing autonomous cargo carriers to optimize logistics along the I-40 corridor in rural and tribal regions. The project aims to improve safety, efficiency, and reduce crash risks through autonomous vehicle technology.
Researchers discovered that stress hormones trigger neutrophils to detach from blood vessel walls and travel to the heart, causing inflammation. Blocking these stress signals with beta blockers may prevent excessive inflammation and improve heart healing.
A study published in PLOS Medicine has identified two new genetic pathways contributing to cardiometabolic disease, including heart disease and obesity. The research analyzed lipid metabolites and their link to disease, suggesting that targeting specific metabolic pathways could prevent or lower the risk of disease.
A University of Oklahoma researcher is leading a global water modeling project to create advanced tools and datasets for managing fresh water sustainably. The Re-Analysis of Water for Society (RAWS) project aims to shed light on how humans can best manage fresh water for long-term sustainability.
Researchers developed DARC-NESS, a model that explains why nightmares persist in children and how to break the cycle through tailored therapy. By focusing on nightmare efficacy and child response mechanisms, clinicians can create effective treatment plans to empower kids to master their dreams.
A hormone called FGF21 reverses obesity in mice by signaling to the hindbrain, a region targeted by GLP-1 drugs. This finding provides insight into the naturally occurring hormone's benefits for weight loss and MASH treatment.
Researchers discovered an unusual interfacial layer that promotes higher growth rates by adsorbing carbon dioxide molecules. The study aims to explore larger hydrate structures for technology development and address real-world problems such as CO2 containment and water desalination.
Researchers are using a revolutionary radar system to transform understanding of lightning and electrification, helping to improve storm warnings and assess damage risk. The system, named Horus, can capture rapid scans of storms, allowing for clearer pictures of lightning plasma and its distinctive polarimetric indicators.
The report analyzes the Indian Health Service's Purchased/Referred Care program's impact on cancer care access for Native patients in Oklahoma, highlighting delays and gaps in services. It provides policy options for tribes to improve cancer care access, including self-determination and regional collaborations.
A new $1.7 million NIH grant will support Carol Webb's research on the protein ARID3a and its role in lupus development and treatment. The study aims to identify genes controlled by ARID3a, understand how it disrupts the immune system, and test potential treatments.
The University of Oklahoma is launching a new five-year, $1 million federal grant-funded training program to address the challenges faced by people experiencing homelessness. Residents in internal medicine and family medicine will receive immersive training in delivering compassionate, comprehensive care to this vulnerable population.
University of Oklahoma researchers created new hybrid materials that emit light quickly when exposed to radiation. The materials combine the strengths of both organic and inorganic components, resulting in a five-fold increase in light emission efficiency compared to organic molecules alone.
Climate change alters high-elevation meadows, causing plant communities to shift towards shrub-dominated landscapes. The changes also affect the soil ecosystem, with declines in mycorrhizal fungi and increases in decomposers.
Cancer cell researchers at the University of Oklahoma have developed a novel 'triangle regulation theory' that explains the development of cancer-induced cachexia and anorexia. The theory reveals how cancer cells recruit immune cells to trigger excess production of growth factor 15, leading to muscle wasting and loss of appetite.
Salesky's research team will address uncertainty in how turbulent processes contribute to cloud formation by using simulations to replicate turbulence and test environmental conditions. The study aims to improve civilian and military weather forecasting models, with significant implications for precipitation and severe weather.
A new Phase II trial will examine whether giving chemotherapy or chemotherapy combined with immunotherapy before surgery can improve survival compared to surgery alone. The trial aims to identify a treatment that will help patients live longer without the cancer returning.
A University of Oklahoma researcher has been awarded a competitive NIH grant to advance tribally defined genomic research approaches. The project, called Partnerships for Indigenous-led ELSI Research (PIER), will strengthen meaningful collaboration with Indigenous communities and promote Indigenous-driven approaches to genomic research.
A study from the University of Oklahoma suggests that maternal indole supplementation can significantly reduce the risk of fatty liver disease in children. The research found that offspring whose mothers received indole maintained healthier livers and had lower blood sugar levels, even after exposure to a Western-style diet later in life.
A new study reveals Africa's oldest known in situ cremation pyre containing the remains of an adult, dated around 9,500 years ago. The discovery suggests that ancient African hunter-gatherer communities had complex ritual practices involving posthumous removal and reburial of body parts.
Researchers at the University of Oklahoma and West Virginia University are studying concept flavored cigarillos to determine their potential for addiction. The study aims to inform the FDA's impending flavor ban on cigar products, which could have wider-reaching implications for e-cigarettes and tobacco-free nicotine pouches.
Researchers estimate 100 trillion insects fly in US skies daily, with stability over past decade but regional fluctuations. Winter temperatures significantly impact insect populations, which may hide species sensitive to environmental change.
Researchers estimated that around 100 trillion insects fly above the US every day using weather radar data. Insect populations remained relatively stable over the past decade, but regional fluctuations were observed, with warmer temperatures leading to declines in insect density.
The University of Oklahoma researcher is working on a project using inverse design techniques and AI to create advanced materials that can quickly switch between conductive and insulating states. The goal is to reduce uncertainty in the discovery process and create a scalable material-design methodology.
A new study from the University of Oklahoma suggests that small genetic differences in two proteins may influence how their eyes develop, affecting the risk of retinopathy of prematurity (ROP). Researchers found four genetic variants specific to eye disease, with two protective and two increasing the risk. Early genetic testing could h...
Researchers at the University of Oklahoma have successfully developed magnetically doped quantum dots by introducing manganese into perovskite nanoparticles. The discovery has significant implications for various technologies, including solar cells, biomedical imaging, and next-generation computing.
A clinical trial led by the University of Oklahoma Health Stephenson Cancer Center has shown promising results with a new drug combination targeting metastatic colorectal cancer in patients with ATM-deficient tumors. The treatment, combining alnodesertib and irinotecan, showed substantial reductions in cancer size in these patients.
Researchers are searching for cellular vulnerabilities in 'superbugs' like E. coli and P. aeruginosa to find new, effective therapeutics. The $5.3 million project aims to develop new ways to deliver lifesaving drugs directly into resistant pathogens.