A global genomics study reveals that genetic variants influence gene activity and protein abundance in multiple tissues, not just blood samples. This analysis identifies causal evidence for 676 genes linked to type 2 diabetes.
The AMALIA project develops a scalable screening platform to identify anti-amyloid therapies, bypassing the challenge of studying amyloid nucleation. This approach enables parallel discovery campaigns on multiple targets, offering unprecedented speed and scalability.
A study published in EBioMedicine found changes in blood samples from almost 1,000 people hospitalized for COVID-19 may pinpoint patients at risk of long-term lung disease. The study identified elevated levels of certain molecules, which could lead to the development of simple blood tests to detect ongoing lung problems.
The NeuroBRIDGE project aims to transform two-photon microscopy for studying neural circuits during natural behaviors. The miniaturized, fibre-optic-based microscope enables high-resolution studies under free-moving conditions.
The CAMP platform enables simultaneous analysis of up to 30 samples, increasing sensitivity by over 50% for rare diseases like hepatoblastoma. This technology facilitates advances towards personalized medicine through deeper and more accurate metabolic analyses.
Researchers found clouds in North Atlantic region formed with fewer, larger droplets, yet remained unchanged in reflectivity; overall water content increased to maintain balance.
A BiVO4 photoanode modified with a highly electronegative fluoride ion shows enhanced adsorption and activation of CH3OH molecules. The formed V–F bond promotes O–H fracture and activates the C–H bond, leading to improved selectivity and efficiency for HCHO production.
A team of researchers has found that a common soil fungus can extract large amounts of residual phosphorus from phosphogypsum, a byproduct of phosphoric acid production. The study shows that more than 40% of the phosphorus locked inside this waste material can be recovered through a biological process.
Researchers found that naturally occurring fungi on and within almond trees can strongly suppress Colletotrichum godetiae, the primary cause of almond anthracnose in the Mediterranean Basin. Several species of Trichoderma and Neurospora intermedia proved effective in suppressing pathogen growth and reducing spore production.
Researchers successfully diagnosed and treated ten PCNSL patients using liquid biopsy, detecting hotspot MYD88 L265P mutations in circulating tumor DNA. This method offers a reliable alternative to surgical biopsies for patients with difficult-to-access lesions or frailty, enabling timely treatment initiation.
The AAVLINK method harnesses Cre/lox-mediated intermolecular DNA recombination to enable efficient full-length gene reconstitution and robust expression of therapeutic genes. This approach overcomes the limited packaging capacity of adeno-associated viruses, offering a strategy for delivering large gene cargoes in gene therapy.
Researchers developed a rapid zebrafish-based functional assay to determine the pathogenicity of novel SMN1 mutations, potentially informing urgent clinical decisions. The test showed that many previously uncertain variants were harmless, reducing distress for families and saving lives.
A new Griffith University study found altered brain connection in people with ME/CFS and Long COVID, leading to cognitive difficulties such as memory problems and slowed thinking. The research used ultra-high field MRI technology to investigate the disruption in brain connectivity during a mentally demanding task.
A new study finds that transcranial magnetic stimulation (TMS) is a cost-effective treatment option for moderate and severe forms of depression. TMS reduces depressive symptoms, eases pressures on informal carers, and helps people get back to work, recovering its costs over time through savings to the NHS.
Research reveals leading US tobacco brands violate Instagram, FTC, and FDA marketing policies to restrict young people's access. Lax/missing age verification, disclosure on brand-influencer relationships, and health warnings are common violations.
Researchers have discovered a neural circuit hidden in an understudied region of the brain plays a critical role in turning temporary pain into chronic pain. Silencing this pathway can prevent or halt chronic pain, offering new hope for treating severe chronic pain with injections or infusions targeting specific brain cells.
Dissociation is a complex survival mechanism in response to overwhelming trauma, affecting memory, identity, and perception. Research confirms its prevalence among individuals who have experienced trauma, and effective dissociation-specific treatment options are needed.
The study found that mania accounts for more than 80% of the genetic variation in bipolar disorder. The researchers identified 71 genetic variants linked specifically to mania, including 18 regions of genes that had never previously been associated with bipolar disorder.
A groundbreaking field-based research study from Nankai University found the average carbon emission of dismantling a single unit of E-waste increased from 1.2513 kgCO2 to 1.3335 kgCO2 between 2013 and 2020, highlighting the urgent need for more efficient recycling technologies.
A new study reveals significant differences in growth patterns between nurse sharks off the coast of Miami and those living just across the Gulf Stream. The research found that juvenile nurse sharks in Biscayne Bay grow more rapidly and reach smaller maximum sizes than their counterparts in Bimini, Bahamas.
Researchers at University of Queensland conducted hearing tests across ocean off Australian coast, finding humpbacks react to higher frequency sounds than expected. The study provides direct evidence humpbacks are highly sensitive to higher frequencies at the upper end of human hearing range.
Recent U.S. policy changes have significant environmental implications, affecting ecosystems and public health. Stanford research projects track the impact of these changes in real-time, from forest management to clean-energy investments and climate migration.
A $4.9 million Gates Foundation grant will support the development of self-cloning crops in India, improving agricultural productivity and accessibility for smallholder farmers. The project aims to expand synthetic apomixis technology into staple crops like pearl millet and Indian mustard.
A landmark study supports the safety of paracetamol and ibuprofen in young children, finding no link to eczema or bronchiolitis. The study, which analyzed data from over 4,000 babies, confirms that both medications are safe to use in the first year of life.
Researchers found that sleeping without pillows can lower harmful high internal eye pressure in people with glaucoma. The study suggests that stacking pillows alter neck position, which compresses the jugular vein and prevents natural drainage of aqueous humor.
A study by University of Exeter researchers found that moths move significantly less under artificial light compared to natural night conditions. The results suggest that light pollution has widespread effects on nocturnal moth activity, irrespective of lighting type, with implications for moth populations and ecosystem services.
Researchers created a 3D chip platform called ASTEROIDS that mimics human physiology and enables precise testing of new drugs and personalized medicine models. The technology has the potential to reduce animal testing in cancer research and improve human clinical outcomes.
Florida Atlantic University will be the first university in Florida to host a large, dedicated quantum computer on site, aiming to accelerate and solidify the state's position as a leader in quantum computing. The university will collaborate with D-Wave Quantum Inc. to advance quantum computing education, research, and applied innovation.
The Vertebrate Genome Laboratory will apply AI to automate manual genome curation processes, expanding genomic representation across underrepresented branches of the Tree of Life. This project aims to generate high-quality genomes for tens of thousands of species, enabling discoveries in biodiversity conservation and medicine.
A global synthesis found that warming is driving faster microbial metabolism, increasing the breakdown of organic matter and greenhouse gas release. Thawing soils also free contaminants like mercury, complicating climate projections.
FI-Chrom uses Hi-C maps to create 3D models of chromosomes, revealing structural and dynamic features such as chromatin loops forming transiently. The open-access program provides insight into chromosome structure in various organisms.
Dr. Candida Rebello's five-year NIH grant will explore lifestyle strategies to reduce excess body fat and declining muscle mass in older adults with obesity. The study aims to protect skeletal muscle health, independence, and quality of life for this rapidly growing population.
A new Phase II trial will examine whether giving chemotherapy or chemotherapy combined with immunotherapy before surgery can improve survival compared to surgery alone. The trial aims to identify a treatment that will help patients live longer without the cancer returning.
Researchers found 'dark energy' in protein structures, indicating energetic frustration between form and function. This 'dark energy' varies by site, revealing the cost of specific functions like binding.
Virginia Tech researchers identified a malformed area in the corpus callosum and pattern of bad connections that may help doctors diagnose Leigh syndrome earlier. The study found that developmental defects can be seen before symptoms appear, suggesting potential for earlier intervention.
A recent study by a UCLA-led team reveals that leftover COVID-19 viral fragments can selectively accumulate on and penetrate star-shaped surfaces of dendritic cells and T cells, killing these immune cells. In contrast, the omicron variant's smaller fragments have little effect on these cells.
Graduate students at MUSC are earning digital badges in science communications, highlighting their ability to explain complex scientific concepts to the public. This program is part of a larger shift towards providing graduate students with valuable skills that apply to multiple career paths in science.
Animal studies reveal complex dynamics of sex, fidelity, and monogamy in various species like wolves, dolphins, and swans. The intimate animal explores the evolutionary roots of human attachment and love.
A Simon Fraser University study reveals Canada's cycling infrastructure expanded by 3,596 km between 2022 and 2024. However, areas with more children and older adults saw less growth in cycling infrastructure, highlighting the need for more inclusive transportation planning.
A UC San Diego study found that older women with a history of depression and anxiety had a 78% higher risk of developing long COVID. The researchers analyzed data from the Women's Health Initiative and hope to inform preventative measures for public health officials and policymakers.
Researchers have found a way to harness the electrical energy generated by protein condensates, constantly shifting membrane-less organelles that govern cell function. This discovery could lead to bioelectrochemical devices for cleaning pollutants and fighting infection.
Researchers at Oregon State University developed a new nanomaterial that generates both hydroxyl radicals and singlet oxygen to kill cancer cells. The material showed potent toxicity in multiple cancer cell lines with negligible harm to non-cancerous cells.
The center will develop cutting-edge computational methods, including AI algorithms, to tackle fundamental geophysical problems. By studying weather and climate on Earth and other planets, the hub aims to shed light on many events that have historically been difficult to forecast.
Researchers at the University of British Columbia have developed a topical CRISPR-based therapy that can correct faulty genes in human skin, potentially treating genetic skin conditions like ARCI and eczema. The treatment, using lipid nanoparticle technology, restores up to 30% of normal skin function.
The ISSCR is hosting a summit on access and affordability in cell and gene therapies to explore pricing, manufacturing, regulation, and reimbursement strategies. Experts will examine key barriers and emerging solutions across the access landscape.
Drivers who participated in a program based on their driving habits showed reduced speeding, hard braking, and rapid acceleration by up to 25%. They continued these safe habits even after the program ended. The programs were equally effective in improving safety scores.
Overactive valosin-containing protein (VCP) disrupts the nuclear pore complex, leading to abnormal TDP-43 trafficking and neuronal damage in neurodegenerative diseases. Inhibiting VCP activity may offer new therapeutic strategies for treating these conditions.
A UH psychologist's study finds that anxiety sensitivity and pain-related anxiety are linked to mental health problems and clinically significant alcohol use among survivors of traumatic sexual assault. The investigation highlights the importance of addressing both types of anxiety in reducing the risk of lifelong challenges.
A study from Florida International University finds that claiming a business page on review platforms like Yelp can lead to a significant drop in average ratings, with a 10% decrease in five-star reviews and a 9.5% rise in one-star reviews. The study also reveals that these lowest-rated reviews become substantially longer and more crit...
A recent study from Penn State College of Medicine researchers found that helper T cells, typically involved in fighting infections, become overly activated in failing human hearts, causing damage. The activation of these T cells highlights the impact of inflammation and immune dysfunction in heart failure.
A new research project aims to develop an eye drop that can detect the fluorescent signal of a protein associated with Alzheimer's disease. If successful, this low-cost and accessible screening tool could help identify patients in their earliest stages of the disease, enabling them to receive early treatment.
A Mount Sinai study found that antibody-producing immune cells called IgG1 plasma cells help patients respond to PD-1 immune checkpoint inhibitors, which have transformed cancer care. The researchers identified IgG1 plasma cells as a critical factor in determining clinical outcomes.
A new study found that nudging both patients and providers with reminders increased flu vaccine numbers by almost 3,000 more people than expected. The researchers believe this could lead to strategies to boost annual flu vaccination rates.
Research suggests that blocking growth factor receptor signaling using cancer drugs may overcome two challenges: managing oral cancer pain and preventing opioid tolerance. This approach could control cancer while addressing pain through a non-opioid, biologically rational approach.
A team of University of Toledo physicists predicts significant growth for cadmium telluride photovoltaics in the US, with a target manufacturing capacity of 100 gigawatts by 2030. The technology offers advantages over silicon photovoltaics, including improved performance in hot and humid climates, and supports national energy security.
Researchers at Salk Institute debut an epigenetic catalog that shows genetic inheritance and life experiences have distinct effects on various types of immune cells, shedding light on individual differences in immune responses and potential new personalized therapeutics.
The four-year grant will provide educators with professional development training, create enduring resources, and develop virtual learning pathways for K-12 students. Over 1,000 teachers and 42,000 students in Nevada will benefit from the curriculum, materials, and resources.
The American College of Medical Genetics and Genomics announces Medical Genetics Awareness Week 2026, celebrating the power of collaboration in medical genetics. The week aims to bridge awareness gaps about the field and its professionals.
A Purdue University team led by Kyle Cottrell has discovered a new therapeutic target for triple-negative breast cancer, a deadly form of breast cancer lacking targeted therapies. The researchers identified dsRNA-binding proteins, specifically PACT, which suppress another protein called RNA-activated protein kinase (PKR).
A study by UC Riverside scientists reveals that the cysts of Toxoplasma gondii contain multiple distinct subtypes of parasites, each with different biological roles. This discovery offers new insights into how the parasite causes disease and why it has been difficult to treat.
A research team has developed a way to produce corticospinal-like neurons that centrally degenerate in motor neuron disease and are damaged in spinal cord injury. The study uses a multi-component gene-expression system called NVOF to precisely fine tune regulatory signals, resulting in mature neurons with distinct characteristics.
A newly excavated archaeological site in central China has uncovered evidence of advanced stone tool technologies, dating back 160,000-72,000 years ago, challenging long-held assumptions about early hominin behaviour in Eastern Asia. The findings suggest that hominins in this region were more inventive and adaptable than previously bel...
A new study in Geology suggests that massive undersea volcanism triggered at least four Triassic extinctions. Marine large igneous provinces were found to be a key driver of these events, accounting for half of the extinctions with an identifiable geological trigger.
A cohort study found that Medicaid expansion under the Affordable Care Act was associated with lower overall mortality among women with breast cancer aged 40-64. The benefits of expanded coverage were uneven, highlighting persistent disparities in healthcare access for certain populations.
Researchers have captured the first radio waves from a rare type of exploding star, revealing the star's final years. The discovery provides an unprecedented look at a massive star's behavior before its death in a supernova explosion.
The book sheds light on the often-ignored contributions of women in economics, highlighting their role as economic agents throughout history. Heggeness shares robust data and anecdotes about women who have thrived economically, from Taylor Swift to unsung heroes like Francis Perkins.
Researchers are developing next-generation adaptive insulin delivery systems using machine learning algorithms and ultra-rapid-acting U-500 insulin to personalize glucose control without manual intervention. The project aims to give people with Type 1 Diabetes their time, attention, and peace of mind back.
A nationwide survey found that 61% of Americans are unaware of non-statin medications to lower cholesterol, while 73% have never heard of lipoprotein(a) or coronary artery calcium score testing. Non-statin options include Ezetimibe, PCSK9 Inhibitors, and Bempedoic Acid, which can help patients at risk for heart disease.
The VERIFHE project aims to develop an open-source library for verifiable homomorphic encryption, enabling private and reliable inference. The ERC Proof of Concept grant will support the development of practical tools for machine learning services.
A new study discovered two previously unidentified fat distribution types associated with extensive gray matter atrophy and accelerated brain aging in men and women. Individuals with 'pancreatic-predominant' and 'skinny fat' profiles showed increased risk of neurological diseases, cognitive decline, and brain health issues.
The University of Virginia has launched a cross-Grounds initiative to advance health and healthcare through data and artificial intelligence. The Collaboratory aims to accelerate discovery, share expertise, and lower collaboration barriers across disciplines.
The MLEDGE project has successfully combined federated learning with cloud and edge computing to develop more secure, efficient, and personalized AI solutions. The project's applications include real-time COVID risk maps and energy consumption optimization in industry.
A large multinational clinical trial found that giving healthcare providers access to patient-reported outcome (PRO) data significantly improves the consistency of how treatment-related side effects are assessed in patients with cancer. This study highlights the importance of integrating the patient's voice into routine clinical evalua...
Researchers developed a high-resolution 3D ultrasonic imaging system for concrete that automatically adapts to different materials, improving contrast between defects and background material. The system uses a wide range of frequencies and can handle diverse materials without manual tuning.
Researchers at the University of Kansas have developed a tornado-forecast system called Warn-on-Forecast System (WoFS) that can predict tornado formation up to an hour before it occurs. The system uses high-resolution simulations and gauges uncertainties, providing guidance on severe weather threats.
Researchers developed miniature 3D tumor organoid models that closely mimic the human brain, revealing how glioblastoma interacts with surrounding brain cells and immune system. The models identified PTPRZ1 as a key regulator of tumor behavior, which helps determine its aggressiveness.
Researchers provide radiation oncologists with practical guidance to identify and protect female sexual organs during pelvic cancer treatment. The study establishes a shared, standardized approach to identifying the bulboclitoris, enabling clinicians to measure radiation dose to these tissues.
The Xigou site in central China has yielded evidence of sophisticated stone tool technologies dating back 160,000 to 72,000 years, revealing that hominins in the region were more innovative and adaptable than previously thought. The discovery challenges long-held views on early human technology in East Asia.
A hospital-based program supporting gun and knife violence victims can halve the likelihood of future harm, according to a Boston University study. Regular engagement with the Violence Intervention Advocacy Program reduced the risk of being revictimized or committing violence by 50 percent two to three years after discharge.
Rutgers University has developed a self-sustaining fund that reinvests revenue from commercialized technologies to support next-wave innovations. The model has generated an estimated 2.5-3.5 times more investment in follow-on funding.
Researchers used MRI analysis to measure glymphatic system activity, finding changes related to IIH stage and pressure levels. The findings suggest a noninvasive test could diagnose IIH more reliably, improving treatment options for patients with symptoms including headaches and vision loss.
A new computational modeling framework uses Type-3 Fuzzy Logic and neural networks to simulate tumor-immune dynamics under uncertainty and chaos. The model generates 'bands of uncertainty' and provides interpretable results, enabling physicians to understand the 'why' behind predictions.
Climate-risk scores are being used in infrastructure design, housing markets, and public policy, but the devil is in the details. Only 4% of highly cited studies shared their data and code, highlighting a structural barrier to cumulative progress.
Chronic wounds heal slowly due to healing disorders, affecting 800,000 people in Germany. Current treatment options lack evidence-based recommendations and patient-reported outcomes are underconsidered.
Researchers have uncovered a new understanding of how cardiac events are interconnected with the brain and nervous/immune systems. They found that sensory neurons in the vagus nerve detect injury and transfer signals to dedicated brain structures, leading to activation of the immune system.
Researchers led by Michael Wasserman are studying pesticide exposure in farming communities in Uganda, using household diaries and silicone wristbands to track human exposure. The study aims to inform communities about safe levels of exposure and suggest ways to reduce it.
Researchers have discovered a way to host graphene's electronic properties in a three-dimensional material, potentially removing hurdles for its use at scale in green computing. The discovery offers opportunities for designing materials with advanced low-energy electronic behaviour.
George Newman, a professor at the University of Toronto's Rotman School of Management, has been identified as an up-and-coming thinker whose ideas are predicted to make a significant impact on management thinking. His research focuses on creativity, identity, and meaning construction, with his work widely featured in prominent outlets.
Shorter-duration antibiotic therapy shows comparable success to longer-duration treatment in children with community-acquired pneumonia. However, more studies are needed for other age groups and diseases like acute otitis media.
A new study published in JAMA Network Open found that acupuncture is effective in reducing migraine without aura pain and improving functionality. The research identified specific brain network connections that predict treatment outcomes, enabling a personalized approach to pain management.
Researchers uncover a hypoxia–m⁶A–Gal-1 regulatory axis that fuels HCC progression by stabilizing Galectin-1 (Gal-1) mRNA, promoting malignant phenotypes. Functional experiments confirmed Gal-1's role in enhancing HCC cell proliferation, migration, invasion, and EMT-driven phenotypic plasticity.
The event brought together stakeholders to discuss improving support for students and graduates, with a focus on university-to-work transitions. Key findings highlighted the negative impact of COVID-19 on graduates' transitions and the importance of soft skills and cross-border employment opportunities.
JMIR Publications invites journalists, researchers, and experts to contribute to its News & Perspectives section with in-depth analysis and commentary on digital health trends. The publication aims to provide well-researched analysis that goes deeper than headlines, with a focus on factual precision, integrity, and empowerment.
A new framework for teaching critical consciousness in children's literature empowers kids to analyze texts with metaphorical concepts of mirrors and windows, fostering empathy and respect for diverse perspectives. The framework acknowledges different qualities of reflection, helping prevent prejudice and promoting social justice.
A Stanford University study found that showcasing past collective efforts on climate change can motivate individuals to take action. The most effective interventions combined evidence of impact with social and emotional benefits, increasing willingness to take public awareness actions by 30% and political actions by nearly 14%.
Researchers have made significant progress in developing AAV-mediated gene therapy for the inner ear, providing a potential cure for genetic forms of inner ear disorders. The approach targets specific cell types and aims to deliver functional genes to correct genetic defects or protect delicate sensory cells.
Researchers at the University of Rochester create a new process to turn ordinary metal tubes unsinkable by etching micro- and nano-pits on their surface, making them superhydrophobic. The tubes stay afloat in water, even when damaged or submerged for extended periods.
A study by SWPS University researchers found that sedentary lifestyle in adolescents can negatively impact their parents' mental health, leading to symptoms of depression. The study also showed that teenagers spend more time sitting than their parents, highlighting the need for family-based health-promoting interventions.
Researchers review EMT mechanisms and its impact on GBM progression, highlighting key signaling pathways and GSCs. EMT-targeted therapies offer promising strategies to disrupt tumor growth and enhance immune responses.
The Advanced Driving Simulation Center enables researchers to realistically test and optimize vehicles, chassis, and advanced driver assistance systems. The simulator's high bandwidth generates fine vibrations, crucial for optimizing electric vehicle comfort.
A new standardized protocol for preoperative CT assessment of the submental artery's origin and course has been developed, enabling precise visualization of its vascular course and caliber. This systematic approach aims to tailor flap design for individual patients, minimizing intraoperative surprises and optimizing outcomes.
The organization aims to support research and therapies that help people live fully and meaningfully despite serious illnesses. The awarded projects focus on delivering psychedelic therapy for anxiety reduction and improving end-of-life care, with the goal of promoting compassion and dignity.
A new study from the University of Michigan found that used electric vehicles (EVs) currently offer the lowest lifetime cost of ownership, with significant savings for drivers. The researchers analyzed virtual vehicle models, monthly gas and electricity prices, and Craigslist data to determine the total cost of ownership for different ...
Two innovative deep-learning algorithms, ClairS-TO and Clair3-RNA, advance genetic mutation detection in cancer diagnostics and RNA-based genomic studies. The tools improve accuracy and accessibility of genomic analysis, opening new horizons for precision medicine and genomic discovery.
Researchers from Adelaide University review the future of optical atomic clocks, finding them one of the most precise measurement tools ever built. The technology has advanced rapidly over the past decade and is well-positioned to become the gold standard for timekeeping, provided technical challenges are addressed.
A new tool developed by WSU researchers uses artificial intelligence to predict daily and weekly snow-water equivalent, outperforming existing methods for about 90% of locations. The tool provides critical information for short- and long-term water management decisions in the Western US.
Research reveals that Sulf1 is essential for both reward-dependent and aversion learning, highlighting its critical role in adult brain function. The enzyme acts through distinct dopamine D1 and D2 receptor pathways, underscoring its importance in neural circuits involved in learning.
A recent study combines heart imaging with proteomics to identify key proteins associated with cardiovascular diseases, offering new insights into pathogenesis and therapeutic development. The research highlights four plasma proteins, AGER, CCN3, FER, and SPON1, as high-priority candidates for drug targeting.
A Swedish study of prematurely born adults found increased morbidity in physical and mental health, yet they reported a high quality of life. The study, which followed participants from birth to age 26-29, suggests that premature birth does not necessarily limit daily life.
The University of Hong Kong (HKU) has established the Hong Kong Base of the State Key Laboratory of Subtropical Building and Urban Science, a comprehensive platform integrating scientific research, talent cultivation, and social service. The base aims to advance subtropical architecture and urban science research, promoting sustainable...
Researchers at the University of Oulu have identified genes associated with an increased risk of pneumonia, including those related to nicotine dependence in older adults. The study used genetic data from over 600,000 individuals to examine causal relationships between smoking, obesity and pneumonia risk.
The University of Hong Kong (HKU) has signed a Memorandum of Understanding (MoU) with the Qatar Foundation's Academic Bridge Program to promote student mobility and collaborative academic initiatives. The partnership aims to support student exchanges, credit transfer options, and joint training programs between HKU and Qatar.
Researchers have discovered that twisting and stacking oxide crystals can create specific atomic configurations that act as an 'invisible fence' to trap or repel electrons. The study reveals charge disproportionation due to subtle distortions in oxygen octahedra, leading to altered electron accumulation patterns.
The G protein-coupled estrogen receptor (GPER) is a key regulator of endocrine resistance in breast cancer, promoting tumor survival and proliferation. Elevated GPER expression is associated with poor therapeutic response and disease recurrence, highlighting its role as a coordinator of tumor-stroma interactions.
The article discusses the integration of heart imaging and proteomics to identify potential drug targets for cardiovascular diseases. The expert panel consensus guidelines establish a foundation for clinical practice, education, and future research in microbiota medicine.
HKU secures top rankings for nine out of eleven subjects in Hong Kong and 7th worldwide for Education Studies. The University's faculty and students contribute to its global leadership through innovative research and teaching.
A team of researchers led by Academy Professor Otso Ovaskainen has developed a prediction model that utilizes citizen bird observations alongside cutting-edge information technology. The new model provides the most accurate predictions yet of bird movements and singing activity, enabling anyone to participate in research.
Researchers discovered that gold nanospheres, named supraballs, can absorb nearly all wavelengths of sunlight, including near-infrared light. This technology, applied to a commercially available electricity converter, nearly doubled solar energy absorption compared to traditional materials.
The RT-FLOW project aims to transform aerodynamic experiments with compact, cost-effective hardware and real-time flow field measurements. It will define requirements for a fast visualization platform and tackle challenges in data-driven spatial resolution enhancement.
The German Research Foundation (DFG) is funding the Specialized Information Service (FID) Jewish Studies for another three years, strengthening research infrastructure. The FID provides tailored information services to researchers in Jewish history, culture, and Israel studies.
Cancer cells tap into the nervous system's power grid by forming synaptic contacts with nerve cells, promoting tumor growth and spread. Venkataramani's research aims to repurpose the drug perampanel for glioblastoma treatment and develop gene therapy approaches to disconnect tumors from the nervous system.
A team of Kuwait Ministry of Health researchers successfully demonstrated the destruction of SARS-CoV-2 virus particles through exposure to high-frequency sound waves. The findings indicate a functional inactivation of the virus, reducing viral load and offering a measurable endpoint for assessing viral inactivation.
A recent study published in Aging & Mental Health found a strong association between social connection and cognitive function in older adults. The researchers created profiles of social environments based on data from the Canadian Longitudinal Study on Aging and found that intermediate and richer social profiles were linked to better c...
Researchers develop origami-inspired robotic grippers for efficient handling of complex objects, enabling improved logistics and automation in the automotive sector. The project aims to reduce costs, time, and material consumption, contributing to environmentally sustainable solutions.
The expert panel developed guidelines for microbiota medicine, focusing on fundamental aspects such as disciplinary definition, diagnostic and therapeutic principles, multidisciplinary collaboration models, and core competencies. These guidelines aim to advance clinical practice and medical education.
A new interface structure design inspired by traditional Chinese mortise and tenon structures improves the mechanical properties and thermal shock resistance of Cf/(HfNbTaTiZr)C-SiC composites. The resulting composite exhibits higher flexural strength and fracture toughness compared to samples without the mortise-tenon structure.
The conference addressed pressing issues including innovation, sustainability, and inclusivity. Keynote speakers emphasized the importance of a predictable environment, comprehensive professional services ecosystem, and connectivity in driving business growth. Hong Kong's unique role as a super connector and value adder was highlighted.
The HKU School of Computing and Data Science has launched its first-ever dual-site semester across Hong Kong and Shanghai, offering students a unique blend of academic learning and industry exposure. The new teaching site in Shanghai empowers students to learn from cutting-edge technology and research ecosystems.
The new white paper outlines practical leadership strategies to strengthen trust between organizations and employees. The authors highlight the importance of improving systems, investing in skill development, and involving employees in decision-making processes.
Researchers develop novel thermometric method based on stimulated Brillouin scattering in gases, offering predictable and calibration-free temperature measurements. The technique enables direct retrieval of temperature from the Brillouin frequency shift, making it inherently absolute.
Researchers developed a potent and highly selective inhibitor of YEATS2, specifically targeting the ATAC complex in lung cancer cells. This strategy led to a significant reduction in tumour growth and metastasis.
A new scientific review summarizes 12 human clinical trials on the cardiometabolic effects of wild blueberries, finding improvements in blood vessel function and beneficial changes to the gut microbiome. Regular consumption of one cup per day may support overall health benefits.
Five IIT researchers receive Proof-of-Concept grants to develop innovative health technologies, including a smart microscope and edible pills. These projects aim to tackle cancer, dyslexia, and diagnostics with cutting-edge technologies like quantum computing and near-infrared photonic chips.
Researchers developed a new method for self-aligned laser transfer printing using Thermal Conductivity Gradient Carbon (TCGC) stamp, ensuring synchronous chip release and mitigating transfer errors. The SALT technique enables heterogeneous integration of diverse micro-objects onto various challenging surfaces with high accuracy and siz...
Restoration of peatlands can deliver significant climate mitigation benefits within two to six decades through the proliferation of Sphagnum moss vegetation. This process reduces greenhouse gas emissions and methane release, making it a pivotal contribution to Finland's land-use sector emission scenarios.
A €150,000 ERC Proof of Concept Grant will help physicist Daqing Wang integrate his
The 2025 HKU International Techno‑Entrepreneurship Challenge concluded with 20 finalist teams advancing to compete for top honours. Medical technology emerged as a clear highlight, with projects focusing on innovative solutions for various sectors.
A new circular motion paradigm enables continuous decoding of hand motion angles using EEG signals and polar coordinates. The experiment showed excellent performance across six deep learning models, with the best model achieving a mean squared error of 1.012 rad².
The study maps where and how millions of animals may be affected by heat stress in Europe. Regional differences were found, with southern European countries such as Italy, Spain, Greece, and Romania likely to face significant impacts.
The PROTECT project develops a platform to assess drug toxicity in pregnancy using 3D bioprinted human foetal tissue. The META-SENSE project creates a compact nanosensor to detect PFAS, while the LANTERN project aims to improve microchip nanofabrication.
Researchers have developed molecular probes called ABATaRs to detect biomolecules using standard Raman microscopes. These new sensors can detect biomolecules at low micromolar concentrations and function as ratiometric sensors, allowing for simultaneous detection of multiple molecules in live cells.
A new study reveals that Western Australia's critically endangered western ringtail possum is severely impacted by extreme heatwaves, with nocturnal activity declining by up to 43% in males. The findings highlight the need for conservation efforts to protect cooling habitats and account for behavioral stress in climate-risk planning.
A deep learning model called deepBlastoid has been developed to evaluate human blastoids with high accuracy and speed. The model achieves an accuracy of up to 87% and processes 273.6 images per second, significantly reducing the manual labor burden on researchers.
The Global Virus Network's 2025 Short Course in Translational Virology brought together over 40 participants from 24 countries to learn about translating bench discoveries into the clinic and shaping public health. Participants gained hands-on experience with data-driven virology, genomic analysis, and clinical decision systems.
The Arctic is experiencing a rise in human-generated underwater noise due to melting ice and increased activity, disrupting wildlife and local communities. A new study from the University of Bath provides a clear framework for monitoring noise in Arctic waters, urging authorities to revise thresholds used to assess noise levels.
Dr. Robert Vinci has been recognized for his pioneering work in reshaping pediatric education, workforce policy, and access to care for vulnerable populations. His innovative approaches have guided hundreds of trainees over four decades and transformed the field of pediatrics.
This study investigates the prognostic value of PNI in patients receiving first-line Ate/Bev therapy for unresectable HCC. The high-PNI group showed improved treatment outcomes, including lower adverse events and longer overall survival.
The RDP-type actuator enhances bidirectional consistency and motion linearity due to its symmetric driving structure and constant contact force. It demonstrates excellent performance across low and high-frequency ranges, showing minimal speed fluctuation and strong load-bearing capacity.
Researchers found that the green-flowered Aeschynanthus acuminatus evolved on the mainland, not in Taiwan, and adapted to shorter-beaked birds. This contradicts the Grant-Stebbins model of plant evolution, which predicted the species would evolve in Taiwan with new pollinators.
The University of Hong Kong's research team developed a novel live-attenuated vaccine, cb1, generating broad immunity against beta-coronaviruses with a single intranasal dose. The vaccine effectively blocks viral transmission in animal models, offering a promising strategy for pandemic preparedness.
Researchers identified CTE as a cause of dementia in advanced cases, with those having the most severe form having four times increased odds for developing dementia. The study also found that CTE is often misdiagnosed during life, leading to inaccurate diagnoses of Alzheimer's disease.
A recent study from Binghamton University School of Management reveals that focusing on human-robot collaboration can generate additional economic value and improve a company's ability to capture a greater share of the competitive market. By leveraging robots in collaborative settings, organizations can foster a positive sense of commi...
Researchers propose an expansive mode of engineering practice that seeks to reduce conflict through the design of technologies like solar panels and water pipelines. The authors argue that procurement, education, and institutional support are necessary for peace engineering to become the norm.
Research finds that framing pro-environmental behavior as patriotic and highlighting successful examples of collective action significantly increase public awareness advocacy, financial advocacy, and political advocacy. This megastudy provides insights to guide those who wish to galvanize the public for collective climate action.
The study reveals that the paraventricular thalamic nucleus (PVT) is the central pathological substrate of bipolar disorder, with notable alterations in cell number and gene expression. This discovery highlights the PVT as a potential diagnostic and therapeutic target for improving patient outcomes.
The collaboration aims to accelerate the development of small molecule inhibitors for treating metabolic diseases. Insilico will utilize its Pharma.AI platform to design and optimize novel molecules, while Qilu will handle subsequent development and commercialization.
Researchers develop versatile molecular platform to synthesize multiple functionalized carbon nanohoops, exhibiting high circularly polarized luminescence and other advanced photophysical properties. The breakthrough method enables multi-site functionalization and creation of chiral nanohoops with remarkable optical performance.
A clinical study will investigate the effects of a three-month at-home intervention with MOVIVE on motor and cognitive responses, utilizing comprehensive assessments and brain imaging techniques. The study aims to inform tailored approaches to assessment and intervention for people with Parkinson's disease.
A new study proposes a global framework to protect the world's most vulnerable regions from catastrophic tipping points due to climate change and human pressure. The research integrates artificial intelligence with Indigenous knowledge to guide sustainable development and achieve the Sustainable Development Goals.
Researchers at Waseda University have developed an integrated smart contact lens that enables real-time intraocular pressure monitoring for early glaucoma diagnosis. The device leverages parity-time symmetry for ultra-sensitive wireless detection, increasing sensitivity by a factor of 183.
PhD students with high trust in their advisors report greater motivation, self-efficacy, and well-being, leading to more research submissions, fellowship awards, and a sense of accomplishment. Trust matters across demographic groups, suggesting its causal role in shaping a successful PhD journey.
Researchers at Chungnam National University have developed an AI model that uses deep learning to predict stable defect configurations in materials. The model, trained on data generated by conventional simulations, can generate results in milliseconds rather than hours, accelerating the material design process.
Researchers at Applied Physics explored whether mathematical acoustic signal structure can influence cellular response independent of intensity. Preliminary evidence suggests that cells respond most strongly at different wavelength regimes, suggesting acoustic selectivity may be achievable through signal design.
Researchers found no difference in neural activity between successful semantic and episodic retrieval, challenging long-standing research tradition. This overlap suggests that the whole brain is involved in different types of memory, potentially leading to new interventions for diseases like dementia and Alzheimer's.
A new study found that prenatal exposure to air pollution is associated with lower cognitive performance in newborns, with stronger associations observed for black carbon and PM2.5. The strongest effects were seen in boys, suggesting potential sex-specific vulnerability.
A growing trend in Holocaust commemoration worldwide is the establishment of museums and exhibitions honoring the Righteous Among the Nations, heroes who risked their lives to save Jews from extermination. These initiatives aim to preserve Jewish heritage, commemorate the memory of the Holocaust, and combat racism and antisemitism.
Researchers at OIST found that combining inner speech with working memory enhances AI learning, enabling easier adaptation to new situations. This discovery holds promise for developing more human-like AI systems capable of handling complex, dynamic environments.
A research team from Osaka Metropolitan University found that optimizing window-to-wall ratio and insulation can reduce energy consumption by up to 27% in subtropical regions. The study provides tailored design guidelines for each climate zone, promoting net-zero energy housing and climate adaptation policies.
Scientists have developed a new way to identify and monitor small mammals using their footprints, tested on two near-identical species of sengi with 94%-96% accuracy. This technology can help reveal ecosystem health and provide a reliable metric for ecosystem integrity.