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American College of Medical Genetics and Genomics


ACMG issues new guidance on reporting variants of uncertain significance in genetic and genomic testing

The American College of Medical Genetics and Genomics (ACMG) has published a statement providing recommendations for the reporting of variants of uncertain significance (VUS) in germline genetic and genomic testing. The guidance aims to promote clarity, consistency, and best practices in the reporting of VUS findings, supporting approp...

SourceAmerican College of Medical Genetics and Genomics·JournalGenetics in Medicine·TypeLiterature review·DateJul 1, 2026

ACMG Foundation to present adaptive bikes to Baltimore-area children with genetic conditions at heartwarming “Day of Caring” event on March 13

The ACMG Foundation will present customized adaptive bicycles to children with genetic or medically complex conditions at the 2026 ACMG Annual Clinical Genetics Meeting. The bikes offer life-changing opportunities for mobility, independence, and participation in everyday activities.

Eva Vailionis, MS, CGC is presented the 2026 ACMG Foundation Genetic Counselor Best Abstract Award by The ACMG Foundation

Eva Vailionis, a cancer genetic counselor at Memorial Sloan Kettering Cancer Center, has been awarded the 2026 ACMG Foundation Genetic Counselor Best Abstract Award. Her abstract on TMEM127 pathogenic variants presents key findings on prevalence and tumor characteristics in patients with these variants.

Bo Yuan, Ph.D., FACMG, named recipient of the 2026 Dr. Michael S. Watson Genetic and Genomic Medicine Innovation Award from the ACMG Foundation for Genetic and Genomic Medicine

Dr. Bo Yuan has been recognized with the 2026 Dr. Michael S. Watson Genetic and Genomic Medicine Innovation Award for his pioneering work in genetic disorders, artificial intelligence-driven tools, and pharmacogenomics. His research aims to improve clinical care, scientific understanding, and public health through innovative technologies.

Internationally renowned clinical geneticist Dr. John C. Carey to receive the 2026 David L. Rimoin Lifetime Achievement Award from the ACMG Foundation for Genetic and Genomic Medicine

Dr. John C. Carey, a globally respected clinical geneticist and educator, will receive the 2026 David L. Rimoin Lifetime Achievement Award for his career-defining contributions to medical genetics. He has authored over 400 peer-reviewed articles and co-authored widely used textbooks.

ACMG achieves full four-year reaccreditation from ACCME, marking 25 years of continuous accreditation

The American College of Medical Genetics and Genomics has been awarded full, four-year reaccreditation by the Accreditation Council for Continuing Medical Education, reflecting its commitment to delivering evidence-based education in medical genetics and genomics. The reaccreditation marks 25 years of uninterrupted accreditation for ACMG.

American College of Medical Genetics and Genomics releases new clinical practice resource on managing RAD51C, RAD51D, and BRIP1 variants

The American College of Medical Genetics and Genomics has published a new clinical practice resource guiding clinicians in managing individuals with heterozygous germline pathogenic variants in RAD51C, RAD51D, and BRIP1 genes. The resource provides evidence-based recommendations on personalized risk assessment, surveillance, and risk-r...

SourceAmerican College of Medical Genetics and Genomics·JournalGenetics in Medicine·TypeLiterature review·DateNov 10, 2025

The ACMG releases 2025 update to secondary findings gene list; SF v3.3

The American College of Medical Genetics and Genomics has released its updated 2025 secondary findings gene list v3.3, adding three new genes to the list and introducing a new publicly available webpage to aid clinical labs in determining reportable variants. The update aims to ensure patient benefit from advances in genomic medicine.

SourceAmerican College of Medical Genetics and Genomics·JournalGenetics in Medicine·TypeSystematic review·DateJul 9, 2025

ACMG response to the NASEM report on newborn screening and recent federal government actions

The American College of Medical Genetics and Genomics (ACMG) commends NASEM for its report on sustaining and advancing excellence in newborn screening. The report outlines nine recommendations to improve the program, including national leadership, multistakeholder input, and expanded education and awareness.

Monica Hsiung Wojcik, MD, MPH, FAAP, FACMG is the recipient of the 2025 Dr. Michael S. Watson Genetic and Genomic Medicine Innovation Award from the ACMG Foundation for Genetic and Genomic Medicine

Dr. Monica Wojcik, a neonatologist and clinical geneticist, receives the prestigious award for her innovative research and clinical practice focused on rare diseases affecting fetuses and newborns. Her work aims to improve diagnosis, treatment, and health services for families affected by these conditions.

The ACMG Foundation for Genetic and Genomic Medicine presents four next generation Fellowship Awards at the 2025 ACMG Annual Clinical Genetics Meeting

The ACMG Foundation has presented four Next Generation Fellowship Awards to talented clinicians, researchers, and scientists. These winners are making significant impact in the field of genomics, advancing diagnosis, and patient care. The award recognizes their dedication to innovative approaches and commitment to improving healthcare ...

The American College of Medical Genetics and Genomics (ACMG) releases highly anticipated evidence-based clinical guideline for phenylalanine hydroxylase deficiency

The American College of Medical Genetics and Genomics has published a new evidence-based clinical guideline for phenylalanine hydroxylase deficiency diagnosis and management. The guideline provides recommendations for treatment, implementation considerations, research priorities, and economic considerations to improve patient outcomes.

SourceAmerican College of Medical Genetics and Genomics·JournalGenetics in Medicine·TypeSystematic review·DateDec 4, 2024

The ACMG Foundation for Genetic and Genomic Medicine presents seven Next Generation fellowship awards at the 2024 ACMG Annual Clinical Genetics Meeting

The ACMG Foundation for Genetic and Genomic Medicine has presented seven Next Generation fellowship awards to promising early career professionals in medical genetics and genomics. The recipients include Xueyang Pan, Bianca Seminotti, and Adriel Yejin Kim, who will support their research projects with corporate donations from Pfizer, S...

The American College of Medical Genetics and Genomics (ACMG) releases points to consider statement on the safety and efficacy of polygenic risk score assessment for embryo selection

The American College of Medical Genetics and Genomics (ACMG) has released a points to consider statement on the safety and efficacy of polygenic risk score assessment for embryo selection. The statement concludes that there is insufficient evidence to support its clinical utility, and further research is needed.

SourceAmerican College of Medical Genetics and Genomics·JournalGenetics in Medicine·TypeLiterature review·DateFeb 23, 2024

International workgroup of cancer genetics experts convened by the American College of Medical Genetics and Genomics develops guidance on clinical management of CHEK2 pathogenic variants and cancer risks

A new clinical practice resource provides valuable information for healthcare professionals caring for individuals with pathogenic variants in the CHEK2 gene. The resource assesses personalized risk estimates based on family history, specific variant, and other factors.

SourceAmerican College of Medical Genetics and Genomics·JournalGenetics in Medicine·TypeMeta-analysis·DateJul 25, 2023

Which CFTR variants should be tested by laboratories? The ACMG releases updated carrier screening recommendations for cystic fibrosis

The American College of Medical Genetics and Genomics has released an updated minimum variant set of 100 CFTR gene variants for carrier screening, replacing the previous 23-variant list. The new recommendations apply to genetic testing to determine carrier status, not diagnosis or newborn screening.

SourceAmerican College of Medical Genetics and Genomics·JournalGenetics in Medicine·TypeContent analysis·DateJun 13, 2023

The ACMG publishes statement on clinical, technical and environmental biases influencing equitable access to clinical genetics/genomics testing

The American College of Medical Genetics and Genomics (ACMG) has published a statement addressing factors that contribute to bias in clinical genetic testing. The statement highlights three main areas: environmental, clinical, and technical biases, which affect health equity for individuals from historically marginalized populations.

SourceAmerican College of Medical Genetics and Genomics·JournalGenetics in Medicine·TypeLiterature review·DateApr 14, 2023

Nara Sobreira, MD, PhD is the recipient of the 2023 Dr. Michael S. Watson Genetic and Genomic Medicine Innovation Award from the ACMG Foundation for Genetic and Genomic Medicine

Dr. Nara Sobreira has developed innovative tools like GeneMatcher and VariantMatcher to aid in rare disease diagnosis, earning her the 2023 Watson Genetic Medicine Innovation Award. She continues to work on expanding genome analysis accessibility through education and research initiatives.

Alexander M. Holtz, MD, PhD receives the 2023 Richard King Award for Best Publication by a Trainee in Genetics in Medicine

Dr. Alexander M. Holtz received the award for his published article on heterozygous variants in MYH10 associated with neurodevelopmental disorders and congenital anomalies. The study highlights primary cilia-dependent defects in Hedgehog signaling, shedding light on a previously unknown autosomal dominant condition.

ACMG publishes evidence-based clinical practice guideline recommending that noninvasive prenatal screening become the standard screening option for all pregnant individuals

The American College of Medical Genetics and Genomics recommends that noninvasive prenatal screening (NIPS) become the standard screening option for all pregnant individuals. NIPS has been shown to have a high accuracy rate, with detection rates of 98.8% for Trisomy 21 and 99.6% for sex chromosome abnormalities.

SourceAmerican College of Medical Genetics and Genomics·JournalGenetics in Medicine·TypeSystematic review·DateDec 16, 2022

ACMG releases update to secondary findings gene list; SF v3.1 adds five genes, including one with variant linked to heart failure in underrepresented populations

The American College of Medical Genetics and Genomics has released an updated recommended minimum gene list for the reporting of secondary findings. The update adds five new genes, four associated with dilated cardiomyopathy predisposition and one with hereditary transthyretin amyloidosis, a cause of heart failure. The new list aims to...

SourceAmerican College of Medical Genetics and Genomics·JournalGenetics in Medicine·TypeContent analysis·DateJun 17, 2022

The ACMG Foundation for Genetic and Genomic Medicine announces Carly Peterson as the recipient of the 2022 ACMG Foundation Carolyn Mills Lovell Genetic Counselor Award

Carly Peterson, a genetic counseling graduate student, received the 2022 ACMG Foundation Carolyn Mills Lovell Genetic Counselor Award. Her platform presentation explored parenting stress in raising children with sex chromosome aneuploidies, using data from the eXtraordinarY Babies Study.

The ACMG Foundation for Genetic and Genomic Medicine Presents Four Next Generation Fellowship Awards at the 2022 ACMG Annual Clinical Genetics Meeting

The ACMG Foundation presented four Next Generation Fellowship Awards to outstanding individuals in medical genetics and genomics. Ibrahim Elsharkawi and Jessica Priestley received the awards for their dedication to biochemical genetics, with support from Bionano Genomics, Spark Therapeutics, Takeda, Sanofi-Genzyme, and Pfizer.

ACMG Foundation/David L. Rimoin Inspiring Excellence Award honors Catherine A. Ziats, MD

Catherine A. Ziats, MD, received the David L. Rimoin Inspiring Excellence Award for her platform presentation on alterations in respiratory epithelial gene SPDEF and severe disease responses to COVID-19 infection. The award recognizes her contributions to advancing our understanding of host genetic factors associated with severe COVID-19.

The ACMG Foundation presents 2021 Pfizer/ACMG Foundation Next Generation Fellowship Awards

Christina Tise, MD, PhD, and Daniel Pomerantz, MD, have been selected as recipients of the 2021 Pfizer/ACMG Foundation Next Generation Fellowship Awards to pursue postgraduate training in clinical laboratory biochemical genetics and medical biochemical genetics. The awards support their one-year fellowships at Stanford University and C...