Researchers at UC San Diego develop new approach using artificial intelligence to predict therapy outcomes and match patients with right treatments, improving cancer care and patient outcomes.
Human healthy aging and longevity are influenced by a dynamic interplay of genetic, epigenetic, metabolic, immune, and environmental factors. Long-lived individuals exhibit distinct characteristics, such as reduced morbidity and preserved physiological functions, which can be attributed to their lifestyle and environmental choices.
The new 3D-printed device, STOMP, enhances tissue-engineering methods by allowing for precise control over cell types and spatial arrangement. This enables scientists to model complex diseases and recreate natural habitats of cells, paving the way for advancements in biomedical research.
A new NIH study found that early childhood weight patterns may signal future obesity risk. The study tracked children's body mass index (BMI) from infancy through age 9 and identified two distinct growth patterns, with a smaller group following a trajectory marked by a sharp rise in BMI.
Measuring ammonia concentration near an Adelie penguin colony found increased levels when wind blew from the colony, suggesting a connection between penguin guano and climate change mitigation. The study suggests that penguin guano may help reduce the effects of climate change on Antarctica by contributing to increased cloud formation.
Dr Manel Esteller received the Jaume Aiguader i Miró Award for his book 'The Secret of Eternal Life', which explains biological mechanisms of ageing and longevity. His research focuses on epigenetic changes linked to premature ageing and extreme longevity.
Researchers from UC3M and UCA propose an integrated approach to tackle rural depopulation, focusing on spatial planning, economic diversification, and infrastructure development. Municipalities with up-to-date urban planning strategies show a 10% average population growth, highlighting the need for sustainable solutions.
A new study presents a two-step method to effectively dismantle bacterial biofilms and prevent regrowth. By using self-locomotive antibacterial microbubblers (SLAM) followed by a mixture of hydrogen peroxide and peroxyacetic acid, researchers were able to prevent the regrowth of biofilms on surfaces, including medical instruments.
Researchers found that increasing spiciness slightly led to slower eating and reduced food consumption without affecting palatability. The study's results suggest adding chilies as a potential strategy for reducing energy overconsumption.
This study reveals low wildfire activity across the Northern Hemisphere during PETM. The spatiotemporal evolution of wildfires was driven by climate change and vegetation succession, suppressing fire occurrence.
Researchers developed a new design that increases the efficiency and stability of perovskite solar cells by up to 20.7%, outperforming previous results without the new compound. The innovative design enhances surface interactions, leading to improved durability and performance.
Researchers developed a tetravalent peptide that specifically inhibits the recruitment of MKK3 to TRAF6, preventing late-stage osteoclast activation and reducing side effects. In mice models, the peptide effectively prevented bone loss with minimal impact on osteoblast function.
Cellular senescence is a key driver of kidney fibrosis, promoting inflammatory and fibrogenic pathways through paracrine signaling and immune activation. Therapeutic strategies targeting senescence offer novel opportunities, but further research is needed to address heterogeneity and translate preclinical findings to clinical practice.
A novel therapy developed by Columbia University scientist Neil Shneider has shown unprecedented functional recovery in patients with a rare form of ALS caused by a genetic mutation in the FUS gene. After six months of treatment, patients experienced up to an 83% decrease in neurofilament light, a biomarker of nerve damage.
The CUNY Graduate School of Public Health and Health Policy Foundation hosted its first-ever Public Health Futures Gala, raising over $650,000 to support students and innovative programs. The event honored Dr. Kyu Rhee with the Chairman's Award for Excellence in Public Health Philanthropy.
Moffitt researchers will present numerous oral and poster presentations covering a wide range of cancer types, including lung, breast, cervical and biliary tract cancers. The center's experts are also available to comment on various cancer research and care topics before and during the meeting.
Researchers propose a new framework, Heterogeneous training with Communication (HeteC), to improve human-AI coordination in open and real-world environments. The framework enhances partner population diversity through mixed partner training and frozen historical partners, as well as incorporates a communication module for mitigating pa...
Researchers from MD Anderson Cancer Center present notable studies on immunotherapy and CAR T cell therapy for various cancer types. These findings show promising results for patients with aggressive and rare cancers.
The team measured the radius of the nucleus of muonic helium-3 with a precision of around 15 times more than previous experiments, providing important reference values for modern ab initio theories. The result is an important stress test for theories and future experiments in atomic physics.
Research finds that Trichoderma's epidithiodiketopiperazine (ETP) modification pathways contribute to its antagonistic effects on pathogenic fungi. ETP structural diversity plays a crucial role in mediating the biocontrol agent's interactions with pathogens.
A new scientific study sheds light on the social dynamics driving demand for bear bile in Vietnam, highlighting the role of gift-giving among close social networks. The findings suggest that targeting key individuals within influential groups could reduce demand and support conservation efforts.
Researchers at UCSF have successfully engineered a shapeshifting protein that can change shape in response to signals, potentially leading to breakthroughs in medicine, agriculture, and environmental applications. This achievement marks the first step towards creating stable yet dynamic proteins using AI-augmented protein engineering.
A 25-year review highlights the stomach cancer-fighting potential of Brazilian plant species, which contain bioactive compounds with potential anticancer properties. The studies suggest that regular consumption of fruits and vegetables rich in polyphenols and flavonoids may help lower the risk of stomach cancer.
Researchers create new quantum biosensor using diamond nanoparticles and specially engineered shell, outperforming previous attempts. The breakthrough sheds light on a longstanding mystery in quantum materials and shows up to fourfold improvements in spin coherence.
Experts outline five ways for doctors to facilitate stronger shared decision-making between patients and their healthcare providers. Using numbers effectively can correct overestimation of risk estimates, making patients more likely to take a physician's recommendations.
Researchers at the University of Bristol have made a significant breakthrough in semiconductor technology, which could revolutionize 6G delivery by accelerating data transfer. The new architecture uses parallel channels and sub-100nm side fins to achieve unprecedented radio frequency performance.
Scientists from the University of Göttingen have made a groundbreaking discovery, finding ruthenium in volcanic rocks on the islands of Hawaii. The finding suggests that material from the Earth's core is leaking into the mantle above, challenging previous assumptions about the planet's internal dynamics.
Researchers from City of Hope will present novel cancer treatment approaches and combinations, including innovative combination therapies for breast, genitourinary, and gastrointestinal cancers. Additionally, they'll discuss the safety of readministering trastuzumab-deruxtecan to metastatic breast cancer patients with low-grade lung co...
Researchers at the University of Pennsylvania developed novel promoters that drive specific gene expression in rod and cone photoreceptors, outperforming most currently used promoters. These tools address the challenge of treating advanced stages of inherited retinal diseases, potentially restoring vision.
The study analyzed the impact of climate change during the late Palaeolithic and found that humans migrated eastwards to adapt to new climate conditions. The European population may have decreased by up to half during the Younger Dryas event, but populations in central and eastern Europe increased.
A study published in PNAS reveals that colorectal cancer cells utilize a protein called TBX3, which regulates embryo development, to contribute to their aggressiveness and metastasis. The discovery opens up possibilities for developing targeted therapies to prevent tumor cell spread.
A new study published in Science suggests that ketamine's antidepressant effects can be sustained for up to two months by enhancing ERK activity with the drug BCI. This breakthrough could improve treatment outcomes for millions of people affected by major depressive disorder.
A study of infants aged 16-21 months reveals low rates of overimitation not driven by social affiliation. Other forms of imitation associated with memory and cognition show a correlation, suggesting an earlier emergence of socially motivated behavior.
Researchers have identified brain regions sensitive to self-death associations in veterans at low risk for suicide. The findings provide insight into the neural mechanisms that contribute to suicidality and may aid in the development of novel treatments targeting the brain mechanisms underlying suicidal thoughts and behaviors.
A study published by the American Psychological Association found that people tend to trust individuals from lower-income backgrounds more than those from privileged upbringings. The research suggests that people draw a clear line between someone's childhood and their current socioeconomic status.
The Konstanz Cluster of Excellence 'The Politics of Inequality' will continue to investigate the political causes and consequences of growing inequality in society. Researchers aim to prevent self-reinforcing processes and reduce structural inequalities.
A new study from Aarhus University found no statistically significant increased risk of neurodevelopmental disorders in children whose fathers were treated with valproate during spermatogenesis. The researchers urge for full transparency and replication of the IQVIA study to ensure the evidence-based basis of precautionary measures.
New genomic evidence suggests that Borrelia recurrentis diverged from its tick-borne relatives and adapted to use human body lice around 6000-4000 years ago. This transition coincided with the widespread use of wool textiles by humans, leading to genome reductions and host specialization.
Researchers at the University of Tokyo have successfully produced green ammonia using sunlight and atmospheric nitrogen, mirroring natural processes found in plants. The process uses two catalysts, one based on molybdenum and another on iridium, to activate water molecules and produce ammonia.
The American Heart Association's Get With The Guidelines - Heart Failure registry reveals lasting benefits for hospitalized heart failure patients and hospitals. Hospitals engaging with the program consistently outperform peers on process measures and patient outcomes.
Researchers at the University of Bristol have discovered that Saturn's moon Titan has an atmosphere that tilts and shifts over time, behaving like a gyroscope. The team analyzed data from the Cassini-Huygens mission to understand how Titan's atmosphere wobbles with the seasons.
Roundworm C. elegans avoids deceased conspecifics due to olfactory cues from metabolites AMP and histidine, leading to reduced fitness and increased egg laying. The detection of these signals may be an evolutionarily maintained mechanism for detecting cellular death.
Sriram Gubbi, a physician-scientist at NIDDK, won the Endocrine Society's 2025 Endocrine Images Art Competition with his image 'The Cosmic Bubble', showcasing follicular thyroid carcinoma cells. The competition celebrates the beauty of endocrine science through microscopy.
A leading cardiovascular disease researcher from Simon Fraser University is ringing the alarm on universal recommendations intended to improve heart health around the globe. The review paper examined the causes behind the causes of CVD, using data from the ongoing collaborative Prospective Urban Rural Epidemiology (PURE) study.
Researchers at GEOMAR identify that EU fisheries management's reliance on national interests and ICES advice leads to overfishing, resulting in the collapse of many fish stocks. A new approach is proposed to set quotas independently of national interests and prioritize sustainable catches.
State capital participation in China boosts corporate environmental engagement, leading to increased environmental responsibility among private firms. The study sheds light on the critical role of state involvement in corporate environmental commitment.
A new smartphone app, ECHAS, can help people determine if they are suffering from a heart attack or stroke and need medical attention. The app, developed by experts at UVA Health and other leading institutions, proved effective in identifying patients with cardiac and neurological emergencies.
Researchers at Caltech successfully controlled the motion of individual atoms, encoding quantum information, and demonstrated hyper-entanglement in massive particles. This experiment could lead to advancements in quantum computation and precision clocks.
A new MIT study reveals that climate change will make it harder to reduce ground-level ozone in certain regions, including eastern North America and Western Europe. In contrast, northeast Asia may see improvements in air quality with decreased nitrogen oxide emissions.
Researchers discovered a DNA switch in TB bacteria that regulates growth and gene expression. By targeting this process, new antibiotics could be developed to make the bacteria easier to eliminate.
Researchers found evidence that introners, a type of selfish gene, are responsible for spreading genetic complexity across species. The study revealed eight instances of horizontal gene transfer between unrelated species, suggesting that introners may hitchhike on giant viruses to transfer between species.
A new report models current wildfire risks across the Southeastern US, projecting changes by the middle of this century under various scenarios. Prescribed fires can reduce wildfire risk through reduced fuels, promoting healthy forest growth.
A new UBC Okanagan study reveals that students are using generative artificial intelligence (GenAI) responsibly to enhance their learning. Most students use AI for its benefits, such as speeding up tasks and improving grades, rather than undermining academic integrity.
Dr. Robin Canup, a leading expert in planetary science, has received the 2025 AAS DDA Dirk Brouwer Career Award for her groundbreaking research on planet and satellite formation, including the Earth-Moon system's origins.
A meta-analysis from the University of Copenhagen shows that flower strips with at least two sown species increase the number of natural enemies by an average of 70 percent. This is due to the diverse range of flowers attracting a broader range of beneficial insects, such as ladybirds and hoverflies.
The new office staff will assist patients making appointments at Mayo Clinic in Minnesota, Arizona, Florida, and London, as well as help with travel arrangements and billing. The services are free of charge and include interpreter support for non-English speakers.
Record-breaking wildfires are rapidly transforming forests from carbon sinks to super-emitters due to warming and drought conditions. Planting trees can even increase wildfire risk in some cases.
Researchers created a new steel alloy combining TRIP effect and L1₂ nanoprecipitates, achieving high tensile strengths of 1.2–1.8 GPa and uniform elongation of 10–30%. This breakthrough offers promising synergy for strength and ductility in uncharted territory.
The Deutsche Forschungsgemeinschaft (DFG) has selected 70 Clusters of Excellence in Germany for funding, with 45 renewals and 25 new projects. The selected clusters will receive €539 million in annual funding over seven years.
A new study finds that high-skilled emigration from developing countries can spur education, innovation, and economic growth in their home countries. This phenomenon is known as brain gain. The researchers also found that high-skilled migrants often maintain professional ties across borders, facilitating trade, investment, and innovation.