Researchers discovered that a specific gene duplication in the fungus Madurella fahalii enables it to neutralize medication, leading to effective treatment challenges. This study highlights the potential of molecular techniques to uncover drug resistance mechanisms and pave the way for targeted therapies.
Exosomes carry tumor-derived DNA, RNA, and proteins, enabling a liquid biopsy platform. They enhance diagnostic specificity and sensitivity, and play dual roles—mediating drug resistance and serving as therapeutic vehicles. Exosomal cargo predicts metastatic potential and survival.
Studies show that people, including doctors, underestimate the significance of social connection for physical health. Research confirms that loneliness and isolation have a substantial impact on health and mortality despite not being listed on death certificates.
Researchers mapped the evolution of Borrelia recurrentis, a type of bacteria causing relapsing fever, by analyzing ancient DNA. The study found that the species likely diverged from its tick-borne cousin around 6,000 years ago and gained new genes over time, allowing it to spread through human lice.
A new low-cost, diode-based laser system safely emulsifies cataract tissue without damaging surrounding tissue. The technology has the potential to significantly reduce cataract surgery costs and complexity, bringing sight-saving treatment to millions worldwide.
New research reveals that turf algae in warming Gulf of Maine waters are chemically inhibiting the recovery of kelp forests, threatening these crucial marine ecosystems. Laboratory experiments show that turf-derived compounds inhibit early growth stages of kelp, altering the chemical ecology and preventing re-establishment.
A new study by QUT researchers reveals that 'classroom readiness' is a policy construct rather than a genuine assessment of teaching capability. Teaching performance assessments oversimplify the demands of diverse classroom settings and assume graduates can seamlessly transition into teaching with minimal guidance.
Researchers have created contact lenses that convert infrared light into visible light, allowing users to perceive multiple infrared wavelengths. In experiments, mice and human participants showed enhanced infrared vision when their eyes were closed, with improved color perception for color blind individuals.
A recent study found that fully protected marine areas in Brazil are contaminated by microplastics, with an average concentration of 0.42 particles per gram of wet tissue. The contamination was detected in all ten integral protection areas studied, with the highest levels found in the Alcatrazes Archipelago Wildlife Refuge.
A new computational tool, CellWalker2, integrates different forms of biological data to reveal relationships between cell types. The tool identifies precise cell types and assigns broader labels based on hierarchical relationships, enabling scientists to compare cell types across experiments and species.
A new study reveals that even weak tropical cyclones significantly increase infant deaths in low- and middle-income countries. The researchers analyzed nearly 1.7 million child records from seven economically disadvantaged countries, finding an average increase of 11% in infant mortality rates.
A recent Ateneo de Manila University study highlights major hurdles to implementing Universal Health Coverage in the Philippines due to inadequate education and poor compensation for healthcare workers. The country faces a shortage of at least 127,000 nurses, with many graduates lacking training in public health and community-based care.
The University of Maryland-led study found that the bay experiences 25 days of heat waves annually, with a 10% uptick in recent years. Satellite data shows varying duration and frequency of heat waves across different regions of the bay, highlighting the need for a marine heat wave warning system.
A Johns Hopkins Medicine study finds that SARS-CoV-2 corrupts white blood cells, specifically neutrophils, to impair the production of immune cells critical for fighting COVID-19. This reprogramming may lead to severe COVID cases by weakening the immune response against the virus.
Researchers from Penn Medicine will present updates on CAR T cell therapy, belzutifan, and immunotherapy for various cancers. The Basser Center for BRCA will also present studies on genetic testing and cancer interception.
Researchers used metabolomics to analyze cerebrospinal fluid samples from tuberculous meningitis patients and found that certain metabolic pathways may contribute to poor outcomes. Three hydroxylated fatty acids with a maximum carbon length of eight were strongly associated with mortality, regardless of HIV status or disease severity.
A growing trend of dog parenting reveals opportunities for humans to fulfill a nurturing drive without the demands of raising biological offspring. Dog ownership offers emotional connection, social support, and purpose, similar to those experienced by parents.
A novel lab method developed by McGill University researchers has identified nine molecules in the blood that were elevated in teens diagnosed with depression. These molecules also predicted how symptoms might progress over time, providing a potential tool for early detection and treatment.
UT-Battelle has donated $225,000 to purchase advanced manufacturing equipment for Oak Ridge High School's Wildcat Manufacturing iSchool program. The equipment includes AI- and robotics-assisted manufacturing systems, enabling students to earn college credit while gaining experience with the latest innovations in intelligent manufacturing.
Researchers have developed a machine learning tool that identifies metabolism-related molecular profile differences between colorectal cancer patients and healthy individuals. The tool, called PANDA, shows promise as a noninvasive method of diagnosing colorectal cancer and monitoring disease progression.
Materials researchers at Harvard have created a way to produce natural rubber that retains its stretchiness and durability while improving its ability to resist cracking. The new material is four times better at resisting slow crack growth during repeated stretching and 10 times tougher overall.
A large-scale genetic study identified the FOXP4 gene as a significant factor in Long COVID, linked to lung health and immune response. The study found a strong relationship between severe COVID-19 cases and Long COVID, highlighting potential biological factors contributing to the condition.
Researchers at the University of Münster developed a new strategy to swap carbon atoms with nitrogen atoms in pharmaceutical components, yielding biologically relevant compounds. The technique expands the synthetic toolbox for skeletal editing and offers new possibilities for drug design.
Moleculera Biosciences, a precision medicine company, is attracting investors with its technology developed by the University of Oklahoma. The company's diagnostic tests have helped properly diagnose over 16,000 patients and have shown remarkable recoveries in those affected by autoimmune disorders.
A study by Tohoku University found that combining rooftop solar panels with electric vehicles as batteries can supply 85% of Japan's electricity demand and reduce carbon dioxide emissions by 87%. The 'PV + EV' system could lower energy costs by 33% by 2030, providing a promising pathway for Japan to achieve carbon neutrality.
Researchers developed fluorescent dyes based on nitrogen-rich pyrazinacenes with strong, tunable fluorescence between the visible and NIR/SWIR regions. The dyes exhibit redox-responsive properties, shifting emission spectra to longer wavelengths for infrared applications.
Researchers have reprogrammed the spleen into a high-performance bioreactor to nurture transplanted cells and demonstrate compatibility with human and animal-derived cells. The study paves the way for addressing organ shortages through cross-species solutions.
Researchers have developed a novel surgical technique to implant multiple tissue grafts in the eye's retina, expanding treatment options for dry AMD. The new method, which maintains eye pressure during graft insertion, promotes photoreceptor survival and regeneration of the choriocapillaris.
Washington State University researchers used microwave technology to create shelf-stable hummus without chemical preservatives. Lentil-based hummus retained 75% of vitamin C after treatment, offering a healthier alternative. The innovative process allows for predictable and rapid heating of pre-packaged food.
Researchers have discovered a new drug that protects the blood-brain barrier, preventing neurodegeneration and cognitive impairment in Alzheimer's disease. The drug targets an enzyme that damages the BBB, which is also affected in traumatic brain injury and aging.
Aurora, a state-of-the-art machine learning model, delivers high-quality forecasts for key environmental systems like air quality, weather, and tropical cyclones. The model's flexibility enables it to be used for various future scenarios, including flood risks, wildfire spread, and renewable energy output.
A study of 900 species over 20 years found that diverse natural communities are more stable than those with fewer species. Functional diversity is a key factor in stabilizing communities, especially for species with different traits.
A study found that adults hospitalized for RSV had significantly higher odds of cardiac events compared to those with COVID-19 or influenza. The findings suggest that preexisting cardiovascular risk patients should consider vaccination against respiratory viral infections.
Researchers at University of Michigan have discovered a rule-breaking silicone that can conduct electricity, upending assumptions about the material class. The semiconducting properties of the silicone copolymer enable its spectrum of colors, with longer chain lengths producing red tones and shorter chains emitting blue light.
Scientists analyzed ancient DNA, fossil shape, and habitat data to determine the factors influencing the size of extinct giant ground sloths. The result shows that size differences among sloths have been primarily influenced by the types of habitats they lived in and climate change.
The Institute for Quality and Efficiency in Health Care found that linzagolix has no suitable comparative data with existing standard treatments like dienogest and GnRH analogues. Comparative studies are crucial to assess the added benefit of new drugs, but placebo comparisons are often unsuitable.
A team of scientists at Stanford University has created an early testing method to identify individuals at risk of taking a life-threatening fall. By analyzing walking patterns and balance issues over time, the researchers can provide clinicians with valuable insights to intervene before falls occur.
The University of Halle has been awarded funding for its Cluster of Excellence, the Center for Chiral Electronics, which will focus on developing new concepts for energy-efficient electronics. The cluster aims to create highly qualified physicists who will make important technological contributions to semiconductor technology.
A new study found that half of the remaining habitat of Australia's most critically endangered species is unprotected, posing a significant risk to their survival. The research identifies 85,000sqm of habitat as crucial for protection and management to halt new extinctions.
Astronomers have identified a rare type of binary star system featuring a rapidly spinning millisecond pulsar and a helium star companion. The system is thought to have formed through common envelope evolution, with the neutron star spiraling closer to its companion before ejecting energy and leaving behind a tightly bound binary.
Researchers developed AI system that detects 'fingerprint' from 3D printed parts, tracing origin to specific machine. This technology has major implications for supplier management and quality control.
A new study found that living in disadvantaged neighborhoods can cause menopause to start earlier, leading to a higher risk of long-term health issues. The research followed nearly 700 women and found those in highly vulnerable areas experienced menopause approximately two years earlier.
Infections from respiratory syncytial virus (RSV) in children requiring primary care led to significant societal economic costs. The study found that the main sources of costs were repeated visits to primary care physicians and parents missing work to care for their sick children, with higher costs for infants under 1 year old.
The University of Bonn has secured funding for all six of its existing Clusters of Excellence and two new initiatives, with a total of eight clusters recognized for their outstanding research. This milestone cements the university's status as a leading research institution in Germany and Europe.
Researchers develop bioinspired dual-phase interpenetrating composite for CCSs, enhancing damage tolerance and energy absorption under both quasi-static and dynamic loading. Polyurea-toughened Al2O3 cellular ceramic structures demonstrate superior mechanical properties with improved load-bearing capacity and energy-absorbing ability.
A joint research team from POSTECH and Hanyang University developed a personalized stimulation control mechanism using evoked compound action potential feedback mechanisms to treat urinary disorders. This technology enables precise adjustment of tibial nerve stimulation in real-time, based on individual nerve responses, improving patie...
Researchers at Umea University developed a method to analyze DNA methylation patterns for children with T-cell acute lymphoblastic leukemia (T-ALL), which can refine risk assessment and individualize treatment. The study found that this analysis may help reduce side effects and improve quality of life.
A recent study published in Medicina found a significant increase in the number of young patients with anorexia nervosa in Japan following the COVID-19 pandemic. The researchers analyzed large-scale clinical data and discovered that the incidence of this eating disorder rose sharply during this period.
Researchers have demonstrated a cryogenic circuit that allows light quanta to be controlled more quickly than ever before, reducing delay by a quarter of a billionth of a second. This breakthrough could contribute to developing modern technologies in quantum information science and communication.
The University of Cologne has been awarded funding for five Clusters of Excellence in aging research, plant sciences, astrophysics, economics, and quantum research. The clusters will focus on fundamental understanding and innovative research to address major challenges like age-related diseases, climate change, and global food security.
The ATN dataset is a multi-cohort study that includes harmonised clinical and biomarker data from over 350 participants across ten European research cohorts. This dataset provides valuable insights into shared disease mechanisms among Alzheimer's disease, Parkinson's disease, and Dementia with Lewy Bodies.
Aston University researchers are investigating the use of AI in creating greener cities, exploring policy tools to reduce emissions and optimize transportation. The project aims to develop decision-support tools for policymakers to improve urban infrastructure management and reduce environmental hazards.
Researchers found that sloths' body size was largely influenced by their habitats, and human activities led to the rapid decline of large-bodied species. The study suggests that secluded forest canopies allowed small arboreal sloths to survive, while direct human pressures drove the extinction of giant terrestrial sloths.
A study found that GADD45A protein plays a crucial role in preventing inflammation, fibrosis, and apoptosis in the heart. Increasing GADD45A activity may slow the progression of pathological hypertrophy and heart failure, offering a promising therapeutic strategy.
The Mongolian healthcare system is shaped by its geographical and cultural context, with strengths in traditional medicine and universal coverage. However, remote areas struggle with inadequate healthcare providers, limited workforce capacity, and inadequate disease prevention strategies., Despite these challenges, the researchers outl...
Researchers develop a bulk passivation technique adding TEMPO to perovskite films, boosting efficiency beyond 20% and maintaining performance for several months. The approach is fast, solvent-free, and compatible with roll-to-roll processing, making it promising for large-scale production.
A team of researchers from UNIGE and UniBE used generative AI to assess emotional intelligence, finding that AIs achieved significantly higher scores than humans. The results also showed that AIs can generate new emotional intelligence tests in record time.
Researchers have developed a breakthrough low-cost polymer for organic solar cells, achieving unprecedented 19.96% efficiency and cost-effectiveness. This innovation could accelerate commercialization of high-efficiency OSCs by reducing production costs while maintaining stability and air-process compatibility.
Researchers developed a gene therapy that can target the airway and lungs using a nasal spray, outperforming previous versions in preclinical models. The innovative tool, AAV.CPP.16, showed promise for treating respiratory diseases like pulmonary fibrosis and viral infections.
A cohort study found children on the path to obesity by age 3.5, highlighting modifiable risk factors that can be targeted in prevention programs. The Environmental influences on Child Health Outcomes (ECHO) cohort provided valuable insights into early-life factors and BMI trajectories.