A deep-learning tool analyzed sinus CT scans, finding it more responsive to changes following treatment than traditional scoring methods. This technology has the potential to measure treatment response with greater precision.
National Jewish Health researchers identified disease-associated gene activity in macrophages and changes in immune cell communication in lung tissue. These findings may lead to targeted therapies and improved diagnosis of pulmonary sarcoidosis.
A new international consensus statement provides practical guidance for clinicians to identify, monitor, and treat RA-ILD. The experts outline key risk factors and recommend a team-based approach involving rheumatologists, pulmonologists, and other specialists.
The Phase 3 SUNRISE trial shows that tezepelumab nearly triples the likelihood of reducing daily oral corticosteroid dose in patients with severe, oral corticosteroid-dependent asthma. Patients treated with tezepelumab achieve greater reductions in oral steroid use while maintaining asthma control and improving key clinical outcomes.
Researchers found no statistically significant changes in joint structures or evidence of inflammation following the 18-day mission. Ultrasound monitoring revealed stable cartilage thickness and tendon integrity.
A study published by National Jewish Health found significant gaps in understanding occupational risks for mineral non-coal miners, with silicosis affecting a substantial portion of the global mining workforce. The research emphasizes the importance of ongoing exposure monitoring and medical surveillance to reduce disease rates.
Researchers found that distinct patterns on lung scans can signal disease severity and predict breathing problems. The study's findings may help doctors tailor treatment approaches for patients with sarcoidosis.
Researchers at National Jewish Health used radiomics to analyze chest CT scans from 320 people with sarcoidosis, identifying four distinct imaging profiles linked to differences in lung function and disease severity. The approach could help advance diagnosis and patient care by providing objective measurements of lung abnormalities.
Researchers have identified protein BCL-2 as a critical mechanism driving persistent pulmonary fibrosis, and a potential therapeutic target to reverse the disease. Blocking BCL-2 with targeted therapy promotes lung repair and reduces scarring in preclinical models.
A new study published in Annals of Allergy, Asthma & Immunology shows that dupilumab treatment significantly restores skin barrier function and reduces inflammation in children with moderate-to-severe atopic dermatitis. The treatment also improves skin health in clinically unaffected areas, highlighting the systemic nature of the disease.
A retrospective review of 91 pediatric patients found no significant difference in reaction severity between children taking inhaled corticosteroids alone and those taking combination therapy. The study suggests continuing asthma controller therapy may be appropriate in many cases.
A new study from National Jewish Health reveals that exposure to burn pit smoke and desert dust can damage the lungs of military service members. The research found that particles linked to burn pit exposure cause stronger inflammation and stress in lung immune cells, leading to chronic breathing problems.
Researchers found that burned pit smoke exposure was strongly associated with higher levels of anthracotic pigment in the lungs of post-9/11 veterans with deployment-related lung disease. This study provides objective, tissue-based evidence that burn pit smoke exposure leaves a measurable impact on lung health.
A new community asthma program on the Navajo Nation increased asthma-related care and awareness among families, particularly among Diné (Navajo) children. The program, led by National Jewish Health, trained healthcare and school staff to provide culturally respectful asthma care.
A new study has identified specific viral combinations that increase the risk of severe respiratory illnesses in infants. The research found that co-infection with rhinovirus and bocavirus nearly tripled the odds of developing a severe lower respiratory infection compared to being infected with just one of the viruses.
Researchers found that small increases in lung scarring over one year signal higher risk of worsening disease, mortality, and steeper declines in lung function. These changes were strongest in patients with less severe disease at baseline, highlighting the potential for earlier intervention to alter disease course.
A recent study found that people with a recent rhinovirus infection are significantly less likely to become infected with SARS-CoV-2. This effect is thought to be linked to the body's antiviral defenses, which can temporarily prime the immune system to fight off other viruses.
Researchers highlight the importance of understanding heart-lung interactions in treating pulmonary vascular disease. Studies show that dysfunction in one organ often exacerbates problems in the other, leading to systemic effects.
A groundbreaking study suggests that the skin may serve as a biomarker for pediatric eosinophilic esophagitis (EoE), a chronic allergic disease of the esophagus. The study found significant deficits in ceramides, lipid molecules essential for the skin's protective barrier, in children with EoE but without atopic dermatitis.
Researchers have identified early changes in the cheek skin barrier of infants that can predict the onset of eczema, or atopic dermatitis. The study found that these changes occur even before any clinical symptoms appear, and may be linked to maternal and environmental influences.
Researchers have developed a novel 23-SNP alpha-1 antitrypsin assay that significantly improves the speed and precision of Alpha-1 Antitrypsin Deficiency (AATD) diagnosis. The test accurately identifies multiple genetic mutations associated with AATD, addressing a long-standing challenge in the medical community.
National Jewish Health researchers introduce 'silicosarcoidosis' to describe patients with overlapping features of silicosis and sarcoidosis. The study highlights the need for clinicians to consider occupational exposures when evaluating patients with sarcoidosis-like lung disease.
A new study explores the ability of individuals with adrenal crisis to accurately and effectively administer emergency cortisol injections. Nearly half of those living with adrenal insufficiency are unable to self-administer life-saving injections during a medical emergency, highlighting the need for improved awareness and preparedness.
Research suggests that CFTR modulators improve lung function during pregnancy and are likely safe for exposed babies. The study analyzed data from 307 pregnancies between 2010 and 2021 and found better maternal health outcomes for those using highly effective CFTR modulators.
A new study reveals that dust storms are associated with a heightened risk of asthma, culture-negative pneumonia, and other health conditions. The research found an increase in emergency department visits for these conditions in three Southwestern U.S. states between 2005 and 2018.
Researchers found that previously thought 'pro-fibrotic' macrophages are not solely responsible for fibrosis and instead may contribute to healthy repair. The study aims to understand the triggers behind these differences in expression, with the goal of harnessing macrophages for lung repair.
A study published in Advances in Therapy found that dupilumab improves signs and symptoms of atopic dermatitis in children aged 6 months to 5 years, including those with co-morbid conditions such as asthma or allergies. The research provides hope for treating pediatric patients suffering from atopic dermatitis.
Researchers found a significant relationship between insomnia, depression, and obstructive sleep apnea in people with asthma, leading to poor asthma control. Regular screening for sleep quality and co-existing mood disorders can help improve overall quality of life.
A new study by National Jewish Health researchers found that air pollutants can disrupt the skin barrier, contributing to the development and exacerbation of allergic diseases. The study's findings highlight the importance of minimizing exposure to pollutants from an early age, with potential long-term effects on future generations.
A new study published in International Journal of Environmental Research and Public Health reveals high levels of silica and other silicates in the lungs of military veterans who have deployed since 2001. This research highlights the importance of controlling particulate exposures in military occupational settings to minimize risk for ...
Newborns can be monitored for potential food allergies using a non-invasive skin tape strip technique, according to researchers at National Jewish Health. The study found abnormal lipids and proteins on the skin could indicate an increased risk of developing atopic dermatitis and food allergies.
Researchers found benralizumab comparable to mepolizumab in inducing remission and reducing relapse in EGPA patients. The study also showed benralizumab reduces need for oral glucocorticoids and lowers blood eosinophil counts.
Researchers at National Jewish Health found that Indigenous coal miners are more likely to develop disabling black lung disease but have limited access to medical benefits. The study highlights the need for updated lung function standards specific to Indigenous populations to address racial disparities in respiratory health.
A study by National Jewish Health found that nearly half of patients with underlying lung conditions have lower vaccine-specific antibody, B cell, and T cell responses compared to healthy individuals. This decreased immunity suggests patients with lung conditions may be less protected against COVID-19.
Current diagnosis of COPD using fixed-ratio spirometry may fail to diagnose the disease in African American patients due to flawed methods. The study found that 21% more results for African Americans were classified as non-COPD, despite showing clear symptoms of COPD.
A recent study published by National Jewish Health has found that children who live close to highly trafficked roads are more likely to develop atopic dermatitis. The study, which analyzed data from 2008-2021, revealed that living within 500 meters of a highly trafficked road increased the risk of developing atopic dermatitis in children.
The COPDGene study tracked emphysema patients over 10 years and found that those who continued to smoke experienced the largest decline in lung density. This significant finding highlights the importance of quitting smoking in managing emphysema progression, particularly for current smokers.
Researchers discovered crystalline silica in lungs of coal miners with non-targeted job duties, increasing the risk of severe black lung disease. The study highlights the importance of monitoring silica exposure in all coal miners, regardless of job duties.
Researchers at National Jewish Health found that daily Colchicine treatment improved fevers and symptoms in two adolescent patients with long COVID. Genetic testing revealed a pathogenic mutation in the MEFV gene, which is associated with periodic fever syndromes.
Researchers at National Jewish Health have discovered biomarkers on the surface of infant skin that can predict the development of atopic dermatitis and other allergic conditions. The study's findings suggest that targeted therapies such as emollients or biologics may be effective in preventing eczema.
A new screening tool, CAPTURE, identifies roughly half of primary care patients with chronic obstructive pulmonary disease (COPD) that could benefit from available treatments. The study confirms the robust nature of this collaborative relationship between numerous stakeholders, particularly primary care-based research networks.
Researchers at National Jewish Health have developed an antibiogram to aid in treating nontuberculous mycobacteria (NTM) infections. The antibiogram provides comprehensive information on antimicrobial resistance patterns for 14 rapidly growing NTM organisms.
Researchers identified saracatinib as a potential treatment for idiopathic pulmonary fibrosis (IPF), a progressive lung disease. The oral therapy was found to reduce tissue scarring and fibrotic responses in cells obtained from normal lung tissue and IPF patients.
A National Jewish Health led study found that children who develop shortness of breath after COVID-19 infection have evidence of peripheral airway obstruction, leading to persistent fatigue and limited participation in sports and everyday activities. The study identified reversible peripheral airway obstruction and lung hyperinflation ...
Researchers at National Jewish Health found pirfenidone effective in slowing ILD progression in RA patients, potentially increasing overall survival. The study was the first prospective treatment trial for this condition.
A National Jewish Health led study found that technology through video game-based cognitive therapy improves attention and executive functioning in patients with systemic lupus erythematosus (SLE). The treatment group showed significant improvement in visuomotor speed and complex attentional sequencing skills compared to the control gr...
Researchers used bacteriophages to treat a young cystic fibrosis patient's antibiotic-resistant mycobacterial lung infection, resulting in a successful lung transplant. The treatment cleared the infection and allowed the patient to discontinue all treatment, living a normal life.
A National Jewish Health-led study found that over a third of identified genetic risk factors for asthma are associated with altered function of airway epithelium. The research discovered genetic changes in genes related to mucus production and type 2 inflammatory pathways, increasing asthma risk.
Researchers at National Jewish Health have discovered that mitochondria do not function properly in patients with post-COVID syndrome, leading to debilitating symptoms. The study's findings may lead to treatments for patients struggling with fluctuating heart rates, extreme fatigue and memory issues.
A new study by National Jewish Health finds that adjusting school start times can benefit parents' sleep, particularly those with children in middle and high school. Parents reported improved sleep duration and reduced daytime fatigue after the start time adjustments.