Researchers achieve highly regio-, stereo-, and enantioselective 1,6-addition of aliphatic Grignard reagents to α,β,γ,δ-unsaturated carbonyl compounds using an iron catalyst with a chiral N-heterocyclic carbene ligand. The achievement offers new opportunities for drug discovery, materials chemistry, and fine-chemical synthesis.
A study by UC Riverside found that Black and Latino teens are more adept at detecting online disinformation, particularly related to race and ethnicity. These teens are quicker to identify false claims and respond with corrective content, often driven by their lived experiences navigating online racism.
A new experimental intranasal spray, INNA-051, will be tested in a randomized Phase 2 trial to determine its safety and effectiveness in reducing illness from respiratory viruses. The study aims to enroll 1,100 healthy adults at increased risk of upper respiratory virus infections.
The latest APA Journal issues explore the intersection of neuroplasticity and substance use, as well as emerging trends in outpatient psychotherapy. The American Psychiatric Association's flagship journals offer insightful research on mental health topics.
A study found that using SGLT2i drugs in patients with gout and type 2 diabetes can lead to lower rates of starting urate-lowering therapy, NSAIDs, and diuretics. This could streamline care and reduce medication burden for these patients.
Scientists at Nagoya University identified a brain circuit that keeps mice awake in unfamiliar environments, releasing neurotensin to maintain wakefulness and protect against potential dangers. This discovery may explain the 'first night effect' in humans, where the brain remains vigilant on the first night in a new place.
Research found that horses exhibit fearful behavior when exposed to human fear odors, adopting the emotional state of fear. This suggests a mechanism of emotional contagion through chemical cues between humans and horses.
Researchers found that narrower soybean leaves can improve how efficiently plants use available light. By altering leaf shape through a single gene, they reduced total leaf area by 13% without affecting yield, resulting in more efficient sunlight conversion into seed.
Researchers have developed an open-source pressure myography tool, HemoLens, which reduces the cost of vascular research to $750 from $40,000. The tool uses affordable manufacturing processes and customizable components, making it easier for researchers to study vascular function.
Individuals who combine climate worry with actions such as volunteering, following a plant-based diet, or avoiding air travel experience fewer depressive and anxiety symptoms. Climate hope in society's ability to mitigate climate change also correlates with reduced mental health issues.
A study found that prenatal alcohol exposure changed aspects of the dopamine system in rhesus monkeys, influencing how quickly they drank alcohol in adulthood. The researchers also discovered individualized neuroadaptive responses to drinking, which may promote the transition to alcohol use disorder.
NTU Singapore is launching three new space projects under the Space Access Programme to accelerate the commercialization of space technologies. The projects include an AI-enabled satellite, a nanosatellite testing next-generation solar cells, and another nanosatellite with advanced propulsion systems.
A new questionnaire-based scale assesses nursing practices supporting fertility preservation decisions in women with cancer. The study highlights three essential dimensions of nursing practice: professional decision-support, communication facilitation, and system-based collaboration.
Researchers discovered that Apex1 plays a crucial role in initiating and progressing bone healing after injury. The protein is required for activating the master regulatory gene Bmp2, which initiates healing by stimulating periosteal expansion and callus formation.
Researchers developed polygenic risk score models to predict breast cancer risk in women of African ancestry, improving accuracy and performance compared to existing models. The new tools could lead to earlier screening, tailored care, and increased survival rates for high-risk women.
Eduardo Miranda, a Stanford University professor, has been recognized for his pioneering work in developing new ground motion models and intensity measures. His research has significantly shaped seismic design provisions and emphasized the use of strong-motion data in both research and teaching.
Researchers have developed special algae that can remove and reuse harmful microplastics from wastewater, cleaning the water as it grows. The engineered algae produces a volatile natural oil called limonene, making it water-repellent and attracting microplastics, which can then be collected and reused to create bioplastic products.
Researchers created a miniaturized ultrasound system that can be used at home or in doctors' offices to scan people at high risk of breast cancer. The new system detects tumors earlier, increasing the chances of successful treatment.
The Vilcek Foundation has awarded $9.6 million to 14 individuals from 12 countries for their contributions to the arts and sciences in the US. This year's prize winners include scientists, artists, and fashion designers who have made significant advancements in their fields.
A recent systematic review has compiled and catalogued publicly available omics data on pituitary tumours, highlighting the need for standardisation and clinical annotation. The resulting catalogue facilitates the reuse of data for future research projects and precision medicine initiatives.
A new study reveals that young adults in Sweden report lower life satisfaction, a weaker sense of meaning, and higher levels of loneliness, anxiety, and depression compared to older age groups. In contrast, older Swedes are among the happiest in the world, with strong close relationships and less loneliness.
A recent study found significant changes in post-COVID respiratory infections among children, with Mycoplasma pneumoniae experiencing a surge after restrictions were lifted. The study also revealed strong interactions between pathogens, including negative correlations and pathogen interference.
A new study found that MET signaling plays a critical protective role in acetaminophen-induced acute liver failure by reducing liver damage and accelerating regeneration. The findings suggest targeting MET signaling could become a game-changer for treating drug-induced ALF, potentially reducing the need for emergency liver transplants.
Dr. George Coukos, a leading authority on tumor immunology and cellular immunotherapy, joins Weill Cornell Medicine to lead the Ludwig Laboratory for Cell Therapy.
Researchers at Queen Mary University of London have developed an AI system called Auto MV that can generate complete music videos directly from full-length songs. The system uses a multi-agent approach to analyze the musical structure and lyrics, plan scenes, and generate images and video clips.
Researchers discovered that microorganisms attached to rock surfaces have a stronger influence on community structure than environmental factors. These 'attached' microbes are highly specialized, generating energy from inorganic substances and contributing to carbon storage.
Researchers found that carrying one mutant copy of ATP13A2 and GBA1 drives a slow, progressive neurodegeneration in flies, leading to movement problems, neuron loss, and disruption in neural communication. Accumulation of glucosylceramide in glial cells is linked to the disease process.
Researchers urge policymakers to re-evaluate accountability in climate policy as the world inches closer to exceeding the 1.5°C target, emphasizing the need for integrated remedies and quantifying equity under overshoot scenarios.
Researchers found that overexpressed Fc gamma receptors on reactive microglia mistakenly identify healthy neurons, leading to their elimination. Immunotherapy targeting these receptors could slow disease progression by preserving dopaminergic neurons.
The study reveals that higher language proficiency is associated with stronger functional connectivity within the brain network responsible for cognitive task performance. Deaf and hearing participants performed tasks similarly, but differences were observed in brain activity patterns.
A study warns that current school-based mental health support for children from multilingual backgrounds can be less effective and inaccessible due to linguistic and cultural challenges. The researchers found that conversations were often 'lost in translation,' leading to reduced parental engagement and attendance.
A team of researchers from Okayama University directly observes the atomic-scale growth of ultra-thin semiconductor crystals using a microreactor. They identify multiple growth regimes and dynamics, shedding light on how crystal shape and quality depend on conditions.
A new study from McGill University identified five distinct biological subtypes of chronotypes, which are linked to unique behavioral and health patterns. The research found that one group of night owls is more vulnerable to depression, while another group of early birds has fewer health problems overall.
Vanderbilt Health has acquired Tennova Healthcare-Clarksville Hospital and its related businesses, including physician clinics and outpatient services. The acquisition expands the health system's ability to serve patients across the region, providing high-quality care in more convenient community settings.
Scientists studying light pollution's impact on moths aim to develop a more detailed understanding of its effects. The Lightstar project will track moths using ultra-lightweight responders and simulate street lighting conditions in field experiments.
A retrospective analysis of 94 adult patients who underwent PEEK cranioplasty found that surface architecture may influence postoperative healing, with smooth implants associated with higher rates of wound complications and infections. Perforated implants showed lower rates of major fluid collections, especially in trauma patients.
OYE-101, a novel intravenous caffeine formulation, aims to accelerate recovery from general anesthesia and deep sedation in adults. The FDA-cleared treatment also seeks to address opioid-induced respiratory depression and related overdose situations.
The European Southern Observatory (ESO) welcomes the cancellation of INNA, a planned industrial complex near Paranal Observatory. The project would have posed a major threat to the darkest skies on Earth and compromised the performance of advanced astronomical facilities.
The FENS Forum 2026 will be Europe's largest neuroscience congress, covering areas of basic to translational research. Journalists can register for free and attend symposia and poster sessions.
The University of Bath has achieved a record number of finalist status in this year's everywoman in Technology Awards 2026. Academics from various departments have been recognized for their leadership, innovation and commitment to advancing women in technology.
A new study found that better speech outcomes with cochlear implants correlate with increased music engagement and longer listening times. The research suggests optimizing implant programming can have broader benefits for patients' quality of life beyond communication.
A comprehensive study shows that OVOCs supply more than half of the radicals responsible for ozone production, challenging conventional control strategies. The findings highlight the importance of comprehensive OVOC observations to improve model accuracy and guide emission control priorities.
A new study by Ohio State University researchers found that some bottled water contains significantly higher levels of microplastics than tap water. The study used a novel method for detecting tiny particles and analyzed water samples from four treatment plants near Lake Erie and six different brands of bottled water.
Researchers at the University of Illinois Urbana-Champaign have developed a new method for synthesizing thermally stable Ni(I) compounds that opens new avenues for building complex molecules. The new catalysts exhibit rapid ligand substitution, exceptional performance in key reactions, and chemo-selectivity.
Research from Bentley University's Center for Integration of Science and Industry shows public companies with price negotiable drugs under IRA were more profitable than comparable companies in the S&P500. The study also found that revenues from these drugs exceeded normal returns on investment before price negotiations began.
A study by UNICAMP researchers found that women with a history of yo-yo dieting have increased body fat, worse metabolic indicators, and reduced brown fat activity. The 'yo-yo effect' impairs metabolism and reduces BAT activity in women.
A team of mechanical engineers has created a wood-based material that can store and release heat to make building temperatures more comfortable. The phase-change material reduces the need for air conditioning by harnessing excess heat from the environment.
A new study published in the Journal of Occupational and Environmental Medicine has identified clear occupational factors and demographic indicators associated with elevated serum levels of per- and polyfluoroalkyl substances among US career firefighters. The research provides vital insights into the factors that influence PFAS body bu...
Scientists at Umeå University found that i-DNA forms in living cells and acts as a regulatory bottleneck linked to cancer. The protein PCBP1 controls its resolution, which can block replication and increase DNA damage risk if not done properly. This discovery opens new avenues for drug development by targeting i-DNA handling.
Researchers developed a machine learning-assisted design tool, μFluidicGenius, to automate microfluidic chip design. The tool enables nonexpert users to rapidly design microfluidic circuits with optimal flow conditions, using a hybrid approach combining machine learning models with mathematical fluid mechanics calculations.
Researchers from EHU's spectroscopy group investigated prolinol's interactions with one, two, and three water molecules, finding that water acts as a conformational switch. The study connects the isolated molecule to behavior in solution, shedding light on how water affects biological systems.
Research from the University of Sharjah reveals that everyday physical activities, such as walking and climbing stairs, are more beneficial for osteoarthritis patients than handgrip strength. These routine actions are powerful indicators of how older adults perceive their independence and enjoyment of life.
The earliest known bird, Archaeopteryx, had unique mouth features such as oral papillae, tongue bones, and bill-tip organs. These structures suggest that early birds evolved specialized ways to find and digest food efficiently, which is key to flight. The discovery provides new criteria for identifying dinosaur fossils as birds.
The UH College of Pharmacy is expanding its graduate program to offer a Doctor of Philosophy and Master of Science in Population Health & Pharmacoepidemiology, addressing a growing demand for training in evaluating medication safety and effectiveness.
Researchers at Newcastle University and the UK Met Office identified a three-layered atmospheric structure associated with heavy rainfall developing within minutes. The findings help explain record-breaking rainfall and flash floods in the UAE and Oman in April 2024, and may aid future improvements in identifying risk.
Researchers at FAU and UMC Mainz found that genes on the deactivated X chromosome are reactivated in human brain cells during embryonic development. This reactivation acts as additional protection, reducing signs of disease symptoms in female brains.
Researchers at Johns Hopkins Kimmel Cancer Center have developed a novel liquid biopsy approach to identify early-stage cancers by measuring DNA methylation patterns. The Epigenetic Instability Index (EII) successfully distinguished patients with early-stage lung and breast cancers from healthy individuals, showing promise in detecting...
A study at Ruhr-University Bochum found that visceral pain induces stronger cognitive and empathic responses than somatic pain. Participants rated visceral pain as more intense and unpleasant, feeling more empathic concern for themselves and their loved ones.
A new study found that while the number of pancreatitis-associated deaths among the elderly decreased between 1992 and 2021, the total cases rose significantly due to population growth. The age-standardized incidence rate per 100,000 fell from 100.21 in 1992 to 85.20 in 2021.
Researchers identify thousands of rapidly evolving receptor-binding proteins, revealing how bacteria can be engineered to deliver proteins into specific human cells. The study provides insights into the evolutionary creativity of bacterial machines and their potential biomedical applications.