Researchers from Kumamoto University identified a genetic 'silencer' element that keeps the human T-cell leukemia virus type 1 (HTLV-1) in a dormant state, evading immune detection. This discovery offers hope for new therapeutic approaches to treat HTLV-1 and potentially even HIV.
Researchers developed a white organic light-emitting diode that operates at an unprecedentedly low voltage of less than 1.5 volts. This breakthrough could contribute to reducing energy consumption in state-of-the-art displays, including television backlights and lighting devices.
A new analysis published in The Journal of Clinical Investigation reveals how leptin affects the brain and its potential use in future therapeutics for type 1 diabetes. Leptin helps regulate appetite and body weight, and insufficient levels lead the brain to activate circuits that mobilize energy sources, including glucose and ketones.
A technology expert predicts AI-based medicine will revolutionise care for Alzheimer’s and diabetes, but access must be made available to all patients. The author highlights key innovations such as diagnostic imaging and surgical robots that will aid in more accurate diagnoses and treatments.
Researchers discovered that subtle differences in molecular structure can significantly affect mRNA-based drug performance. The study found that optimizing stereoisomers of ionizable lipids like ALC-315 could lead to safer vaccines, as the (S,S)-form delivers mRNA efficiently with reduced toxicity.
A new study finds that partisan hostility is a key driver of protest participation in the US, exceeding concern for actual issues. Hostility towards opposing parties was a major factor in all three analyzed movements, with Americans in highly partisan counties more likely to protest.
Researchers highlight the importance of understanding heart-lung interactions in treating pulmonary vascular disease. Studies show that dysfunction in one organ often exacerbates problems in the other, leading to systemic effects.
ARDD 2025 to feature Nobel laureates and pharmaceutical industry executives discussing cutting-edge aging research and clinical applications. The event aims to advance healthspan and longevity science through evidence-based approaches.
The latest nTIDE report shows a decline in employment-to-population ratio for people with disabilities, but labor force participation remains unchanged. Employment rates declined from 38% to 37%, while labor force participation decreased only slightly from 41.9% to 41.6%.
Researchers developed a new method to activate water-splitting catalysts at an oven temperature of just 300 °C, boosting oxygen evolution efficiency by nearly sixfold. This breakthrough enables large-scale energy storage and conversion using solar and wind power.
Researchers have identified a protein called eIF2A that plays a crucial role in guiding melanoma cancer cells as they spread throughout the body. Targeting this protein could be a new approach to impede metastasis and improve healthcare outcomes for patients with melanoma.
Five papers published in ACS journals provide new strategies for protecting natural water sources, including innovative technologies and sustainable solutions. The findings also highlight the importance of ensuring global access to safe drinking water, supporting human health and well-being.
Global net primary production increased significantly between 2003 and 2021 due to land's photosynthetic increase, but declined in marine algae. The study highlights the importance of terrestrial ecosystems in offsetting ocean declines.
A new study found antimicrobial resistant bacteria spreading rapidly among children with severe malnutrition in Niger. The bacteria can cause life-threatening infections like pneumonia and sepsis, which are difficult to treat with antibiotics.
A study published in Nature Medicine reports final results of a Phase 3 trial showing pembrolizumab plus axitinib offers longer overall and progression-free survival compared to sunitinib for advanced kidney cancer patients. The treatment combination has been linked to higher objective response rates.
Senescent cells in the liver contribute to fat accumulation, inflammation, and fibrosis, while chronic steatosis accelerates hepatic decline. Interventions targeting senescence are emerging, including senolytic cocktails and lifestyle measures like exercise and calorie restriction.
SFU researchers create new tool that allows users to relight photographs like in computer graphics software, providing more control over lighting. The approach uses a neural network to transform rough previews into realistic images, making it an invaluable tool for VFX artists and filmmakers.
Researchers developed an amorphous silicon optoelectronic device with minimal defects using a low-temperature process and precise hydrogen dilution control. The device maintained its performance while reducing production costs by over 60% compared to conventional methods.
Researchers have discovered a primate-specific cytokine called IGFL2 that plays a crucial role in regulating inflammation in rheumatoid arthritis. IGFL2 boosts the production of autoantibodies and activates immune cells, further amplifying inflammation and joint damage.
Researchers developed a new class of 2.5D MOFs using triptycene-based molecules, enabling high-quality single crystals for detailed structural and functional studies. The materials exhibit strong electronic and magnetic correlations in the interlayer direction, paving the way for next-generation MOF-based technologies.
Two reviews by Drs Komaroff and Dantzer highlight the biological problems causing long-lasting symptoms in Long COVID and ME/CFS, including inflammation, energy production issues, and immune system dysregulation. These conditions are grouped under post-acute infection syndromes, which may be treated with targeted therapies.
Researchers identified a sugar molecule called sialic acid that helps cancer cells evade the immune system. By engineering beta cells to produce this molecule, they found it possible to tolerate these cells and prevent their destruction. The study offers new hope for treating type 1 diabetes without immunosuppression.
Researchers have gained a deeper understanding of the 5-HT1A serotonin receptor, a key player in regulating mood, emotion, and cognition. The study reveals that certain cellular signaling pathways are favored over others, and drugs can influence their strength of activation.
A new imaging method, combining cryo-TEM and EELS, allows for simultaneous visualization of structure and elemental distribution in nanomaterials. The technique has been successfully applied to organic nano-materials and biomaterials like hydroxyapatite particles.
The study found that the pandemic affected development, interactions, and connections among youth and parents, causing anxiety, grief, and strained relationships. However, it also led to increased spending time together, personal growth, and creative coping mechanisms.
Researchers from NUS have tracked changes in gene expression and splicing patterns in skeletal muscle after a 16-week lifestyle intervention program involving supervised exercise and dietary changes. The study found that participants lost weight and improved insulin sensitivity, with specific genes showing evidence of G x L interaction.
Researchers developed a novel radioimmunotherapy that successfully eliminated cancer stem cells (CSCs) in preclinical models of ovarian cancer. The therapy, targeting CSC-associated biomarkers L1CAM + /CD133 + , showed significantly increased cytotoxicity compared to existing treatments.
The survey highlights a dual-path framework for harnessing large language models' intrinsic reasoning and integrating them with external methodologies. Large language models are employed for step-by-step reasoning methods, enabling the decomposition of complex tasks and exploration of multiple reasoning paths.
A recent study reveals three distinct inflammatory drivers of asthma exacerbations in children, including epithelial pathways, macrophage-driven inflammation, and mucus hypersecretion. These findings suggest that targeted therapies may not be enough to prevent flare-ups, emphasizing the need for more personalized treatment approaches.
A new AI tool can learn to read medical images with far less data, cutting down the amount of required data by up to 20 times. The tool improves upon medical image segmentation, a labor-intensive task often performed by experts, and boosts model performance in settings with limited annotated data.
Researchers identify packing density as key factor affecting membrane elasticity, offering new insights into homeostasis and cellular behavior. This discovery has significant implications for drug delivery applications and the development of lifelike artificial cells.
A US study found that young adults with hearing difficulties have lower educational attainment, are less likely to be employed, and earn less than their peers. The effects are particularly pronounced among Black and Hispanic individuals. Hearing loss can limit job opportunities due to communication challenges.
Researchers discovered that components in young human blood serum can restore youthful properties to skin when combined with bone marrow cells. This study highlights the role of bone marrow in supporting skin health and may lead to novel approaches to address age-related changes.
A new study finds that living in rural areas in the first five years of life may be a risk factor for developing type 1 diabetes, whereas urban environments are associated with lower risk. The research identified significant high-risk clusters in rural areas and low-risk clusters in cities.
Research from the University of Birmingham finds that party tourism creates an environment for sexual assault by normalizing extreme behavior and prioritizing economic revenue over women's safety. The study highlights how destinations silence victims to protect their reputation, reinforcing a culture of silencing survivors.
A new analysis of over a million online reviews reveals that negative reviews often focus on communication and administrative issues, such as payment problems and poor treatment. Positive reviews, on the other hand, frequently mention reassuring interactions with clinicians and staff, emphasizing kindness, helpfulness, and patient anxi...
University of Tennessee faculty members will conduct research and teaching abroad through the Fulbright U.S. Scholar Program. The recipients include Christopher Cherry, Virginia Corrigan, Bernard Issa, Hector Pulgar, and Tong (Toni) Wang.
US adolescents spend nearly an hour per school day on smartphones, with most of this time dedicated to social media. The study highlights developmental differences in smartphone use, with younger teens using less than older adolescents.
The DFG presents a statistical analysis showing the involvement of subject areas in Clusters of Excellence, mirroring that of ongoing research. The results reveal a broad disciplinary range among researchers, with notable connections between artificial intelligence and other fields.
Young adults with higher genetic risk for depression show reduced brain activity in response to rewards and punishments, while sex-dependent neural responses were also observed. This study highlights potential early indicators for depression before symptoms fully manifest.
Negative patient experiences in online health care facility reviews frequently revolve around poor communication and administrative issues. Positive reviews emphasize supportive staff interactions.
Hollings researchers use natural language processing to identify primary cancer types in medical notes, improving treatment accuracy and personalized care. The AI model achieves high accuracy rates, outperforming standard medical codes in identifying primary cancer diagnoses.
A large study found that Medicare beneficiaries with multiple sclerosis who received broader coverage of MS treatments had significantly lower risk of developing new or worsening symptoms. Researchers warn that formulary exclusions for specialty drugs could lead to worse health outcomes.
Researchers developed a radiotracer targeting CD24 protein on liver tumor cells, accurately detecting tumors in mice. PSMA PET/CT scans also tracked prostate cancer spread in patients, predicting shorter survival for those with interlesional progression.
A new study provides an unprecedented cellular map of stone cell development in pears, enabling targeted breeding and cultivation strategies to improve fruit quality. Lignification trajectories reveal a cascading process that spreads systematically, offering insights into the early stages of stone cell formation.
The University of Copenhagen announces Immortal Dragons as a Tier 4 sponsor of the upcoming ARDD 2025 conference. The fund supports moonshot longevity startups in areas like wholebody replacement, gene therapy, and special economic zones. Nobel laureates will also be featured at the event.
The Arctic Challenge for Sustainability II research program has led to a cross-disciplinary study on sustainable development in the Arctic for Indigenous peoples. The goal is to improve health, well-being, and security of Arctic communities while conserving ecosystem structures and resources.
A new Stanford University study finds that most US households (60%) can reduce their electricity costs by 15% and weather local or regional blackouts with solar-battery systems. The systems would meet about half of the household's electricity needs on average, allowing them to save money or see no rise in costs.
A new study published in JAMA Health Forum suggests that Medicare could save $3.6 billion annually by eliminating or reducing low-value tests and procedures for patients who do not benefit from them. This reduction in unnecessary care could also result in $800 million less in out-of-pocket costs for older adults.
ARDD 2025 will feature cutting-edge research and clinical applications in healthy longevity medicine. Mitra Bio's sponsorship aims to support longevity science community and share insights from its skin aging space expertise.
The article provides reporting recommendations for studies evaluating chatbot health advice, highlighting the importance of standardization in interpretability. Key findings include the need for clear guidance on chatbot performance metrics and data quality control.
Researchers developed a regional explanation method to capture nonlinear relationships between molecular features and properties, offering fine-grained insights into chemical stability. The method was validated on two datasets, demonstrating broad applicability across different chemical domains.
Research reveals that Faecalibacterium prausnitzii inhibits the growth of Fusobacterium varium, promoting a balance in the gut microbiota. This interaction is likely to occur through direct contact between the bacteria, and may have implications for improving intestinal health.
University of Oklahoma Associate Professor Dustin Condren has been named a 2025-2026 Fulbright U.S. Scholar to conduct archival research on Soviet films from the 1920s and 1930s in Germany.
People with MS show higher healthcare use up to 15 years before symptoms appear, highlighting opportunities for earlier identification and intervention. The study analyzed health records of over 12,000 people in BC and found distinct patterns of healthcare engagement before symptom onset.
A new bacterial cellulose-based hemostatic dressing enables rapid and sustained bleeding control, accelerating wound healing through a triple synergistic mechanism. The material demonstrates excellent biocompatibility and overall safety in comprehensive biosafety evaluations.
Researchers from HKU mapped urban light pollution in Hong Kong, revealing an uneven distribution with a disproportionate share coming from decorative lighting installations. The study suggests regulating non-essential commercial lighting and optimizing building illumination to reduce light pollution levels.
A deep learning-based model enables fast and accurate stroke risk prediction by segmenting carotid arterial vessel lumens, vessel walls, and plaques in MRI images. The model achieves high accuracy in plaque segmentation, outperforming manual methods, and completes assessment in under 3 seconds.
A global study identified DNA markers for stuttering, providing a genetic link that will allow clinicians to predict which family members will experience the speech disorder. The research also found a link between stuttering and neurodiversity, emotional regulation, and musical rhythm.
Gray wolf pups are born nearly helpless, but their mothers take risks to move them close to prey, such as elk, which is crucial for conservation efforts. The study's findings counter years of assumptions that migratory mammals can escape predation in spring due to immobile offspring.
Researchers introduce a dual-ligand modulation strategy to break coordination symmetry in cMOFs, enhancing electromagnetic wave absorption. This approach is found to elicit dipole polarization loss and improves EWA performance, as demonstrated by Cu2.25/Co0.75 with excellent absorption bandwidth and reflection loss.
NUS Nursing introduces Singapore's first Doctor of Nursing Practice programme and three Master's programmes to enhance nursing expertise and leadership. The Doctor of Nursing Practice is a two-year part-time program empowering nurses to lead care through advanced clinical expertise and critical thinking.
The study aims to create a path forward for improved treatment, access to clinical trials, and personalized care for communities with limited access to care. Recent studies highlight the need to address systemic barriers that prevent many people from receiving advanced care.
Physicists used a machine-learning method to identify surprising new twists on the non-reciprocal forces governing a many-body system. The AI approach provides precise approximations for these forces, correcting common theoretical assumptions with an accuracy of over 99%.
A multicenter study found that preoperative Mini-Cog scores can predict postoperative delirium risk in elderly patients. The study used a mendelian randomization analysis to identify genetic variants associated with cognitive performance, suggesting that preoperative screening may help identify high-risk patients.
A study by Texas A&M University found that cannabis use is more common among non-Hispanic Black men with chronic health issues, particularly those with pain, stress and depression. The research suggests a two-way relationship between cannabis use and worsening physical and mental health.
Researchers developed a microrobot that uses internal visual tracking to achieve precise movement and stability. The system enables real-time self-correction during motion, paving the way for compact, autonomous surgical tools capable of operating deep inside the human body.
Researchers at NJIT used artificial intelligence to discover new porous materials capable of revolutionizing multivalent-ion batteries. The AI-driven approach uncovered five entirely new materials with large, open channels ideal for moving bulky multivalent ions quickly and safely. These findings offer a promising solution for the futu...
Developed by a research team at POSTECH, the robot uses human muscle proteins as inspiration to generate strong force while navigating through tight spaces. The technology has potential applications in various fields, including medical settings, industrial environments, home cleaning, and caregiving robots.
Researchers have developed a novel synthetic ligand using AI-based computational protein design, activating the Notch signaling pathway in T-cells. This breakthrough enables broadened clinical T-cell production and advances immunotherapy development.
A new study uses molecular imaging to uncover structural defects in conjugated polymers formed through aldol condensation, a versatile and environmentally friendly synthesis method. By understanding these defects, researchers can develop more sustainable materials for electronics, computing, and other applications.
Researchers found that mangrove populations have nearly tripled in areas with oysters, leading to significant acidification of oyster reef sediment. Oyster shell dissolution could impact reef viability and services like filtration and storm surge reduction.