A study found that physiology-guided complete revascularization in older patients (75 years+) with myocardial infarction and multivessel disease provides sustained benefit at 3 years compared to culprit-lesion-only treatment. This approach may improve outcomes for elderly patients with complex coronary artery disease.
A new study by the University of Gothenburg suggests that thawing permafrost played a significant role in raising carbon dioxide levels after the last ice age. Researchers estimate that this carbon exchange may have accounted for almost half of the rising CO2 levels.
A new study by Tulane University's Newcomb Institute found a measurable link between prolonged extreme heat and increased domestic violence-related emergency calls in New Orleans. When temperatures stayed above the top 10% for five consecutive days, calls rose by 7%. The researchers recommend integrating domestic violence prevention in...
Researchers found that women with high hsCRP levels had a significantly increased lifetime risk of coronary heart disease, stroke, and major cardiovascular events. Statin therapy can help reduce risk among these individuals by 38%.
A novel wearable eye patch using fluorescence sensors detects lysozyme levels in tears for early eye disease detection. The sensor's sensitivity is high enough to monitor lysozyme at concentrations as low as 1.5 nanomolar.
A study by Professor Chunxiu Gong's team identified the clinical presentation of Cornelia de Lange syndrome (CdLS) and genetic alterations in Chinese pediatric patients. The researchers found that 12 patients presented with classic CdLS, while others showed global developmental delays and growth retardation.
A new imaging approach enables visualization of specific lipids in cells, revealing that non-vesicular lipid transport by proteins is the primary mechanism maintaining organelle membrane composition. This breakthrough has implications for understanding lipid imbalances in diseases and accelerating discoveries of new drug targets.
Researchers at EPFL developed BindCraft, an open-source AI platform that uses AlphaFold2 to generate novel binders with desired functional properties. The platform reduces the need for high-throughput screening and makes protein design more democratized.
A study by Mount Sinai-Duke University identifies specific DNA variants in the DENND1A gene that increase testosterone production in PCOS patients. This finding could lead to new therapies targeting the genetic source of elevated testosterone levels in PCOS, which is a common condition affecting reproductive-age women.
A new U-M study found that xylazine does not amplify the decrease in breathing rate caused by fentanyl use, but reduces heart rate more than fentanyl. This reduction in heart rate may be a more important driver of increased overdose risk, highlighting the need for further research into polysubstance use involving opioids.
A new study found that warning voters about false claims and providing them with information on election security measures can increase confidence in the results. In the US and Brazil, prebunking was more effective than credible sources in decreasing beliefs about election fraud.
Researchers at Pusan National University have developed a novel, multi-resin dispensing process for fiber-reinforced polymer fabrication, enabling precise patterning of mechanical properties within a monolithic structure. The breakthrough composite material combines flexibility and strength for advanced robotic applications.
Researchers developed AI systems to enhance fusion energy experiments, predicting disruptions and monitoring plasma states with high accuracy. The tools improved reactor safety by 94% and achieved a 96.7% success rate in recognizing plasma conditions.
Researchers have made a breakthrough in understanding post-seismic velocity changes by studying the effects of friction at grain contacts. The team found that contact sliding and aging are responsible for these time-dependent changes in wave velocities.
A study by University of Birmingham researchers found that corporate net-zero pledges often lack the substance needed to drive real change. Many companies use vague language and focus on direct emissions, omitting substantial indirect emissions generated by their products.
Researchers at Cornell University have discovered genetic triggers that cause male and female bovine embryos to develop differently. Male embryos prioritize genes associated with energy metabolism, leading to faster growth, while female embryos emphasize genes related to sex differentiation and inflammatory pathways.
A remote randomized clinical trial found that mail-based atrial fibrillation screening with an electrocardiogram patch increased AF diagnosis in older patients at moderate to high risk of stroke over 2.5 years. The study suggests that this method could be a potential strategy for stroke prevention.
Researchers have discovered a new class of X-type antiferromagnetic materials that exhibit sublattice-selective spin transport and unconventional magnetic dynamics. This breakthrough enables precise control of the Néel vector, a crucial operation for antiferromagnetic spintronic data writing.
Researchers developed a high mechanical durability hydrogel electrolyte using urea as a zincophilic solubilizer, allowing for stable Zn stripping/plating in a dendrite and passivation-free manner. The material enhances the battery's overall performance and retention over time.
A clinical trial led by Tohoku University has found that lubiprostone can prevent the decline of renal function in patients with chronic kidney disease. The study evaluated the effects of lubiprostone on kidney function and found that it improves mitochondrial function, which exerts a renoprotective effect.
A new Philippine study reveals that the country's hottest days are more likely to produce hail, contradicting its typical balmy climate. The research used satellite and radar data to confirm the presence of strong updrafts and favorable conditions for hailstorms during hot periods.
Researchers at Aarhus University have developed a method to measure plant roots using DNA technology, revealing their essential role in food production and climate. The new method enables accurate measurement of biomass and species distribution, opening up applications in climate research, plant breeding, and biodiversity analysis.
Biocontaminant explores biological contaminants in diverse ecosystems, including air, water, and soil. The journal publishes innovative control and remediation strategies to mitigate health and ecological impacts.
Researchers discovered that languages from different continents and populations become more similar after contact, with rates of borrowing ranging from 4-9%. The team found that linguistic features are not consistently transferable, challenging long-held assumptions about language learning.
Scientists have identified a protein called 4E-T that plays a central role in maintaining the dormant state of immature oocytes. The loss of this protein allows for the resumption of maturation, with important regulators and proteins activated to initiate the next steps.
The proposed GACBS algorithm leverages GPU parallelism to improve the performance of the CBS solver for the MAPF problem. Experimental evaluations demonstrate significant speedup ratios, outperforming CPU-based approaches by up to 46x.
A recent University of Cincinnati study reveals that employees with high self-confidence are less affected by societal stigma, while supportive management can help mitigate emotional exhaustion. The research suggests that pride in one's job is crucial to offsetting negative judgments from others.
The 2026 Hertz Fellowship application is now open for doctoral students in applied sciences, engineering, and mathematics. The fellowship offers up to five years of funding and lifelong professional support to pursue groundbreaking research.
Researchers found that a high fiber diet reduced Alzheimer's-related frailty and tremor in mice by restoring balance in the gut immune system. This discovery provides a potential new therapeutic pathway for the disease.
A recent study identifies four novel proteomic subtypes of GSRCC: Metabolism, Microenvironment Dysregulation, Migration, and Proliferation. Key prognostic biomarkers PRDX2 and DDX27 were also identified, with PRDX2 linked to favorable prognosis and DDX27 associated with poor survival outcomes.
Scientists at the University of Alabama at Birmingham created novel mouse models with mutations in the DHDDS gene to study retinitis pigmentosa (RP) 59, a genetic cause of blindness. The studies revealed that both T206A/K42E and K42E/K42E mouse models exhibited changes in retinal structure and function similar to human RP59 disease.
Recent advances in glycoproteomic technologies reveal the critical role of glycosylation in kidney health and disease. Aberrant glycosylation patterns underpin a spectrum of kidney diseases, from immunoglobulin A nephropathy to diabetic kidney disease and renal cancer.
A study by Alfred Wegener Institute revealed that microalgae in the Southern Ocean played a significant role in reducing global atmospheric CO2 levels 14,000 years ago. The findings suggest that changes in sea ice extent had a direct impact on algal productivity and carbon transport to the deep sea.
Researchers discovered that disrupting protein quality control slows tumor growth in rhabdomyosarcoma, a rare and aggressive cancer primarily affecting children. The treatment, which targets the proteostasis network, significantly slowed or stopped tumor growth in mice implanted with human RMS tumors.
Researchers at ETH Zurich discovered that cancer cells can transfer their mitochondria to healthy fibroblasts, reprogramming them into tumour-associated fibroblasts that support cancer cell growth. The mitochondrial transfer mechanism involves the protein MIRO2, which is produced in high quantities in cancer cells.
A study by Stockholm University revealed a planet-forming disk with an unexpectedly high abundance of carbon dioxide, challenging long-standing assumptions about planetary birthplaces. The discovery was made using the James Webb Space Telescope and suggests intense ultraviolet radiation may be reshaping the chemistry of the disk.
A new Rice University study finds hormonal contraceptives shape how women experience emotions in the moment and remember emotional events later. Women on hormonal contraceptives showed stronger emotional reactions and remembered fewer details of negative events when using emotion regulation strategies.
Researchers have proposed a third prototype of antiferromagnetic tunnel junction, paving the way for faster and denser spintronic devices. The new design, which relies on interface effects rather than bulk properties, allows for strong spin polarization and high performance.
Dr. Roxana Mehran is recognized for her exceptional contributions to cardiovascular medicine, including designing and implementing randomized clinical trials and outcomes research projects. She has also focused on personalized medicine and developed individual risk scores for bleeding and acute kidney injury.
Researchers discovered a new way to enhance light emission in nanoparticles, leading to the visualization of infrared radiation. The technique, which involves simultaneous excitation with two near-infrared beams, could have applications in microscopy and photonic technologies.
A multi-omics study identified a key RNA-driven network behind colorectal cancer progression and immune resistance. Restoring a specific long non-coding RNA (lncRNA) expression reactivated tumor suppressor genes and enhanced immune cell infiltration, promoting anti-tumor effects.
Researchers at Salk Institute discover a new microprotein, SLC35A4-MP, that regulates mitochondrial structure and function in brown fat tissue. The study reveals the microprotein's role in maintaining healthy cellular metabolism and regulating body temperature.
Researchers have developed new PET tracers to monitor immune responses and inflammation beyond the lungs throughout the course of SARS-CoV-2 infection. These breakthroughs offer a new way to visualize changes in lymph nodes, spleen, and bone marrow, supporting faster and more comprehensive imaging.
The system uses magnetoelectric power-transfer technology to deliver precise electrical stimulation to organs like the heart and spinal cord. The more devices in the network, the more efficient it is, offering a less invasive alternative to traditional implantable medical devices. This technology has potential for treating conditions s...
A new multi-objective optimization algorithm, PNSGA-II, was introduced to optimize the optical path length and ratio of optical path length to volume of multi-pass cells. The designed cell achieved an optical path length exceeding 80m, significantly improving LITES sensor sensitivity.
Researchers developed satellite pixel-scale estimation models to quantify aquatic vegetation coverage and area, addressing challenges in ecological monitoring. The models offer a powerful tool for long-term analysis of lake ecosystem dynamics and carbon sink assessments.
Researchers developed a photocatalytic system using single-atom platinum on carbon nitride to co-produce hydrogen and lactic acid from lignocellulose. The catalyst achieved higher hydrogen production rates and higher conversion yields of lactic acid, offering a scalable and sustainable solution for clean energy and chemical production.
The study develops a novel polarimetric binocular three-dimensional imaging method leveraging multi-feature self-supervised learning. It simultaneously improves image clarity and enables accurate depth estimation in turbid water, a critical advancement for marine exploration.
Researchers at Michigan State University have developed a hydrogel that can be applied to the scalp before chemotherapy treatment, helping to restrict blood flow and prevent hair loss. The temperature-responsive gel is designed to be easily washed off once treatment is complete.
Researchers in Chinese cities have found a distinct chemical regime governing the formation of secondary organic aerosols, driven by high VOC concentrations and gaseous nitrous acid. This shift is attributed to complex interactions between atmospheric environmental factors, which accelerate SOA formation and intensify regional pollution.
MIT researchers developed a sustainable electrolyte that quickly breaks down when submerged in organic solvents, allowing for easy recycling of components. The new material could revolutionize the battery industry by simplifying the recycling process and reducing electronic waste.
A new study published in PNAS reveals how prostate tumors respond to treatment by identifying key cellular features. The researchers created a comprehensive cellular atlas of mouse prostates using single-cell RNA sequencing, multiomics, and spatial transcriptomics, which provided insights into the progression of human disease.
Researchers at Cranfield University have developed a DNA-free gene editing technique for raspberries, which could lead to the creation of more sustainable and resilient varieties. The new method uses CRISPR-Cas9 technology to edit the genome of raspberry protoplasts, resulting in faster breeding times and reduced food waste.
The PREVENT equations provide more accurate risk estimates and support personalized treatment for adults with high blood pressure. The new guidelines recommend using the PREVENT equations to tailor and personalize preventive care, aiming to achieve marked improvements in patient outcomes.
Climate experts Svante Bodin and Örjan Gustafsson recommend reforms to increase responsiveness, improve communication channels, and tailor scientific outputs to pressing policy needs. The proposed changes aim to unlock the combined potential of IPCC and UNFCCC, enabling more effective climate action.
A recent survey by Ohio State University Comprehensive Cancer Center found that 80% of Americans are unaware of the lack of noticeable symptoms in early-stage prostate cancer. The disease is treatable if caught early, and regular screening is crucial.
A new exosome-based therapeutic agent has been developed to treat traumatic CNS injuries, alleviating neuronal apoptosis and restoring glial homeostasis. The treatment, SeNExo, promotes neuronal repair and reduces oxidative damage, showing potent therapeutic benefits in mouse models.
Researchers at Purdue University develop atomic-scale spectroscopy using ultrathin 2D materials, enabling improved resolution for NMR spectroscopy. The breakthrough has potential applications in quantum computing and quantum communications.
Researchers at Rice University developed a mathematical model that sheds light on ovarian aging and menopause timing. The study reveals synchronized and predictable patterns of follicle depletion, accelerating during midlife, which helps explain why menopause typically occurs at similar ages for most women.
A new approach to the Chan-Evans-Lam reaction enables the synthesis of multiple natural products, including novel vinylic ethers. This breakthrough expands the potential for complex, biologically active compounds in drug research.