Researchers from NUS Medicine and St. Jude Children's Research Hospital have discovered how blood cells release S1P, a key signalling lipid, into the bloodstream. S1P plays a crucial role in keeping blood vessels healthy and supporting normal cell function. The study used cryo-electron microscopy and computer simulations to capture a d...
A short mitochondrial protein, STMP1, helps maintain the heart's energy-producing structures and protects against inflammation and failure. Researchers found that restoring STMP1 or blocking inflammation can significantly protect heart function.
Researchers developed a bioinspired lipid nanoparticle that delivered gene-editing machinery to the liver, reducing low-density lipoprotein (LDL) cholesterol by over 20% and showing fewer signs of inflammation and toxicity. The nanoparticles also demonstrated positive effects on inflammation and healthy blood flow in cell experiments.
A global study led by the Institute for Health Metrics and Evaluation found that road injuries in Singapore resulted in 9,680 years of healthy life lost in 2023. The study also highlights the need for safer roads, vehicles, and enforcement to prevent deaths and serious injuries.
Researchers discovered a 'master switch' driving tumour growth in aggressive breast cancer and a targeted drug slowing tumour growth. The drug reduced cancer cell viability and tumour growth by 40-60% and extended survival in laboratory models.
A new study by NUS Medicine tracked the professor's physiological changes over time, introducing a personalized regimen of fasting, exercise, and nutrition. The DELTA study found significant improvements and challenges traditional approaches to health monitoring, focusing on function rather than static markers.
A multi-year strategic partnership aims to advance longevity science, understanding the connection between skin ageing and systemic health indicators. The collaboration seeks insights into how skin influences overall quality of life.
A global study led by NUS Medicine found that Singaporeans have the highest life expectancy and healthy life expectancy, but a growing number of years are spent in poor health. The morbidity gap has widened globally, with people spending more years lived with illness or disability.
The report documents Singapore's journey and approach toward urban heat resilience, examining a sustained, multi-stakeholder response. It identifies six key dimensions of a coordinated response, including high-level political commitment, science partnerships, and community empowerment.
The Aileen Wee Professorship in Liver Diseases aims to catalyse partnerships between experts and address cancer and healthcare challenges. Prof Aileen Wee, a renowned authority in hepatobiliary pathology, will lead the professorship.
A large study of nearly 40,000 women found that plant-based diets with lower insulinemic potential can help women manage their weight and reduce the risk of obesity during menopause. Women who followed a diet rich in whole grains, nuts, legumes, and vegetables had a significantly lower risk of developing obesity.
The Lancet MedZero platform offers product-level carbon data for hospitals and health systems worldwide, enabling evidence-based decision-making and supporting climate action. With over 14,000 entries launched, the platform aims to help healthcare institutions reduce waste, improve patient care, and tackle climate change.
The partnership aims to generate evidence on the potential of MitoQ to slow or improve markers of biological ageing and support longevity. Mitochondria-targeted antioxidants like MitoQ are crucial in producing energy while reducing oxidative stress, a key contributor to ageing.
Researchers have found that combining pembrolizumab and lenvatinib shows promise in treating recurrent clear cell ovarian and endometrial cancers with poor responses to standard treatments. The LARA trial provides encouraging responses for patients with this rare and difficult-to-treat cancer subtype.
Researchers developed a method to estimate vascular age from consumer wearables' PPG signals, predicting accurate results with a mean error of six to seven years. The technique uses a deep learning model and may lead to earlier detection of cardiovascular risk and more effective preventive care.
International researchers have developed a checklist of best practices for cancer microbiome research, emphasizing the importance of preventing contamination and validating findings. The guidelines aim to improve reproducibility and confidence in the field, supporting future discoveries about microbes and cancer.
A NUS Medicine study reveals that caffeine can restore social memory impaired by sleep deprivation. Caffeine targets a specific brain pathway to reverse disruptions in neural communication and plasticity. The study provides insights into the effects of caffeine on cognitive function and memory.
Singapore's breast cancer incidence is rising, but mortality rates are falling, mirroring global trends. The country's strong healthcare system and high-screening participation have contributed to improved survival rates.
The MOH–NUS Postgraduate Fellowship in Biomedical Ethics aims to equip healthcare professionals with knowledge and understanding of biomedical ethics, ethical analysis and reasoning. The first awardee, Ms Kwek Shi Qi, will conduct a research project to map barriers and drivers for nurses mediating ethical conflicts in frontline work.
The study found that the intranasal vaccine booster Clec9A OMNI induced significantly stronger neutralising antibody responses and robust T-cell responses in the lungs and nasal tissues, offering robust protection against SARS-CoV-2 Omicron infection. This breakthrough may address current shortcomings of COVID-19 mRNA vaccines, includi...
The new Concurrent Degree Programme combines Bachelor of Science (Nursing) with Master of Science (Biomedical Informatics), equipping nurses with strong capabilities in clinical practice and informatics. Graduates will confidently use complex digital systems and apply insights in real-time to deliver high-quality patient care.
The NUS-IHME Global Burden of Disease Research Centre aims to bridge the gap between longevity and healthy ageing by examining the impact of extreme heat, antimicrobial resistance, and other environmental shifts. The centre will provide critical data and insights to inform health strategies across Southeast Asia.
Researchers at NUS Medicine discovered that genetic vectors can efficiently spread antibiotic resistance within the gut, enabling even highly virulent bacteria to acquire drug resistance. This finding sheds light on the emergence of 'superbugs' in healthcare settings.
The ŌURA–NUS Joint Lab combines wearable biometric data with sleep science expertise to study how sleep and physical activity shape long-term health outcomes. The lab aims to generate insights that help individuals, clinicians, and health systems shift from reactive care to proactive preventive health.
Researchers propose a neuroscience framework explaining how motivation fundamentally reshapes memory. Two motivational moods - an interrogation-driven mood supported by dopamine and an imperative-driven mood supported by noradrenaline - are associated with different neural contexts, determining the type of memory formed.
Researchers at NUS Medicine have found a critical driver of neural stem cell function during ageing, called DMTF1. Restoring DMTF1 expression can restore neural stem cell regeneration capabilities in aged brain cells.
The Global Centre for Asian Women’s Health has partnered with NUS Medicine to host the Women’s Health Impact Tracking (WHIT) platform, which measures progress on closing the women’s health gap across a set of conditions and countries. The platform provides clear, comparative insights to support decision-making and inform policies.
Researchers discovered that calcium alpha-ketoglutarate restores key memory-related brain functions disrupted in Alzheimer's disease. The molecule enhances synaptic plasticity, protects neurons from degenerative changes, and supports healthier cognitive ageing.
Researchers found that methylene blue can reverse brain damage caused by cerebral malaria and identified a nine-gene blood signature to diagnose the disease. The study's findings offer new clues on immune processes involved in brain injury and suggest potential for early intervention and clearer treatment decisions.
Researchers found that Asian and Singaporean women with PCOS have better reproductive outcomes, including higher pregnancy rates and oocyte retrieval per cycle, compared to women without PCOS. Women with PCOS tend to maintain a higher ovarian reserve as they age, allowing for more robust responses to fertility treatment.
Associate Professor Shefaly Shorey has been appointed Editor-in-Chief of Midwifery, a leading international journal in midwifery and maternal health. She aims to champion high-quality, compassionate care through evidence-based practice, honours dignity, strengthens equity.
The study used advanced neuroimaging methods to identify early, network-level changes in over 3,000 individuals at varying levels of risk for psychosis. Individuals at high clinical risk exhibited early disruptions in brain network organisation despite mild clinical symptoms.
Researchers found that short and irregular weekday sleep significantly disrupts glucose metabolism, increasing type 2 diabetes risk. Even with extended weekend sleep, the body's ability to process glucose is impaired. Regular sleep patterns are crucial for glucose regulation and may impact the development of insulin resistance.
A new scholarship has been established at NUS Medicine to support students in the Master of Clinical Mental Health and Psychotherapy programme, enabling them to train as mental health professionals. The S$3 million gift from the Elaine and Eduardo Saverin Foundation will cover tuition fees and provide a monthly stipend for 18 months.
Researchers developed an RNA-based therapeutic strategy targeting mutant KRAS genes, stimulating the immune system to attack tumours. The treatment, combining antisense oligonucleotides and immunomodulatory RNA, effectively killed cancer cells in laboratory studies, reducing tumour burden and extending survival.
Researchers have demonstrated that doxycycline can improve survival rates and neurological outcomes in children with Central Nervous System Tuberculosis. The study found that treating CNS-TB laboratory models with doxycycline alongside standard TB drugs suppressed inflammation, preserved brain tissue, and improved vascular integrity.
Researchers from NUS Medicine and CHA University have developed AI-assisted diagnostic tools for male infertility, identifying hidden patterns in clinical data. A novel compound, MIT-001, has been shown to reverse age-related embryo decline by targeting ferroptosis, a form of cell death driven by iron and oxidative stress.
Researchers at NUS Medicine found that social interactions trigger memory-enhancing signals to the CA1 region of the hippocampus through metaplasticity, strengthening 'memory proteins'. Regular social interactions are crucial for this process, as time-limited effects suggest.
Researchers found that certain individuals can carry large amounts of antibiotic-resistant E. coli ST131 without symptoms and unknowingly pass it on to household members. The study suggests that these
A study published in the Journal of Neuroscience found that mutations in the CHRNA3 gene are associated with lowered sensitivity to alcohol and delayed avoidance behavior. This suggests that normal function of the chrna3 gene helps control alcohol exposure, leading to individual differences in alcohol sensitivity.
BH3 mimetics demonstrate potent anti-cancer activity by targeting pro-survival BCL-2 proteins, effectively eradicating leukaemia cells with complex mutations. The review highlights several important findings about BH3 mimetics and their role in treating acute myeloid leukaemia.
The new Molecular Imaging and Theranostics Centre at NUH and NUS Medicine enables faster, safer and more precise diagnoses, while researchers can observe real-time tracer movement throughout the body. This opens possibilities for validating next-generation diagnostics and therapies, advancing theranostics.
Researchers have developed a new mRNA vaccine technology using albumin-recruiting lipid nanoparticles to deliver vaccines precisely to lymph nodes, avoiding liver toxicity. The approach outperformed traditional delivery systems in laboratory tests, producing strong antitumor T-cell responses and high levels of neutralizing antibodies.
The new centre supports multiple clinical trials in parallel, enabling comprehensive evaluations of organ health across physiological systems. It also provides hands-on training opportunities for healthcare professionals, bridging the gap between theoretical knowledge and practical application.
Researchers have developed a new technique called Dual transposon sequencing to rapidly identify genetic interactions in bacteria. This method reveals vulnerabilities that could be targeted by future antibiotics.
Researchers developed a novel RNA-based therapy using lipid nanoparticles to silence a gene causing ceramide buildup in the liver, reducing inflammation and scarring. The treatment shows promise for millions of patients worldwide and could eventually benefit those with heart disease, obesity, and diabetes.
The NUS Medicine will receive a S$2 million grant from Novo Nordisk Foundation and Temasek Foundation to strengthen microbiology testing for severe bacterial infections across Asia. The DETECT-Asia programme aims to combat antimicrobial resistance, which is driving socio-economic inequity and claiming millions of lives globally.
The Singapore government has launched a nationwide initiative to help seniors age well through dance, combining movement, rhythm, and storytelling. The program, co-developed by NUS Nursing and Lions Befrienders, benefits over 280 seniors with improved physical health, cognition, and emotional well-being.
Researchers developed an engineered strain of gut-homing bacteria that induces mature tertiary lymphoid structures, associated with improved survival and stronger treatment responses. The therapy also restored healthy gut microbiota and showed excellent biocompatibility.
A new study by NUS-MOH reveals Singapore's healthcare system is more sustainable than previously estimated, with world-class healthcare at 20% lower carbon intensity. The report provides crucial evidence on where healthcare emissions lie, enabling leaders to target reductions and safeguard patient care.