Researchers have identified tyrosine phosphatase 1B (PTP1B) as a key molecular target in immunogenic cell death (ICD), a type of regulated cell death that activates the immune system against cancer cells. Two platinum-containing compounds, Pt-NHC and PlatinER, trigger ICD by blocking PTP1B's enzymatic activity.
A team of researchers proposes a transdisciplinary approach to address antimicrobial resistance by developing integrated modelling architectures. The current mathematical modelling approaches lack translation from science to policy due to fundamental gaps in data and knowledge.
Financial incentives have shown promise in promoting pro-social and health-promoting behaviors, but challenges persist, including ensuring additionality, monitoring compliance, and addressing social equity concerns. The review highlights key findings on the effectiveness of cash rewards, non-cash incentives, and conditionality in One H...
Researchers from Dalian Institute of Chemical Physics determined the structural motifs of water undecamer cluster, including three low-energy configurations. The study provides crucial insights into the evolution of water's hydrogen-bond network and paves the way for size-dependent studies on solvation processes.
Researchers mapped out the structure of a key player, augmin, in exhaustive detail, revealing its role in plant cell division and shape regulation. The study's findings could lead to new medical treatments and strategies for breeding higher-quality rice and cotton crops.
Researchers developed a novel lab-based tick feeding system that enables controlled studies on tick physiology, microbiome dynamics, and pathogen acquisition. The platform supports the feeding and reproduction of bush ticks without animal hosts.
A new clinical study aims to improve communication between patients and families about genetic risks of colorectal cancer. The trial will compare two methods of sharing genetic test results with close relatives, with the goal of learning which approach helps more family members get necessary genetic testing.
Researchers developed a spray shield that adheres to transplant organs using mussel-derived adhesive protein, reducing immune rejection and its side effects. This innovation enables targeted delivery of immunosuppressants directly to the transplanted site, increasing success rates in xenograft transplantation.
A coalition of experts warns that carbon markets may be penalizing First Nations' long-term stewardship due to their 'additionality' requirements. The definition of 'additionality' often rewards restoration on degraded land, excluding protected ecosystems and traditional owners' custodianship.
Preclinical studies reveal that MR hinders cell proliferation, triggers cell cycle arrest, and enhances standard treatments. Early-phase clinical trials report positive results on safety and tolerability, suggesting utility of MR as a complementary treatment strategy.
Researchers have uncovered the microscopic mechanism of alkali species dissolution in water clusters using a new spectroscopy station. The study found that only three water molecules can separate Ba and OH in neutral BaOH clusters, and this process is facilitated by hydrogen bonding and electrostatic interactions.
A new report from the University of East Anglia warns that charities using AI-generated images risk breaking the fundamental bond of trust with the public. The study found that when AI images are used, the humanitarian cause disappears from the conversation, and the public engages with charity rather than the cause itself.
A new study by King's College London found that specialist palliative care can reduce NHS costs by up to £8,000 per person and improve quality of life. Home-based specialist palliative care was associated with reduced costs, while hospital-based care also showed cost savings.
A study found a significant decrease in acetaminophen use during pregnancy and a surge in leucovorin prescriptions after the September 2025 White House briefing. Leucovorin prescriptions increased approximately 71% above expected levels, mainly for children with autism diagnoses.
Researchers discovered that CBD and CBG can significantly reduce liver fat and improve metabolic health by creating a backup energy reserve and restoring cellular cleaning crews. These compounds also showed promising effects on treating metabolic diseases, including reducing body fat mass and improving insulin sensitivity.
Researchers propose a new measure for recovery from substance use, recognizing incremental progress, to reduce stigma and improve quality of life. The study found strong associations between proportion of remission and quality-of-life measures, suggesting a paradigm shift in how recovery is measured.
Researchers developed a method to convert waste plastic mulch film into useful chemicals through catalytic pyrolysis. The study found that temperature controlled the product distribution and long-term stability of the catalyst, with optimal conditions producing valuable olefins and easily regenerable tar.
A recent study in mice has identified the brain circuits responsible for why we help others, finding a common neural basis in parenting and prosocial behavior. The research suggests that evolution may have linked the biological drive to care for offspring with the urge to comfort distressed peers.
A new injection therapy uses self-amplifying RNA to prompt the body's release of the natural heart-protective hormone ANP for several weeks. This approach aims to reduce harmful scarring, preserve healthy heart muscle and improve heart function after a heart attack.
The 22nd Carbon Research International Forum will examine the benefits of organic carbon amendments for improving soil health and sequestrating carbon in agricultural systems. Researchers will discuss recent approaches to managing organic carbon inputs in soils to support both productivity and climate outcomes.
Research reveals complex interactions between soil microbes, viruses, and microplastics, influencing soil health and ecosystem recovery. Innovations such as phage-assisted microbial augmentation aim to enhance plastic degradation in soils.
Sarah and Ross Perot, Jr. received the 2026 Legacy Award for their vision and leadership in supporting brain health initiatives, particularly for U.S. military service members and veterans. The award honors their commitment to elevating human potential and cognitive resilience.
Researchers identified a drug-and-supplement combination therapy that reduces senescent cells, inflammation, and injury in diabetic kidney disease. The treatment approach involves senolytics, which selectively target senescent cells.
A new study from Memorial Sloan Kettering Cancer Center reveals that analyzing a patient's genomic profile can predict breast cancer resistance to CDK4/6 inhibitors. The researchers found that inheriting a BRCA2 mutation and other genetic alterations increase the likelihood of resistance. This discovery provides a new strategy for pred...
A study found that improving the gap between biological age and chronological age is associated with a lower risk of stroke and improved signs of damage in the brain. Participants who narrowed their biological age gaps were 23% less likely to have a stroke, while those with larger gaps had worse brain scans and higher risks.
A new study reveals Americans' doubts about driverless cars go beyond safety concerns, with many fearing mass job losses and widening income inequality. Over six in ten adults would probably or definitely avoid riding in a self-driving car.
A team at Rice University developed a new type of electric heating element using carbon nanotube fibers, which deliver more heating power per unit mass than conventional metal-alloy heaters. This innovation has the potential to electrify industrial heating, a critical step toward reducing carbon emissions.
A study predicts that forest damage in Europe will more than double by 2100 due to increased wildfires, storms, and bark beetle activity. The team used AI-based simulation models to estimate the impact of global warming on forest ecosystems.
Researchers at UC San Diego discover a new way to re-educate the immune system to attack ovarian cancer tumors by blocking protein FAK. The study offers hope for developing better treatments by turning the tumor environment from immune-suppressing to immune-activating.
A new report finds that nearly nine in 10 primary care providers use standardized paper assessments, but are interested in adopting digital cognitive assessments. The surveys revealed key priorities for enabling broader adoption, including providing more support to clinicians.
A comprehensive review synthesizes the science behind vagus nerve modulation therapies, which use controlled signals to influence brain circuits and inflammation. The authors identify key mechanisms and propose next-generation treatments tailored to individual patients and conditions.
Researchers at Stanford University have developed a promising approach to using well-studied semiconductors to improve infrared light-emitting diodes and sensors. The new technology has the potential to lead to smaller, sleeker, and less expensive infrared devices with improved defect tolerance.
Researcher Dr. Julia Jennifer Beine uncovers forgotten translator Ljuba Metzl of the Salzburg Festival play Cenodoxus, shedding new light on her story. Metzl's translation is now lost, but her biography reveals a talented young philologist who was overlooked by history.
Researchers at University of Rochester discover that learning makes brain cells work together, sharing information to improve sensory perception. This coordinated effect only appears when subjects are actively performing a task and making decisions based on what they see.
Researchers created an ideal glass material through mathematical modeling, exhibiting enhanced properties like high melting point and resistance to breaking. This discovery could lead to new materials with desirable properties, revolutionizing manufacturing processes for various industries.
Researchers at WashU Medicine have developed a new cellular immunotherapy that uses brain cells called astrocytes to clear away dementia-related proteins, such as amyloid beta. The treatment requires just a single injection and has shown promise in mice by reducing the amount of plaques in half.
Researchers use mathematical calculations to recreate lightning-like discharge in everyday materials like acrylic and quartz. The study could enable the study of a powerful natural phenomenon at a lab bench and potentially lead to advances in meteorology and X-ray sources.
A new study demonstrates that blocking a signaling protein called FAK helps mobilize an anti-tumor immune response, allowing tumor-fighting cells to approach tumors and shift the behavior of other immune cells to work against them. This approach achieved the best effects on immune cell recruitment, tumor size reduction, and survival ti...
New Jersey Institute of Technology researchers are developing AI-powered solutions to analyze prosthetic limb data and reduce skin issues in veterans. The AI system aims to improve comfort and reduce complications in patients with lower limb loss.
Forest damage in Europe is projected to increase by up to 20% by 2100 under all climate scenarios. Annually disturbed forest area could rise from 180,000 to 370,000 hectares per year, increasing pressure on other sectors to reduce emissions.
Researchers found that inhibiting glucose transport can overcome tumor resistance to chloroquine treatment by inducing mitochondrial damage and oxidative stress. The study suggests a new combination therapy strategy for treating lung squamous cell carcinoma and subsets of adenocarcinoma with limited treatment options.
Researchers at Worcester Polytechnic Institute developed an AI tool that analyzes brain scans to predict Alzheimer's disease. The method is accurate in detecting the disease among normal brains and those with mild cognitive impairment, highlighting key anatomical changes such as volume loss in the hippocampus and entorhinal cortex.
The Antscan platform combines innovative 3D imaging and AI to digitize over 2,200 ants from museums and private collections. The resulting 3D images enable researchers to investigate biodiversity, shape-genome variation, and environment in a new way.
A unique hornwort plant-derived Rubisco subunit enables clustering into carbon-concentrating structures, increasing CO2 levels and improving photosynthesis efficiency. This breakthrough innovation offers a potential solution to boost nutrient efficiency and yield in agricultural crops.
A combination of GLP-1 receptor agonist semaglutide and bimagrumab results in greater weight reduction while preserving lean mass in adults with obesity. The therapy combination addressed lean mass loss associated with GLP-1-based therapies, showing substantial weight loss over 72 weeks.
New research finds that chromosomal inversions help Atlantic silversides maintain genetic differences suited to cold and warm waters, influencing growth rates and vertebrae numbers. This discovery suggests a fundamental role for chromosomal inversions in local adaptation and may shape population responses to ocean warming.
Scientists developed a photonic crystal light sail with high reflectivity and low mass, enabling faster travel across the solar system. The structure features a narrow photonic band gap centered at the propulsion wavelength, resulting in high reflectivity within that spectral window.
A new genomic study of koala populations found that rapid demographic rebound restores genetic variation and drives recombination, easing the harmful effects of inbreeding. This recovery is driven by recombination, which shuffles existing genetic material into new combinations, helping to restore functional diversity.
Researchers at NYU Langone Health found that herpes simplex virus uses protein ICP4 to make human cell nuclei more fluid-like, allowing for faster replication. This makes the nucleus easier for the virus to copy itself and increases production rate of new viral copies
A recent study analyzing koala genomes found that populations previously considered most at risk are now showing signs of genetic regeneration. The research, published in Science, challenges long-held assumptions about genetic risk in endangered species.
A study by Dr Marigo Raftopoulos found that 71% of professionals think AI performs 'very' or 'extremely' well due to its ability to save time and improve processes, accuracy and efficiency. However, 84% are concerned about the risks associated with AI, including cyber security, job losses, and military uses.
A new Cornell University study reveals that exposure to diverse microbes and allergens as adults may worsen the development of allergic airway inflammation compared to newborns. Researchers found a break point where protection from microbial exposure might wane, depending on life stage and timing.
Researchers have developed genetically altered astrocytes that express chimeric antigen receptors (CARs) capable of clearing accumulations of amyloid-β in the brains of mice. These CAR-expressing astrocytes, called CAR-A, substantially reduced Aβ buildup and prevented disease progression in a mouse model of Alzheimer’s disease.
A new study by the SETI Institute suggests that stellar activity and plasma turbulence near a transmitting planet can broaden an otherwise ultra-narrow signal, spreading its power across more frequencies. This makes it more difficult to detect in traditional narrowband searches.
Researchers found a set of light-sensing genes essential to pineoblastoma formation in the developing pineal gland. They extended the finding to medulloblastoma and retinoblastoma, indicating a common developmental state and potential shared therapeutic dependency.
A new study reveals that apocalyptic thinking is no longer fringe and significantly influences how people interpret and respond to global threats. Beliefs about the end of the world are diverse and predict how individuals perceive and react to risks like climate change, pandemics, and emerging technologies.
Researchers discover a unique protein component, RbcS-STAR, that helps concentrate carbon dioxide around Rubisco, boosting photosynthetic efficiency. This breakthrough could lead to more sustainable food production by improving crop yields while reducing environmental impact.
Researchers from Hospital for Special Surgery (HSS) conducted three studies on osseointegration, a surgical procedure attaching prosthetic limbs directly to bone. The studies found substantial improvements in mobility and patient satisfaction for both femur- and tibia-level amputations, challenging prevailing beliefs about patient bene...
A new study predicts increasing wildfires and insect outbreaks in European forests due to climate change, altering landscapes and biodiversity. The model simulates changes in forest disturbance rates under three climate scenarios, with wildfire and bark beetle outbreaks projected to intensify.
A new method has been developed to enable nondestructive diagnosis of the electrolyte in rechargeable batteries through the battery casing using special nuclear magnetic resonance techniques. The technique, known as ZULF NMR, allows for the direct detection and quantification of electrolyte components without damaging the battery.