A randomized trial found that etomidate is safe to use and significantly decreases the risk of dangerously low blood pressures during tracheal intubation compared to ketamine. This new evidence supports the use of etomidate as a safer alternative for critically ill adults.
Researchers at Brown University have created a bioluminescence tool that enables the measurement of activity in living brain cells without damaging them. The CaBLAM tool uses bioluminescent light production to capture single-cell and subcellular activity at high speeds, allowing for longer recordings and reducing hardware requirements.
A phase two trial found that adding dinutuximab beta to chemotherapy improves the best objective response rate and overall survival time for children with relapsed or refractory neuroblastoma. The treatment resulted in a significant increase in patients' tumors shrinking after six cycles of treatment.
Scientists have developed a new approach to analyzing polarization data, offering a more accurate understanding of complex materials. The elliptical vectorial metrics model simplifies the interpretation of polarization information, improving biomedical imaging and material design.
Cliff Megerian, MD, FACS, received the Sam Miller Goodness Award for his compassionate care, world-class research and relentless commitment to kindness. The Values-in-Action Foundation recognized UH's dedication to making Northeast Ohio a better place.
A new study reveals that global measures of food insecurity, such as the Integrated Food Security Phase Classification System, tend to understate the severity of hunger crises. The researchers found that up to 66.2 million people, or one in five, may be going uncounted due to conflicting data and conservative assessments.
Researchers developed a mouse model replicating human GI problems in DM1, uncovering a key mechanism and opening the door to new treatments. The study found that food moved slower through the intestines and colon of mice lacking MBNL proteins, suggesting constant muscle contraction.
A secondary analysis of the WISDOM trial found a substantial number of women with clinically actionable genetic variants, many not qualifying for current guidelines. This study supports broader access to genetic testing for personalized breast cancer risk assessment.
Researchers at Arizona State University introduce powerful tools to analyze microbial family trees and biological data, strengthening microbiome research, disease tracking and environmental monitoring. The new software library scikit-bio provides a foundation for analyzing large biological datasets.
Researchers at Penn State have identified a deliberate imbalance in the shape of viral shells that helps them infect their hosts. The 'loaded die' design creates a spring-loaded genome that positions genetic material precisely, allowing viruses to rapidly hijack host machinery and replicate.
The Kinsey Institute invites researchers to apply for competitive awards providing in-person access to its extensive library and special collections on topics including sex, relationships, gender, and human behavior. Applications are due February 13, 2026.
Researchers found that indoor tanning users in their 30s and 40s have more skin mutations than people twice their age, particularly in areas exposed to tanning beds. This can lead to an increased risk of skin cancer, including melanoma.
A new study led by Northwestern University finds that tanning bed use increases melanoma risk by almost threefold, with DNA changes detected in areas protected from sun exposure. The study's findings support a broader field of DNA injury caused by tanning beds.
Recent studies explored novel biomarkers for kidney cancer spread detection, heart scans for ATTR amyloidosis diagnosis, and radiation therapy delivery for neuroendocrine tumors. Additionally, researchers developed a new PET tracer to track heart-healing cells after a heart attack.
The University of Toronto has launched Electric Vehicle Innovation Ontario (EVIO), a partnership between industry and academia to develop next-generation electric vehicle technologies. The program will generate over $30 million in economic activity, expand firm-level R&D capacity, and create new Canadian intellectual property.
Researchers suggest melatonin may play a significant role in managing SLE and its complications, including lupus nephritis. Studies have shown melatonin can reduce renal inflammation and oxidative stress, but more robust clinical trials are needed to confirm its effectiveness.
A study published by Michigan Medicine suggests that AI can help increase the chance of people with risky drinking patterns or signs of alcohol use disorder getting outreach and help. The NLP tool analyzed full text of health records and identified over 47,500 patients with some sign of risky drinking.
Biologists have discovered that the talin protein is crucial for successful cell adhesion in animals, a mechanism likely developed from single-celled organisms. The study reveals the evolutionary conservation of this ancient adhesion mechanism, providing new insights into the origins of animal tissues and organs.
The WISDOM randomized clinical trial found risk-based breast cancer screening to be equally effective as annual screening in detecting advanced cancers. However, it did not reduce breast biopsy rates. The study suggests a safer and more efficient approach to breast cancer screening.
Scientists developed an objective index for monitoring and detecting shear lines over the Philippines, accounting for up to 20% of extreme rainfall days. The detection method is useful for weather forecasting, early warning systems, and understanding how this weather system evolves.
A study from Rangsit University shows that a simple bypass protocol guided by mean transit time can improve symptoms in 80% of patients with chronic cerebral occlusion or moyamoya disease. The protocol uses non-stress testing to evaluate cerebrovascular reserve and predict postoperative improvement.
This study resolves atomic structures of NPFFR1-Gi complexes using cryo-EM, demonstrating a 'message-address' binding mechanism. RFRP-3 binds ~20-fold more potently than NPFF due to stabilizing contacts with ECL2 and TM3/TM4. Novel ligands could enhance analgesic efficacy while mitigating opioid tolerance and dependence.
This study reveals that macrophages in the pleural cavity contribute to cancer progression by infiltrating lung tumors and suppressing anti-tumor immunity. Genetic ablation of these macrophages suppresses tumor growth, highlighting their pro-tumorigenic function.
Researchers at AIMR discovered that Europium substitution in Cu2O catalysts allows for selective control of electrochemical CO2 reduction products. By leveraging the Eu3+/Eu2+ redox couple, they demonstrated how subtle changes in electronic structure can favor either C-C coupling or deep hydrogenation.
The study demonstrates a significant association between the overall asynchrony index (OAI) and patient outcomes in COVID-19-associated severe pneumonia. Patients with a high asynchrony burden had significantly higher intensive care unit mortality and fewer ventilator-free days, highlighting the importance of PVA monitoring.
Researchers at HKU developed an AI-driven brain model that accurately captures fear in real-world scenarios, offering new hope for targeted therapies. The discovery showed oxytocin specifically reduces both subjective fear and neural signature in social contexts.
A new policy paper highlights five critical areas for advancing data-driven policymaking to curb the rising burden of non-communicable diseases in Europe. The paper emphasizes the need for inclusive data collection, solid governance, and real-time policymaking to address inequalities and ensure equitable healthcare.
A large-scale study identified risk factors and clinical features of ICI-ITP, a rare but serious complication of anti-cancer immunotherapy. The study found that patients with ICI-ITP tend to have lower platelet counts at the start of treatment, experience additional immune-related adverse events, and have a higher risk of death.
Researchers have developed a novel nanomedicine, mPEG@ELA-11, which demonstrates significant potential in treating atherosclerosis by suppressing macrophage foam cell formation and inflammation. The study found that mPEG@ELA-11 reduces atherosclerotic plaque area and necrotic core size compared to free ELA-11.
A global study found that patients with mature nodal T-cell lymphoma who relapsed within 12 months of initial treatment had worse survival outcomes, but improved survival when treated with targeted therapies instead of chemotherapy. The results suggest the need for personalized treatment strategies for high-risk patients.
A cross-sectional study found that state-level SNAP policies associated with higher program enrollment also lowered county-level food insecurity rates. The study suggests that these policies may help address rising food insecurity rates.
Researchers at LMU developed a new approach to molecular design for perovskite-silicon tandem cells, achieving an efficiency of 31.4%. The breakthrough involves using brominated molecules to neutralize defects and improve charge transport on rough surfaces, leading to higher efficiencies and increased stability.
The American College of Lifestyle Medicine (ACLM) praises two new CMS models, ELEVATE and ACCESS, which promote whole-person care approaches and flexible reimbursement. The ELEVATE model provides $100 million for evidence-based interventions, while the ACCESS model shifts payment to patient health improvements.
Researchers discovered that parasitic plants produce substances in their seeds that trigger the development of feeding organs, allowing them to attach to hosts quickly and effectively. This 'self-activation' mechanism enables parasites to infest hosts with high success rates, making them difficult to control.
A new research review found that avatar customization in video games can reduce gender dysphoria and increase gender euphoria in transgender players. The study suggests that games can be affirming spaces that support identity development, particularly for individuals with limited access to care.
Researchers found that IBD patients perceive pain as more unpleasant and intense due to fear learning, which is linked to the emotional component of pain. This suggests that psychological approaches, such as cognitive behavioral therapy, should be investigated for treating chronic abdominal pain in IBD patients.
A new study maps three decades of income inequality data globally, revealing worsening trends for half the world's population but 'bright spots' in regions with effective policies. Regional efforts such as investments in public health and education in India and cash transfer programs in Brazil show promise in reducing inequality.
Researchers found that glycation stress, caused by methylglyoxal, promotes aortic stiffening and cellular senescence. Natural compound Gly-Low, containing nicotinamide and alpha-lipoic acid, reversed these effects and reduced stiffness in aging mice.
Researchers have discovered that a single covalent bond between DNA and histone proteins can effectively lock the nucleosome, preventing it from moving or being remodeled. This study reveals how certain forms of DNA damage can rigidify chromatin and profoundly interfere with key genetic processes.
Researchers have made significant progress in treating non-small cell lung cancer (NSCLC) with targeted therapies, including tyrosine kinase inhibitors (TKIs) that target specific gene mutations. These treatments have shown effectiveness across various patient groups and improved outcomes for those with actionable mutations.
A new probabilistic metric has been developed to improve the assessment of user privacy in digital databases. The metric provides a more accurate measurement of protection levels by estimating the probability that one individual resembles another user based on the data set within the system.
A research team has mapped individual synaptic types in the hippocampus, a brain structure critical for learning and memory. The study provides unprecedented resolution of which proteins are present in each type of synapse and their quantities, revealing patterns that help explain how connections perform different functions.
In this study, researchers identified Fibulin-7 as a key protein produced by adipogenic stem and precursor cells that promotes AT fibrosis and disrupts metabolic homeostasis in obesity. The findings suggest that FBLN7 may represent a potential target for therapeutic intervention to alleviate diet-induced AT fibrosis.
A study from Michigan Medicine found that only 24% of public insurance patients and 30% of private insurance patients received primary care follow-up within one week of ICU discharge. Younger, healthier children were more likely to receive timely care. The lack of guidance led researchers to investigate this issue.
The international journal aims to leverage cutting-edge research findings to promote civil engineering's intelligent transformation. Key priorities include serving as an innovation hub, building an intellectual support base for strategic underpinning, and establishing a cross-disciplinary convergence platform.
A new research article reveals that the rules of use for Sámi reindeer husbandry create challenges for self-governance and adaptation to climate change. The rules were designed to promote sustainability but have not been effective in accommodating adjustments, leading to conflicts between authorities and herders.
A research team from City University of Hong Kong has developed innovative packaging material solutions using patented chemical additives to control material microstructures. This approach aims to improve the performance and production efficiency of advanced 3DIC packaging, enabling faster and more reliable connections in stacked chips.
Dr. Shannon McGarry's work explores eye tracking methodologies to monitor operator performance in complex environments. Her research aims to inform display and control system design, enhancing warfighter effectiveness.
Recent advances in synthetic biology enable optimized oncolytic bacterial therapeutics, providing safe, effective, and personalized cancer therapies. Three major induction strategies - exogenous input-responsive, autonomous bacterial signal-responsive, and tumor microenvironment-responsive gene circuits - enable precise regulation of b...
A new clinical trial found that varenicline, a medication for quitting nicotine, was effective in vaping cessation regardless of cannabis use. Cannabis use did not appear to be a barrier to successful vaping cessation, and participants who used cannabis had similar odds of achieving abstinence as those who did not.
The 2025 Global Rights Project report highlights troubling trends in worldwide inhumane treatment, with state-committed atrocities reaching an all-time high in 2022. The US is at high risk for mass atrocities due to its history of human rights violations and lack of commitment to international norms.
A mobile health intervention, Young, Empowered & Strong (YES), improved quality of life and symptoms in adolescent and young adult breast cancer survivors. The study found significant reductions in general and cancer-specific quality of life scores after six months.
Breast cancer survivors experienced significant improvement in perceived cognitive impairment with real acupuncture, outperforming sham acupuncture and usual care. Real acupuncture also showed benefits in objective cognitive function, particularly when compared to sham acupuncture.
Researchers identified a way to suppress daily fluctuations in immune cells' activity, which may prevent tissue damage during daylight hours. A drug that targets neutrophils was found to alleviate inflammation and protect against infections.
A new study suggests that nerve block may reduce the need for opioid medications to control postoperative pain in infants undergoing cleft palate surgery. The regional anesthetic technique, known as suprazygomatic maxillary nerve block (SMNB), was found to significantly lower opioid use and hospital length of stay.
A study by CNIC reveals that neutrophils, a type of immune cell, are less aggressive at night, resulting in less severe heart attacks. Researchers developed a pharmacological strategy to block the molecular clock in neutrophils, reducing their harmful potential during infarction.
The album marks a new era for the singer, exploring themes of performance, love, and empowerment. Scholars analyze Swift's shift from teen country singer to showgirl persona, finding optimism and hope in songs like 'Eldest Daughter' and 'Opalite'.
A matched prospective analysis of 676 women found that menopausal hormone therapy was not associated with an increased risk of breast cancer in those with BRCA mutations. This suggests a personalized approach to menopause management for these women, balancing the risks and benefits of MHT use.
Scientists have successfully replicated human neural circuits using assembloids, a type of miniature organoid derived from induced pluripotent stem cells. The study shows that the thalamus plays a crucial role in shaping cell-type specific neural circuits in the human cerebral cortex, promoting cortical growth and maturation.
A new study proposes a two-stage decision-making framework for lithium governance in Latin America, highlighting the role of external pressures, internal politics, and industry development. The research suggests that engagement strategies must consider these factors to succeed in the region.