Researchers discovered that plant proteins like OsNTP4 can assemble RNA chains directly from free nucleotides, challenging traditional RNA synthesis mechanisms. These proteins can generate RNA products without a template or primer, and their activity has been found to be intrinsic to the protein itself.
Researchers identified cell-type-specific circadian gene programs and phase-specific pathway activities in liver and skeletal muscle. The study provides evidence for a cell-type-resolved circadian landscape and candidate transcription factors, suggesting potential circadian therapeutic windows.
A 74-year-old Chinese man presented with persistent nail separation, which led to the discovery of subungual amelanotic melanoma. The lesion was initially misdiagnosed, but histopathological evaluation revealed atypical melanocytes, prompting treatment and successful removal of the tumor.
Exosome/sEV therapy may support re-epithelialization in diabetic wounds through direct and indirect mechanisms. However, evidence linking exosome/sEV treatment to coordinated epithelial-mesenchymal plasticity-associated state transitions remains limited.
Researchers developed a novel composite hydrogel film with controlled release of antioxidant phycocyanin, showing strong antibacterial activity and remarkable antioxidant capacity. The film's structure and release mechanism were optimized for sustained release and bioactivity retention.
A Central South University team developed a hybrid prediction model to give mobile robots a
Research found that micro-nano bubbles increase redox potential, enhance carbon, nitrogen, and phosphorus cycling genes, and reduce greenhouse gas emissions in waterlogged soils. This technology provides a low-cost green remediation pathway for waterlogged farmland.
DHHC13 controls lysosomal cholesterol egress through palmitoylating NPC1, a key enzyme in cholesterol transport. The modification of NPC1 by DHHC13 enables lysosomal localization and protein stability, maintaining cholesterol homeostasis.
A study found that biodegradable mulch film made from cow manure reduces fertilizer input by 30% while maintaining yield and improving soil health. The film promotes nutrient activation through microbially-mediated mechanisms, increasing nutrient availability and reducing pollution.
Large language models can generate well-structured lesson plans, but they often lack contextual awareness, differentiation, and pedagogical depth. AI tools can assist with initial organization, but final adaptation and application lie with teachers.
A systematic review of 13 studies finds that child-centered play therapy improves social interaction, communication, emotional regulation, and repetitive behaviors in children with autism spectrum disorder. The review highlights the benefits of AI and virtual reality in personalized intervention, with a proposed two-dimensional child-l...
Research reveals that positive electric fields better understand the plant's physiological network, promoting growth and improving photosynthetic efficiency. The study found that +HVEF enhanced stomatal conductance, increased chlorophyll content, and activated key photosynthetic enzymes.
Researchers developed a 3D numerical model of AEMWEs and optimized gas diffusion layer properties using active learning. The optimal configuration improved gas uniformity, heat transfer, and electrochemical performance. Permeability, electrical conductivity, and porosity were found to be crucial factors in mass transport and heat trans...
The study establishes a three-dimensional numerical model of AEMWEs and reveals the regulatory mechanisms of permeability, electrical conductivity, and porosity on mass transport and heat transfer. The optimal GDL parameter combination improves electrochemical performance and suppresses local heat accumulation.
A new model combines a Transformer backbone with physical constraints to predict SOH, achieving high precision and outperforming existing methods. The model's fusion of multiple features and incorporation of physical constraints significantly enhances its anti-interference ability.
High-throughput workflows enable highly integrated and programmed experiments to generate large, reproducible experimental datasets. However, limitations remain, including deviations between kinetic and non-kinetic control conditions, and the potential elimination of excellent catalysts under elevated pressures or induced activation.
Researchers developed a machine learning interatomic potential to explore γ-Al₂O₃'s structural landscape, revealing two low-energy configurations: γ-NAV and γ-AV. These models show significant disorder and abundant penta-coordinated Al³⁺ sites, which are preferred anchoring sites for Pt atoms.
Researchers at Shandong University of Technology and Dalian University of Technology report a nickel-cobalt layered double hydroxide electrocatalyst that selectively converts isobutanol to isobutyric acid. The catalyst exhibited significantly enhanced performance compared to monometallic hydroxide electrodes.
Researchers develop zirconium-modified LiMn₂O₄ film electrode to enhance selective lithium extraction from brine. The electrode exhibits improved structural stability and electrochemical kinetics, leading to increased lithium intercalation capacity and reduced manganese dissolution.
Researchers examine the research progress of electromagnetic induction heating in energy chemical processes, highlighting susceptor design and reaction coupling. Key findings include the use of carbon-based and macroscopic metal susceptors for efficient heating and reaction coupling.
Researchers developed a multi-step crosslinking strategy to improve CO₂ separation in MOF-based mixed matrix membranes. The approach enhanced CO₂ solubility and selectivity, while maintaining interfacial compatibility and improving mechanical properties.
The two-step process achieves a higher yield and produces no highly toxic byproducts, but consumes more oxygen and ammonia. The one-step process has a cost advantage and lower life cycle emissions, with potential for improved sustainability through catalyst development and process optimization.
Researchers found that pore size and silanol groups on silica carriers are crucial for efficient catalyst design. The Ni3P/SiO2-I catalyst achieved optimal performance with abundant Si-OH groups and large mesopores, promoting activity and selectivity.
Researchers studied n-hexane catalytic cracking over HZSM-5, finding that initial isomerization plays a crucial role in propylene and ethylene formation. The study revealed that isomerization pathway exerts opposing regulatory effects on ethylene and propylene production.
Researchers developed a multimodal AI model to predict octane numbers of fuel blends with high accuracy, outperforming conventional linear blending rules. The model achieved an R² of 0.9373 and an MAE of 4.04 for pure-component RON prediction, and 0.9736 and an MAE of 1.46 for mixture RON prediction. The model also enabled inverse fuel...
Researchers developed a multilevel structural regulation strategy to overcome impedance mismatch in CNTs, enabling broadband microwave absorption from 2-18 GHz. The optimized absorber demonstrated continuous reflection loss below -10 dB and effective absorption bandwidth of 16.0 GHz.
A comprehensive review highlights the transformative potential of layered double hydroxide nanomaterials in treating complex diseases. The unique layered structure enables precise loading of drugs, genes, and imaging agents, making them ideal for theranostics.
Researchers develop a structure-property-device performance framework for lead-free perovskite optoelectronics, enabling improved device performance through spacer engineering, compositional tuning, and defect passivation. This framework highlights emerging opportunities in AI-assisted materials discovery and industrial-scale processing.
Researchers developed a cost-effective method to enhance the strength and thermal stability of 3D printing resins using modified mineral acicular wollastonite. The modified resin showed better thermal stability and reduced curing shrinkage, improving dimensional accuracy of printed parts.
This prospective multicenter study found obinutuzumab plus bendamustine to be highly effective in treating newly diagnosed indolent B-cell lymphoma in Chinese patients, with high response rates and manageable safety profile. Notably, the complete response rate was higher than reported in comparable Western studies, suggesting Chinese p...
This study compared clinical characteristics and outcomes between hospital-acquired and community-acquired pleural infection in a large Chinese patient population. The results showed that hospital-acquired pleural infections were more common, had more resistant pathogens, and resulted in higher mortality rates compared to community-acq...
PDRG1 expression is significantly upregulated in HCC tissues and associated with advanced tumor stage and poor prognosis. PDRG1 activates the Wnt/β-catenin pathway, promoting cell proliferation, migration, and invasion.
Researchers have developed an injectable hydrogel microsphere system to enhance bone regeneration by creating a protective environment for bone-forming cells. The system, made of sodium alginate and black phosphorus, promotes faster bone healing and improves cell survival rates.
The study found that obese individuals exhibited bulging during global maneuvers, whereas non-obese individuals showed bulging only during a curl-up. Shear-wave elastography captured dynamic mechanical response of the abdominal wall, revealing fundamentally different biomechanical properties in obese versus non-obese individuals.
The loss of chromosome Y in hematopoietic cells is a biologically meaningful event with direct functional consequences for human health. Hematopoietic loss of chromosome Y is linked to various diseases, including cardiovascular disease, neurodegenerative conditions, and cancer.
This review examines the dual effects of Bupleuri Radix through the gut-liver axis, revealing its hepatoprotective and anti-inflammatory effects. The review highlights the importance of saikosaponins, microbial biotransformation, and the gut-liver axis in understanding BR's biological activity and potential toxicity.
Exosome-based therapies have demonstrated remarkable efficacy in promoting epithelial wound healing and reducing inflammation in corneal ulcers and dry eye disease. The therapies also show antifibrotic effects and potential as gene therapy delivery vehicles or modulators of cellular metabolism for corneal dystrophies.
The journal aims to pioneer a holistic understanding of disease as a dynamic ecosystem, integrating study of micro-environment, microbiota, metabolite, nervous system, and pathophysiology. Pathology Research covers a broad spectrum of pathology-related disciplines, including surgical and molecular pathology, artificial intelligence in ...
FPR2 plays a pivotal role in maintaining intestinal homeostasis and promoting tissue regeneration through the PKC-ERK signaling axis. The study reveals that FPR2 activation regulates the proliferation and differentiation of intestinal stem cells and transit-amplifying cells, suggesting a potential therapeutic target for intestinal damage.
A study published in Life Metabolism reveals that high progesterone exposure during pregnancy can significantly improve menstrual cyclicity in PCOS patients and a PCOS-like mouse model. Postpartum, 60.60% of patients with irregular cycles showed improved menstrual regularity, with progesterone treatment normalizing estrous cyclicity an...
A new study found that fasting induces the accumulation of TCA cycle metabolites in brain lysosomes, which could support neuronal metabolic resilience. The researchers also propose three possible routes for the origin of these metabolites, including mitochondrial delivery and local interconversion supported by lysosome-associated signals.
A 10-year prospective cohort study in China found that ABC risk factors carry greater cardiovascular relevance in younger adults, while associations become less pronounced at older ages. Higher HbA1c, systolic blood pressure, and LDL-C levels were associated with increased cardiovascular risk, with varying degrees of strength across ag...
Researchers analyzed 42 pediatric ependymomas, identifying subtype-associated metabolic programs and linking them to clinical aggressiveness. The study found that the ST-YAP1 subtype had the most distinct metabolic profile, while the ST-RELA subtype was characterized by a lipid-utilizing metabolic program.
Exercise improves glucose tolerance and insulin sensitivity, restoring islet architecture and function in type 2 diabetes. The study reveals that exercise reduces inflammation and promotes a pro-inflammatory state in islet macrophages, which can compromise β-cell function.
A new PCSK9 vaccine candidate, PVC3, has been shown to induce sustained anti-PCSK9 antibodies and reduce hypercholesterolemia and atherosclerosis in mouse models. The vaccine also demonstrated a favorable preclinical safety profile, with no overt systemic toxicity or major histopathological abnormalities observed.
Endothelial CPT2 loss impairs fatty acid oxidation, promoting kidney fibrosis and renal injury. This impairment leads to reduced acetyl-CoA availability, activating an endothelial-to-mesenchymal transition (EndoMT)-like program.
Researchers identified a hierarchical nerve network in aortic perivascular adipose tissue, which is required for cold-induced blood pressure rise. Local ablation of sympathetic nerves in this tissue prevented cold-induced hypertension, underscoring its specificity.
Researchers found that ZRSR1 reduces hepatic lipogenesis and insulin resistance in mice, independently of minor intron splicing, by regulating the LXR-SREBP1c lipogenic pathway. This discovery broadens the known functions of minor-spliceosome proteins and reveals a new regulatory layer in fatty liver biology.
A prospective cohort study found that higher residential greenness was associated with lower type 2 diabetes risk in Chinese adults. Participants in the highest greenness tertile had a 51% lower risk of incident T2D compared to those in the lowest tertile, with the risk decreasing monotonically with increasing greenness.
A study reveals RAS signaling creates a specialized codon-defined translational program to boost production of proteins required for tumor growth and drug resistance. By targeting METTL13, a molecular regulator of CGA decoding, researchers found a potential vulnerability in RAS-driven cancers.