Researchers developed a cost-effective method to enhance the strength and thermal stability of 3D printing resins using modified mineral acicular wollastonite. The modified resin showed better thermal stability and reduced curing shrinkage, improving dimensional accuracy of printed parts.
This prospective multicenter study found obinutuzumab plus bendamustine to be highly effective in treating newly diagnosed indolent B-cell lymphoma in Chinese patients, with high response rates and manageable safety profile. Notably, the complete response rate was higher than reported in comparable Western studies, suggesting Chinese p...
This study compared clinical characteristics and outcomes between hospital-acquired and community-acquired pleural infection in a large Chinese patient population. The results showed that hospital-acquired pleural infections were more common, had more resistant pathogens, and resulted in higher mortality rates compared to community-acq...
PDRG1 expression is significantly upregulated in HCC tissues and associated with advanced tumor stage and poor prognosis. PDRG1 activates the Wnt/β-catenin pathway, promoting cell proliferation, migration, and invasion.
Researchers have developed an injectable hydrogel microsphere system to enhance bone regeneration by creating a protective environment for bone-forming cells. The system, made of sodium alginate and black phosphorus, promotes faster bone healing and improves cell survival rates.
The study found that obese individuals exhibited bulging during global maneuvers, whereas non-obese individuals showed bulging only during a curl-up. Shear-wave elastography captured dynamic mechanical response of the abdominal wall, revealing fundamentally different biomechanical properties in obese versus non-obese individuals.
The loss of chromosome Y in hematopoietic cells is a biologically meaningful event with direct functional consequences for human health. Hematopoietic loss of chromosome Y is linked to various diseases, including cardiovascular disease, neurodegenerative conditions, and cancer.
This review examines the dual effects of Bupleuri Radix through the gut-liver axis, revealing its hepatoprotective and anti-inflammatory effects. The review highlights the importance of saikosaponins, microbial biotransformation, and the gut-liver axis in understanding BR's biological activity and potential toxicity.
Exosome-based therapies have demonstrated remarkable efficacy in promoting epithelial wound healing and reducing inflammation in corneal ulcers and dry eye disease. The therapies also show antifibrotic effects and potential as gene therapy delivery vehicles or modulators of cellular metabolism for corneal dystrophies.
The journal aims to pioneer a holistic understanding of disease as a dynamic ecosystem, integrating study of micro-environment, microbiota, metabolite, nervous system, and pathophysiology. Pathology Research covers a broad spectrum of pathology-related disciplines, including surgical and molecular pathology, artificial intelligence in ...
FPR2 plays a pivotal role in maintaining intestinal homeostasis and promoting tissue regeneration through the PKC-ERK signaling axis. The study reveals that FPR2 activation regulates the proliferation and differentiation of intestinal stem cells and transit-amplifying cells, suggesting a potential therapeutic target for intestinal damage.
A study published in Life Metabolism reveals that high progesterone exposure during pregnancy can significantly improve menstrual cyclicity in PCOS patients and a PCOS-like mouse model. Postpartum, 60.60% of patients with irregular cycles showed improved menstrual regularity, with progesterone treatment normalizing estrous cyclicity an...
A new study found that fasting induces the accumulation of TCA cycle metabolites in brain lysosomes, which could support neuronal metabolic resilience. The researchers also propose three possible routes for the origin of these metabolites, including mitochondrial delivery and local interconversion supported by lysosome-associated signals.
A 10-year prospective cohort study in China found that ABC risk factors carry greater cardiovascular relevance in younger adults, while associations become less pronounced at older ages. Higher HbA1c, systolic blood pressure, and LDL-C levels were associated with increased cardiovascular risk, with varying degrees of strength across ag...
Researchers analyzed 42 pediatric ependymomas, identifying subtype-associated metabolic programs and linking them to clinical aggressiveness. The study found that the ST-YAP1 subtype had the most distinct metabolic profile, while the ST-RELA subtype was characterized by a lipid-utilizing metabolic program.
Exercise improves glucose tolerance and insulin sensitivity, restoring islet architecture and function in type 2 diabetes. The study reveals that exercise reduces inflammation and promotes a pro-inflammatory state in islet macrophages, which can compromise β-cell function.
A new PCSK9 vaccine candidate, PVC3, has been shown to induce sustained anti-PCSK9 antibodies and reduce hypercholesterolemia and atherosclerosis in mouse models. The vaccine also demonstrated a favorable preclinical safety profile, with no overt systemic toxicity or major histopathological abnormalities observed.
Endothelial CPT2 loss impairs fatty acid oxidation, promoting kidney fibrosis and renal injury. This impairment leads to reduced acetyl-CoA availability, activating an endothelial-to-mesenchymal transition (EndoMT)-like program.
Researchers identified a hierarchical nerve network in aortic perivascular adipose tissue, which is required for cold-induced blood pressure rise. Local ablation of sympathetic nerves in this tissue prevented cold-induced hypertension, underscoring its specificity.
Researchers found that ZRSR1 reduces hepatic lipogenesis and insulin resistance in mice, independently of minor intron splicing, by regulating the LXR-SREBP1c lipogenic pathway. This discovery broadens the known functions of minor-spliceosome proteins and reveals a new regulatory layer in fatty liver biology.
A prospective cohort study found that higher residential greenness was associated with lower type 2 diabetes risk in Chinese adults. Participants in the highest greenness tertile had a 51% lower risk of incident T2D compared to those in the lowest tertile, with the risk decreasing monotonically with increasing greenness.
A study reveals RAS signaling creates a specialized codon-defined translational program to boost production of proteins required for tumor growth and drug resistance. By targeting METTL13, a molecular regulator of CGA decoding, researchers found a potential vulnerability in RAS-driven cancers.
The article proposes a new statistical governance framework to standardize energy-use tracking in global data centers. AI-driven identification workflows and non-intrusive load monitoring are used to distinguish data center workloads from mixed-use commercial premises.
A recent study found that sleep traits significantly increase the risk of hemorrhoidal disease, with insomnia being a major contributor. The analysis suggests that sleep disruption acts primarily as a driver of hemorrhoidal pathology, rather than a consequence.
A new study found that microgravity causes the lower eyelid to rise in astronauts, altering corneal topography and vision. The phenomenon, known as reverse ptosis, was observed in 62% of astronauts, with changes similar to those seen in short-term parabolic flights.
China's ozone pollution has increased despite PM2.5 declines, with urban areas under VOC-limited conditions; large-scale NOx reduction is a proposed near-term control strategy. Ambient ozone direct catalytic decomposition coatings can deliver localized ozone removal at a lower projected economic cost.
LASIK surgery shows moderate improvement in quality of life but higher patient satisfaction rates compared to contact lenses. Complication rates are lower for LASIK, but dry eye issues are more prevalent with both methods.
Minimally invasive laryngeal surgery has shifted toward precision functional preservation with high-definition endoscopy and updated laser systems. Surgical strategies prioritize vocal function reconstruction with optimized microflap techniques and autologous tissue grafts.
The OSPREY trial found that proximal hypoglossal nerve stimulation significantly improved apnea-hypopnea index and oxygen desaturation in patients with moderate-to-severe obstructive sleep apnea. The treatment has expanded eligible patient populations and is now approved for use in the US.
Researchers discovered a simian-specific gene, SAGE1, that enhances germline genome stability by promoting homologous recombination. SAGE1 expression improves DNA repair efficiency and reduces mutation accumulation in spermatogonia from humans and macaques compared to mice.
A recent Canadian study evaluated the appropriateness and reliability of ChatGPT-4.0 responses to common patient-oriented urological questions using CUA guidelines as the benchmark. The study found that only 40% of responses met the appropriateness threshold, with higher scores for fact-based and domain-specific queries.
The INR-DR framework reduces streak artifacts in CT images with improved anatomy preservation. It outperforms traditional methods, offering a general strategy for inverse problems in sparse-view and low-dose CT.
The new journal, Neuropsychiatric Research, aims to address the challenges of neuropsychiatric disorders by exploring the brain–behavior interplay. Key findings include a projected tripling of dementia cases and rising incidence of mental disorders among adolescents and young adults.
A study of 441,844 UK Biobank participants found that a healthy lifestyle can cut the risk of hearing impairment by 14%, with metabolic biomarkers playing a dominant role. Metabolic dysfunction was identified as the primary biological pathway linking lifestyle to auditory health.
The rotational chair test offers unique diagnostic value for various vestibular disorders, detecting residual function and subtle deficits. It supports personalized rehabilitation and guides treatment for conditions like Ménière’s disease and persistent postural-perceptual dizziness.
Researchers developed a multiscale framework to understand liquid transport in fibrous membranes. At the single fiber scale, fiber diameter and curvature regulate droplet nucleation, adhesion, and migration. The study also explores droplet transport mechanisms at 2D fiber network and 3D multilayer scales.
Researchers find molybdenum carbide formation on metal oxide supports enhances reverse water gas shift activity. The study identifies ionic potential as a key descriptor for support selection, providing a practical framework for designing high-performance Mo-based RWGS catalysts.
A novel framework, CA-Mamba2, uses state-space modeling enhanced by coordinate attention to capture long-term temporal dependencies and nonlinear degradation characteristics in lithium-ion batteries. It achieves superior performance on public datasets, demonstrating strong generalization capabilities.
Researchers engineered Cupriavidus necator H16 to convert CO2 into p-coumaric acid, producing a 1,593.3% increase in yield under autotrophic conditions. The breakthrough establishes a framework for CO2-based biomanufacturing and paves the way for producing phenylpropanoids from industrial CO2 emissions.
Researchers found that lithocholic acid, a secondary bile acid, can alleviate fatty liver in mice and non-human primates when administered at CR-mimetic doses. The study identified two safe regimens, 0.25 mg/kg and 0.5 mg/kg twice daily, without detectable toxicity.
A study examines genetic variants on the X chromosome for association with ESRD risk, identifying several loci significantly linked to ESRD. The findings collectively explain a portion of ESRD heritability and provide insights into potential disease mechanisms.
Cohort studies reveal associations between glycan patterns and disease states in cancer, cardiovascular disease, and autoimmune disorders. Glycan biomarkers may enable earlier detection and treatment selection.
Research identifies novel FAK splicing variants in small cell lung cancer that promote proliferation, migration, and invasion. These variants confer resistance to chemotherapy and radiation, highlighting a new therapeutic vulnerability. Targeted therapy with FAK inhibitors shows promise.
A prospective cohort study found a graded association between sarcopenia and infection risk, with stronger associations for respiratory infections and sepsis. Muscle health influences immune function through myokines and amino acid mobilization.
A study found that heavy drinking amplifies the risk of cardiometabolic multimorbidity attributed to adverse childhood experiences in middle-aged and older Chinese adults. Individuals with high ACE exposure who engaged in heavy drinking had substantially higher risk compared to those who did not drink heavily.
Recurrent mutations in chromatin remodeling genes, such as PBRM1, BAP1, and SETD2, are associated with impaired DNA damage repair and altered tumor immune microenvironments. These genetic alterations can lead to synthetic lethality and influence treatment response.
The vascular system plays a critical role in mediating muscle-bone interactions, influencing both their development and health. Therapeutic strategies targeting the vascular-musculoskeletal axis hold promise for preventing and treating sarcopenia and osteoporosis.
Neuroimaging studies reveal that systemic diseases profoundly affect brain structure and function, while brain disorders can influence peripheral organ systems. Cardiovascular diseases, metabolic disorders, autoimmune diseases, and infectious diseases are all associated with characteristic patterns of brain changes.
A nationwide real-world study investigated the incidence of HBV reactivation in Chinese IBD patients receiving infliximab, identifying key risk factors and characterizing outcomes. The study recommends universal HBV screening before biologic therapy initiation and tailored management strategies based on HBV serology and disease activity.
A new study introduces a novel approach to personalized learning resource recommendation, treating resources as part of an intricate knowledge network. The Unified Learning Resource Recommendation Method (ULRRM) integrates multidimensional graph information to deliver accurate and context-aware recommendations.