The article proposes a new statistical governance framework to standardize energy-use tracking in global data centers. AI-driven identification workflows and non-intrusive load monitoring are used to distinguish data center workloads from mixed-use commercial premises.
A recent study found that sleep traits significantly increase the risk of hemorrhoidal disease, with insomnia being a major contributor. The analysis suggests that sleep disruption acts primarily as a driver of hemorrhoidal pathology, rather than a consequence.
A new study found that microgravity causes the lower eyelid to rise in astronauts, altering corneal topography and vision. The phenomenon, known as reverse ptosis, was observed in 62% of astronauts, with changes similar to those seen in short-term parabolic flights.
China's ozone pollution has increased despite PM2.5 declines, with urban areas under VOC-limited conditions; large-scale NOx reduction is a proposed near-term control strategy. Ambient ozone direct catalytic decomposition coatings can deliver localized ozone removal at a lower projected economic cost.
LASIK surgery shows moderate improvement in quality of life but higher patient satisfaction rates compared to contact lenses. Complication rates are lower for LASIK, but dry eye issues are more prevalent with both methods.
Minimally invasive laryngeal surgery has shifted toward precision functional preservation with high-definition endoscopy and updated laser systems. Surgical strategies prioritize vocal function reconstruction with optimized microflap techniques and autologous tissue grafts.
The OSPREY trial found that proximal hypoglossal nerve stimulation significantly improved apnea-hypopnea index and oxygen desaturation in patients with moderate-to-severe obstructive sleep apnea. The treatment has expanded eligible patient populations and is now approved for use in the US.
Researchers discovered a simian-specific gene, SAGE1, that enhances germline genome stability by promoting homologous recombination. SAGE1 expression improves DNA repair efficiency and reduces mutation accumulation in spermatogonia from humans and macaques compared to mice.
A recent Canadian study evaluated the appropriateness and reliability of ChatGPT-4.0 responses to common patient-oriented urological questions using CUA guidelines as the benchmark. The study found that only 40% of responses met the appropriateness threshold, with higher scores for fact-based and domain-specific queries.
The INR-DR framework reduces streak artifacts in CT images with improved anatomy preservation. It outperforms traditional methods, offering a general strategy for inverse problems in sparse-view and low-dose CT.
The new journal, Neuropsychiatric Research, aims to address the challenges of neuropsychiatric disorders by exploring the brain–behavior interplay. Key findings include a projected tripling of dementia cases and rising incidence of mental disorders among adolescents and young adults.
A study of 441,844 UK Biobank participants found that a healthy lifestyle can cut the risk of hearing impairment by 14%, with metabolic biomarkers playing a dominant role. Metabolic dysfunction was identified as the primary biological pathway linking lifestyle to auditory health.
The rotational chair test offers unique diagnostic value for various vestibular disorders, detecting residual function and subtle deficits. It supports personalized rehabilitation and guides treatment for conditions like Ménière’s disease and persistent postural-perceptual dizziness.
Researchers developed a multiscale framework to understand liquid transport in fibrous membranes. At the single fiber scale, fiber diameter and curvature regulate droplet nucleation, adhesion, and migration. The study also explores droplet transport mechanisms at 2D fiber network and 3D multilayer scales.
Researchers find molybdenum carbide formation on metal oxide supports enhances reverse water gas shift activity. The study identifies ionic potential as a key descriptor for support selection, providing a practical framework for designing high-performance Mo-based RWGS catalysts.
A novel framework, CA-Mamba2, uses state-space modeling enhanced by coordinate attention to capture long-term temporal dependencies and nonlinear degradation characteristics in lithium-ion batteries. It achieves superior performance on public datasets, demonstrating strong generalization capabilities.
Researchers engineered Cupriavidus necator H16 to convert CO2 into p-coumaric acid, producing a 1,593.3% increase in yield under autotrophic conditions. The breakthrough establishes a framework for CO2-based biomanufacturing and paves the way for producing phenylpropanoids from industrial CO2 emissions.
Researchers found that lithocholic acid, a secondary bile acid, can alleviate fatty liver in mice and non-human primates when administered at CR-mimetic doses. The study identified two safe regimens, 0.25 mg/kg and 0.5 mg/kg twice daily, without detectable toxicity.
A study examines genetic variants on the X chromosome for association with ESRD risk, identifying several loci significantly linked to ESRD. The findings collectively explain a portion of ESRD heritability and provide insights into potential disease mechanisms.
Cohort studies reveal associations between glycan patterns and disease states in cancer, cardiovascular disease, and autoimmune disorders. Glycan biomarkers may enable earlier detection and treatment selection.
Research identifies novel FAK splicing variants in small cell lung cancer that promote proliferation, migration, and invasion. These variants confer resistance to chemotherapy and radiation, highlighting a new therapeutic vulnerability. Targeted therapy with FAK inhibitors shows promise.
A prospective cohort study found a graded association between sarcopenia and infection risk, with stronger associations for respiratory infections and sepsis. Muscle health influences immune function through myokines and amino acid mobilization.
A study found that heavy drinking amplifies the risk of cardiometabolic multimorbidity attributed to adverse childhood experiences in middle-aged and older Chinese adults. Individuals with high ACE exposure who engaged in heavy drinking had substantially higher risk compared to those who did not drink heavily.
Recurrent mutations in chromatin remodeling genes, such as PBRM1, BAP1, and SETD2, are associated with impaired DNA damage repair and altered tumor immune microenvironments. These genetic alterations can lead to synthetic lethality and influence treatment response.
The vascular system plays a critical role in mediating muscle-bone interactions, influencing both their development and health. Therapeutic strategies targeting the vascular-musculoskeletal axis hold promise for preventing and treating sarcopenia and osteoporosis.
Neuroimaging studies reveal that systemic diseases profoundly affect brain structure and function, while brain disorders can influence peripheral organ systems. Cardiovascular diseases, metabolic disorders, autoimmune diseases, and infectious diseases are all associated with characteristic patterns of brain changes.
A nationwide real-world study investigated the incidence of HBV reactivation in Chinese IBD patients receiving infliximab, identifying key risk factors and characterizing outcomes. The study recommends universal HBV screening before biologic therapy initiation and tailored management strategies based on HBV serology and disease activity.
A new study introduces a novel approach to personalized learning resource recommendation, treating resources as part of an intricate knowledge network. The Unified Learning Resource Recommendation Method (ULRRM) integrates multidimensional graph information to deliver accurate and context-aware recommendations.
The study integrates metasurfaces with photodetectors to create ultra-compact, multi-functional optoelectronic imaging systems. By combining metasurfaces with image sensors, researchers break intrinsic absorption limits and enable true single-shot, multi-dimensional perception.
A systematic evaluation of polyglycol-based foam control agents has identified FCA332 as a robust option for industrial fermentation processes. The agent's low viscosity, moderate cloud point, and favorable surface tension make it an ideal choice for balancing operational efficiency with biological safety.
A new group contribution method, ACGC+, significantly improves prediction accuracy for nine key phase transition properties in organic compounds. The method incorporates local structural information to differentiate isomers and structural variations.
A prospective cohort study found that higher residential greenness was associated with lower type 2 diabetes risk, especially among individuals with higher genetic susceptibility. The study suggested that environmental exposure may play an important role in shaping metabolic phenotypes and influencing diabetes risk.
Researchers developed a data-driven framework to identify optimal scale-up patterns for modular CO₂ reduction reactors. The study found that different performance objectives require distinct architectural hierarchies, with total annual cost influenced by substrate-level features and CO₂ conversion dictated at the stack level.
A new study reveals ZRSR1's role in restraining hepatic lipogenesis by controlling the LXR-SREBP1c pathway. In mice with high-fat diet-induced obesity and steatosis, ZRSR1 overexpression reduced liver triglyceride accumulation and insulin resistance.
Researchers developed a hierarchical porous carbon cathode with a unique dual-ion relay storage mechanism, overcoming kinetic and capacity mismatches. The material exhibited high specific capacity, excellent rate capability, and outstanding cycling stability.
Researchers developed a method to quantify and mitigate thermal interference in electrical capacitance tomography (ECT) measurements. The results showed that room-temperature calibration can be applied at high temperatures without compromising reconstruction integrity. Increasing wall thickness significantly amplifies measurement error...
Researchers developed Ce-doped BiOI catalysts for efficient CO₂ conversion to cyclic carbonates, overcoming limitations of conventional homogeneous catalytic systems. The proposed mechanism involves oxygen vacancy-mediated Lewis acid-base pairs, facilitating epoxide adsorption and reducing the energy barrier for epoxy ring-opening.
The UBR4-KCMF1-Calmodulin (UKC) complex is a stress-responsive machinery that regulates protein degradation and stress signaling. It employs UBE2A as its E2 enzyme and requires substrates with pre-attached ubiquitin moieties for efficient modification.
Designing T-cell engagers aims to optimize activity and toxicity through molecular engineering, dosing regimens, and patient selection. Strategies include spatiotemporal control of T-cell activation and tumor-selective cytotoxicity to enhance efficacy while minimizing harm.
BAM15 rescues obesity-induced defects in oocyte maturation and embryonic development through improved mitochondrial function. The compound activates PPARγ signaling, restoring genes associated with cytoskeletal organization and energy metabolism.
Researchers used non-human primates to investigate MANF's function, revealing its essential role for astrocyte survival specifically in monkeys. The study highlights the importance of utilizing non-human primate models to evaluate therapeutic strategies targeting MANF-related pathways.
Researchers mapped single-cell chromatin accessibility in testicular tissues from normal and NOA patients, revealing a wave-like TF network orchestration and transient epigenetic licensing window. Disrupted TF networks and genetic variants disrupt downstream spermatogenic networks.
Researchers developed a rapid fabrication strategy for superhydrophobic/superaerophilic coatings using flame pyrolysis of PDMS, achieving high water repellency and drag reduction. The coating exhibits excellent dynamic stability, enabling complete droplet bouncing within 15 ms.
Researchers have developed a thermoelectrocatalytic process using La-substituted SrTiO3 to produce H2O2 from O2 and H2O. The optimized doping level enables dual redox reactions, producing a stable rate of 412 μmol⸱L−1⸱g−1⸱h−1 at 130 °C.
Helical carbon nanotubes offer unique geometrical characteristics, enabling improved mechanical entanglement with host-resins. Chemical functionalization enhances their molecular interactions and dispersion-uniformity, leading to enhanced composites properties.
The article reports on the preparation of ZnO nanoflakes modified with noble metals Au, Pt, and Pd via UV reduction, resulting in enhanced gas-sensing properties. The Au/ZnO material demonstrated superior response to isopropanol and investigated potential sensing mechanisms.
Researchers developed a class of senary Fe–Co–Ni–Si–B–Y MPEAAs with high saturation magnetization, exceptional thermal stability, enhanced microhardness, and acceptable corrosion resistance. These materials have potential applications in soft magnetic alloys for offshore wind power systems.
Researchers developed smart hydrogels with tunable mechanical properties, environmental responsiveness, and biodegradability for tissue regeneration. These advanced scaffolds have potential in emerging areas like drug delivery systems and wound dressings.
Researchers developed DMCGuard to address inconsistent security policies across various IoT management channels. The framework provides a robust solution for preventing unauthorized access in smart environments without modifying underlying protocols.
Researchers developed an ultrasensitive SERS-based method for Pb2+ detection using L-cysteine-functionalized bismuth nanoparticles. The method achieves a low detection limit of 0.005 nmol⸱L−1, outperforming conventional lead ion detection techniques.