A study found that secukinumab significantly improved skin scores in moderate-to-severe plaque psoriasis patients with subclinical enthesitis, reducing inflammation before irreversible damage occurs. Ultrasound revealed marked thinning at enthesial sites, particularly the right Achilles tendon.
Skin, a new international dermatology journal, has launched in Beijing to provide a high-quality platform for Chinese researchers to publish original studies on skin and venereology. The journal will adhere to rigorous academic standards and prioritize rapid global dissemination.
Steroid-induced rosacea (SIR) and steroid-induced rosacea-like dermatitis (SIRD) require different management approaches due to distinct pathologies. SIRD is a curable condition with intense itching, dryness, and scaling, while SIR presents lifelong episodic flushing and redness.
A 24-year-old woman presented with unexplained darkening of her hands, feet, gums, and tongue, later diagnosed with rare Addison's disease. After treatment, her symptoms resolved completely, highlighting the vital role of dermatologists in recognizing systemic diseases through skin manifestations.
A new case report highlights the danger of Marjolin ulcer after decades, a rare but aggressive skin cancer arising in long-standing burn scars or chronic wounds. The patient underwent successful surgical removal and remained cancer-free after one year of follow-up.
Researchers optimized four critical stainings for hyperphosphorylated Tau, β-amyloid, α-synuclein, and phosphorylated TDP-43 using comparative testing of antigen retrieval conditions. The optimized protocols yielded consistent results with the Netherlands Brain Bank, confirming reliability, repeatability, and international compatibility.
A new interfacial modification layer composed of a chlorinated conjugated polymer is introduced to address device performance limitations in tandem solar cells. This strategy leads to significant improvements in charge extraction and non-radiative recombination, resulting in record power conversion rates.
The 2026 Chinese Guidelines for the Diagnosis and Treatment of Alopecia Areata introduce a new therapeutic ladder, prioritizing JAK inhibitors for severe chronic cases and routine screening for autoimmune comorbidities. The guidelines also emphasize long-term follow-up to prevent relapse.
Researchers developed a drone-mounted IRS system with virtual bounce paths to bypass blockages and jamming, reducing outage probability by an order of magnitude. The optimized system provides real-time optimization for critical scenarios and cost-effectiveness for civilian networks.
A new AI paradigm, Dermatology AI 2.0, enhances rare skin disease diagnosis by up to 32.9% through causal algorithms, while predicting eczema flares with over 90% accuracy. This technology frees dermatologists to focus on complex cases and patient care, potentially cutting diagnosis delays.
Researchers developed a data standardization pipeline to transform heterogeneous clinical records into analyzable research resources for psoriasis. The approach enables the creation of integrated specialty databases and AI-assisted clinical decision support tools.
Researchers developed biodegradable tissue-carriers from natural biopolymers for effective delivery of anti-aging compounds. These carriers mimic the skin's extracellular matrix, offering controlled release and reducing skin irritants.
Liquid ammonia has high energy density and is compatible with existing infrastructure, making it attractive for decarbonizing marine shipping and heavy-duty transport. However, challenges such as low reactivity and high NOx emissions must be addressed through advanced injection strategies and combustion control.
A review in Engineering highlights advances in sorption-enhanced catalytic hydrogenation of carbon oxides, improving reaction efficiency with selective water vapor removal. Zeolites and fixed-bed reactors are studied for their potential in this technology.
A new study outlines the technical status and future outlook of ammonia-fired power generation, positioning it as a viable hydrogen energy carrier and low-carbon fuel. The technology has been developed for gas turbines and coal-fired boilers, with significant reductions in emissions and improved performance.
The review provides fundamental insights into combustion kinetics for biomass-derived oxygenated fuels, highlighting distinct reaction patterns across fuel categories. It outlines priority directions to improve predictive kinetic models, such as expanding experimental datasets and adopting advanced computational tools.
The review highlights advancements in intelligent coal-fired power technologies, including ubiquitous sensing systems and advanced control algorithms. Intelligent transformation enables flexible operations and long-term sustainability of coal-fired generating units.
A new study reveals critical limitations in cement carbonation as a climate mitigation strategy, highlighting severe temporal asymmetry and performance uncertainty. The authors call for time-explicit accounting, strict verification, and policy prioritization of established decarbonization levers.
PLSaoNET proposes a partial least squares (PLS)-assisted optimization network to tackle the challenges of industrial sensing data. The model introduces a PLS-based initialization mechanism and stratified sampling-based training strategy, achieving better modeling accuracy and robustness.
A new four-stage system integration pathway is proposed to guide global energy system transformation toward carbon neutrality. The pathway focuses on progressive system integration, electrification, smart grids, and long-term exploration of advanced energy technologies.
The study introduces a modified deep lateral wall decompression technique that improves visual acuity, exophthalmos, and intraocular pressure with low complication rates. This approach suggests a safer option for TAO management, warranting further exploration.
A new dual-broadband liquid-crystal programmable metasurface (LCPM) enables flexible beam manipulation across two frequency bands, supporting high-speed data transmission under various modulation schemes. The device offers stable non-line-of-sight links and reliable communication at extended propagation lengths.
This review provides a comprehensive overview of gene therapy tools and strategies for hereditary hearing loss. Advances in inner ear gene delivery platforms, including AAV vectors and cell-specific promoters, have improved the translational development of gene therapies.
A 60-year-old man developed purpura fulminans after a cat lick, leading to extensive nasal and lip necrosis. Reconstruction using a paramedian forehead flap and conchal cartilage grafts resulted in satisfactory outcomes.
The article outlines China's power grid transformation pathways, typifying scenarios, and key technical requirements for system change. Rapid wind and solar growth will reshape stability mechanisms, while traditional innovation models face path dependence.
Researchers investigated the mechanisms of autologous rib cartilage graft resorption in microtia, revealing chronic inflammation, gene imbalance, and mitochondrial dysfunction as key factors. This study advances auricular reconstruction by providing a solid theoretical foundation for optimizing fixation materials and developing targete...
Insufficient insurance coverage for emerging hydrogen technologies threatens the global net-zero energy transition. The article highlights the need for closer collaboration between engineers, industry, academia, and insurers to address unmanaged risks and unlock wider deployment of hydrogen systems. Parametric insurance and performance...
New complexity in shock-induced mineral alteration and impact chronology are revealed in samples from the Moon, Asteroids, and Mars. Dynamic high-pressure techniques replicate key aspects of natural impact P–T–t paths at the nanosecond scale.
This study evaluates ChatGPT-4o's alignment with official grades on Finland's national high-stakes matriculation examination. The results show that GPT-4o's grades closely matched human evaluations, with 75% of scores within ±2 points.
This paper introduces PEG-Prompt, a novel prompting framework that integrates the Paul-Elder critical thinking model to assess course project reports from six dimensions. Experiments on four mainstream LLMs demonstrate significant performance improvements in reducing scoring errors and enhancing alignment with human evaluations.
The study found that NAO's compact design and predictable interaction reduced intimidation and boosted sustained engagement among autistic students. Statistical analyses revealed significant improvements in attention duration, communication frequency, interaction scores, and positive emotions.
Researchers have resolved human M-channel structures, revealing its architectural principles and a rational drug design strategy. The channel displays remarkable stoichiometric plasticity, with varying subunit configurations generating functional currents.
A new study identifies CLPTM1L as a regulator of membrane raft formation and EGFR-dependent proliferative signaling in glioblastoma. High CLPTM1L expression was associated with shorter patient survival, while depletion impaired GBM cell viability and proliferation.
Research reveals significant differences in hearing and vestibular function in unilateral Meniere's disease patients without endolymphatic hydrops. The study provides a foundation for future subtype classification and personalized clinical management by combining symptoms, functional tests, and MRI findings.
A minimally invasive salvage technique using ultrasound-guided endoscopic retrieval successfully removes a deeply embedded cervical fish bone after failed open exploration. The method provides real-time navigation and higher accuracy with no radiation or significant trauma.
Researchers from Fudan University published a study on modified sigmoid sinus wall reconstruction using bone cement, demonstrating a 96.2% overall success rate for symptom resolution. Symptoms typically resolved within four weeks, providing evidence for optimizing surgical techniques and material selection.
A new study demonstrates a tandem catalytic approach that converts waste polyethylene and carbon dioxide into separable liquid aromatics and carbon monoxide under atmospheric pressure. The catalyst system achieves high selectivity toward separable aromatics, with an aromatic yield of up to 75.3 wt%.
Researchers have developed new chemical recycling methods for polyurethane (PU) foams, including hydrogenation, acidolysis, and chem-solvolysis. These approaches can recover polyols and aromatic amines, which can be used to produce new PU materials.
Researchers develop a two-step catalytic process to upcycle PET plastics into lactic acid and 1,4-cyclohexanedicarboxylic acid without external hydrogen. The method yields high-value chemical intermediates with improved economic viability of chemical plastic recycling.
Researchers establish kinetics-guided depolymerization of polyethylene terephthalate (PET) to produce high-performance thermoplastics with improved sustainability. The approach yields well-defined oligomers suitable for direct repolymerization, simplifying operations and reducing energy consumption.
Researchers developed a surface polarity reconstruction method using silane coupling agents to modify conventional supported metal catalysts. This approach enhances the hydrogenolysis of waste polyolefins by optimizing catalyst surface polarity and reducing polymer chain entropy, leading to improved catalytic activity.
Emerging biocatalytic strategies for plastic depolymerization leverage AI-enabled enzyme design and multi-enzyme cascades to enhance sustainable recycling. Researchers develop novel biocatalysts through de novo design, overcoming constraints with structural similarity to natural hydrolases.
YTHDF2 plays critical roles in regulating HSC fate, immune cell development, and tumor-immune interactions. It also modulates the tumor microenvironment to promote tumor progression.
Aging across the female reproductive tract is characterized by declining estrogen, cellular senescence, and chronic inflammation. Multi-omics datasets provide a powerful framework to measure biological age and reveal tissue-specific vulnerabilities.
Paligenosis is a three-stage process involving autophagy, stemness gene induction, and proliferation. It ensures efficient regeneration in tissues like the stomach and pancreas, but its dysregulated activation can drive metaplasia and cancer. The review discusses biomarker prospects for distinguishing adaptive repair from malignant drift.
Researchers synthesized preclinical and clinical evidence of mRNA cancer vaccines across various cancers, including melanoma, non-small cell lung cancer, and acute myeloid leukemia. Key findings include improved recurrence-free survival in patients treated with mRNA-4157 plus pembrolizumab for melanoma.
H2AK119Ub is a versatile histone mark that organizes the genome into functional domains, orchestrates gene silencing, and maintains cell identities during development. Disruption of its signaling network is recognized as a driver of human diseases, particularly cancer.
The journal MedScience aims to integrate cutting-edge insights across medical sciences, focusing on emerging fields like cell therapy, AI-driven drug discovery, and precision medicine. This new platform serves as a dynamic hub for international academic exchange and translation of scientific breakthroughs into clinical practice.
High-altitude exposure disrupts the gut ecosystem, leading to dysbiosis, impaired barrier function, and increased intestinal permeability. The gut microbiome influences host energy metabolism, immune responses, and acclimatization capacity, and alterations are linked to diseases such as metabolic disorders and colorectal cancer.
Additives in plastics represent a major understudied frontier in recycling science. Mainstream recycling technologies face distinct challenges with additives, including gradual accumulation of unwanted compounds and limited detection methods.