Researchers developed defect-rich silicon-carbon composite anodes with initial discharge capacities exceeding 6,500 mAh g⁻¹, outperforming conventional silicon-anode expectations. AI-assisted design optimized the formulation, revealing a trade-off between capacity and efficiency.
Researchers identified a key driver of liver fibrosis progression: FSP1+ macrophages that activate PGK1 through lactylation. This self-reinforcing loop amplifies glycolytic signaling, promoting liver fibrosis. A cell penetrating peptide targeting PGK1 lactylation blocks fibrosis progression in preclinical models.
Researchers have discovered a novel agrochemical target, C31, that inhibits Xanthomonas bacterial leaf blight by targeting the RNA polymerase alpha subunit, RpoA. This study demonstrates the potential of liquid-liquid phase separation as an innovative approach to developing new plant disease control strategies.
This study reveals that Porphyromonas gingivalis induces neuroinflammation and cognitive impairment via microglial ferroptosis triggered by the NOX4/PPAR-α/PGC-1α pathway. The findings provide a molecular target for drug repurposing to intervene in periodontitis-associated Alzheimer's disease.
Research team uncovers driving mechanisms behind population diversity in brain functional connectome. Lifestyle factors and gene expression shape brain functional topography, contradicting biological essentialism.
Elevated Pim1 expression promotes abnormal Th17 cell differentiation in inflammatory arthritis. Targeting Pim1 with Nilotinib inhibits Th17 cell differentiation and alleviates inflammatory arthritis symptoms.
Researchers develop a surface-engineering method that enables efficient electroluminescence from lanthanide nanocrystals, overcoming their insulating nature. The approach promotes fast intersystem crossing and efficient triplet-energy transfer, leading to high-performance light-emitting diode devices with multicolor emission.
Researchers found that zirconia implants trigger an immune-inflammatory niche marked by macrophage involvement and COL6A2/CD44 signaling. In contrast, titanium implants support a regenerative microenvironment with collagenase-1/stromal-derived cell differentiation 1 (SDC1) signaling.
Researchers developed multifunctional metal–organic framework nanoparticles that degrade HK-2, suppress glycolysis, and induce cuproptosis. CHNDs showed stronger anticancer activity than either the HK-2 degrader or the copper nanoplatform alone, disrupting protein homeostasis and cancer energy metabolism.
Researchers introduce a photoisomeric additive that anchors mobile ions and stabilizes the material during UV exposure, improving device performance. The study shows improved film quality, reduced degradation, and enhanced power conversion efficiency.
The study reports a green ion-exchange, self-catalytic strategy for turning pulp-waste lignin into high-performance wood adhesives. The optimized LA/CA adhesive showed strong dry and wet performance, meeting Type I plywood requirements and reducing costs by up to 69.6% compared to petrochemical-based adhesives.
Researchers are using 3D cardiac constructs to model cardiovascular diseases and test new drugs. These constructs can capture the complexity of human cardiac tissue, including its electrical activity, metabolism, and cellular communication. The field is advancing with biomaterials, AI-assisted screening, and improved standardization.
Researchers developed a single-molecule platform to monitor asymmetric evolution in Diels-Alder reactions, revealing the molecular origin of reaction chirality. They proposed an excess-compensation mechanism for chiral amplification and achieved precise control over stereoselectivity and regioselectivity.
Researchers developed Cel-T plastic, a novel cellulose-based supramolecular plastic with high mechanical strength, thermal stability, and versatile shapeability. The material combines the strengths of polylactic acid, polymethyl methacrylate, acrylonitrile-butadiene-styrene, and polyethylene terephthalate.
Antimicrobial peptides influence amyloid fibrillization through three mechanisms: structural compatibility, directional seeding asymmetry, and surface-mediated catalysis. This review proposes a bidirectional pathogen-amyloid feedback loop, linking infection and neurodegeneration.
A new AI system enables real-time spine positioning and analysis during MRI scans, improving accuracy and reducing variability. The system was tested in a multicenter study involving 1,522 patients, showing significant improvements over manual interpretation for diagnosing lumbar disc herniation and spinal canal stenosis.
A recent study found that lycopene protects porcine intestinal epithelial cells from DON-induced damage by inhibiting PGAM5-mediated mitophagy-dependent ferroptosis. Lycopene increases tight junction proteins, reduces ROS levels, and stabilizes mitochondrial function, restoring barrier integrity.
Researchers engineer bacterial vesicles into multifunctional tools that can kill pathogens, boost vaccines, and deliver targeted therapies. Engineered BEVs address key limitations of existing therapies, including improving vaccine responses and antibiotic delivery.
Researchers analyze brain imaging data, microbiome profiles, and clinical assessments to identify biomarkers for precision mental healthcare. Early findings suggest certain electroencephalography features serve as non-invasive biomarkers indicating disease severity and treatment response.
This study reveals that HDAC3 epigenetically represses RASAL1, a key antifibrotic regulator, leading to enhanced fibroblast activation and extracellular matrix deposition in renal fibrosis. Restoring RASAL1 expression or inhibiting HDAC3 activity attenuates renal fibrosis.
Research found that sleep and diet impact immune cell proportions and protein expression, with long-term late sleep onset triggering inflammation. The study's indexes reflect human immune health or chronic diseases, providing a foundation for future health assessment and management.
Postoperative rebleeding is a critical complication of minimally invasive surgery for intracerebral hemorrhage, significantly reducing survival rates and functional recovery levels. The review outlines standardized definitions, dual pathogenic mechanisms, risk profiling, and stratified prevention strategies to address this challenge.
A comprehensive review of BNCT suggests it can precisely target and destroy cancer cells while sparing healthy tissue. The therapy has shown promising results in extending overall survival and improving quality of life for patients with various types of malignant tumors.
Researchers developed a microwave-coupled solvent system to efficiently convert hemicellulose into furfural, achieving high yields under mild conditions. The approach demonstrated significant energy savings compared to conventional heating methods.
Researchers developed a self-stealth metasurface that achieves in-band and out-of-band radar cross-section (RCS) reduction across multiple frequencies. The metasurface enables real-time digital control for beamforming, information modulation, and smart surfaces, resolving performance/power/integration trade-offs.
Optical biosensors offer promising solutions for rapid, portable, and on-site pesticide detection. Key biorecognition elements such as enzymes, antibodies, aptamers, and molecularly imprinted polymers enable high-selectivity detection and minimize environmental impacts.
A biomimetic smart insole system integrates high-resolution sensing, autonomous energy supply, and AI-assisted gait diagnosis to monitor lower limb function and disease progression. The system achieves ultra-low detection limits and maintains mechanical stability, addressing existing bottlenecks in wearable gait monitoring.
This study reveals the regulatory role of BCAT2-mediated BCAA catabolism in VSMCs and its impact on intraplaque calcification in diabetic atherosclerosis. BCAT2 deficiency attenuates vascular calcification severity, decreases calcium salt deposition, and suppresses osteogenic phenotypic transition of VSMCs.
A positive feedback loop between UBE2V1 and HIF-1α drives HCC progression by facilitating tumor growth and metastasis. UBE2V1 promotes HCC progression by competing with HIF-1α for VHL protein binding, leading to sustained HIF-1α stabilization.
Researchers have discovered plant defense strategies against antibiotic stress, including chloroplast-centered adaptation and microbiome coordination. Plants accumulate antibiotics in roots, activate detoxification enzymes, and restructure endophytic bacterial communities to counter stress. These findings suggest plants as bioremediati...
Generative AI in medical imaging enables data synthesis, image enhancement, and modality translation to improve diagnosis and treatment outcomes. The review discusses challenges and future prospects, including convergence with large-scale foundation models and multimodal information for holistic understanding.
The research team created a fiber memristor-based physical reservoir computing system that enables seamless, continuous, and unobtrusive sleep monitoring. The system achieved 94.8% accuracy in snore event detection, 95.4% in sleep stage classification, and 93.5% in multi-modal fusion tasks.
This study reclassified patients according to modern WHO Classification criteria, revealing molecular subtyping limitations, pathway co-activation patterns, and strong anatomical-molecular correlations. IDH1/2 mutations and TERT promoter mutations played key roles in determining prognosis.
Researchers propose an integrative framework to explain sepsis-induced granulopoiesis shift. Immature neutrophils exacerbate tissue damage and contribute to immune paralysis. Precision interventions targeting metabolic pathways and biomarker-guided stratification are suggested.
Research team uses AI-driven approach to analyze Chang'e-6 samples, revealing higher shear strength and irregular shape of far-side lunar regolith. The findings suggest a more stable foundation for future lunar bases, but also pose new challenges for drilling and rover mobility systems.
Researchers develop synergistic ultramicropore-confined and electronic-state modulation strategies in sustainable lignin-derived hard carbon to achieve robust sodium-ion batteries. The material exhibits high reversible capacity and initial Coulombic efficiency, making it a promising anode candidate.
Researchers develop a multifunctional hydrogel system with broadband electromagnetic interference shielding and infrared stealth performance, exceeding that of commercial-grade materials under various harsh conditions. The gel's mechanical robustness and environmental stability are enhanced by a synergistic MXene treatment strategy.
The nanozymes hypothesis suggests that natural mineral nanozymes played a crucial role in the origin of life on Earth, catalyzing the generation of prehistoric small life molecules from nonliving matter. These nanozymes enabled informationization of energy into molecules necessary for living systems.
Chronic sleep disruption persistently impairs social memory by differentially encoding oxytocin release in hippocampal CA2 during novelty encoding and prelimbic cortex during retrieval of familiar individuals. Restoration of PVN-OXT neurons enhances OXT release and produces sustained behavioral recovery.
The study identified glutamate-dopamine co-transmitting neurons as critical for regulating reward behavior, with disruptions in VTA communication leading to impaired nicotine response. This research provides a new perspective on the neural underpinnings of addiction and psychiatric disorders.
Researchers have developed an innovative endovascular brain-computer interface (EBCI) that enables precise and minimally invasive diagnosis and treatment of Alzheimer's disease. The EBCI can reach key deep brain regions involved in memory circuits, providing a natural implantation pathway for electrode delivery.
Inhaled polystyrene nanoparticles induce lung injury by disrupting redox balance and triggering inflammation. Oxidative stress leads to mitochondrial dysfunction, respiration impairment, and apoptosis in lung cells.
A new study reveals the CDK12-FOXA1-MDM2-p53 signaling axis promotes prostate cancer development through FOXA1 modification. The study identifies S234 phosphorylation as a critical site, and a CDK12 inhibitor THZ531 effectively blocks this pathway, reducing tumor growth.
Researchers developed a novel nanoparticle system to cross the BBB, target infection sites, and release antibacterial agents locally. This strategy effectively disrupts biofilms, eliminates drug-resistant bacteria, and reduces neuroinflammation.
Researchers decode the molecular mechanisms of toad venom's medicinal properties, revealing a link to serotonin receptor interactions. The study identifies key components and their selective agonist activities on depression-related receptors, shedding light on traditional Chinese medicine's modern interpretation.
In sepsis, endothelial cells undergo programmed death-apoptosis, pyroptosis, ferroptosis, and excessive autophagy, leading to barrier collapse. Targeted therapeutic strategies include glycocalyx protectors, barrier stabilizers, anticoagulant approaches, which aim to repair or replace the damaged endothelial barrier.
Researchers explore microneedle technology as a novel delivery system for efficient and minimally invasive intradermal drug delivery. The review highlights the design of functional microneedles with specific structures to overcome biological barriers in various tissues, improving therapeutic outcomes.
Researchers developed QSteed, a resource-virtualized and hardware-aware quantum compilation framework, to address challenges in real quantum computing processors. The framework reduces compilation times and improves circuit execution fidelities by leveraging a prebuilt VQPU database and hardware-aware compilation strategy.
Researchers propose a hierarchically converged defect-engineering strategy to construct a multidimensional ZnO/Bi₂O₃/BiOCl/BP/MXene heterojunction photoelectrode framework. This targets modulation increases the electrochemically active surface area, optimizes energy-level alignment, and establishes efficient carrier transport pathways.
Scientists create ultra-homogeneous CuS nanosheets supported on N-doped porous carbon, triggered by covalent S species, for efficient HMF electrooxidation. The optimized catalyst achieves a high current density of 335 mA cm^-2 at 1.5 V vs. RHE.