ISM4808, a PHD inhibitor for chronic kidney disease-related anemia, has achieved its first milestone with successful completion of the Phase I clinical trial. The treatment stimulates endogenous erythropoietin production and improves iron utilization, offering improved efficiency and safety compared to existing treatments.
This study reclassified patients according to modern WHO Classification criteria, revealing molecular subtyping limitations, pathway co-activation patterns, and strong anatomical-molecular correlations. IDH1/2 mutations and TERT promoter mutations played key roles in determining prognosis.
Researchers at Nagoya University found that magnetic fields keep the equator spinning faster than the poles in stars, preventing a rotation flip even as they slow down with age. This contradicts 45 years of theoretical predictions and could help scientists solve stellar mysteries.
A new brain imaging study identifies two distinct subtypes of ADHD, each associated with unique brain structure and behavior patterns. The first subtype is linked to attention-related symptoms, while the second subtype shows widespread reductions in grey matter volume and increased disease severity.
Researchers at Duke-NUS Medical School found that testing air and surfaces can detect a broader range of poultry viruses, including highly pathogenic avian influenza strains, which traditional surveillance may miss. Environmental sampling can provide a more comprehensive view of viral circulation in live poultry markets.
A tiny clump of moss played a crucial role in proving a crime had taken place at Burr Oak Cemetery in Illinois. The moss's age was determined to be only a year or two old, bolstering the case against the cemetery employees, who were ultimately convicted in 2015.
A thermally-responsive lubricant infused surface (TLIS) was developed to resist mineral scaling under temperature change and water flushing conditions. The TLIS achieved descaling efficiencies of 91.4% in the first cycle, even after multi-cycles, making it a durable solution for thermal and fluid systems.
A study published in Translational Exercise Biomedicine found that low-intensity treadmill exercise preconditioning significantly reduced brain injury and improved neurological outcomes after ischemic stroke in mouse models. The exercise group showed lower infarct size, increased microvessel density, and reduced inflammation.
A global study found that safeguarding 7.3% more mangrove areas can increase their resilience by 13.3%, with climate-smart conservation being achievable and affordable
Seventy-one undergraduate students presented their research at the annual poster competition, with 10 winners recognized for outstanding presentations. The winners were selected by judges from every career level and represented various fields of biophysics.
The 70th Biophysical Society Annual Meeting Awards Ceremony recognized 35 student research achievement award winners for their exceptional poster presentations. The winners were selected by judges from the Society's Subgroups, with students from over 30 countries participating in the competition.
Teens are getting significantly less sleep, with over 50% reporting less than 5 hours per night, a rise from 2007 when it was around 30%. This short sleep is linked to emotional regulation issues, poor academic performance, and increased risks for obesity and diabetes.
A large US study published in The BMJ found that GLP-1 receptor agonists used to treat type 2 diabetes and obesity may also help lower the risk of addiction to various substances. The study associated GLP-1 receptor agonists with reduced risks of adverse outcomes such as overdoses and drug-related emergency department visits and deaths...
The GOAL-Trauma study found significant variation in blood transfusion strategies for patients undergoing emergency abdominal surgery following trauma, with higher-resource settings using component therapy and lower-resource settings relying on whole blood transfusions.
A global study of 23,000 people found that Gen Z men are more likely to agree that a wife should obey her husband and have traditional views on decision-making within a marriage. Meanwhile, Gen Z women showed less agreement with these statements compared to Baby Boomer women.
Researchers found that GLP-1 medications are effective at reducing the risk of developing substance use disorders across all major addictive substances, including a 14% reduced risk for developing any substance use disorder. The study also showed significant reductions in severe harm, including overdose and death, among patients with p...
Patients who stop taking weight loss drugs like Ozempic and Wegovy experience rapid weight regain of up to 60% within a year, but sustain around 25% of lost weight. Researchers found that individuals may maintain healthier eating habits even after treatment ends.
Researchers have discovered that microscopic oil droplets can fold themselves into precise six-pointed star shapes while remaining liquid inside. The team identified the physical mechanism responsible for this unusual geometry, revealing a fundamentally new route for shape change in elastic interfacial crystals.
In England, over a third of councils face industry legal threats for clean air campaigns; the stove industry lobbied local authorities to ignore public health risks. Key findings include wood burning's significant contribution to fine particle air pollution and its link to various health conditions.
A new medication called zorevunersen has been found to reduce seizures in children with Dravet syndrome by up to 91%, improving their quality of life and behavior. The study, led by University College London and Great Ormond Street Hospital, also showed the potential to reduce the impact of the condition on mental processes.
Recent advances in tubular solid oxide fuel cells provide a comprehensive overview of innovative geometric designs and real-world applications. These cells offer a promising technology for addressing global energy challenges with higher energy conversion efficiency and fuel flexibility.
A new study reveals that ammonia released from intensive livestock farms can stimulate soil microbial processes that generate nitrous oxide, a powerful greenhouse gas contributing to climate change. The research highlights an overlooked pathway linking livestock pollution to global warming.
Phase 1/2a clinical trials demonstrate significant seizure reduction and improvement in symptoms of Dravet syndrome, a genetic disorder affecting cognitive function, motor skills, and behavior. The treatment, zorevunersen, targets the underlying cause of the disease by enhancing the normal SCN1A gene.
Researchers designed modified biochars with phosphorus and magnesium to improve compost quality by retaining nitrogen and accelerating humification. The study found that these materials reduced ammonia emissions and promoted microbial activity, resulting in higher nitrogen retention and improved soil fertility.
Electrical engineers at Duke University have developed the fastest pyroelectric photodetector, capable of capturing light from the entire electromagnetic spectrum. The device requires no external power and operates at room temperature, making it suitable for on-chip applications and multispectral cameras.
Mayo Clinic researchers have identified a hidden 'movement map' deep within the brain, which could help surgeons reduce side effects from epilepsy procedures and guide future treatments for speech and movement disorders. The discovery was made using advanced brain-recording technology to create individualized maps of patients' brains.
The American Heart Association and Laerdal Medical have launched Self-Guided Learning, a flexible resuscitation training delivery model, to provide equitable access to high-quality training. The model allows learners to complete HeartCode Complete courses on their own schedule, using advanced simulation technology to verify skills.
Youth football is associated with nearly 1 in 5 traumatic brain injuries (TBIs) in children and young adults. Football players are also more likely to experience repeat TBIs, with 37% of cases occurring in athletes who participated in the sport.
A York University-led study used machine-learning models to analyze 64 immune biomarkers in people with and without HIV who received COVID-19 vaccines. The researchers found clear vaccine-initiated immune response biomarkers between the two groups, but also identified outliers that provide insights into the complex nature of the immune...
A study found that people with changes in their activity patterns were more likely to have worsening disability and loss of brain volume than those whose patterns did not change. Wearable sensors measure physical activity, time spent sitting or inactive, and circadian rhythms.
Researchers propose a hybrid approach of combining conventional and microwave frying to achieve lower oil content without compromising flavor and texture. The study found that microwave frying resulted in faster moisture loss, shorter cooking time, and lower oil intake, suggesting an economically feasible option for industrial production.
Research reveals hygienic honey bees have enhanced innate immune responses and increased survival when infected with Nosema ceranae, a widespread adult bee pathogen. This discovery offers a promising avenue for strengthening bee health through selective breeding.
NYCST has selected projects for Round 2 funding, focusing on groundbreaking space-related technology development and supply-chain resilience. The consortium aims to address workforce shortages and mature critical technologies through partnerships between industry and top-tier research institutions.
Researchers mapped participants' eye movements to identify patterns when viewing spider images, revealing attention is drawn to spider-specific features like webs and eggs. The study aims to better understand the mechanisms underlying arachnophobia, paving the way for more effective mental health treatments.
A study by the University of Washington found that medical student applications to residency programs in states with new abortion restrictions decreased sharply following the Dobbs decision. Applications to specialties related to reproductive health dropped notably, indicating a potential impact on future physician workforce.
A team led by Paul Bastard aims to discover antibodies that open new avenues for early detection, prevention and treatment of cancer. Ludwig Institute scientists will employ novel protein profiling technologies to capture telltale patterns linking antibody repertoires and disease states.
Researchers at Baylor College of Medicine have identified a potential therapeutic strategy for Rett syndrome by guiding brain cells to produce more functional MeCP2 protein. The approach, which involves deleting a specific ingredient from the gene that produces the protein, has shown promise in mice and cells derived from patients with...
Researchers developed an AI-based liquid biopsy test that detects early liver fibrosis and cirrhosis, and reveals signals of broader chronic disease burden. The test uses genome-wide cell-free DNA fragmentation patterns and repeat landscapes to identify disease-specific signatures.
Researchers found that low-viscosity liquids like milk take around 30 seconds to drain 90% of a thin film, while more viscous fluids like olive oil require over nine minutes. The study provides insight into everyday physics and its applications in the kitchen.
A network of genes connected to the nervous and immune systems can predict liver cancer risk, fatigue, and depression from viral hepatitis infection. The neuroimmunoma biomarker may monitor disease progression and indicate possible psychiatric complications.
Research at Michigan State University reveals how cocaine addiction is notoriously difficult to treat due to its impact on brain function. The study found that chronic cocaine use changes brain activity, particularly in the hippocampus and reward centers, leading to compulsive behavior.
A recent study has precisely dated the end of a geomagnetic field reversal, revealing asynchronous land–ocean responses to ancient ocean anoxia. The findings provide new insights into Early Cretaceous geodynamics and the evolution of marine and terrestrial carbon cycles.
Researchers found that exposure to microbes induces a lasting immune memory in fibroblasts, protecting lungs from allergic reactions for months. This discovery opens up new possibilities for developing preventive strategies for respiratory allergies.
A Stanford Medicine-led study reveals that the US method for ranking children on heart transplant waitlists does not consistently prioritize the sickest patients. The current system fails to capture medical urgency, leading to higher waitlist mortality rates and potential unfair treatment of some patients.
New 3D reconstructions of a key sensory organ in ctenophores show unexpected structural and functional complexity. The findings suggest that an elementary brain may have already appeared in our most ancient relatives, challenging the current understanding of nervous system evolution in animals.
The study found that the extract reduced cell damage compounds by over 75% and preserved skin health with over 60% of cells remaining alive. The researchers developed a natural dye, produced by Talaromyces amestolkiae fungus, which can be used in cosmetic formulations while maintaining safety and functionality.
Researchers from CASUS at HZDR developed a reliable computational framework to study polyheptazine imides' electronic and optical properties. This work confirms the potential of these materials for photocatalytic reactions, including water splitting and carbon dioxide reduction.
Researchers developed a high-speed photoacoustic microscope to track red blood cells in the mouse brain, allowing for single-cell resolution imaging of microvascular structures. This enables study of cerebral small vessel disease, cognitive impairment and dementia.
Researchers identified distinct spatial tumor-immune ecologies that differentiate stable disease from progressive disease in non-small cell lung cancer patients. Tumors that progressed were characterized by immune suppression before treatment began, while stable disease tumors showed stronger colocalization of immune cells. Machine lea...
The Tibet ASγ Experiment has measured magnetohydrodynamic turbulence on scales below one parsec within the gamma-ray halo surrounding the Geminga pulsar wind nebula. The study found that particle diffusion is strongly suppressed near Geminga and the turbulent properties follow a Kolmogorov-type scaling law.
A study at George Mason University found that nursing students in an AI-enhanced health informatics course showed statistically significant learning gains compared to traditional students. The course used AI-generated videos and clinically contextualized assignments to improve student engagement and outcomes.
A study published in PLOS found that LGB+ workers in the NHS do not experience pay gaps compared to their heterosexual colleagues. However, those who have disclosed their sexual identity tend to receive higher pay, while those who have not disclosed are at risk of a pay penalty.
Researchers have found that increasing mutant MeCP2 protein levels can improve symptoms in mice and cells from patients with Rett syndrome. The approach, which guides brain cells to skip a specific ingredient, has shown promise in treating the rare neurodevelopmental disorder.
A team of researchers has developed a practical and powerful all-solid-state battery using lithium-sulfur conversion chemistry. By optimizing particle size and material arrangement, they achieved a discharge capacity of 1500 milliampere-hours per gram of sulfur, bringing the technology closer to realizing its theoretical capacity.
The initiative aims to strengthen Estonia's scientific excellence, train new generations of scientists and engineers, and translate frontier technologies into industrial value. The project plans to create a critical mass of top-level scientists in Estonia capable of leading both research and technology development.
A new study by Geerat Vermeij and Tracy Thomson found that mollusks evolved unique physical traits at a frequency of once every 2 million years in early history, declining to about one trait every 9 million years. The evolution of these traits has become increasingly predictable over the 540-million-year history of mollusks.
A study of charred food in pots reveals that prehistoric Europeans consumed a wide variety of plants, including grasses, berries, and leaves, alongside fish and seafood. The findings emphasize the importance of plants in early European diets and suggest that ancient cuisines were more complex than previously thought.
A study published in PLOS One found that individuals experience a more negative reaction to the time change from daylight saving time (DST) to standard time (ST) in the fall, compared to the transition from ST to DST in the spring. Social media sentiment analysis revealed a depressive impact in early fall.
A team of researchers led by Rice University bioengineer Omid Veiseh is developing a first-of-its-kind regenerative treatment aimed at restoring damaged lymphatic vessels and potentially curing lymphedema. The therapy, called ELIXIR, uses engineered human retinal pigment epithelial cells to rebuild broken lymphatic vessels.
Researchers found that environmental and biological factors significantly impact mosquito sound variability between species and individuals. Controlling for these variations is crucial to improve AI-based acoustic classification accuracy.
The novel approach outperforms standard CAR-T cell therapy in preclinical studies using mouse models of glioblastoma and ovarian cancer. Armored CAR-T cells eliminate tumors, reshape the tumor environment, and boost immune-cell activity.
A new study reveals how birds shift their shape in flight to navigate obstacles, offering insights into improved UAV designs. The research, published in Journal of the Royal Society Interface, used motion capture and wind tunnel modeling to analyze a Harris's hawk's flight patterns.
A recent study reveals that tropical insects have limited ability to adapt to climate change, with many species unable to tolerate high temperatures. The research highlights the threat of far-reaching consequences for entire ecosystems, particularly in regions like the Amazon.
Researchers at Simon Fraser University have found that women's blood clots more slowly and then forms faster and stronger in microgravity, sparking concerns about health monitoring protocols for female astronauts who spend six months or more in orbit. This combination increases the risk of serious medical events, such as pulmonary embo...
A recent study found that AI programs are up to 97% accurate at detecting pictures of deepfake faces, but performed at chance levels when it comes to detecting deepfake videos. Humans correctly identified real and fake videos about two-thirds of the time, picking up on subtle inconsistencies in movement and facial expressions. The stud...
The study discovered that restoring cellular vibration decreases cancer growth and severity in laryngeal cancer. Researchers exposed cancer cells to sound-wave vibration, leading to a decrease in a protein promoting cancer growth.
Three UCF medical students presented their groundbreaking research on improving pediatric care for children with cleft palates and skull deformities. Their studies explored the use of robotic surgery, high-tech imaging, and new surgical approaches to enhance patient outcomes.
The NLRP3 inflammasome plays a dynamic role in regulating acute wound healing by synchronizing macrophage behavior and promoting tissue restoration. Temporally modulating NLRP3 activity improved tissue regeneration, reduced scarring, and enhanced healing quality.
Researchers found that disabling TRIM13 enhances survival in a mouse model of polymicrobial sepsis. The study suggests targeting TRIM13 or its associated ER quality control machinery as a potential strategy for reprogramming immune competence.
A new study explores the market effects of unleashing generative AI on creative endeavors, finding that low-quality 'AI slop' harms consumers and professionals. High-quality AI, however, can enhance professional work while providing consumers with better content options.
In a new study, researchers found that increased nitric oxide levels can lead to a biochemical domino effect, pushing the key cellular control system mTOR into overdrive in some forms of autism. By interrupting this pathway, the team observed prevention of TSC2 modification and normalization of mTOR activity.
Georgia Tech has been awarded a significant grant to develop a novel therapy for lymphatic disease, a condition characterized by chronic pain and limited treatment options. The research team, led by Susan Napier Thomas, aims to move beyond symptom management and address the unmet need for patients with this disease.
A study by UC Irvine chemists reveals that a subtle chemical change in an eye lens protein can make it more likely to clump together over time, suggesting an early step in cataract formation. The research focuses on proteins called crystallins, which help keep the eye lens clear and are meant to last a lifetime.
A team of MIT engineers identified tacit knowledge in volunteers who classified images, shifting focus to easier-to-classify areas without awareness. Bringing this concealed knowledge to the surface enhances experts' performance, suggesting a method for boosting learning experience in disciplines requiring keen observation skills.
Researchers create heat-sensitive protein switches that can be used to tightly regulate protein activity and cellular functions, opening up new possibilities for non-invasive control.
Researchers from Johns Hopkins Medicine have created the open-source AstroID database to organize and analyze clinical and genetic data from cancer patients. The database allows for the study of multiple tumor types and longitudinal patient experiences, streamlining data collection and analysis.
Researchers found that glucose levels sustain increased STAT3 activation in colorectal cancer cells. Targeting glucose metabolism could inhibit STAT3 and lead to novel therapeutic strategies.
A new study published in the Journal of Adolescence suggests that autonomy is not a single entity, but rather two distinct psychological experiences: autonomy satisfaction and autonomy frustration. These experiences steer adolescents toward markedly different academic and emotional outcomes. The research highlights the importance of re...
Treatment with psychedelics triggers large-scale reconfiguration of brain network dynamics driven by myelin remodeling, which might augment or sustain therapeutic effects. The study suggests that enhancing myelination could be a viable strategy to promote longer-term neural health and recovery from PTSD.
A UBC-led global review found water-quality impacts from wildfires often emerge months or years later, with contamination intensifying over time. The study highlights the need for long-term fire retardants and preparedness planning to protect drinking water sources in fire-prone provinces.
A team of scientists using the James Webb Space Telescope discovered a cold spot within Io's auroral footprint with temperatures much lower than expected and extraordinarily high densities. This finding opens up new ways to study Jupiter and its moon system, potentially revealing similar phenomena in other planetary systems.
A scoping review found that shorter, simpler programs with caregiver support lead to better outcomes for dementia patients. Mind-body interventions can improve depression, anxiety, stress, and quality of life, especially when tailored to individual needs.
University of Pittsburgh engineers develop predictive models for longitudinal cracking on concrete pavements to improve road performance and reduce repairs. The project aims to create a nationwide infrastructure solution by pinpointing root causes and developing mechanistic-empirical models.
A study in Barcelona found that pedestrianisation reduces noise levels by 3.1 dB, exceeding WHO guidelines, but finds no impact from pedestrian activity, which takes over acoustical space previously dominated by motorised traffic.
Researchers develop interferometric Image Scanning Microscopy (iISM) technique to deliver high-resolution imaging of intracellular structures in live cells without fluorescent labels. The method improves contrast-to-noise ratio and enables faster acquisition speeds, opening new opportunities for studying nanoscale cellular dynamics.
A new study found that a diet with a lower ratio of polyunsaturated fatty acids to monounsaturated fatty acids can make T cells more resilient and resistant to cell death. This discovery could potentially enhance vaccine protection and improve the success of cancer treatments.
Researchers develop a hybrid nanovesicle platform that addresses oxidative stress, inflammation, and impaired blood vessel growth in diabetic wounds. The treatment improves wound closure, vascular regeneration, and immune balance in diabetic mouse models.
A research team analyzed 2.2 million thunderstorm events to identify a physical explanation for their formation. The study found that differences in soil moisture generate near-surface winds, leading to intense thunderstorms. High-resolution satellite measurements of soil moisture were crucial for this analysis.
Cats are prone to kidney disease due to a unique biological quirk, accumulating modified triglycerides with special ether-linkages. This study proposes that these fats may be an early sign of long-term stress within the kidney, potentially contributing to tissue damage over time.
A new machine learning approach accelerates Raman spectrum prediction for fast-ion conductors, revealing liquid-like ion motion. The method identifies low-frequency Raman signatures associated with high ionic mobility and relaxational host-lattice dynamics.
Children's Hospital of Philadelphia researchers highlight the need for parents and pediatricians to understand generative AI's potential benefits and risks for children of different ages. Early childhood (0-5 years) requires close supervision, while middle childhood (6-11 years) and adolescence (12+ years) require critical thinking ski...
A European consortium is developing AI-powered therapy assistants to help doctors adhere to medical guidelines. The GUIDE-AI project aims to reduce the complexity of guideline navigation, particularly for chronic diseases such as heart failure and asthma.
Abarco trees show strong early growth but sensitivity to air humidity and sunlight intensity, according to a new six-year study. The research provides critical guidance for reforestation and sustainable forest management in Colombia's tropical regions.
A new study found that nearly 25% of UK teachers received no training on supporting neurodivergent pupils, with most reporting brief and limited sessions. The researchers highlight a mismatch between the complexity of pupils' needs and the training teachers are currently receiving.
Researchers from ETH Zurich have developed a single-atom catalyst that enables more efficient CO2-based methanol synthesis. The new catalyst, composed of isolated indium atoms on hafnium oxide, allows for the use of precious metals in an economically viable manner.
Researchers discovered that antibacterial coatings, initially effective against bacteria, can lose their performance over time. The study found that ZnO-based coatings maintained their antibacterial properties, unlike TiO2-based materials which degraded and lost effectiveness after prolonged exposure to UV-A light.
A research team developed an innovative analytical technology to precisely examine intrinsically disordered proteins, a key cause of neurodegenerative diseases. The technology enabled accurate identification of protein structures at the atomic level, revealing how temperature and genetic mutations affect protein structure.
Researchers have identified brain neuropeptides as key drivers behind delayed antidepressant effects for the first time. The study found that medication-driven serotonin levels primarily serve as a 'starting signal' while the peptide plays a central role in brain recovery.
A decision-support system improved depressive and anxiety symptoms, increased medication adherence, and reduced symptoms over time for patients with major depressive disorder. The system used clinical and demographic predictors to tailor treatment, resulting in better outcomes for patients compared to usual care.
A large-scale study found that human activity is consistently changing the ecosystems of Northern European lakes, altering food webs and affecting salmonid fishes. The research used stable isotopes to examine the impacts of hydropower and human modification on lake environments.
The American College of Surgeons has released a national framework outlining measurable workplace standards for surgeons, aiming to improve surgeon well-being and patient safety. The framework provides customizable standards that can be incorporated into departmental policies and employment contracts.
Semaglutide and tirzepatide prescriptions increased dramatically between 2018 and 2025, while MBS use rates declined substantially starting in 2023. Recent shifts in MBS use may be more pronounced in certain patient subgroups, such as those seeking sleeve gastrectomy or with lower BMIs.
Researchers found that interactions with healthy cells determine a tumor's ability to survive, grow, and progress. The team discovered a 'distress signal' sent by the tumor to nearby fibroblasts creates a supportive micro-environment that shelters the tumor from being cleared.
The AI model can accurately identify disease-causing mutations in human genes and is capable of designing new genomes that are as long as the genomes of simple bacteria. Evo 2 has been trained on over 100,000 species across the entire tree of life and can process genetic sequences of up to 1 million nucleotides at once.
A Mayo Clinic study found that women with abnormal Parkinson's-related protein levels accumulate Alzheimer's-related pathology faster, leading to faster disease progression. The study analyzed data from 415 participants and showed that women's brains progress up to 20 times faster than men's in this regard.
A newly granted patent unveils an innovative energy-dissipation device designed to protect buildings and infrastructure from earthquakes, strong winds, and man-made vibrations. The device is simple, low-cost, and power-independent, making it a viable solution for low-income countries with high seismic risk.
Researchers Judith Holler and Anna K. Kuhlen argue that conversation is not a linear exchange of words, but rather a jointly managed activity in which meaning emerges through coordination. Visual signals like gestures and facial expressions play a crucial role in composing and comprehending meaning.
Researchers at DGIST have developed a technology to precisely control anion defects in eco-friendly quantum dots, enabling record-breaking solar hydrogen production efficiency. The defect-minimized eco-friendly quantum dots exhibited increased charge carrier concentration and prolonged lifetime, allowing for efficient charge migration ...
A study by MedUni Vienna found that up to one-third of patients with advanced alcohol-related cirrhosis can achieve complete regression of liver-related complications through consistent abstinence from alcohol. This 're-compensation' also leads to simultaneous recovery of liver function and a significant reduction in mortality rates.
Researchers found that specific gut bacteria can sense diet and translate information into signals that tell fat cells to burn energy. A low-protein diet activated precise gut microbes that promote beige fat production, leading to improved glucose control and lower cholesterol levels.
Researchers found interactions between soil moisture patterns and wind in the lowest atmosphere influence where storms develop, providing clues to forecasters about location. The study aims to improve certainty about upcoming storms on hot days and save lives, livestock, and property.
Cancer cell-derived small extracellular vesicles can be excreted into urine, according to researchers who tracked their journey in mouse models. The study reveals that glomerular cells actively transport sEVs across the filtration barrier, supporting their use in emerging urine-based cancer diagnostics.
The discovery of Eosteus chongqingensis and Megamastax amblyodus provides a major breakthrough in understanding the evolution of bony fishes, revealing primitive characteristics that evolved much earlier than previously thought. These findings confirm South China as the cradle for the origin of jawed vertebrates.
Researchers analyzed data from over 62,000 participants, finding that loneliness partially mediated the link between anxiety and suicidal thoughts as well as depressive symptoms and suicidal ideation. Targeting loneliness may be a crucial strategy to prevent progression from these conditions.
A new AI-powered tool, Merlin, has been developed to assess 3D abdominal CT scans, identifying anatomical features and predicting disease onset years in advance. The tool surpassed traditional automated tools in tasks such as diagnosing diseases and predicting patient outcomes, with accuracy rates of up to 81%.
A new study by UNC Charlotte scientists has discovered a self-clustering mechanism in the Polycomb protein CBX2 that is essential for initiating gene-repressive condensates and guiding stem cells toward their proper fates. The researchers found that CBX2 clusters recruit two Polycomb repressive complexes, creating multicomponent repres...
A team of researchers uses Quantum Fisher Information to separate individual parameter relevance from cross-parameter correlations in QAOA. This analysis reveals strongly non-uniform parameter relevance that varies with circuit architecture and depth.
A randomized study of 14 young adults found that sparkling water consumption reduced subjective fatigue and improved executive function while playing virtual soccer for three hours. Players who drank sparkling water also committed fewer fouls and had better game enjoyment compared to those drinking plain water.
Researchers used UAV-LiDAR technology to measure deposits on abandoned mountain roads, estimating decadal-scale debris supply. The study found that debris supply increases with steeper slope angles and larger contributing areas, posing a risk for debris flows.
Researchers have developed a new type of solid-state magnesium-air rechargeable battery using nitrogen-doped porous graphene as the cathode. The battery exhibits superior performance and safety compared to traditional systems, with improved chloride resistance and high catalytic activity.
Olivia Asher, a Ph.D. candidate in bioinformatics at UGA, has been selected for the 2026 AIBS & SURA Public Policy Fellowship. She will work with AIBS and SURA policy staff in Washington, DC, to gain hands-on experience with science policy and advocacy efforts.
Scientists have identified five distinct species of antbirds, including two new species, by integrating AI, vocal analysis, and traditional museum work. The study reveals that populations separated by major Amazonian rivers have evolved into distinct species.
This study assesses the educational impact of introducing interest-matched examples in data science education, showing a positive effect on students' motivation and understanding. The findings suggest that instructional approaches grounded in intrinsic motivation theory can improve data science education quality.
A study by the University of Gothenburg found that young adults are more likely to consume healthcare through online apps, especially when no patient fees are charged. Women tend to have higher consultation rates than men, who experience a sharper decline in consultations once they turn 20.
A study by MIT researchers found that nitrous oxide can hamper the growth of certain soil bacteria dependent on vitamin B12 for methionine biosynthesis. The findings suggest that N2O production in agricultural settings could influence microbial communities, potentially impacting crop health.
Recent studies identify distinct gut microbial communities in people with dyslipidemia, suggesting a connection between the gut microbiome and heart disease precursor. The researchers found higher levels of Bacteroides caccae and lower levels of bacteria linked to metabolic stability. Future research aims to restore functional balance ...
Florida Atlantic University has received a $4.5 million grant from the US Air Force to establish a high-fidelity platform for autonomous decision-making and real-time sensor fusion research. The T-1A Jayhawk simulator will be used to study cognitive performance, situational awareness, stress and decision-making under pressure.
The researchers created a 3D-printed model of the left side of the heart that contracts and beats, allowing for rehearsing of important heart surgeries on a model that acts like the real thing. The model was successfully used to repair a defective mitral valve and demonstrate reduced regurgitation.
A new study from Hiroshima University revealed that pre-employment career resilience, particularly optimism about the future, plays a crucial role in forming vocational identity and coping with reality shock. The study suggests university-level programs to promote career resilience before students enter the workplace.
The SimTac simulator accurately models biomorphic sensors using particle-based deformation, light-field rendering, and neural network prediction. It achieves high performance in optical and mechanical response accuracy, adaptability to diverse morphologies, and simulation efficiency.
Researchers found that black soldier fly larvae can break down RNA viruses in organic waste, reducing potential risks. The larvae's frass still contained some active viruses, highlighting the need for additional treatment.
Research supports a nuanced view of IMF reforms, finding them welcome in autocracies but contentious in democracies. The study suggests IMF programs can align national economic policy with domestic preferences, with implications for global economic governance.
New studies reveal that medication nonadherence in people with chronic obstructive pulmonary disease (COPD) is often caused by affordability and limited understanding of medications. This can lead to quicker lung function decline, more frequent exacerbations, and a higher symptom burden.
Research reveals that salivary bacteria from gum disease alter gut metabolism, driving osteoclast activity and systemic bone loss. Microbial metabolites like indole-3-lactic acid inhibit osteoclast differentiation and activity.
A recent study has shed light on the processes that drive mitochondrial uptake and its benefits for cells. Isolated mitochondria were found to be taken up by mesenchymal stromal cells, enhancing proliferation and cytoprotection, and improving energy metabolism.
A new study challenges the common method used worldwide to measure genetic progress in crop breeding, finding that most reported gains are due to maintenance breeding, not genetic improvements. This has significant implications for agricultural research policy and investment, highlighting the need for more robust evaluation methods.
A new report sets out ten priority areas for improving climate education in UK schools, calling for coordinated support across the whole education system. The experts argue that while the curriculum review is a welcome step, real change requires attention to issues such as teacher training and sustainability actions.
A global team led by UC San Diego's Ludmil Alexandrov is receiving a $25 million Cancer Grand Challenges award to decipher the molecular origins of cancer. The team aims to identify unique patterns of DNA damage and their sources, which could lead to new prevention and treatment strategies.
Researchers have demonstrated that stem cell treatment can be effective even when initiated after motor deficits appear in cerebral palsy. The study used stem cells from human primary tooth pulp to treat chronic-phase cerebral palsy in rat experiments, showing improved motor and learning functions in the treated group.
A new study has demonstrated the safety of short-term vaginal estrogen therapy in younger survivors of endometrial cancer. The research shows that local, low-dose vaginal estrogen does not increase a woman's risk of cancer recurrence, providing hope for women who have experienced this type of cancer.
Researchers from the University of Waterloo have identified the key factor behind estrogen's protective effects against high blood pressure, finding vasodilation to be the crucial mechanism. This discovery holds promise for more effective treatment options for women after menopause, when estrogen levels naturally decline.
Researchers investigated which characteristics of crystals made them fascinating to early humans, using experiments with chimpanzees. The chimps showed a strong attraction to transparent and crystalline properties, suggesting that this attraction may have deep evolutionary roots.