About The Study: In this cross-sectional study of 62,685 participants from the All of Us Research Program, loneliness partially mediated the association between anxiety symptoms and suicidal ideation as well as depressive symptoms and suicidal ideation. Targeting and reducing loneliness may present a transdiagnostic approach to arrest the progression from anxiety and depressive symptoms toward suicidal ideation.
Corresponding Author: To contact the corresponding author, Katherine Musacchio Schafer, PhD, email katherine.m.schafer@vumc.org .
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(doi:10.1001/jamanetworkopen.2026.0596)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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