Depression
Articles tagged with Depression
Single dose of psilocybin provided rapid relief from depression in new study
Contact lenses treat depression in mice as effectively as anti-depressant medication
Rewiring rumination: A targeted brain-based approach to depression
Study validates accuracy of depression screening for people with chronic pain
Higher BMI is associated with more financial problems, loneliness, and stress
Better decision-making, better stress management: Study explains link between resilience and decision-making behavior
A new study finds that individuals with higher resilience tend to place greater weight on positive aspects in cost-benefit decisions, a process mediated by brain activity. This regulated handling of negative information is linked to increased acceptance and improved psychological resilience.
Depression dampens anticipation, not enjoyment
Probing links between decision-making and mental resilience
Researchers found that individuals with stronger brain responses to negative information were more resilient in their thoughts and feelings. They accepted more offers with mixed consequences, indicating a lower value on negative outcomes. This study suggests that controlling negative thoughts may enable people to build mental resilience.
Study points to metabolic health as a key factor in mood disorders
A study links insulin resistance and leptin dysregulation to cognitive impairment in bipolar disorder, highlighting the potential of targeted clinical pathways. Metabolic alterations are associated with cognitive deficits and poorer performance in memory and attention.
Genes linked to neuronal communication appear altered in immune cells of patients with depression
Researchers discovered that genes linked to neuronal communication are also altered in immune cells of patients with depression, reinforcing the systemic nature of the disease. This finding paves the way for developing blood tests to identify and diagnose depression, as well as new treatment approaches targeting inflammation.
AI-generated images of depression depict more stereotypes and arouse greater stigmatization
Digital therapy outperforms referrals to campus clinics among college students
A digital therapy app was found to be more effective in treating anxiety disorders, depression, and eating disorders among college students compared to traditional campus clinics. The study, which tested the app's effectiveness over six months, showed a significant increase in symptom-free students and services uptake.
Scientists finally see inside the ‘black box’ of depression treatment
Psychedelic substances: Who can they help – and who might they harm?
Genotype-guided antidepressant prescribing for patients with depression
A randomized clinical trial found that genotype-guided prescribing of SSRIs did not improve depression symptoms at 3 months but showed higher remission rates at 6 months. Future studies should focus on the long-term impact of this approach.
Adjunctive antipsychotics in major depressive disorder
This systematic review and meta-analysis found differences in efficacy and acceptability of adjunctive atypical antipsychotics for major depressive disorder. The study highlights the need for more well-controlled studies on maintenance efficacy of these medications.
Ketamine infusions and rapid reduction of suicidal and depressive symptoms in major depressive episode
A systematic review and meta-analysis found single and repeated intravenous ketamine infusions to be efficacious in reducing suicidal and depressive symptoms in acute major depressive episodes. Longer-term outcomes remain unclear.
Better cognition tied to higher relapse risk after depression remission
A new study with over 3,700 UK participants found that better cognitive functioning may be associated with a higher risk of future depressive episodes in those with a history of depression. In contrast, worse cognitive performance was linked to a lower risk of relapse in both individuals with previous depression and control participants.
One dose of psilocybin changes the human brain
Researchers found that psilocybin causes temporary shifts in brain entropy, leading to increased insight and emotional self-awareness. This correlates with improved well-being and cognitive flexibility, suggesting the psychedelic trip is key to its therapeutic effects.
How can the same genetic mutation lead to different clinical outcomes?
Researchers developed a framework to study the impact of genetic variants on neurodevelopmental disorders. By analyzing induced pluripotent stem cells, they found that genetic background can lead to different clinical outcomes in individuals with the same deletion on chromosome 16.
Marker of biological aging linked to cognitive symptoms of depression
Researchers found that accelerated biological aging of a type of white blood cell called monocytes is linked to cognitive and mood-related symptoms of depression. This discovery could lead to earlier diagnosis and personalized treatment for depression, particularly in high-risk populations such as women with HIV.
Reverse engineering ketamine’s effects may lead to new antidepressants
Researchers identified a specific subset of opioid receptors on interneurons in the prefrontal cortex that ketamine targets to relieve depressive symptoms. Combining small doses of three drugs targeting the same pathway may provide an effective alternative to ketamine with fewer side effects.
Language of helplessness: How we write about ourselves reveals symptoms of depression
A study by SWPS University found that people with depressive symptoms use less active language, such as 'I am incapable' instead of 'I achieve goals'. This analysis of social media posts shows promise for early detection and prevention of depression.
The link between reduced inpatient care and suicide
A nationwide ecological study found a statistical correlation between fewer psychiatric beds and higher suicide rates in Sweden. The study suggests that investing in outpatient care may not be enough to prevent suicides, highlighting the need for further research into healthcare resource allocation.
Why is it hard to fully enjoy positive moments?
Dampening, a phenomenon where positive emotions are diminished, can undermine well-being over time. Research found that future-focused thoughts, such as 'positive feelings won't last,' are strong predictors of depressive symptoms.
Brain-computer interface based on Rice research wins FDA approval for first clinical trial
Motif Neurotech has received FDA approval to begin the first clinical trial of its therapeutic BCI device, DOT, for treatment-resistant depression. The study will test the device's effectiveness in delivering electrical stimulation to brain circuits linked to depression.
How a mental health strategy helps young adults navigate cancer diagnosis
Researchers at Rutgers University tested the efficacy of Bright IDEAS, a problem-solving skills training intervention, in reducing depression and anxiety symptoms and improving health-related quality of life among young adults with cancer. The study found significant reductions in symptoms and improvements in quality of life compared t...
New research suggests exposure to fathers’ depression in pre-adolescence is associated with poor educational outcomes among males
New research suggests exposure to fathers' depression in pre-adolescence is associated with poor educational outcomes among males, but not females. Early identification and family-centered support can help promote school success and long-term well-being for affected sons.
ADHD and chronic pain, an overlooked connection
A study published in Scientific Reports reveals a connection between ADHD-related traits and chronic pain, highlighting the importance of addressing ADHD in pain management. The research suggests that treating ADHD may help reduce chronic pain severity.
Under embargo: Families and friends speak out on electroconvulsive therapy’s silenced risks
A new study reveals that electroconvulsive therapy (ECT) can lead to significant negative impacts on standard of living, personal relationships, and even brain damage. Relatives and friends of ECT patients report long-term effects including memory loss, emotional blunting, and loss of independence.
Research alert: First large‑scale survey estimates that 2.8% of US population used psilocybin in the past year
A recent study estimates that 2.8% of US residents over 12 used psilocybin in the past year, highlighting the need for clinicians to be aware of its use among patients with depression. The findings also underscore the importance of longitudinal studies and increased public health surveillance as de-criminalization efforts progress.
USC-led team receives funding to build next-generation medical device that uses tears to monitor health
A USC-led team is working on a medical device that uses tears to monitor health, starting with dry eye disease. The device aims to provide continuous monitoring and automated medication delivery, improving patient comfort and treatment efficacy.
Transcranial alternating current stimulation (tACS): Mechanisms and clinical applications in neuropsychiatric disorders
tACS modulates brain oscillations, induces synaptic plasticity, and regulates neurotransmitter release to alleviate symptoms of various neuropsychiatric conditions. Personalized approaches are essential for treatment efficacy.
Support from a trusted adult in childhood can mitigate the long-term impact of abuse
A study published in the Journal of Aggression, Maltreatment & Trauma found that feeling safe with a trusted adult during childhood reduces the risk of depression, chronic disease, and poor health. The presence of protective adults significantly mitigates the long-term impact of abuse.
Bullying and adverse social climate take measurable toll on mental health of gender-diverse youth
Research found that gender-diverse teens reported higher rates of psychological stress and psychotic-like experiences, which can lead to depression, anxiety, and other serious mental health disorders. Bullying and unsupportive legislation drove these findings.
Pediatric Investigation study uncovers the link between academic burnout, internet gaming, and depression
A recent study found that academic burnout is associated with increased internet gaming and depression in Chinese adolescents. The study highlights the importance of targeted prevention strategies, including mental health check-ups, counseling sessions, stress management programs, and attentional bias modification training.
The brain’s emotional hub is linked to alcohol use differently in young men and women
A study found divergent neural pathways for drinking patterns in young men and women, highlighting the importance of sex-specific prevention strategies. Amygdala reactivity was associated with depressive symptoms in males, while females showed a 'threat-avoidance' profile with lower alcohol risk scores.
Depression can reduce income for years
A new study from the University of Southern Denmark finds that people with depression experience significant income loss, with losses averaging 17% lower than those without depression. Income loss persists and grows over time, even after diagnosis.
Loneliness is a critical step on the road to suicide: Study
A Vanderbilt University study analyzed 633,000 survey participants and found that loneliness played a critical role in suicidal ideation. Reducing loneliness could
Smartphone app developed by mental health researchers improves mental habits and functioning in randomized trial
A randomized trial tested HabitWorks, a smartphone app offering personalized exercises to target interpretation bias. Participants reported significant improvements in interpretation bias, functioning, and overall mental health symptom severity.
Mount Sinai enrolling patients in DoD-funded clinical trial of drug-free neuromodulation therapy for postpartum depression
Researchers are testing whether SAINT, a non-invasive brain stimulation therapy, can quickly relieve symptoms of postpartum depression. The study aims to find faster and more effective treatments for women experiencing depression after childbirth.
When the nervous system starves the brain: Autonomic dysfunction unmasked as a hidden driver of treatment-resistant depression
A study published in Brain Medicine suggests autonomic dysfunction, particularly parasympathetic and sympathetic imbalances, contributes to depressive symptoms in patients unresponsive to conventional antidepressants. Low-dose medications targeting these imbalances may offer a new approach to treatment.
Testosterone level not a given sign of well-being
A higher testosterone level does not always indicate well-being in men, according to a study at the University of Gothenburg. Muscle health and inflammation are linked to testosterone levels, but symptoms like fatigue and depression have weaker connections.
USC announces a joint biomedical engineering department, bridging medical and engineering schools to accelerate health care innovation
The new joint department combines expertise in medical devices, neuroengineering, imaging science, and more to advance biomedical research and translate discoveries into meaningful health advances. The partnership aims to accelerate the translation of discoveries into improvements in human health.
Toward strategies for extending ketamine’s antidepressant effects
Researchers identified NOX-1 as a key molecular target to prolong ketamine's therapeutic benefits. Combining ketamine with NOX-1 inhibitors significantly extended its antidepressant-like effects. K-4, a novel AMPAR modulator, also showed rapid antidepressant effects that persisted for at least 2 weeks.
Emotions in motion: How movement may signal mental health issues
A recent study published in Gait & Posture found that analyzing a person's walk and getting up from a chair can identify elevated depression and anxiety symptoms. The researchers used machine-learning models trained on data from participants' movements combined with information about their mental state, achieving high accuracy rates.
Lasting income costs of mental and physical illness
A study estimated income losses from individual perspectives in Denmark from 2000 to 2023 after hospital diagnoses of depression, alcohol use disorder, stroke, and breast cancer. The researchers found that income losses were largest for mental disorders, with average losses growing over time, particularly among younger individuals.
GH001 vs placebo in patients with treatment-resistant depression
Researchers found that GH001 significantly improved depression symptoms in patients with treatment-resistant depression, outperforming placebo. The treatment was well-tolerated and suggests a potential novel treatment option.
The cost of resilience: BGU study reveals the mental toll of war on Israel’s teachers
A new BGU study examines the emotional labor of teachers during wartime, revealing that those who fake emotions are at higher risk of psychological collapse. The research emphasizes the importance of fostering internal motivation and clear educational identities to mitigate teacher attrition.
New medicine piggybacks onto fat absorption pathways to allow oral delivery and support clinical trial in major depressive disorder
A new approach allows oral delivery of drugs previously requiring injection by piggybacking on natural fat absorption pathways. The medication, GlyphAllo, bypasses the liver's security checkpoint and is absorbed through the gut's lymphatic system, allowing it to enter the bloodstream directly.
Probing and rescuing dysfunctional brain circuits in depression
Researchers are using preclinical mouse models and patient studies to identify cellular and circuit-level mechanisms driving mood-state transitions. The goal is to develop new treatments by rescuing dysfunctional brain circuits in depression.
Fathers’ mental health deteriorates long after the birth of their child
A new study published in JAMA Network Open reveals that fathers' mental health declines over time after the birth of their child, with increased risk of anxiety and substance abuse diagnoses returning to pre-pregnancy levels. However, depression and stress-related disorders continue to rise by over 30% one year after childbirth.
Inflammation linked to depression in women with diabetes, but biomarkers paint complex picture
A study found that inflammation markers may signal depression in women with type 2 diabetes, but vary based on depression symptoms and measures. The research suggests a path toward precision mental health by identifying specific inflammatory biomarkers linked to different dimensions of mental health.
TikTok’s mental health ‘minefield’
A systematic review of social media platforms reveals that TikTok contains a substantial proportion of misleading information about mental health and neurodivergence, with higher rates of misinformation than other platforms. The study emphasizes the importance of credible sources and evidence-based content to combat spreading false ide...
Post-game depression: Polish scientists first to create tool to measure this phenomenon
Researchers from SWPS University develop Post-Game Depression Scale (P-GDS) to capture players' experiences after finishing video games. The study reveals RPG fans are most at risk of intense P-GD, associated with stronger depressive symptoms and lower well-being.
Why chronic pain leads to depression for some but not others
Research suggests that persistent pain drives progressive changes in the hippocampus, a brain region involved in emotional regulation. This can shape whether people develop depression or remain emotionally resilient. The study's findings challenge the idea that depression is an inevitable consequence of long-term pain.
FAU researchers find concerning rise in US teen obesity over a decade
A concerning rise in adolescent obesity has been found, with overall rates climbing to 15.9% in 2023. Obesity patterns also reveal a decline in weight-loss attempts, with females more likely to attempt weight loss but fewer adolescents reporting efforts in 2023.
Adverse childhood experiences and treatment-resistant depression
A cohort study found that adverse childhood experiences (ACEs) were associated with an increased risk of treatment-resistant depression in adults. Preventing ACEs and incorporating ACE history into clinical assessment may help identify individuals at elevated risk for treatment resistance.
Spousal loss linked to higher risk of dementia, mortality among men, but not women
A new study finds that widowed men experience poorer physical and mental health, while widowed women show resilience and improved well-being after losing their spouse. The study highlights the need for gender-specific strategies to support recovery after spousal loss.