Researchers discovered a molecular pathway connecting lncRNA-encoded micropeptides, macrophage polarization, and tumor progression in liver cancer. The study found that the micropeptide CTXND1 suppresses mTORC1 signaling in macrophages, thereby limiting tumor growth.
Researchers developed a room-temperature free-radical polymerization route for quasi-solid-state gel electrolytes, enabling uniform gelation and improving energy density. The approach uses high-ESPmax activators to activate acrylate monomers, suppressing harmful side reactions and preserving cathode structure.
A large multicenter study of 17,415 Chinese participants found that mosaic chromosomal alterations (mCAs) are associated with a 22% higher risk of colorectal cancer. mCAs also further distinguished colorectal cancer risk within strata of inherited genetic susceptibility and lifestyle exposures.
Researchers developed Prioritized Integrative Target Optimization (PITO) to link human genetics to therapeutic target ranking and herbal candidate discovery for thyroid disease. The framework uses multimodal genomic integration and network analysis to guide multi-target research in traditional Chinese medicine.
Researchers developed a twisted molecule design strategy to address limitations in conventional perylene diimide-based electron-transport layers. The strategy achieved organic solar cells with efficiencies exceeding 20%, improved bending durability, and reduced dependence on expensive silver electrodes.
Researchers developed functionalized titanium disulfide (TiS2) membranes with improved antibiotic rejection and resistance to water-induced degradation. The optimized membrane achieves high rejection rates for various antibiotics and maintains stable performance over multiple cycles.
Researchers identify HDAC3 deacetylase activity as essential for zygotic genome activation, coordinating histone acetylation and chromatin accessibility. Loss of HDAC3 activity leads to embryonic developmental defects and dysregulation of major ZGA genes.
Researchers found that historical writers tended to overstate or understate climate severity in records, likely influenced by their own memories. The study suggests that correcting for human memory filters could improve climate reconstructions and explain fading risk awareness between disasters.
A Danish-Dutch research team re-examined the dating of 27 medieval skeletons and found that freshwater fish consumption can significantly distort radiocarbon dates, leading to incorrect age assignments. This phenomenon, known as the 'freshwater trap', affects not only Denmark but also potentially across Europe.
A novel anti-Alzheimer's drug discovery strategy was established using an LPS-induced neuroinflammatory cell model. Benzoylaconitine (BAC) was identified as the most effective anti-Alzheimer's candidate compound, showing anti-inflammatory effects and modulating the cholinergic signaling pathway. In vivo validation in 5xFAD mice demonst...
The new instrument captures wind and temperature variations at three atmospheric heights, providing a broader context for atmospheric disturbance research. The findings show reasonable agreement with meteor radar observations and validate atmospheric models, extending the coverage beyond the current altitude range of radar measurements.
The study evaluated the combination of enzalutamide and talazoparib in patients with high-tumor-burden metastatic prostate cancer. The results showed that the combination delayed radiographic progression-free survival and reduced the time to PSA progression.
The 2026 Bundibugyo outbreak tested the assumption of cross-protection between ebolavirus species, highlighting the need for a broader framework. The recommended approach includes pan-ebolavirus diagnostic targets, multivalent vaccines, and updated therapeutic platforms.
A study published by the Deutsche Forschungsgemeinschaft investigated the use of new approach methods in the life sciences. The researchers aimed to improve data analysis and visualization, leading to more accurate results.
Researchers developed a yolk-shell structured catalyst that efficiently desulfurizes bulky sulfur compounds. The optimal catalyst achieved high desulfurization efficiencies and turnover frequencies, demonstrating the potential of precise yolk-shell thickness control in designing high-performance catalysts.
Researchers developed Gradient Purification Defense (GPD) to protect decentralized federated learning systems from poisoning attacks. GPD retains beneficial information in malicious parties, securing the model and improving accuracy, outperforming state-of-the-art defenses in scenarios with heterogeneous data distributions.
Researchers have developed DNA nanostructure-based ECL biosensors with enhanced sensitivity, stability, and reproducibility. These platforms detect pathogen nucleic acids, microRNAs, proteins, and intracellular markers using enzyme-free amplification circuits and CRISPR-Cas modules.
A study published in Cancer Cell describes an experimental drug that breaks down the barrier protecting solid tumors, allowing killer T cells to attack. The drug, FEBP-sTβRII, changes the activity of genes in the blood and reprograms immune cells to recognize cancer, leading to durable tumor immunity.
The team created ultra-dense waveguide arrays with a spacing of 750 nm, suppressing crosstalk and introducing minimal propagation loss. They also used artificial gauge fields to design and compensate dispersion in conventional couplers, achieving broadband optical signals on chip.
Researchers have found that major volcanic eruptions can temporarily strengthen marine cold spells, affecting global climate patterns and ocean temperatures. The study, published in Ocean-Land-Atmosphere Research, analyzed reconstructed ocean temperatures from 1850 to 2024, revealing varying regional responses to volcanic winters.
A study found a significant connection between late-winter Pacific-North American (PNA) pattern activity and East Asian tropical cyclone activity during the following summer. The researchers identified two ocean-mediated pathways linking winter atmospheric variability to summer tropical cyclone activity.
A promising biomarker, GHB-pentose, has been discovered to detect GHB in urine for up to three days after intake, providing a longer detection window. The biomarker has also been found in deceased individuals, potentially helping investigators determine if GHB was ingested before death.
The INFINITY project aims to overcome semantic fragmentation and ethical ambiguity in European cultural heritage by linking information to historical and social contexts. By transforming fragmented collections into clear, transparent, and interconnected knowledge graphs, INFINITY enables users to find and properly use cultural objects.
A new study found that changing magnetic dimensionality in Cr2₋δTe2 increases spin-wave frequency by over five times, from 37 GHz to 194 GHz, but with stronger damping and localized propagation. This understanding can help design high-frequency devices based on layered magnetic materials.
Breast cancer survivors may experience accelerated biological aging due to chemotherapy, leading to an increased risk of earlier death from other causes. The study found that those who received more cytotoxic chemotherapy regimens lost an average of 9.4 remaining life years due to aging-related diseases.
Researchers have identified a key transporter gene that controls nickel accumulation in cereal grains and uncovered its role in amino acid metabolism, seed vigor, and yield formation. The study found that nickel transport links nitrogen metabolism with yield formation and seed vigor.
A newly developed AI agent called MLP Copilot has made atomic modeling easier by bridging computational tools and scientific evidence with human supervision. The framework has been used to investigate aluminum nanoparticle oxidation, revealing two behaviors of particles with an existing oxide shell.
Researchers at Tohoku University have found that tiny shifts in water molecule orientation can flip magnetic partnerships between metal ions, offering a new tool for designing magnetic materials. Hydrogen bonding can be used to carry magnetic coupling across large distances within a crystal.
Scientists have created quantum dots with a precisely controlled interfacial layer, achieving high photoluminescence efficiency and color purity. The resulting red-emitting quantum dots showed a photoluminescence quantum yield of 95.3% and narrow emission linewidth of 78 nanometers.
Researchers studied the biomechanics of jump serves, finding that hand orientation affects ball spin. A greater forward tilt increased topspin, while a greater sideways tilt increased lateral spin.
A tiny sensor could one day measure blood pressure continuously, comfortably, and accurately without an inflatable cuff. The device uses silicon photonics and optoacoustic technology to measure blood pressure in real time and over extended periods.
A Japanese study found that strong neighborhood social ties positively affect residents' attitudes towards recycling and behavior. Residents with stronger ties were more likely to engage in waste separation and perceive proper waste separation as expected by others in the community.
A new catalyst, hydroxide-activated hydrogen spillover, has been developed to simplify nitrogen reduction and enable efficient ammonia synthesis at ambient conditions. The catalyst achieves a record-high ammonia yield rate of 40.67 μg h⁻¹ cm⁻² with a Faradaic efficiency of 24.9%, marking a significant step toward sustainable, decarboni...
Researchers develop two-step approach to synthesize multi-helical nanographenes with controlled handedness and tunable optical properties. The method enables the selective construction of complex chiral structures with potential applications in advanced chiroptical materials and optoelectronic devices.
The researchers propose a three-tiered proteostasis model that links arginine methyltransferases to immune regulation through three distinct layers: methylation of histone and non-histone proteins, generation of free methylarginines, and methyltransferase-independent functions.
A team of researchers has developed a method to turn insulating boron nitride into a p-type semiconductor, demonstrating high-performance transistors on a 2-inch wafer. The approach involves incorporating carbon into boron nitride to create p-type semiconducting behavior.
JMIR Medical Informatics launches an e-collection on planetary health informatics, focusing on clinical-environmental data integration, informatics architectures, and sustainable health systems. The call for papers aims to advance planetary-scale learning health systems and address health challenges driven by climate change.
The Glenn Foundation for Medical Research has awarded $3 million in grants to 29 early career researchers in 2026. These grants support postdoctoral investigators and junior faculty in aging research, with a focus on extending healthy years of life.
FAU's CA-AI will establish educational pathways for quantum technologies starting at the early-college level, combining foundational education with advanced coursework and hands-on research. The program aims to prepare students with skills applicable to emerging quantum technologies.
A new study reveals that the CASS4 gene plays a crucial role in Alzheimer's disease by directing brain-cleaning immune cells, which can be disrupted leading to the buildup of toxic plaques. This discovery offers new hope for the development of treatments or prevention strategies by targeting the gene or microglia in the brain.
Viacure Therapeutics, a spin-off from Helmholtz Munich, is developing an antibody therapy to protect insulin-producing beta cells and restore their function in type 2 diabetes. The therapy aims to preserve or regenerate beta cells, supporting the body's ability to regulate blood glucose.
A new West Health-Gallup Center on Healthcare study found that nearly 90% of physicians use AI in their work, but only 20% have received formal training. Patient comfort with AI-driven healthcare hinges on provider oversight, with 56% of patients comfortable when AI makes decisions subject to a provider override.
Researchers created a sensor that detects mercury ions by changing color and emitting near-infrared light, allowing for faster and simpler testing outside labs. The sensor can identify low concentrations of mercury ions, even in food and water samples, and may be used to monitor mercury contamination in the environment.
REALworld: AML aims to create a rigorous dataset that researchers can use to better understand pediatric AML and improve clinical trials. The initiative engages current and former pediatric AML patients and their families to build real-world evidence.
Researchers found that awake brain mapping can lead to more individualized and optimized lead placement, resulting in better tremor control, fewer side effects, and wider therapeutic windows. The study suggests that this approach can provide clinically useful information even as imaging and surgical technologies advance.
A survey of nearly 2,000 adults in Denmark, the UK, and the US found that people judge the risks of hormone-disrupting chemicals by how they get into the body, with food and drink being the biggest concern. People who knew more about EDCs also believed they were more vulnerable to them.
The Endocrine Society establishes the Jesse Roth Award to recognize outstanding research in hormone action, diabetes, or metabolism. C. Ronald Kahn is the inaugural winner, who will deliver a lecture at ENDO 2027 and receive an honorarium and travel grant.
The University of Oxford and Boston Children's Hospital are establishing a genetic medicines hub to design, test, and accelerate genetic medicines for neurodevelopmental disorders. The hub will develop a scalable platform for antisense oligonucleotide therapies, improving efficiency and reducing duplication in the development of geneti...
An experimental study found that AI can enhance creative tasks, but human involvement is crucial for quality and satisfaction. The 'Human Creativity' and 'Copilot' conditions showed higher quality and satisfaction rates compared to 'Human Confirmation' and human-only approaches.
Researchers analyzed ice cores from the Arctic region to reconstruct atmospheric levels of toxic heavy metals during the second Industrial Revolution. The study found that the Anaconda Copper Mine's emissions potentially led to widespread health impacts for millions of Americans and Canadians.
A new study identifies three subtypes of PMDD, each with unique patterns of symptoms, suggesting personalized treatment approaches and a better understanding of the condition. The research also explores the biological mechanisms underlying symptom patterns and potential treatments, including the role of brain function in women with PMDD.
Regular coffee consumption changes how the gut functions, affecting gut bacteria diversity and pH levels, with potential benefits for digestion and bowel movements. Frequent coffee drinkers had lower pH in the small intestine and more contractions in the colon, which could support healthy digestion.
Researchers identified changes in the accretion disk and X-ray variability that precede jet ejection activity by up to 10 days, suggesting a possible predictor for these phenomena. Monitoring the inner radius of the accretion disk may enable astronomers to forecast jet ejections more accurately.
Researchers from Tokyo University of Science developed a method to fill MOF pores with ionic liquids, increasing material's hardness and preserving structure during etching. This approach enables precise microfabrication at room temperature, extending MOF applications for devices like sensors and catalytic devices.
A longitudinal study in Japan found that living arrangements among older adults significantly impact mental health, with distinct gender differences. Men living alone face higher depression rates, while women living with spouses also experience mental health issues, highlighting the need for gender-sensitive support programs.
Researchers at Hoag Memorial Hospital Presbyterian discovered a molecular warning signal in the blood that identifies serous tubal intraepithelial carcinoma, an early precancerous stage of ovarian cancer. The breakthrough may enable detection years earlier, transforming ovarian cancer surveillance and prevention.
Scientists at the University of Basel have controlled 'forbidden' vibrations in single nitrogen molecules, enabling precise measurements of molecular vibrations. This breakthrough has potential applications in molecular clocks, quantum bits, and tests of fundamental laws of physics.
A study by Fujita Health University found that watching a patient education video about surgery before consultation can reduce uncertainty and shorten doctor–patient discussion. The results showed a 40% reduction in consultation time, and a lower decisional conflict score in the video group.
A WSU study found that the average person would pay a 10% premium for eco-labeled tires, with a median price increase of $76 for a set of four tires. The study, funded by the Salmon Safe organization, surveyed nearly 700 people in California, Oregon, and Washington, and found that approximately 25% would pay a premium of $225 for salmo...
Researchers have detected signs of neuronal injury in individuals carrying the genetic mutation that causes Huntington's disease, even before symptoms appear. Elevated levels of neurofilament light chain (NfL) were found in individuals classified in the earliest stage of the disease, suggesting different biological conditions may coexist.
A new species of giant rodent, Yakamys sirindhornae, was discovered in southern Thailand, dating back 34 million years. The fossil finds suggest that massive rodents evolved repeatedly in different regions, including Southeast Asia.
Researchers propose that unstable repeat DNA may contribute to the missing heritability of schizophrenia and bipolar disorder, suggesting a link to glutamine variation. The proposed mechanism involves glutamine dysregulation in astrocytes, which can lead to psychosis.
A 1878 monograph by Ludwig Kirn is being recognized as a key contributor to the development of manic-depressive illness. The review highlights Kirn's clinical approach, which identified recurring patterns in patients, and his insights on the persistence of underlying illness between attacks.
Researchers at the University of Waterloo have developed a hybrid cooling system that targets hotspots on computer chips with a single drop of boiling coolant, reducing temperature by up to 17°C in 15 seconds. The system combines immersion cooling with targeted spot cooling, offering a potential solution for thermal management in data ...
A new review examines the relationship between tumors and the nervous system, suggesting that psychedelics may be able to 'listen' to the system and provide relief from cancer-related symptoms. The review also explores the potential for psychedelics to modulate the immune system and reduce inflammation in cancer patients.