A new roadmap for stroke recovery prioritizes genetic and blood biomarkers to drive precision neuro-rehabilitation and biotherapy. The framework seeks to understand the underlying biology of brain repair after a stroke, with the goal of developing effective biotherapeutics.
A phase 2 clinical trial found that combining two immunotherapies with standard chemotherapy prior to surgery improved pathologic complete response rates in high-risk, early-stage HER2-negative breast cancer patients. The regimen demonstrated strong activity among patients with ImPrint-positive tumors, including high pCR rates.
A recent analysis found that while genomic testing increased among Medicare recipients, many patients still lack next-generation sequencing tests. This limits their access to precision medicine and targeted therapies. The study highlights the need for further research on how increased testing impacts patient outcomes.
A global review of migratory bird population status reveals that over half of the world's migratory bird species are declining globally. The study emphasizes the need for a new approach to biodiversity conservation, addressing complex threats throughout the birds' lifecycles and international flyways.
A recent clinical trial found that a combination of THC and CBD significantly reduced agitation in people with late-stage dementia. The study, which enrolled 120 participants, showed a 6.27-point reduction in mean agitation scores after 2 weeks and a sustained reduction at 12 weeks.
A new study from Georgetown University's Berkley School of Nursing found that youth-led environmental design can foster a unique form of 'Situated Strength' among high school students in rural Appalachia. The project transformed an unused concrete pad into a multifunctional wellness space, supporting emotional regulation and resilience.
Researchers at Georgetown University Medical Center found that the brain can remodel its architecture to automate learned tasks, enabling true multitasking. This challenge previous theories on human multitasking and has implications for artificial intelligence capable of building on prior learning.
Researchers identify RAGE receptor as key driver of age-related increase in breast cancer metastasis. Analyzing mouse models and human data, they found that aged mice develop more lung metastases than younger mice, despite similar primary tumor growth.
The Health Security Operations Center will monitor infectious disease transmission and deliver timely information to health officials, health systems, and the public. Drawing on data from wastewater monitoring, hospitalizations, and real-time health reports gathered from host cities, the HSOC aims to anticipate and mitigate large-scale...
A new study found that high school students who perceive sun protection as inconvenient or uncomfortable are less likely to engage in sun-safe behaviors. Teens who view tanning as enhancing appearance or social appeal also tend to neglect UV radiation protection.
Early-stage drug development worldwide has nearly doubled over the past decade, with China's share increasing from 8% to 32%, according to Georgetown University researchers. The number of early-stage programs increased by 82.4% from 10,417 in 2015 to 18,999 in 2024.
Scientists at Georgetown University have found that ezrin's closed form binds to RNA, influencing gene translation and supporting cancer cell growth. The discovery may lead to new treatments for osteosarcoma and other ezrin-dependent cancers.
A comprehensive review of 82 studies found no evidence of Ginkgo biloba's benefit for cognitive impairment, but suggests a possible benefit for dementia. The supplement was not associated with an increased risk of serious harm compared to placebo.
Pancreatic cancer cells use specific microRNA molecules to reprogram nearby immune cells called macrophages, helping tumors grow. By blocking this communication, researchers found a potential way to reverse the process and restore macrophage function to fight cancer.
Georgetown University researchers discovered a method to enhance the function of T cells, making them more effective in killing cancer cells. By inhibiting PARP, an enzyme that detects DNA abnormalities, scientists can boost the body's immune response against tumors.
Researchers developed a new method to identify effective treatment combinations for glioblastoma by analyzing individual cell types and their gene expression signatures. This approach has the potential to personalize cancer treatment and may be useful for other cancers and diseases.
Researchers found that eradicating aging cells in mice with a combination of dasatinib and quercetin reduced senescent cells, improved memory, and decreased seizures. The study's results suggest a potential new approach to treating temporal lobe epilepsy.
Researchers found that increased activity of a specific protein in the brain can alter learning processes associated with rewards. This discovery may lead to better treatments for conditions like addiction and depression.
Researchers found estrone hormone drives inflammatory activity in postmenopausal women with obesity, increasing risk of aggressive breast cancer. Lifestyle interventions may not be sustainable, but GLP-1 drugs show promise as a therapy.
A new study analyzing dozens of published papers found that medical humanities approaches identified crucial barriers and opportunities for intervention, including systemic information gaps and stigma-related barriers. The study highlights the importance of a human-centered approach in understanding health inequities.
Experts emphasize powerful therapeutics and successful programs like Global Fund and PEPFAR have saved millions of lives. However, funding pauses led to thousands of deaths, and further action is needed to avoid millions more HIV infections and deaths.
A new study found that a low-glutamate diet significantly improved migraine symptoms in veterans with Gulf War Illness, with measurable brain changes detected. Cortical thickness decreased in patients on the diet, suggesting a potential treatment for chronic neurological symptoms.
A clinical study suggests that immunotherapy can be effective in treating mesothelioma, a rare cancer affecting the lining of the lungs. The trial found improvements in time to tumor growth and overall length of survival for patients with operable diffuse pleural mesothelioma.
Researchers found that brain areas typically involved in hand tool use are still active when individuals use their feet, indicating a more flexible organization. This organization can arise without typical motor experience, providing evidence for action-type as a core driving factor in motor organization and development.
A NIH-funded study by Georgetown University researchers found that strokes can rob a person's ability to use word meanings to recognize words while reading. The study, published in the journal Brain, identified a key brain region and connections affected by this deficit.
Researchers discovered that tuning interspecies stickiness and tendency to bundle enables precise control over network formation and rheological performance. This framework enables programmable control over material structure and mechanical properties, inspired by biological tissues.
Researchers at Georgetown University found that claim denials for cancer-related advanced genetic testing increased between 2016 and 2021, despite a recent Medicare national coverage determination. The study analyzed nearly 30,000 claims filed by over 25,000 unique Medicare beneficiaries and suggests uncertainty remains around coverage...
A new analysis finds a significant increase in people dying at home due to ischemic stroke, reversing a 10-year decline, with rural communities and Black Americans more likely to die in less specialized care environments. The study also reveals rising death rates from stroke, despite improvements in access to palliative care.
Researchers developed a new brain imaging technique to predict and guide stroke patients' recovery by analyzing white matter tracts leading to the limbs. The study found that atrophy in these tracts is strongly correlated with motor recovery after a stroke, enabling clinicians to tailor rehabilitation strategies.
A new study compares the allosteric regulation of Escherichia coli and Mycobacterium tuberculosis cAMP receptor proteins, revealing distinct regulatory mechanisms despite structural resemblance. The findings suggest species-specific control over bacterial gene regulation and have potential implications for drug development.
A recent study labels whiteness as a fundamental determinant of health in rural America, highlighting unique factors that contribute to poorer health outcomes. Rural white Americans face higher rates of heart disease, stroke, and cancer compared to their urban counterparts due to limited access to healthcare and socioeconomic disparities.
A new study from Georgetown University Medical Center and MedStar Health researchers found that cognitive difficulties, lack of social participation, and self-perceived poor recovery are key drivers of depression after a stroke. Contrary to previous studies, physical disability was not a significant predictor of depression in this study.
The Center for Global Health Practice and Impact (CGHPI) at Georgetown University Medical Center has been awarded $27.5 million by the CDC/PEPFAR to expand its work in Haiti addressing HIV/AIDS. The new program, TIDE Plus, will strengthen care delivery models and support patient-led organizations to sustain the HIV response.
The authors recommend short-term voluntary vaccination of farm workers at exposure risk, medium-term refreshment of vaccine stockpiles, and long-term exploration of pre-pandemic immunization strategies to build population immunity. They call on global partners and governments to address H5N1 and other pandemic influenza threats through...
Global regulatory bodies, particularly in low- and middle-income countries, need enhanced capacity to ensure timely and safe access to essential medical products. Experts suggest expanding regulatory pathways to prioritize public health by enabling faster reach of diagnostics, therapeutics, and vaccines.
A study by Georgetown University neuroscientists reveals that the primary visual cortex develops a unique connectivity pattern in people born blind, stable over time and distinct from individuals who can see. This finding has profound implications for understanding brain development and may help launch personalized rehabilitation and s...
A comprehensive analysis of 62 studies on oral nicotine pouches reveals potential risks for youth, including nicotine dependence and confusing labeling. The study's findings suggest that while these products may be less harmful than cigarettes, they still pose significant health concerns.
A comprehensive needs assessment of Muslims in the Washington D.C. area reveals lower cancer screening rates compared to the general population. The study emphasizes the importance of culturally sensitive health initiatives to improve cancer screening rates among this community.
A new detailed analysis of a patient's second cancer after receiving CAR-T therapy provides valuable guidance for clinicians. The study reveals that CAR-T related second cancers can occur, often with lymphomas, and highlights the need for early detection and management.
The phase 2 clinical trial of BXCL701 in combination with pembrolizumab showed a 50% progression-free survival rate and significant reductions in CA19-9 markers, indicating potential anti-cancer effects. The treatment has also shown low blood pressure as the main side effect.
A new study finds that individuals with cognitive declines before an Alzheimer's diagnosis experience a significant increase in credit card and mortgage delinquencies. The research, led by Georgetown University, shows that financial outcomes deteriorate consistently over the quarters leading up to diagnosis.
A new study conducted with Washington, DC residents who experienced homelessness during pregnancy found that structural inequities exacerbate health outcomes. The study emphasizes the importance of stable housing early in pregnancy to improve health outcomes for birthing people and infants.
A new study on aspirin's role in breast cancer treatment highlights critical issues related to health equity and aging, with implications for future disease intervention trials. The study found that aspirin did not decrease the risk of cancer recurrence or improve survival among breast cancer survivors.
A study of nearly 4,000 individuals found significant impairments in processing speed, working memory, and executive function among perinatally HIV-infected children and adolescents. The findings highlight the need for better diagnosis and treatment in low- and middle-income countries to improve long-term cognitive outcomes.
A large study found that antibiotics provided no measurable impact on cough severity or duration in patients with lower-respiratory tract infections. Advanced lab tests confirmed bacterial and viral infections, but treatment didn't affect resolution time.
Researchers found that abnormalities occurred specifically in the anterior neostriatum within the basal ganglia, a structure deep in the brain. The discovery has the potential to improve both diagnosis and treatment of developmental language impairments.
Researchers at Georgetown University Medical Center found that amnesia following head injury is due to inadequate reactivation of neurons involved in forming memories. They were able to reverse the amnesia in mice using lasers, potentially allowing cognitive impairment caused by head impact to be clinically reversed.
A team of neuroscientists discovered that people who are blind can recognize basic faces using the fusiform face area, a region crucial for face processing in sighted individuals. The researchers used a device that translates images into sounds to study brain activity.
The Georgetown Global Health Center has launched PHAROS, a first-of-its-kind wildlife disease database that collects records of viruses and bacteria in wild animals. The platform aims to predict pandemics like the weather by allowing scientists to share and manage their data, with the goal of making 'one health' a data-driven field.
Researchers used computer modeling to analyze cancer incidence and mortality rates among diverse populations, confirming the validity of the approach. The studies aimed to address critical public health issues by identifying leverage points to increase equity in cancer burden among Black populations.