A new survey across seven large countries in the Global South reveals both depth of climate knowledge and trade-offs citizens face when weighing climate policies against other urgent needs. Strong support is found for earmarking revenues from carbon taxes for health and education programs.
A new review warns that strobilurin fungicides, widely used in farming, are contaminating staple foods, water, and human bodies. Small amounts can cause harm, interfering with cell energy production and potentially disrupting hormones.
Six Japan-led programs will be presented at the Science Summit UNGA80, addressing global challenges such as food and water security, rare diseases, inclusive education, and research ethics. The programs are open to a global audience and offer free registration.
The Global RETFound initiative aims to develop the world's first globally representative AI foundation model in medicine, addressing health inequalities and AI bias. The project involves a diverse dataset of over 100 million fundus photographs sourced from 65+ countries.
A comprehensive study assesses decarbonization's ramifications on global poverty and inequality, revealing the potential for redistributing domestic carbon revenues to alleviate poverty. However, careful policy design and international cooperation are crucial to address social development issues in developing countries.
Scientists have synthesized organic compounds that exhibit universal magnetic behavior attributed to linear band dispersion (LBD). The discovery accelerates understanding and application of quantum materials for advanced IT technologies.
This article introduces post-quantum cryptography, emphasizing its mathematical foundation in lattice theory and positive definite quadratic forms. The study explores the shortest vector problem (SVP) and closest vector problem (CVP), crucial problems for further development of lattice-based cryptography.
The International Telecommunication Union is strengthening its collaboration with academia to gather insights on emerging technology trends. The new Academic Advisory Body will produce informative policy briefs and forward-looking analyses on the evolving role and impact of innovation.
Researchers have created face-/edge-shared 3D perovskitoid single crystals with suppressed ion migration, providing a new pathway for stable and high-sensitivity X-ray detection. The team's design addresses the long-standing issue of ion migration in traditional perovskites.
A novel, low-cost catalyst made from peanut shell-derived biochar and BiFeO₃ achieves rapid inactivation of antibiotic-resistant bacteria (ARB) within minutes. The system demonstrates high efficiency and durability, offering a potential solution to tackle antibiotic resistance pollution in aquaculture wastewater.
A nationwide study of secondary school pupils in England found that bright children from poorer backgrounds are twice as likely to be admitted to hospital with mental health problems. They are also more likely to be treated for alcohol and drug use, self-harm, and pregnancy-related issues.
The new textbook bridges the gap between traditional divisions in teaching and practicing tectonics, seismology, geodesy, and geodynamics. It provides a basis to explore fundamental connections between the planet's deep interior and surface.
Developing fly embryos use different strategies to prevent 'tissue tectonic collision', a fundamental engineering problem during development. The cephalic furrow forms and disappears without leaving a trace, but its evolutionary significance was unclear until now.
A new study found that Australian women of reproductive age taking GLP-1 receptor agonists are not using effective contraception, despite known risks during pregnancy. The research revealed a higher risk of pregnancy among younger women with diabetes and those without diabetes in their early thirties.
Researchers developed photo-inducible binary interaction tools (PhoBITs) to precisely control gene expression, cell signaling, and immune responses. PhoBITs enable targeted treatment with minimal side effects, opening new avenues for cancer therapy, immunotherapy, and regenerative medicine.
A new study found that the end of COVID-era federal funding led to a significant increase in uninsured children visiting emergency departments in Texas, with 45.2% more visits than before. The share of commercially insured patients also rose 12.5%, while Medicaid-insured visits declined by 11.7%.
A review analyzes strategies for energy-level alignment in perovskite solar cells, including perovskite absorber engineering and ETL/HTL optimization. Real-world case studies validate the effectiveness of these approaches.
A large portion of people with diabetes remain undiagnosed or receive suboptimal care. The study found that 44% of those aged 15 and older with diabetes are unaware of their condition, with substantial regional diagnosis and treatment disparities.
A multilayer film developed by University of California engineers reflects heat while letting through light needed for photosynthesis. This could make greenhouses more water- and energy-efficient, with minimal impact on crop yields. The film reduces near-infrared light passing through by almost 90%.
Researchers have developed a game-changing solution for wastewater treatment, delivering unprecedented performance in electrochemical oxidation of persistent pollutants. The 3D-printed electrodes reduce reliance on critical raw materials and cut fabrication costs by 30%, offering a scalable, metal-free path to sustainable water treatment.
Researchers have developed an artificial cartilage material that responds to pH changes in the body, releasing anti-inflammatory drugs precisely where and when needed. This approach could improve arthritis treatment outcomes by continuously delivering pain-relieving medication.
As Arctic permafrost thaws, geochemical reactions unleash metals like cadmium, harming fish and disrupting ecosystems. The Salmon River's transformation poses indirect threats to Indigenous communities and other species.
Researchers developed a novel zwitterionic electrolyte additive using anionic group design to eliminate hydrogen evolution reactions and zinc dendrite growth. MPC emerged as the most effective additive due to its dual functionality, offering promising solutions for ultra-stable and long-life aqueous zinc-ion batteries.
Researchers used AI models with integrated clinical and claims data to predict chronic kidney disease (CKD) progression to end-stage renal disease (ESRD). The study found that the models outperformed single data source models and reduced racial bias. The findings can inform likelihood and management of CKD, supporting targeted interven...
Researchers have developed a new approach to manufacturing multicolour lenses using metamaterials, overcoming major limitations of metalenses. The design enables polarisation independence and scalability through mature semiconductor nanofabrication platforms.
Stefan Kappe, a leading expert in genetic engineering of parasites, has been appointed as the new Director of the Center for Vaccine Development and Global Health at UM School of Medicine. He will focus on developing genetically engineered live-attenuated pathogens to combat malaria infection.
Researchers developed an AI tool to assess tambaqui fish stress levels based on their lower half body coloration. The study found that stressed fish became darker, and the trait is heritable, impacting animal welfare and farming practices.
The article explores the fundamental principles and applications of current oral anti-tumor and anti-infective vaccines, discussing considerations necessary for designing future oral vaccines. Oral vaccines can be used for tumor therapy and prevention of various infectious diseases, improving immune defense.
Researchers explore FtsZ's potential as a therapeutic target for bacterial cell division, highlighting current advances and future directions. Despite progress, challenges persist, including weak binding affinities and evolving drug resistance.
A 14-year study highlights the importance of diagnosing and treating obstructive sleep apnea in people with type 2 diabetes. The research suggests that continuous positive airway pressure (CPAP) treatment can reduce mortality risk by up to 26%.
Researchers found that neutrophil protein Relmy pokes holes in heart cells, promoting dangerous heart rhythms and cell death. The study suggests targeting immune cells may help prevent sudden cardiac death and arrhythmias.
Resistance mutations and the blood-brain barrier pose significant hurdles to targeted treatment efficacy in NSCLC patients with brain metastases. Emerging evidence suggests that ABCB1 and ABCG2 drug transporters play a crucial role in differential efflux of targeted inhibitors at the BBB.
The Lung Cancer Genetics Study has launched an open-source data platform, offering no-cost access to de-identified data from consenting participants. Researchers can conduct analyses on germline genotyping, self-reported health and exposure data, and cancer-causing driver mutations, with longitudinal datasets to be added over time.
A population-based study found that CT radiation exposure before conception may increase the risk of spontaneous pregnancy loss and congenital anomalies. Women with prior CT scans were more likely to experience miscarriages, ectopic pregnancies, or stillbirths, as well as birth defects in their offspring.
Keith Cole has received a five-year grant from the National Institute on Aging to conduct integrated research on dual decline, mobility, cognition and aging. This research aims to identify predictors and treatment targets for older adults at risk of physical and cognitive decline.
A research team at DGIST has successfully developed a drop-and-spread inkjet printing technique to fabricate high-sensitive biosensors. The technology enables precise sensor fabrication without expensive equipment, showing potential for early diagnosis and real-time monitoring of neurological diseases.
Researchers at Penn State developed CitraBoneQMg, a biodegradable scaffold that combines magnesium and glutamine with citric acid to promote bone growth. The implant increased bone growth by 56% in rats compared to traditional implants, demonstrating its potential for treating complex fractures.
Researchers used multiple agronomic models to examine the effects of climate-smart agricultural practices on carbon sequestration and greenhouse gas emissions. The study found positive effects in both studied locations under a baseline scenario, but negative effects in a worst-case scenario.
A new study reveals cancer cells can convert a ketone into acetyl-CoA through an alternative pathway, reshaping the relationship between diet and cancer. This finding suggests that glucose may not always be the primary nutrient source for cells, adding to the complex understanding of cellular metabolism.
Researchers at Indiana University School of Medicine have developed a novel candidate drug that shifts the behavior of immunosuppressive regulatory T cells, turning them from cancer protectors into tumor fighters. The study shows promising results in clearing triple-negative breast cancer tumors and treating other aggressive cancers.
A study found that fine particulate matter air pollution exposure is associated with increased dementia severity and Alzheimer disease neuropathologic changes. Population-based studies are needed to better understand this relationship.
Researchers discovered a new reductive uric acid pathway that functions without oxygen, which builds upon current knowledge of uric acid degradation. The study found that this pathway produces a metabolite called yanthine, which is elevated in patients with gout and could serve as a biomarker for diagnosing or monitoring the condition.
Researchers developed a novel optical sieve method to detect, classify and count nanoplastic particles in real-world environments. The innovation provides hope for scalable monitoring of global plastic pollution with far-reaching implications for human health and the environment.
Researchers developed a mathematical framework that shows economic growth and environmental sustainability are compatible in developing countries. A 'kindergarten rule' level of pollution abatement is necessary for successful implementation, depending on factors like clean technology availability and foreign aid.
A team of researchers has created a reliable method for accurately recording greenhouse gas emissions from corporate sustainability reports. The dataset, published in Scientific Data, provides a rigorous and transparent foundation for evaluating automated approaches to sustainability reporting.
A team of researchers from Japan has synthesized a novel 2D material, 2H-NbO2, which exhibits strongly correlated electronic properties with two-dimensional flexibility. The discovery paves the way for realizing advanced quantum materials in next-generation electronic devices.
Researchers found that mutations in the CFAP410 gene change its interaction with another protein, making motor neuron cells more vulnerable to DNA damage and cell death. This discovery provides new insights into the mechanisms underlying Motor Neurone Disease and highlights potential targets for new therapies.
Researchers have successfully tested drone-delivered Automated External Defibrillators (AEDs) for out-of-hospital cardiac arrests in the UK. The technology shows promise, but there were delays once the drone arrived on scene, highlighting the need for more support from bystanders and call-handlers.
Researchers at DGIST developed a high-performance color-conversion layer that delivers vivid color reproduction while maintaining performance even when stretched by more than 50%. The new technology enables direct linkage of quantum dots with stretchable polymers, overcoming challenges in commercializing flexible displays.
A new review emphasizes the importance of both physical activity and reduced sedentary time for optimal skeletal health. Emerging evidence reveals that prolonged sitting and inactivity can harm bone health, even among regular exercisers.
A clinicopathologic study identified high-grade serous carcinomas in cervical biopsies as secondary to upper genital tract tumors, mostly of endometrial origin. Accurate diagnosis is crucial for proper management.
Prochlorococcus, a cyanobacteria and photosynthesizing organism, is threatened by ocean warming. The microbe's optimal temperature range is between 66 and 86 degrees, but rising temperatures may lead to reduced productivity and impact the marine food web.
Researchers have developed a new light-based chip that cuts power consumption for image recognition tasks by up to 100 times, using lasers and microscopic lenses fabricated onto circuit boards. This breakthrough enables faster performance and potentially strain-free AI systems.
Researchers created a genetically engineered model of lung cancer in naked mole rats, showing that these animals require multiple genetic mutations for tumors to form. The study reveals that tumors developed highly diverse and infiltrated by immune cells, opening the door to future studies on tumor microenvironment.
A clinical study suggests that immunotherapy can be effective in treating mesothelioma, a rare cancer affecting the lining of the lungs. The trial found improvements in time to tumor growth and overall length of survival for patients with operable diffuse pleural mesothelioma.
Researchers at DGIST developed an implantable wireless neural interface capable of delivering drugs precisely to deep brain regions without external equipment. The device's micro-pump and microchannel structure enable precise drug infusion, overcoming the blood-brain barrier's limitations.
This study identifies a high-efficient platform for discovering key anti-Notum constituents from herbal medicines, with 5-Methoxypsoralen emerging as a promising anti-GIOP agent. The compound promotes osteoblast differentiation and activates Wnt signaling in dexamethasone-challenged osteoblasts.
A research team at DGIST developed a Direct Optical Lithography (DOL) technology that patterns Quantum Dots (QDs) at ultra-high resolution, improving color reproduction and device performance. The technology achieved 2 μm patterning with excellent precision and stability.
A new luteolin nanomedicine is designed to deliver the fat-clearing compound precisely to atherosclerotic plaques, boosting fat clearance and improving artery stability. The treatment reduces plaque size, lipid burden, and inflammation, making it more stable and reducing the risk of rupture.
A study by Carnegie Mellon University found that gradually releasing TV shows increases consumer engagement and subscription rates. Participants in the gradual-release group were 48% more likely to continue using the platform than those in the all-at-once release group, leading to increased subscription retention.
The Gabriella Miller Kids First Pediatric Research Program has released its 36th study, introducing significant new data updates to two existing studies. These advances aim to uncover the genetic foundations of childhood cancers and congenital conditions. With over 110,000 data files available, researchers can explore publicly accessib...
A large-scale study led by New York University found that children receiving biofeedback speech therapy improved their 'r' sound pronunciation at a much faster rate than traditional methods. This technology-enhanced treatment approach uses visual feedback to improve speech, making it easier for children to adjust and reducing frustration.
Reconstructive spectrometers combine miniaturized encoding hardware and computational reconstruction algorithms for high-fidelity spectral analysis. The field has seen significant advancements, enabling real-time spectral analysis in diverse environments, with applications ranging from healthcare to consumer electronics.
A new study found that nearly half of all adults in the U.S. have high blood pressure, and inaccurate images of blood pressure measurement contribute to potentially wrong conclusions about their blood pressure levels. The study highlights the importance of using accurate images to demonstrate proper technique for measuring blood pressure.
A new study finds that sargassum seaweed can significantly slow down sea turtle hatchlings in Florida, increasing their risk of predation and heat exposure. Researchers found that even small amounts of sargassum can impede hatchlings' progress, with leatherbacks taking 54% longer to crawl through light sargassum.
A study found that nearly half of spontaneous DNA damage in human oocytes localizes to telomeres and accumulates with donor age. Telomeric DNA damage compromises oocyte quality, leading to chromosomal instability and reduced maturation rates.
Integrating automated smoking cessation interventions into pediatric primary care significantly increased treatment received and reduced cigarettes smoked among parents. The study found that the interventions led to a greater reduction in cigarette use, improved quit rates, and increased health navigator support.
The Nationwide Herp Adoption Program provides a health-verified solution for surrendered reptiles and amphibians, offering invaluable training opportunities for future veterinarians. The program protects wild amphibians and reptiles by reducing the release of unwanted pets into the wild.
A study by the University of Konstanz found that plant species which have expanded rapidly in their European home regions are more likely to become widely naturalized globally. The researchers identified common characteristics among these successful plant species, including being tall, ecologically versatile and highly competitive
Kenneth Lutchen, a renowned biomedical engineer and higher education leader, has been appointed to lead Boston University's $500 million research enterprise. He will focus on advancing discovery, scholarship, and collaboration.
A new study reveals the Levant Basin as one of the world's most concentrated graveyards for plastic packaging, with research findings showing extremely high seafloor concentrations of plastic bags and packaging. The basin acts as a final sink due to high pressure and sedimentation.
A Rutgers study found that nicotine pouches are used by most adults who have quit other tobacco products or e-cigarettes. The product has low usage rates overall, but may offer harm reduction benefits for those with a history of tobacco use. Researchers emphasize the need for continued monitoring and regulation of oral nicotine pouches.
The study demonstrates the clinical feasibility of simultaneous cell isolation technology, capturing tumor cells and microenvironment cells with high efficiency. The technology improves sensitivity and precision of liquid biopsy, increasing accuracy of early diagnosis and treatment response monitoring.
A researcher at IIT Genoa, Eli Slenders, has been awarded an ERC Starting Grant to build a new microscope that can track molecules inside cells and detect disease onset. The grant will enable him to establish his own research group and study the position and speed of biomolecules.
Researchers found that dengue infection can reprogram the body's immune system, leaving a lasting genetic imprint that influences future infections. This effect is not seen with vaccination, but rather with gene activity patterns in specific types of immune cells that the dengue virus infects.
Researchers harness AlphaFold 3 to predict how T cells recognize peptides, opening avenues for precision immunotherapy and vaccine design. The approach enables in silico identification of immunogenic epitopes that could serve as vaccine targets.
A team of scientists has identified rogue DNA rings as early drivers of glioblastoma growth, suggesting a window of opportunity for earlier detection and treatment. The study suggests that targeting these DNA rings could lead to more effective treatments.
A new study finds that yoga is less effective than traditional exercise in enhancing vascular health, particularly among sedentary adults. Structured exercise consistently outperforms yoga in improving vascular function.
A KAIST research team has developed a wearable sensor that can analyze multiple metabolites in sweat, enabling precise monitoring of internal metabolic changes over time. The patch uses nanophotonics and microfluidics technologies to collect and analyze sweat components without labeling.
A novel bivalent molecule effectively suppresses inflammatory cytokines in human nasal epithelial cells, leading to therapeutic benefits in an AR mouse model. The chemical degradation of Keap1 induced by homoPROTAC KEAP1 demonstrates efficacy in managing AR symptoms, oxidative stress and inflammation.
The article discusses an AI-integrated quality prediction and diagnostics framework for small-sample pharmaceutical manufacturing, achieving state-of-the-art results with improved accuracy and stability. The proposed PeDGAT model enhances model stability in small samples, offering a panoramic view of attribute relationships across units.
A new study reveals the complex brain circuits involved in growth hormone release during sleep. The findings provide a map for understanding how sleep and hormone regulation interact, potentially leading to new treatments for sleep disorders and degenerative diseases.
Light pulses have been shown to temporarily weaken repulsive forces between electrons in neighboring metal atoms, allowing for more efficient electron mobility. This discovery offers a new way to manipulate material properties with light, potentially leading to more efficient solar energy conversion and other applications.
A new vision plan for Innovation District Copenhagen outlines a comprehensive strategy to strengthen cooperation between businesses, educational institutions, and public actors. The district is set to become Denmark's new beacon for Life Science, with the goal of creating thousands of new jobs and attracting investments of billions.
Researchers have developed a silicon chip that uses light to perform convolution operations for AI, reducing energy consumption and increasing speed. The chip achieves near zero energy performance, leap forward for future AI systems.
A new 'metabolic clock' uses data from over 13,500 participants to predict a person's biological age and detect early markers of disease. The tool analyzes blood samples using NMR metabolomics and machine learning to estimate health parameters.
The £250 million investment will create an Advanced Marine Technology Hub at the University of Plymouth, leveraging its expertise in autonomous marine systems, maritime cyber security, and renewable energy. This initiative aims to boost the city's economy and enhance UK's national resilience.
The DeLLphi-303 trial demonstrates tarlatamab's safety and efficacy as a first-line maintenance treatment for ES-SCLC, with median OS of 25.3 months and PFS of 5.6 months. The combination also showed a manageable safety profile, with cytokine release syndrome being the most common adverse event.
A novel genome-wide association study identifies previously unrecognized connections between human genetics, gut fungi, and chronic disease. The study establishes that host genetics can influence the fungi that live in the gut and provide clues about their abundances.
Steve Canty has been appointed as the new director of the Smithsonian's Marine Global Earth Observatory (MarineGEO) network. As part of this role, he aims to expand how MarineGEO collaborates with communities to co-develop solutions for protecting and restoring coastal environments globally.
Researchers found that distinct neural representations of color are conserved across people's brains, enabling scientists to predict the color and brightness of observed stimuli using brain activity comparisons. This study provides new insights into the universal aspects of human color perception.
A study published in PNAS reveals that hybridization between the two species has been crucial to the survival of the Balearic shearwater, a critically endangered seabird. Hybridization introduces genetic diversity and adaptive potential, benefiting small and threatened populations.
Researchers at King Abdullah University of Science and Technology (KAUST) have developed a system to convert captured carbon dioxide into industrial-grade ethylene, a crucial commodity in plastics, textiles, and construction. The innovation reduces energy costs by 0.8 gigajoules per metric ton compared to existing electrolysis systems.
Scientists have developed a new device to probe the existence of dark matter particles across a wide mass range below one mega electron volt. The QROCODILE experiment uses an improved superconducting nanowire single-photon detector to detect changes in direction, which can help filter out non-dark-matter events.
The study highlights the importance of support networks during adolescence, including family connectedness and school and peer relationships. Stronger connections are associated with better mental health outcomes, lower rates of depression and suicidal ideation, and increased resilience.
Researchers found that male mice become aggressive after witnessing familiar peers attack intruders, not strangers. The study suggests that familiarity with attackers may be a risk factor for violent behavior in males.
A study found that living in areas with high air pollution concentrations accelerates cognitive decline and worsens Alzheimer's disease by increasing the buildup of toxic proteins in the brain. Exposure to fine particulate matter, such as PM2.5, was associated with increased risk of severe amyloid and tau pathology.
Dr. Gianluca Ianiro has been awarded a €1.5 million ERC Starting Grant to investigate the precision modulation of the gut microbiome in post-infectious irritable bowel syndrome. The project aims to identify key microbial species associated with acute disease and develop novel modulation strategies.
A new USF study discovers that chameleons and salamanders use the same biological mechanism to fire their tongues at extreme speeds, with potential applications in biomedical devices and space retrieval tools. The researchers hope to expand their studies to examine how animal tongues retract with such speed and precision.
The 2026 Ocean Sciences Meeting will be held in Glasgow, Scotland from February 22-27, 2025. The event will bring together 6,000 scientists, students, and educators to discuss breaking research on the ocean sciences and critical issues affecting a sustainable future for our oceans.
Researchers created phase diagrams for organic solar cells and found that mixing behavior depends on temperature, requiring additional parameters for accurate prediction. The work could accelerate the development of improved materials for high-efficiency solar cells.
The study reveals that subtropical regions have the lowest carbon footprint, while temperate and tropical regions face greater challenges. Practical strategies like recycling crop waste and using a mix of synthetic and organic fertilizers can slash emissions without sacrificing yield.
A new study from the University of Birmingham has found that immune ageing may be a driver of rheumatoid arthritis rather than a consequence of the disease. The research detected features of immune system ageing in the earliest stages of RA, even before clinical diagnosis, suggesting that early intervention is possible.
A new blood-based biomarker study identifies a link between self-reported cognitive decline and blood-based biomarkers, paving the way for a simple blood test to diagnose Alzheimer’s disease and related dementias. The approach could be faster, less-invasive, and more affordable than existing screening tools.
University of Oklahoma mechanical engineering professor Dong Zhang is leading efforts to advance EV battery technologies, exploring advances in battery mechanisms and chemistries. His NSF-funded work aims to develop physics-based models to predict the performance of battery cells with silicon-graphite composite material.
Researchers found that frail patients with residual intra-abdominal bacteria or fungi are at a higher risk of developing postoperative ileus and infections. The study suggests that incorporating frailty assessment and prehabilitation programs into surgical planning may help reduce complications.
A new hydrogel has been developed to combat vaginal changes caused by menopause, offering a hormone-free alternative for treatment. The study found that the hydrogel improved vaginal tissue thickness and reduced inflammation, providing potential relief from symptoms such as dryness and pain.
Researchers at the University of Stuttgart have developed a new method to detect tiny nanoplastic particles using an optical sieve, which is less expensive and faster than traditional methods. The test strip can be used to analyze environmental samples, blood or tissue for nanoplastic particles.
Research reveals that smallmouth bass and channel catfish are changing their diets to avoid competing with or being eaten by the invasive flathead catfish. The study found that flathead catfish have a higher trophic position than resident predators, exerting strong control over the ecosystem.
A new study demonstrates the safety and potential benefits of a perioperative combination immune checkpoint blockade in resectable mesothelioma. Patients treated with the regimen lived a median of 28.6 months, with nearly 36% alive and recurrence-free at follow-up.
Researchers at MIT introduce the concept of a neutrino laser that uses cooled radioactive atoms to produce amplified neutrino beams. By cooling rubidium-83 to near absolute zero, the team predicts accelerated radioactive decay and production of neutrinos. This innovation could lead to new applications in medicine and communication.
Research reveals that chemotherapy impairs molecular and behavioral measures of the primary biological clock found in the brain. In a study on female mice, paclitaxel treatment disrupted circadian rhythm-related gene expression and behavioral adaptations to light challenges.
A new study reveals that corporations disclose little about their ocean-specific impacts, especially on biodiversity and ecosystems. The research highlights crucial gaps in current reporting frameworks and provides an important baseline for future comparisons.
Researchers found distinct effects of single disease-causing gene variants across different brain regions, pointing to hippocampal disruptions as a key factor in cognitive problems beyond seizures. This study provides an early step toward understanding why current treatments often fall short and may help identify new therapies.
A new study reveals that sharks and rays adjust their growth and reproduction in response to changing food availability, affecting population growth and recovery. This flexibility makes it challenging to predict species' responses to pressures like overfishing and environmental change.
Tiny extracellular vesicles influence ovarian development and function, affecting gene expression and hormone production.
A novel C-3-substituted oleanolic acid benzyl amide derivative, A5, exhibits high efficiency and broad-spectrum anti-influenza activity against influenza A virus by targeting PA–PB1 interactions. It also modulates host macrophage inflammation and demonstrates synergistic effects when combined with oseltamivir.
A cohort study found GLP-1 RAs offer body mass index-dependent cardiovascular benefits and consistent kidney protection for type 2 diabetes patients. The study suggests BMI stratification is crucial for guiding treatment decisions.
The study found that PRMT1 downregulation leads to increased RIPK1 activation, causing necroptosis and apoptosis in cerebral I/R injury. PRMT1 overexpression protects against I/R injury by suppressing RIPK1 activation.
A new poll finds that just 43% of women believe diet influences hot flashes, despite research showing a significant reduction with a low-fat, plant-based diet. A study published in Menopause Journal found that such a diet reduces moderate to severe hot flashes by 88% and helps women lose weight.
A Finnish study found that aspirin therapy does not provide significant relief for people suffering from chronic rhinosinusitis with nasal polyps who are hypersensitive to NSAIDs. Only a small number of patients benefited from the therapy, while a significant number experienced adverse effects.
Researchers found a hormone combination of growth hormone and testosterone to be safe and effective in improving muscle mass, strength and mobility in men with facioscapulohumeral muscular dystrophy (FSHD). The treatment resulted in gains of up to 4.5 lbs of lean muscle and improved walking ability by 37 meters.
Researchers at Northern Arizona University have discovered a partnership between algae and bacteria that creates a clean-nitrogen machine, turning atmospheric nitrogen into food for river ecosystems. This discovery boosts populations of aquatic insects, which young salmon rely on for growth and survival.
Researchers found that apolipoprotein D reduces the protective antiviral type I interferon response in older individuals, leading to more severe disease outcomes. This discovery offers a potential target for therapeutic intervention to protect against severe influenza virus infection in the elderly.
A new study argues that adolescents and young adults are the main drivers of language change, rather than young children. The research finds little evidence that early learning mistakes spread through communities and highlights the role of everyday language use among older speakers.
This study reveals the complex relationships between rheumatoid arthritis and various organs, including the cardiovascular, respiratory, and gastrointestinal systems. The findings suggest that RA functions as a hub within an expansive web of interacting disorders.
A novel drug target, CD300a, has been identified to suppress immune cell activation and prevent chronic heart and kidney failure after acute tissue injury. The treatment preserves cardiac function and reduces renal fibrosis in mice with genetic deficiency of CD300a.
A new study published in the American Cancer Society's journal reveals that nearly 1 in 10 patients undergoing surgery for early-stage cancer will initiate opioid prescriptions long-term. The research found that those with a prior history of chronic pain, comorbidities, and lower socioeconomic status were at higher risk.
Concurrent durvalumab therapy did not improve overall survival compared to consolidation alone in unresectable stage 3 NSCLC patients. The trial enrolled 662 patients and showed median OS was 41.5 months in the concurrent arm versus 39.4 months in the consolidation arm.
A UK study found that lung cancer screening can benefit older adults up to age 80 who are eligible for surgery. The research, presented at the International Association for the Study of Lung Cancer World Conference on Lung Cancer, showed comparable survival rates between younger and older patients treated with surgery.
A meta-analysis of randomized trials comparing video-assisted thoracoscopic surgery (VATS) and open lobectomy found a 21% reduced risk of death in VATS patients. The study also showed no difference in disease-free survival between the two groups.
The NADIM ADJUVANT Phase III trial suggests that adding nivolumab to adjuvant chemotherapy can reduce recurrence risk and may offer meaningful clinical benefit for patients with completely resected stage IB–IIIA non-small cell lung cancer. The three-year relapse rate was 26.7% in the experimental arm versus 40.1% in the control arm.
A phase III trial found hypofractionated radiotherapy (HypoRT) with concurrent chemotherapy provides similar survival outcomes and reduced toxicity compared to the standard six-week conventional fractionated radiotherapy (ConvRT) schedule for patients with limited-stage small cell lung cancer (LS-SCLC). Patients receiving HypoRT experi...
Researchers at ETH Zurich found that exergame training improved cognitive performance, memory, and structural brain changes in individuals with mild cognitive impairment. The study suggests a potential causal effect of the training on disease-modifying effects and plans for longer-term studies are underway.
The Phase 1CA240-0007 trial demonstrates a 29% overall response rate and 80% disease control rate for BMS-986504 in heavily pretreated patients with MTAP-deleted NSCLC. The agent selectively targets the PRMT5-MTA complex while sparing normal tissue.
Problem gambling in minors is linked to a higher risk of suicide, substance use disorder, theft, and assault. The Canadian Medical Association Journal urges the federal government to expedite legislation to regulate sports betting advertising and protect young people from its harms.
New research published in CMAJ found that Black adolescents with mental distress are less likely to access mental health care, with Black girls being the least likely. The study highlights the need for culturally responsive and sex-specific adaptations to care, as well as policy changes to equalize mental health service use.