Researchers discovered a long-lived monocyte-derived population in the lung that provides essential support for durable T cell immunity. The study suggests that enhancing interactions between innate immune cells and memory T cells could be one such strategy.
Researchers developed a 3D human stem cell-derived retina model to study CLN3-Batten disease, a rare inherited condition causing early vision loss and progressive neurological decline. The model showed that damage to RPE support cells can trigger photoreceptor degeneration, highlighting a complex picture of the disease.
Experts warn that US suicide deaths are undercounted due to misclassification of drug overdoses as accidental deaths. A new measure, self-injury mortality, aims to shift the focus from intent after death to accounting for behaviors prior to death.
Researchers found that myotonia amplifies the disease's effects on muscles, and therapies targeting it could help preserve muscle function. By eliminating myotonia, muscles showed healthier tissue and improved gene expression, suggesting a new treatment approach for myotonic dystrophy
A new study describes a gene therapy strategy that uses the brain's glymphatic transport system to distribute engineered viral vectors throughout the brain. This approach enables preferential targeting of human glial cells while minimizing exposure to other cell types and organs, addressing two major challenges in neurological medicine.
A new study found that reinforcing natural daily rhythms improves sleep and brain waste clearance after a stroke, leading to better outcomes. The researchers tested various interventions targeting the body's internal clock and found promising results in mouse models of stroke.
A new study from the Wilmot Cancer Institute highlights the benefits of yoga in improving four domains of physical and psychological side effects experienced by cancer patients. Yoga was found to have a significant positive effect on overall mood disturbances, anxiety, and fatigue among survivors.
A study proposes that sleep disruption may be connected to increased risk of dementia through the brain's waste clearance system. The glymphatic system, active during sleep, helps remove metabolic waste, and its disruption may lead to cognitive decline.
The University of Rochester Medicine's Flow Cytometry Resource has been selected as one of 32 global laboratories that set the standard for cutting-edge research support. The facility delivers advanced cytometry services, including analytical and spectral flow cytometry, high-parameter cell sorting, and mass cytometry.
A new study suggests that a low dose of ibuprofen can help alleviate chemo-brain symptoms in cancer patients, but exercise remains the most beneficial intervention. Researchers randomized 86 patients to receive either exercise plus ibuprofen or other treatments and found that exercise significantly improved cognitive function.
A new study uses optogenetics to control specific communication pathways in the common marmoset brain, offering a clearer view of complex behavior and brain disorders. This method enables researchers to manipulate individual long-range brain circuits with greater precision than before.
A new study suggests that exercise can improve mental sharpness and reduce cognitive decline in cancer patients undergoing chemotherapy. Researchers found that patients who exercised while on chemotherapy maintained their daily step goals and reported improved mental clarity, while those who did not exercise experienced significant dec...
A new analysis shows that 42% of treated patients were functionally cured, marking a game-changer for an incurable disease. Recurrence rates declined drastically over time, from 6.8% in the first five years to 0.6% between 15 and 20 years.
A new study reveals that brain rhythms shift attention multiple times per second, affecting focus and increasing susceptibility to distractions. This rhythmic occurrence may help us avoid overfocus on one thing, but also make us more prone to digital alerts and visual stimuli.
Researchers at the University of Rochester found that the brain analyzes global patterns of image motion caused by eye movements to understand how objects move and where they are located in 3D space. This discovery challenges conventional ideas that image motion produced by eye movements is visual noise to be subtracted off.
The US saw a decline in nursing home capacity between 2019 and 2024, with rural areas experiencing the greatest declines. The decline was linked to longer hospital stays and increased distance between patients' homes and available nursing facilities.
Researchers found that children and young adult cancer survivors age faster and experience accelerated cognitive decline due to treatment effects. The study suggests that quitting smoking, exercising, and improving nutrition can help reverse these aging changes.
Researchers discovered that female brain immune cells called microglia express more interferon-related genes when responding to amyloid-β plaques, causing more harm to neuronal connections. This finding suggests a potential sex-specific treatment approach for Alzheimer's disease.
A study from the University of Rochester Medical Center found that farm-exposed infants develop higher levels of protective antibodies and have an earlier maturation of their antibody-producing system. This early development is associated with a lower risk of developing egg allergy.
The study found that children with at least one complex chronic condition now account for more than two-fifths of pediatric bed days and nearly three-fifths of hospital charges. The concentration of these children in urban teaching hospitals has real implications for where care happens, who delivers it, and how it is paid for.
A new study found that the national shortage of primary care physicians has worsened in rural areas, with a net loss of 11% nationwide over 7 years. The greatest losses were in the Northeast, where there was a 15.3% decrease in family physicians practicing in 2023.
A new urine test can detect SORD deficiency, a common cause of inherited nerve disease, earlier and more cheaply than genetic tests. The test has brought understanding and access to care for affected families, particularly in the Old Order Amish community.
Researchers have discovered a novel delivery method for CBD that effectively targets the brain's nerve cells, providing pain relief without adverse side effects. The study found that CBD-IN, a nano-micelle formulation of CBD, calms overactive nerve circuits in the areas responsible for sensing touch and pain.
Researchers have discovered that Batten disease progression varies by sex and age, with male mice showing early auditory problems that improve with age, while female mice experience persistent difficulties. The study provides a new model for tracking brain function over time and testing treatments for this devastating disease.
Researchers discovered a unique protein in bowhead whales that repairs damaged DNA, potentially contributing to their remarkable longevity. The protein, CIRBP, is present at 100-fold higher levels in bowhead whales compared to other mammals.
A comprehensive, multidisciplinary approach led to a nearly 72% lung cancer screening rate at the University of Rochester Medical Center. The program's success was attributed to collaboration among primary care and specialty teams, leveraging technology to flag eligible patients and streamline screenings.
A new framework for US vaccine policy aims to rebuild trust by acknowledging shared blame, abandoning absolutist tactics, and promoting community-based education. The medical community must own its share of responsibility in addressing declining vaccination rates and rising outbreaks of vaccine-preventable diseases.
Researchers used precise neural activity measurements from epilepsy patients to study how brain processes speech. The findings suggest the auditory cortex operates on a fixed, internal timescale independent of speech structures, providing a consistently timed stream of information.
Researchers found a hormone combination of growth hormone and testosterone to be safe and effective in improving muscle mass, strength and mobility in men with facioscapulohumeral muscular dystrophy (FSHD). The treatment resulted in gains of up to 4.5 lbs of lean muscle and improved walking ability by 37 meters.
Researchers have discovered that microglia, the brain's immune cells, play a key role in how the brain adapts during adolescence. This understanding may transform how neurodevelopmental disorders are treated during this window and possibly into adulthood. The study also found that microglial contact with axons increases dopaminergic ci...
A cardiac device trial published in eClinicalMedicine found that improving enrollment of females in such trials can better guide care for all patients. One-year interim study results revealed that participants assigned male at birth were twice as likely to die or experience life-threatening heart rhythm abnormalities, while females sho...
Research at the University of Rochester Medical Center and University College Dublin has revealed key insights into multisensory integration in the brain. The study found that when changes occur in both visual and auditory inputs, auditory and visual decision processes unfold in parallel but come together in the motor system.
In a breakthrough study, researchers at the University of Rochester Medical Center found that microglia cells respond differently than neutrophils to photoreceptor damage in the retina. This discovery has high implications for treating vision loss caused by photoreceptor cell damage.
Research reveals that prenatal PFAS exposure can alter infants' developing immune systems, leading to lasting imprints on their ability to fight disease. Exposure to low levels of PFAS was associated with changes in key T-cell populations, including T follicular helper cells and regulatory T cells.
A study found that early antibiotics exposure can impair infant immune systems, disrupting lung immunity and making them vulnerable to respiratory infections. Supplementing with a naturally occurring metabolite called inosine may help restore their ability to fight such infections.
A new study identifies postoperative delirium as a preventable complication affecting roughly one in 30 older adult patients, significantly increasing their risk for poor outcomes. Simple cost-effective strategies can curb downstream costs and suffering associated with this condition.
Early life exposure to perfluorohexanoic acid (PFHxA) may increase anxiety-related behaviors and memory deficits in male mice. Researchers found that males exposed to higher doses of PFHxA showed mild developmental changes, including decreased activity levels and increased anxiety-like behaviors.
A study on long-lived bats found that they possess robust tumor-suppressor mechanisms that protect against cancer. The researchers discovered that increased activity of the p53 gene is a key defense against cancer, and that safely increasing telomerase enzyme activity could be a way to apply their findings to humans.
A study by University of Rochester Medical Center researchers reveals that caregivers of medically complex children (CMC) can build resilience by practicing self-care and building support networks. The study identifies three critical strategies for successful adaptation, including developing a support community and engaging in coping s...
Scientists discovered that taurine drives leukemia growth by promoting glycolysis and is produced by normal cells in the bone marrow microenvironment. Researchers identified taurine transporter expression as essential for leukemia cell growth, leading to potential new therapeutic targets.
Researchers discovered a unique subset of immune cells that recognize certain foods as allergenic, leading to increased inflammation and allergy risk. Urban infants had higher levels of these aggressive Th2 cells, while rural children had more regulatory T cells promoting immune balance.
Researchers used a virtual reality game to investigate how brief anxiety impacts spatial learning and threat recognition. Participants who learned to distinguish between safe and dangerous areas showed better spatial memory and lower anxiety.
Calmming the brain's immune cells via norepinephrine may prevent or lessen Alzheimer's inflammation and damage. The study highlights a key role of norepinephrine in mitigating early inflammatory changes and neuronal injury.
Researchers studied active and passive touch tasks using virtual reality and EEG to better understand how people with autism process touch. The study found that individuals with autism showed little variation in brain response to active and passive touch, suggesting difficulty predicting consequences of actions.
Researchers have discovered that the adult brain can generate new neurons that integrate into key motor circuits, potentially reversing damage in Huntington's disease. These newly generated cells replace lost neural networks and connect with complex brain networks responsible for motor control.
The University of Rochester's Wilmot Cancer Institute has been named the nation's 73rd designated cancer center by the National Cancer Institute. This prestigious designation recognizes the institute's excellence in cancer research, patient care, and community outreach.
Experts argue that AI mental health chatbots for kids may impair social development and worsen existing health inequities. Pediatric therapists rely on family relationships to ensure child safety, but AI chatbots lack this contextual information. The authors advocate for careful consideration of data representation and potential misuse.
Researchers found that women who received text message reminders were twice as likely to get their cervical cancer screenings within 150 days compared to those without reminders. The study suggests a promising low-cost approach to increasing cancer screenings in underserved populations.
Researchers investigate how repetitive blows to the head impact brain health, potentially leading to neurodegenerative diseases. The study aims to detect and mitigate acute effects of exposure to repetitive head hits using objective measures.
Researchers found that biotin supplementation reverses neurotoxicity in human nerve cells, improving mitochondrial function and reducing cell loss. Biotin metabolism was identified as a modifier of manganese-induced neurodegeneration, offering potential therapeutic strategy for Parkinson's disease