Researchers have found that microglia function differently in adult male versus female mice when given an enzyme inhibitor, with potential broad implications for how neurological diseases are studied. This discovery highlights the necessity of gender-specific research and may lead to new disease-modifying therapies targeting microglia.
A study published in Cell describes the synchronized oscillations that occur during non-REM sleep, including norepinephrine, cerebral blood volume, and CSF flow. The research highlights the critical role of these oscillations in powering the glymphatic system, which removes protein waste associated with neurodegenerative diseases.
A team of researchers from Wilmot Cancer Institute and University of Rochester Medical Center investigate how social networks influence cancer patients' treatment decisions. They plan to analyze 300 local individuals aged 65+ with advanced cancer, tracking their networks and decision-making processes.
A study of over 6,000 adolescents found that those with symptoms of gaming addiction showed lower brain activity in the decision-making and reward processing region. This suggests a link between reduced sensitivity to rewards and problematic gaming behaviors.
Researchers at the University of Rochester Medical Center have discovered a potential biomarker for psychosis diagnosis by analyzing brain connectivity patterns. The 'somato-visual' biomarker shows promise in predicting psychosis onset and stratifying patients into clinically meaningful subgroups.
A new RNA-based technology called StitchR facilitates effective use of gene therapy for difficult-to-treat, large-gene diseases like muscular dystrophies. It delivers two halves of a gene separately, resulting in seamless reconstitution of large mRNA in affected tissues.
Researchers have developed a new tool that collects and analyzes extracellular vesicles to detect cancer cells more accurately. The digital approach allows for simultaneous analysis of multiple biomarkers, enabling earlier detection of cancer at curable stages.
Aging adults face increased risk of life-threatening complications when undergoing elective noncardiac surgeries too soon after a heart attack. Delaying surgery for three to six months following a heart attack can significantly reduce this risk, according to new research published in JAMA Surgery.
New RSV vaccines have been found to be highly effective in preventing severe respiratory illness and hospitalizations, with an 80% efficacy rate. However, vaccination rates remain low, especially among older adults, highlighting the need for better understanding of risk factors and improved healthcare provider education.
A new treatment approach using immunotherapy has shown promising results in treating advanced Hodgkin lymphoma, with a remarkable 92% survival rate. The innovative clinical trial, led by Wilmot Director Jonathan Friedberg, also minimizes long-term side effects and toxicities.
Researchers found lower neuron density in regions of the cerebral cortex responsible for tasks like memory, learning, and problem-solving in children with autism. In contrast, other brain regions like the amygdala showed increased neuron density, suggesting unique promise in characterizing individuals with autism.
University of Rochester researchers have refined a noninvasive method called BL-OG that harnesses light to activate neurons in the brain. The technique has the potential to transform invasive procedures used to treat Parkinson's disease and other neurological conditions by providing a safer, less invasive alternative.
Researchers identified a crucial protein, TIMP3, overproduced in AMD and found that blocking its activity can reduce drusen formation, suggesting a promising treatment strategy. The study offers new avenues for preventing AMD and improving the lives of millions affected by this disease.
A study by researchers at the University of Rochester Medical Center found that high levels of specific antibodies in breast milk provide protection against rotavirus, a common gastrointestinal disease. The findings highlight the importance of optimized breastfeeding practices to improve infant health globally.
Researchers discovered ponsegromab, a monoclonal antibody, improves symptoms of cachexia by blocking the GDF-15 hormone. The treatment shows minimal side effects and boosts weight gain and patient activity in cancer patients.
Researchers discovered a key molecule, PAF, that controls the destiny of immune cells and turns them against cancer. The study highlights the importance of targeting PAF to develop new therapies for various types of cancer.
Researchers successfully restored the brain's waste-clearing process by reviving cervical lymph vessel function in aging mice, utilizing a known drug to boost efficiency. This breakthrough could pave the way for future therapies targeting neurodegenerative diseases.
A nationwide study found that brentuximab vendotin significantly improved the quality of life for young patients with high-risk pediatric Hodgkin lymphoma. Nearly 44% of patients reported poor quality of life before treatment, but researchers saw significant improvement as treatment progressed.
A study published in JAMA Surgery shows that liver transplants significantly improve progression-free survival rates for patients with unresectable colorectal liver metastases compared to other therapies. At three years, 90% of transplant patients remained cancer-progression free, whereas only 42% of those receiving alternative treatme...
Researchers describe how a spreading wave of disruption and brain fluid flow triggers headaches, detailing the connection between aura symptoms and migraine pain. The study identifies potential new drug targets for migraines, including proteins that bind with sensory nerves in the trigeminal ganglion.
A new study creates a framework to reduce confusion around fish consumption during pregnancy and provide clearer guidance on risks and benefits. The research found that consuming low-mercury fish was beneficial, while high-mercury fish was detrimental to neurodevelopment.
A team of researchers has created a new approach to deliver drugs precisely to surgically repaired tendons using nanoparticles, reducing scar tissue formation and improving function. The treatment targets the Acp5 gene, which is highly expressed at the injury site, and delivers medication directly to the healing tendon.
Researchers have developed a study using smartwatches to monitor Parkinson's symptoms over time in early-stage patients. The study found significant declines in gait and tremor, as well as changes in speech, with the smartwatch detecting these changes more effectively than traditional tools.
Researchers at the University of Rochester Medical Center found that ketones can rescue impaired neuronal function in the hippocampal network. This study suggests a potential therapeutic approach for preventing or delaying neurodegenerative diseases like Alzheimer's.
A small study at the University of Rochester Medical Center found that women with stage 4 breast cancer who followed a whole-foods plant-based diet experienced significant weight loss, improved cholesterol levels, and reduced fatigue. The diet also showed promise in reducing inflammation and changes in blood levels of amino acids.
The study highlights a lack of research on cancer disparities among older adults, leaving the cancer care system ill-equipped to address unique needs. Researchers emphasize the need for targeted interventions and policies to promote health equity in this rapidly growing population.
A new hypothesis paper proposes that Parkinson's disease starts in either the brain's smell center or the body's intestinal tract, tied to environmental factors. The study suggests that exposure to pesticides, air pollution, and tainted food may predispose to the disease.
Researchers discovered that good airflow and filtration in schools can significantly reduce COVID-19 infections among children with intellectual and developmental disabilities. The study found that classrooms with high-efficiency air filters had lower infection rates, highlighting the importance of improved ventilation systems.
A new bioluminescence imaging technique allows for real-time monitoring of oxygen concentration in the brain, revealing previously undetected areas of temporary hypoxia. The method enables researchers to study diseases associated with hypoxia, such as Alzheimer's and vascular dementia.
Male roundworms use diverse chemical and physical signals to determine the sex, age, nutritional health, and mating history of potential mates. They prefer hermaphrodites that have not previously mated with another male and are nutritionally healthy.
Research shows that lowering doses and adjusting chemotherapy schedules for older adults with advanced cancer can reduce toxic side effects and preserve daily functions. Over 30% of patients benefited from treatment regimen modifications, with a 15% reduced risk of serious clinician-rated toxic effects.
A growing number of rectal cancer patients are choosing a watch-and-wait approach over surgery, with the number increasing nearly 10% between 2006 and 2020. This approach requires frequent follow-ups but may allow patients to avoid long-term bowel dysfunction.
A new study found that changes in brain function, specifically the auditory sensory memory system, may be a potential biomarker for Batten disease. Researchers measured brain activity using electroencephalography (EEG) and found a decline in response as the disease progressed.
Researchers at the University of Rochester Medical Center find that microglia can trigger cognitive deficits after radiation exposure, potentially targeting them for therapy development. Mice studies showed that blocking a specific pathway in microglia prevented cognitive decline, offering hope for improving patients' quality of life.
Researchers found that calcium channel blockers can reverse symptoms of myotonic dystrophy in animal models, a potential new treatment for the disease. The study suggests that targeting the calcium channel could improve muscle function and health, offering hope for patients with this debilitating condition.
Neurons in the ventrolateral prefrontal cortex (VLPFC) work together to process social interactions by combining facial and vocal information. The study found that individual neurons did not exhibit strong responses to expressions or identities, but population-level activity could be decoded to reveal the identity and expression in vid...
Researchers discovered a 'genomic tug of war' between decitabine and H2A.Z in animal studies, which could influence how well patients respond to decitabine. High levels of H2Z may help cancer cells overcome this effect, allowing them to grow.
Researchers have made a breakthrough in understanding the genetic changes that occur during tumor migration, and discovered a drug that can obstruct this process. A new clinical trial at the University of Rochester's Wilmot Cancer Institute will test the effectiveness of the experimental drug NP137.
New research reveals a cocktail of approved drugs can quickly reduce brain swelling and improve outcomes in animal models of brain injury. The study suggests reopening lymph nodes as an emergency pressure release valve for the brain, addressing cerebral edema as the leading cause of TBI-related deaths.
AI medical devices can improve diagnosis and treatment, but their accuracy and limitations must be carefully considered. Developers must ensure transparency about AI's performance and limitations to avoid harming patients and exacerbating health inequities.
Researchers recommend strategic use of neurodevelopmental disorder (NDD) screening on populations with developmental delays, rather than universal genomic sequencing. This approach aims to prevent over-diagnosis and stigma, while providing targeted support for children at risk.
National guidelines recommend mindfulness meditation, yoga, and music therapy for cancer patients experiencing anxiety and depression. The guidelines are based on strong evidence from clinical studies, providing a comprehensive approach to managing these common side effects of cancer treatment.
Researchers found that young and healthy human glial progenitor cells can outcompete older and diseased cells in the adult brain, replacing them with healthier ones. This breakthrough has strong therapeutic implications for treating neurological disorders like Huntington's disease.
A new study reveals that Black patients with ICDs have a significantly higher rate of post-implant cardiac events and risk of death compared to white patients. The study also shows that Black patients are more likely to discontinue medications after one year, but the reasons for this are unknown.
New research reveals low use of monoclonal antibodies and oral antiviral drugs in US nursing homes, despite high risk of resident populations. The study analyzed data from the Center for Disease Control and Prevention National Healthcare Safety Network during the COVID-19 pandemic.
Researchers developed a new method to deliver drugs into the inner ear, using the cerebrospinal fluid flow. This innovation restored hearing in deaf mice and may pave the way for gene therapy to treat human hearing loss.
A new study published in the Journal of the American Medical Association found that pediatrician and family collaboration can address obesity. The study showed that three times as many children in the treatment group had a clinically meaningful reduction in body mass index (BMI), resulting in improved cardiometabolic outcomes.
A new evidence-based framework proposes integrating palliative care into neurology teams to address the total pain of neurologic illness, including psychological, social, and spiritual distress. This approach aims to screen for and prevent suffering by incorporating a palliative care model from day one.
Researchers created a detailed 3D image of the synapse, a key juncture in neuronal communication. The model reveals the precise geometry of interactions between individual cells, which may hold the key to understanding neurodegenerative diseases.
Scientists at the University of Rochester Medical Center discovered a link between Alzheimer's disease and hearing loss in mice, finding that plaque location in the brain may contribute to hearing decline. The study suggests that tracking disease progression through amyloid PET imaging could be a potential biomarker for hearing loss.