A new study shows that gene therapy delivered by nanocarriers can repair damaged discs and reduce signs of back pain in mice. The treatment, which uses naturally derived nanocarriers to deliver genetic material for a protein key to tissue development, restored structural integrity and function to degenerated discs.
The National Center to Reframe Aging is collaborating with the University of Minnesota and the Minnesota Leadership Council on Aging to promote positive attitudes towards aging in Minnesota. The partnership aims to reframe aging issues and increase support for policies and programs that benefit older individuals.
Research finds that female brains have narrower and less dense axons, making them more prone to damage from concussion. This leads to more severe cognitive deficits in females compared to males after a head injury.
A new study estimates animal reproduction costs, finding that indirect costs are often larger than previously thought. This challenge longstanding theories on animal growth and life histories.
Scientists at ETH Zurich have engineered a thermal trap that can deliver heat at temperatures of over 1000 degrees Celsius using solar radiation. This technology has the potential to decarbonize energy-intensive industries on a large scale, making it an important step towards reducing greenhouse gas emissions.
New approach uses calculation to predict band convergence in materials, allowing for rapid creation of high-performance thermoelectric devices. The method enables elimination of unnecessary possibilities, increasing efficiency and reducing false starts.
A Danish-Spanish collaboration is launching the REACT initiative to develop early detection and prevention methods for atherosclerosis. The project aims to identify new means to detect atherosclerosis at earlier stages and at a younger age, enabling precision treatment and prevention.
A study of over 2600 people found a significant correlation between loneliness and various mental health problems, including depression and psychosis. The researchers suggest that loneliness can increase the risk of developing these conditions, although causality cannot be determined.
Researchers found a significant disparity between the placebo group and those receiving varenicline, with a quit rate of 45% compared to 30% in the placebo group. The study suggests that varenicline may be effective in helping adults quit using e-cigarettes.
A new study found that military physicians provide better treatment to high-ranking patients than lower-ranking ones, with more effort and resources allocated to those above their rank. This highlights the existing power dynamic between doctors and patients in the US Military Health System, favoring the physician's discretion.
A recent study by experts suggests that Keir Starmer's emphasis on probity and competency in politics is symptomatic of the 'juridification' of politics. This trend prioritizes rules, norms, and procedures over values-based politics, leading to a reliance on law and administration to address public policy issues.
Researchers from MIT and the University of Basel developed a physics-informed machine-learning framework that can automatically map out phase diagrams for novel physical systems. This approach leverages generative models, making it possible to detect phase transitions without requiring huge training datasets. The technique has potentia...
Researchers have successfully developed a broadly useful method for constructing gamma chiral centers on simple carboxylic acids using C-H activation. The new approach enables easy access to privileged structures for pharma industry drug discovery programs, potentially speeding up the development of new medicines.
Wang Jian's group and collaborators have discovered charge-4e and charge-6e superconducting states in CsV3Sb5 ring devices, marking the first experimental observation of multi-charge superconductivity. These findings open up new perspectives for exploring novel multiple-fermion states.
Researchers develop a new method to grow single-crystal perovskite hydrides, allowing for accurate measurement of intrinsic H- conductivity. The technique enables the production of high-quality crystals with minimal imperfections, paving the way for sustainable energy technologies and hydrogen storage applications.
A long-term study published in the Journal of Epidemiology & Community Health found that men with diabetes are at a greater risk of developing cardiovascular disease, leg/foot complications, and eye disease compared to women. The study analyzed data from over 25,000 people with diabetes and found that men were 51% more likely to develo...
Physicists from TU Darmstadt propose a new approach to define and measure the time required for quantum tunneling. They suggest using Ramsey clocks, which utilize the oscillation of atoms to determine the elapsed time. The proposed method may correct previous experiments that observed particles moving faster than light during tunneling.
Researchers have developed a non-invasive optical-acoustic imaging method using short laser pulses to create images of muscle tissue. This breakthrough technology has the potential to improve diagnosis and treatment of spinal muscular atrophy (SMA), a rare genetic disorder causing muscle degeneration.
Researchers have engineered an AAV that efficiently crosses the blood-brain barrier and delivers genes to the brain in humanized mice. This could lead to new treatments for severe genetic brain disorders with no current cures or few treatment options.
Four new research papers demonstrate progress in germline-targeting HIV vaccines, which could offer broad protection. The approach involves priming young B cells to produce broadly neutralizing antibodies against HIV, a crucial step towards developing an effective vaccine.
Researchers review cell-based therapies for comprehensive sepsis management, highlighting the potential of mesenchymal stem cells and innate immune cells like macrophages. The review also emphasizes the need for further studies on optimal dosage, administration routes, and storage methods to maximize efficacy and safety.
Researchers found that American athletes borrow Canadian English accent features for hockey-specific terms and jargon, but not underlying pronunciation rules. Adopting these dialects is a way players portray their identity through speech.
Researchers at Osaka Metropolitan University discovered that persimmon tannin improves the growth of Saccharomyces cerevisiae in the presence of ethanol. The antioxidant properties of persimmon tannin limit oxidative damage, allowing yeast to thrive and increasing bioethanol production efficiency by 8.9-fold.
Researchers have identified a range of genetic variations associated with both syndromic and non-syndromic CHD. Genetic testing technologies are yielding valuable insights into CHD genetics, enhancing comprehension of clinical and research settings.
A study led by the University of Pennsylvania School of Medicine found that offering patients a choice between colonoscopy and at-home tests more than doubled colorectal cancer screening rates. Approximately 10% of participants received colonoscopies, while around 11% completed at-home fecal immunochemical tests.
Researchers found that Pleistocene hunter-gatherers settled in Cyprus around 14,257 to 13,182 years ago, suggesting the island was attractive for early human habitation. The rapid expansion of the population coincided with increased temperature, precipitation, and environmental productivity.
Researchers analyzed diets of 856 schoolchildren in Germany, finding potential to reduce greenhouse gas emissions by changing eating habits. However, nutrient adequacy was not optimized, highlighting the need for context-related nutritional recommendations.
A meta-analysis suggests combining microsatellite instability (MSI) and tumor-infiltrating lymphocytes (TIL) can optimize prognostic assessment in early-stage colorectal cancer. Patients with high MSI and TIL had the best prognosis, while those with low immune cells found in the tumor tissue had a poor outcome.
Researchers at Ragon Institute of MGH, MIT and Harvard have developed a comprehensive platform for HIV vaccine research using the mRNA-LNP system. The platform has shown promising results in preclinically validating next-step boost immunogens and providing new insights into the basic biology of antibody responses.
A new study reveals that AlphaFold's predictions can be as accurate as experimental structures, enabling the acceleration of drug discovery projects. The algorithm's potential for advancing medicine is vast, with the possibility of significantly expediting project timelines by up to a few years.
A new study finds that listening to mental health podcasts reduces stigma, supports the development of mental health literacy, and increases help-seeking. The research highlights the importance of accessible platforms for education and encourages listeners to develop self-compassion and positive attitudes towards help-seeking behavior.
A study found that tool use among sea otters allows access to larger prey, reducing tooth damage. Female otters, which are more likely to use tools, can consume prey up to 35% harder than males.
Researchers discover Striated Caracaras' playful behavior, showing they interact with objects for fun and explore novel items. The study sheds light on how these birds learn about their environment and could provide insights into the evolution of play in nature.
Researchers found that PFAS are introduced into the Great Lakes through precipitation and accumulate at different rates in each lake. The northern lakes are accumulating PFAS, while Lake Ontario is eliminating them. This study could inform future actions to mitigate PFAS presence in the Great Lakes.
A new study reveals that jellyfish in the Arctic Ocean are expected to expand their habitats poleward, with some species potentially tripling in size. This could have significant cascading impacts on the entire food web and affect fish populations already under pressure.
A new method of determining sperm whale communication reveals that groups living in close proximity develop similar vocal styles, indicating social learning between neighbouring clans. The study provides evidence for the existence of social learning in sperm whales.
Researchers have discovered a liquid biopsy biomarker that can identify the effectiveness of treatment at an early stage, enabling more individualized treatment for melanoma patients. The biomarker, SHOX2 methylation in circulating cell-free DNA, was found to be elevated in 60% of melanoma patients and correlated with response to therapy.
Researchers at BIH developed a theory on traveling waves of activity in the human brain, which influences cognitive processes such as learning and remembering. Understanding these waves can support treatment of patients with cognitive disorders, including schizophrenia, epilepsy, and Parkinson's disease.
Researchers found spider webs match acoustic particle velocity for wide range of sound frequencies. Spider silk responds to air particles in a sound field, not just sound pressure, and may inspire new microphone designs.
Global life expectancy is forecasted to increase from 73.6 years in 2022 to 78.1 years in 2050, with a convergence of increased life expectancy across geographies. The trend is largely driven by public health measures that have prevented and improved survival rates from cardiovascular diseases, COVID-19, and other communicable diseases.
Judges and physicians hold vastly different opinions on appointing legal guardians for people with dementia. Cognitive and neuropsychiatric symptoms, such as memory impairment and impulsivity, are evaluated differently by medical and legal professionals. Research emphasizes the need for consistency in assessments to ensure equal treatm...
The Global Burden of Diseases study reveals a 49.4% increase in global disability-adjusted life years (DALYs) attributable to metabolism-related risk factors between 2000 and 2021. High blood pressure, high blood sugar, and high BMI are key contributors to poor health and early death.
Researchers developed a high-resolution sensor to track real-time dynamics of ATP levels in cells and within subcellular compartments. The iATPSnFR2 sensor has high sensitivity across a wide range of ATP concentrations, enabling accurate tracking of ATP levels and their dynamics.
A recent study by Bryan Roth and colleagues validated the accuracy of AlphaFold2 in modeling ligand binding sites, leading to promising results for drug discovery. The researchers found that up to 54% of potential compounds interacted successfully with the target proteins, paving the way for new treatments.
The study reveals that the pyramids were concentrated in a narrow desert strip due to a former river branch, known as Ahramat, which is now buried beneath farmland and desert. The findings suggest that the river branch was used for transporting construction materials and could help prioritize archaeological excavations along its banks.
Research found that distractions while engaging in hedonic activities lead to lower enjoyment and satisfaction, resulting in overconsumption. Participants who were distracted during lunch reported lower enjoyment and satisfaction, which was associated with increased snacking later in the day.
China's Earth Observation System has evolved into a sophisticated network of satellites supporting various global applications, including sustainable development, meteorological forecasting, and disaster response. The system's capabilities are enhanced by new technologies, allowing for real-time global surveillance and data collection.
A team of researchers led by Dr. Ahmed discovered that two FDA-approved antibiotics can induce heart regeneration in mammals, showing promise for treating heart failure. The study found that the antibiotics improved cardiac output and reduced fibrotic scar tissue, suggesting a potential new therapy.
Eye & ENT Research bridges basic science and clinical applications, offering the latest findings and methodologies for researchers and clinicians. The journal promotes global collaboration and supports contributors in advancing ophthalmology and otolaryngology fields.
A study published in PLOS Biology found that stressed participants were more likely to help the victim than punish the perpetrator in a simulated third-party intervention task. The researchers observed higher brain activation in regions linked to decision-making and mentalizing when stressed participants chose to help.
A Japanese research team used machine-learning-driven modular assembly systems to create a more efficient gene editing tool. The study demonstrated an improvement in genome editing efficiency by 5%, showcasing the effectiveness of engineering zinc-finger nucleases through structural modeling.
Research identifies areas with high rates of depression and poverty, highlighting the need for region-specific interventions. The study found that socioeconomic conditions account for up to 39% of recorded depression levels across England, with pockets of high depression rates in areas such as the North West and North East.
Researchers from six teams in five labs worldwide used self-driving labs to discover 21 top-performing OSL gain candidates, accelerating the discovery process by months. The decentralized workflow enabled rapid replication of experimental findings and democratized the discovery process.
A recent study reveals that a cellular process called transfer Ribonucleic acid (tRNA) modification influences the malaria parasite’s ability to develop resistance. This breakthrough discovery could help researchers develop new drugs to combat resistance and better tools for studying RNA modifications.
Researchers have developed a synthesis method for introducing difluoromethyl groups into pyridines, a promising approach for new drugs and agrochemicals. The method allows precise introduction of the group at specific sites, overcoming a long-standing challenge in the chemistry field.
A study by ISGlobal found that high primary health coverage significantly reduced child mortality in Brazil, Colombia, Ecuador, and Mexico. The analysis predicts that increasing PHC coverage could avoid 142,285 child deaths by 2030 in these countries.
A recent survey on aircraft noise and annoyance conducted during the pandemic era reveals flaws in existing methods to assess and mitigate noise impacts. The study suggests that annoyance levels are a proven correlation to overall noise levels, contradicting current industry practices.
The American Society for Radiation Oncology's (ASTRO) 66th Annual Meeting will be held in Washington, D.C., featuring over 170 exhibitors showcasing state-of-the-art cancer care technologies. Registered attendees can access livestreams of scientific and educational sessions, both in-person and virtually.
Researchers found a new pathway to cancer cell death led by the Schlafen11 (SLFN11) gene. This discovery could have implications for cancer treatment and patient outcomes.
A new sensor has given unprecedented look at changes in cell's energy currency, allowing researchers to study fluctuations in ATP levels. This enables scientists to track how changes in ATP affect the cell and contribute to diseases like Parkinson’s.