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Science News for March 11, 2024


Does worsening metabolic syndrome increase the risk of developing cancer?

A new study published in CANCER reveals that individuals with worsening metabolic syndrome are at a higher risk of developing various types of cancer. The study followed 44,115 adults in China and found that those with an elevated-increasing pattern of metabolic syndrome scores had a significantly higher risk of developing multiple typ...

SourceWiley·JournalCancer·DateMar 11, 2024

Serum iron overload activates the SMAD pathway and hepcidin expression of hepatocytes via SMURF1

Researchers investigated the molecular mechanism of serum iron overload-induced BMP/SMAD pathway and hepcidin expression. SMURF1, a master regulatory function, mediates Holo-Tf-induced SMAD1/5 activation and hepcidin expression. The inhibition of SMURF1 may represent a therapeutic strategy for iron overload-related diseases.

SourceXia & He Publishing Inc.·JournalJournal of Clinical and Translational Hepatology·DateMar 11, 2024

Synergistic proton and oxygen-ion transport in fluorite oxide-ion conductor

Scientists have successfully developed a new structure family of oxide proton conductors as an alternative solid oxide fuel cell operated at low temperature. They achieved remarkable proton conductivity of 0.158 S cm−1 at 500°C by surficially transporting protons along oxide-ion conductor GDC particles.

SourceBeijing Institute of Technology Press Co., Ltd·JournalEnergy Material Advances·TypeExperimental study·DateMar 11, 2024

Permitless open carry laws may lead to more firearm-related suicides

A study published by the American College of Surgeons found that permitless open carry laws in states without such restrictions had a significantly higher rate of firearm-related deaths and total suicides. The researchers suggested that the ease of access to firearms under these laws may be responsible for the increase in suicide rates.

SourceAmerican College of Surgeons·JournalJournal of the American College of Surgeons·DateMar 11, 2024

Emergency room culture may deter medical students from selecting specialty

A new UCLA Health study found that women and individuals who don't fit traditional norms in the emergency room environment are underrepresented due to the challenging cultural dynamics. Most medical students who pursued emergency medicine despite this hurdle indicated they needed mentorship, representation, and exposure to the specialty.

SourceUniversity of California - Los Angeles Health Sciences·JournalAcademic Emergency Medicine·TypeSurvey·DateMar 11, 2024

A simple and robust method to add functional molecules to peptides

Researchers from Tohoku University developed a unique chemical reaction to attach two distinct functional molecules to the N-terminus of peptides with a glycine amino acid, achieving site-selective modification and stable carbon-carbon bonds. The method shows potential for labeling diverse peptides and larger proteins for purification,...

SourceTohoku University·JournalAngewandte Chemie International Edition·DateMar 11, 2024

Analysis reveals long-term impact of calcium and vitamin D supplements on health in postmenopausal women

A 20-year analysis found that calcium and vitamin D supplements reduced cancer mortality by 7%, but increased cardiovascular disease mortality by 6% in postmenopausal women. The study suggested that cancer incidence depends on pre-supplementation status, while CVD mortality is higher among supplement users.

SourceAmerican College of Physicians·JournalAnnals of Internal Medicine·TypeNews article·DateMar 11, 2024

Giving particle detectors a boost

Scientists at Argonne National Laboratory have developed a nanocryotron, a prototype for an on-off switch that can amplify weak electrical signals from tiny particles in collider experiments. The device could help facilitate the operation of new particle colliders and improve the accuracy of observations.

SourceDOE/Argonne National Laboratory·JournalApplied Physics Letters·DateMar 11, 2024

Study: Predicting steps in a random process

Physicists develop new method to efficiently determine all possible first-passage times and their probabilities, capturing randomness of both walker and environment. This approach builds on existing ideas and could improve predictive analyses in fields such as biology, migration systems, and financial markets.

SourceSanta Fe Institute·JournalPhysical Review E·DateMar 11, 2024

Flexible artificial intelligence optoelectronic sensors towards health monitoring

Researchers from Tokyo University of Science developed a flexible paper-based sensor that operates like the human brain, enabling low-power and efficient health monitoring. The device can distinguish 4-bit input optical pulses and generate currents in response to time-series optical input, with rapid response times.

SourceTokyo University of Science·JournalAdvanced Electronic Materials·TypeExperimental study·DateMar 11, 2024

New study finds female entrepreneurs do better with guidance from female mentors

A new study found that female entrepreneurs who receive guidance from female mentors experience significant improvements in performance, including a 32% sales increase. The study suggests that female-to-female mentorship dynamics yield more positive and supportive engagement, leading to better outcomes for female entrepreneurs.

SourceInstitute for Operations Research and the Management Sciences·JournalMarketing Science·TypeCase study·DateMar 11, 2024

Dangers of smell impairment highlighted in new research

A recent study conducted by the University of East Anglia found that over a third of people with smell disorders have experienced gas safety scares in the last five years. The research also showed that 32.2% of respondents had encountered safety concerns related to food, while 14.8% experienced gas incidents involving hurt individuals.

SourceUniversity of East Anglia·JournalEuropean Archives of Oto-Rhino-Laryngology·TypeObservational study·DateMar 11, 2024

Tuning a terahertz wave filter

Researchers at Tohoku University have created a tuneable terahertz wave filter that can achieve higher transmission rates and better signal quality than conventional systems. The new filter uses Fabry-Perot interferometry to control the filtering effect, enabling selective transmission of desired frequencies.

SourceTohoku University·JournalOptics Letters·DateMar 11, 2024

New research shows sexual minority adults more willing to use digital health tools for public health

A new study published in the Journal of Medical Internet Research found that sexual minority adults are more willing to use digital health tools for screening and tracking compared to heterosexual adults. The study, which analyzed data from a COVID-19 survey, highlights the need for diverse populations to be considered in the developme...

SourceJMIR Publications·JournalJournal of Medical Internet Research·TypeData/statistical analysis·DateMar 11, 2024

Novel molecules from generative AI to phase II

Researchers used generative AI to design a lead molecule for treating fibrosis, a biological process associated with aging. The compound, INS018_055, demonstrated significant efficacy in preclinical studies and showed promising results in clinical trials, accelerating drug discovery and providing new therapeutic options.

SourceInSilico Medicine·JournalNature Biotechnology·DateMar 11, 2024

A new sensor detects harmful “forever chemicals” in drinking water

Researchers at MIT have developed a new sensor that can detect tiny quantities of perfluoroalkyl and polyfluoroalkyl substances (PFAS) in drinking water. The device uses lateral flow technology and can measure concentrations as low as 200 parts per trillion, offering a potential solution for consumer testing and industrial applications.

SourceMassachusetts Institute of Technology·JournalProceedings of the National Academy of Sciences·DateMar 11, 2024

Most survivors of childhood cancer don't get the tests needed to detect serious long-term adverse effects

A study found that up to 87% of childhood cancer survivors are not following recommended screening guidelines, leaving them vulnerable to late effects such as heart disease and certain cancers. The lack of awareness and barriers to adherence may contribute to this low rate, highlighting the need for improved support and education.

SourceCanadian Medical Association Journal·JournalCanadian Medical Association Journal·TypeObservational study·DateMar 11, 2024

Cicadas’ unique urination unlocks new understanding of fluid dynamics

Researchers studied cicadas' jet-like urination to challenge insect pee paradigms. They found that larger animals like cicadas can emit jets due to gravity and inertial forces, unlike smaller ones that typically produce droplets. This discovery has far-reaching implications for bio-inspired engineering and monitoring applications.

SourceGeorgia Institute of Technology·JournalProceedings of the National Academy of Sciences·TypeObservational study·DateMar 11, 2024

This protein pic could help develop new cancer treatments

The study reveals that LAG-3 exists as a dimer, with two molecules forming the functional checkpoint protein. An antibody used to demonstrate therapeutic efficacy in animal models blocks activity by binding to the dimer interface. This new understanding may lead to better cancer treatments targeting this protein.

SourceStanford University·JournalProceedings of the National Academy of Sciences·DateMar 11, 2024

Higher bacterial counts detected in single-serving milks

Researchers at Cornell University found higher bacterial counts in single-serving milks packaged in small paperboard containers, particularly after seven and 14 days of storage. The study suggests that carton-filling machinery may contribute to these higher counts, highlighting the need for improved cleaning and sanitation protocols.

SourceCornell University·JournalJournal of Dairy Science·DateMar 11, 2024

Robotic interface masters a soft touch

EPFL researchers have developed a haptic device called SORI that can accurately recreate the softness of various materials, from marshmallows to beating hearts. This technology has potential applications in medicine, such as training medical students to detect cancerous tumors and providing sensory feedback to surgeons using robots.

SourceEcole Polytechnique Fédérale de Lausanne·JournalProceedings of the National Academy of Sciences·TypeExperimental study·DateMar 11, 2024

Key protein linked to immune disorders

Researchers found that STAP-1 plays a crucial role in activating T cells, which are white blood cells critical to defending against infections and maintaining overall health. The study suggests that STAP-1 may be involved in the development of immune disorders such as multiple sclerosis and asthma.

SourceHokkaido University·JournalThe Journal of Immunology·TypeExperimental study·DateMar 11, 2024

Increases in suicide rate linked to ‘shocks’ in the economy

A study by the University of Southampton found a strong connection between daily suicides, people's expectations formed by professional economic forecasts, and subsequent economic performance. Negative economic shocks can lead to feelings of lack of identity and purpose among vulnerable populations, increasing the risk of suicide.

SourceUniversity of Southampton·JournalSocial Science & Medicine·TypeData/statistical analysis·DateMar 11, 2024

Rice storage under controlled conditions: Changes in its physicochemical and functional properties

Researchers discovered controlled storage affects rice's physicochemical properties, including gelatinization degree and water absorption capacity. The study suggests optimal temperatures can enhance cooked rice quality, offering farmers a practical strategy to minimize pest contamination risks.

SourceEscuela Superior Politecnica del Litoral·JournalJournal of Stored Products Research·TypeExperimental study·DateMar 11, 2024

Trauma screening may improve mental health service recommendations for children

A new study from Penn State finds that incorporating a trauma screening into child welfare evaluations leads to better identification of traumatic stress reactions and more appropriate service recommendations. The screening, developed by Christian Connell and Jason Lang, has been shown to increase referrals for specific trauma-focused ...

SourcePenn State·JournalJournal of Traumatic Stress·TypeData/statistical analysis·DateMar 11, 2024

Tuberculosis bacteria also present in 90% of those with symptoms, who are not diagnosed with TB

A study by Amsterdam UMC and University of Cape Town found that Mycobacterium tuberculosis is present in the respiratory aerosol of 90% of suspected TB patients, including those with negative sputum tests. This raises concerns about unknowingly transmitting infection and highlights the complexity of TB transmission.

SourceAmsterdam University Medical Center·JournalProceedings of the National Academy of Sciences·TypeRandomized controlled/clinical trial·DateMar 11, 2024

How do neural networks learn? A mathematical formula explains how they detect relevant patterns

Researchers at the University of California - San Diego developed a mathematical formula that reveals how neural networks learn to detect relevant patterns in data. The Average Gradient Outer Product (AGOP) formula helps interpret which features the network is using to make predictions, improving the accuracy and reliability of AI syst...

SourceUniversity of California - San Diego·JournalScience·TypeComputational simulation/modeling·DateMar 11, 2024

Muscaris grapes: molecular secret of lychee note revealed

A team of researchers has successfully identified the odorants responsible for Muscaris grapes' characteristic lychee note, shedding light on its molecular secret. The study's findings provide a scientific basis for breeding innovative grape varieties with distinctive fruity aromas.

SourceLeibniz-Institut für Lebensmittel-Systembiologie an der TU München·JournalJournal of Agricultural and Food Chemical Engineering·TypeExperimental study·DateMar 11, 2024

New research sets trap for potentially deadly sandfly

Scientists have discovered the specific enzyme responsible for producing a pheromone attractant in a deadly sandfly species. This breakthrough could lead to the development of commercial traps to control the spread of Leishmaniasis, a disease that causes skin ulcers and can be fatal if left untreated.

SourceUniversity of Nottingham·JournalProceedings of the National Academy of Sciences·TypeExperimental study·DateMar 11, 2024

Exploring the therapeutic potential of natural mushroom compounds to address psychiatric disorders

A new study suggests that mushroom extract containing psilocybin demonstrates superior efficacy in stimulating neuroplasticity and promoting new connections between nerve cells. The research found that the extract had a more potent and prolonged impact on synaptic plasticity compared to chemically synthesized psilocybin.

SourceThe Hebrew University of Jerusalem·JournalMolecular Psychiatry·TypeExperimental study·DateMar 11, 2024

Sting operation out of gas

Researchers question whether micronuclei activate the cGAS-STING pathway, a key innate immune response to foreign nucleic acids. The study found that MN more commonly recognizes DNA during cell division without triggering STING activation.

SourceKyoto University·JournalLife Science Alliance·TypeExperimental study·DateMar 11, 2024

AI may predict spread of lung cancer to brain

A new study uses AI to predict whether early-stage lung cancer will spread to the brain, allowing for more targeted and effective treatment. The algorithm achieved an accuracy rate of 87%, outperforming human pathologists in some cases.

SourceWashU Medicine·JournalThe Journal of Pathology·TypeImaging analysis·DateMar 11, 2024

COVID-19 had greater impact on life expectancy than previously known, but child mortality rates continued to decline during the pandemic

A new study reveals that COVID-19 had a profound impact on global life expectancy, with a 1.6-year drop from 2019 to 2021, while child mortality rates continued to decrease by 7% in 2021 compared to 2019. The study found that some countries experienced high excess mortality due to the pandemic.

Black high school students less likely to enroll in AP math courses than white students with similar academic preparedness, study finds

New York University researchers found that Black high school students are less likely to enroll in AP math courses compared to White students with similar academic preparedness. The study uses a new method to measure student disparities, accounting for limitations of previous studies.

SourceNew York University·JournalSociological Science·TypeData/statistical analysis·DateMar 11, 2024

Harnessing nature's shield: enhancing sun protection with lignin nanoparticles in cosmetics

Researchers found that compact lignin nanoparticles with specific chemical structures and particle sizes boost the UV resistance of sunscreens, making them more effective than traditional formulations. The study suggests that lignin nanoparticles can be used as natural-based materials for improving sun protection in cosmetic applications.

SourceKeAi Communications Co., Ltd.·JournalCarbon Resources Conversion·TypeExperimental study·DateMar 11, 2024

Breakthrough in nanostructure technology for real-time color display

Researchers at UNIST have developed a groundbreaking technology that enables the real-time display of colors and shapes through changes in nanostructures. Utilizing block copolymers, they achieved the self-assembly of photonic crystal structures on a large scale, mimicking natural phenomena observed in butterfly wings and bird feathers.