Aging cats with chronic kidney disease (CKD) have lower levels of key kidney transporter genes, leading to impaired waste removal. Monitoring these transporters and toxin buildup may help detect CKD early and improve treatment options.
Researchers at the University of Pittsburgh have developed a new way to grow T cells that can live longer and better destroy cancer cells in mice. By adding a compound called dichloroacetate to growth media, they created T cells less reliant on glucose and more efficient at using other energy sources.
Researchers developed two low-resource sessions to improve PCC staff wellbeing, focusing on social support, self-belief, and feedback. Feedback from staff was positive, with high satisfaction and feasibility ratings.
A new study reveals striking similarities and critical gaps in how three major countries measure healthcare quality, with an emphasis on family medicine and process-focused metrics. The findings underscore the need for a more balanced approach that includes all aspects of medical care, from infrastructure to patient outcomes.
Researchers from ANEMEL have developed highly stable anion exchange membrane electrolysers that can produce hydrogen without using platinum-group catalysts. The new technology surpasses state-of-the-art solutions in performance and long-term stability, holding promise for industrial applications.
Researchers at Leipzig University developed a new standardised numberinng system for adhesion G-protein coupled receptors (GPCRs) to improve comparability and analysis. The system is based on AI analysis of over 14,000 modelled structures and facilitates deeper insights into disease-relevant mutations in GAIN domains.
A deadly ciliate parasite has decimated sea urchin populations in the Caribbean, Red Sea, and Indian Ocean, with mortality rates reaching over 90%. The International team of researchers is working to track the disease and preserve sea urchins, which play a crucial role in maintaining coral reef health.
A new study found that empathy responses peak in young adulthood, with increased sensitivity to social pain. This development demonstrates that empathy strengthens as people age, but also accompanies reduced ratings of pain for others, highlighting the complexities of empathic responses.
Researchers at Istituto Italiano di Tecnologia and Imperial College London demonstrate the connection between hand movement patterns and motoneuron control patterns, enabling natural control of bionic limbs. The study reports successful testing of a soft prosthetic hand with individuals with physical impairments.
Researchers found that fewer veterans reported having access to firearms than expected, with only 5% included in discussions. The study also revealed that most veterans with opioid access did not accept overdose-reversing medication, highlighting the need for improved suicide safety planning.
A novel lab-on-chip platform uses acoustofluidics to efficiently separate rare circulating tumor cells, enabling real-time diagnosis. The system's precision and energy efficiency hold promise for improved cancer diagnostics and personalized medicine.
A KAUST-led research team discovered EZH1 plays a dual role in circadian regulation, stabilizing RNA Polymerase II and reshaping chromatin to activate or silence genes on schedule. This ensures genes involved in metabolism, sleep, and other essential processes rise and fall on cue.
Researchers identified a potential new treatment for aggressive sarcoma arising in nerves, using a pre-clinical platform that combines inhibitors targeting specific mutations. The triple combination of MEKi-BETi-CDKi showed promising results in shrinking tumors and even eliminating some cases, offering hope for improved treatment options.
A new study found that oxytocin treatment can improve apathy symptoms in patients with frontotemporal dementia. The trial, conducted across 11 sites in Canada and the US, showed a significant improvement in apathy levels when patients received oxytocin compared to placebo.
Researchers have developed a perovskite X-ray detector that uses cascade engineering to reduce dark current, enabling high-quality medical images at ultra-low doses. The device achieved a detection limit of 100 nGy·s−1, a significant improvement over previous limits.
Rising temperatures alter lignin deposition in plant cell walls, requiring adaptive strategies for a resilient supply chain. Understanding regional variations, exploring alternative sources, and developing climate-resilient plant varieties are crucial to mitigate the effects of global warming.
Researchers discovered that pancreatic β cells produce a neuroprotective agent called Fibroblast Growth Factor 23 (FGF23), which can stop amyloid-β-induced neuronal cell death. FGF23 may increase ribosomal proteins, helping to maintain homeostasis in neurons.
Genes & Development has appointed Professor Andrew Dillin as Editor-in-Chief and Dr. Eric Sawey as Executive Editor, expanding the journal's scope into new fields such as physiology, metabolism, and molecular neuroscience. The journal will continue to publish groundbreaking discoveries in molecular and cellular biology.
A new study found that ocean temperatures have more than quadrupled since the late 1980s, rising from 0.06°C/decade to 0.27°C/decade. This accelerating warming is driven by the Earth's growing energy imbalance and is expected to lead to even more rapid temperature increases in the future.
A team of scientists at Linköping University has developed a method to anchor conductive polymers to individual living cell membranes without affecting the cell's functions. This innovation opens up new possibilities for treating neurological diseases with high precision.
A study of 1,485 participants across 14 countries reveals significant national and gender differences in exclusionary behavior. Men and ideologically right-wing participants are more likely to propose unequal splits.
A new method of testing the metabolic effects of thousands of active substances at the same time has been developed by researchers at the University of Basel, providing valuable insights into the modes of action of known medications. The study reveals previously unknown mechanisms and potential side effects.
The use of flame retardants in plastic battery enclosures has no demonstrated benefit and poses significant health risks. These chemicals can migrate into the air, house dust, and eventually end up in recycled products, exposing new generations to harm.
A study found a link between oral microbiome and dementia risk, with certain bacteria associated with better executive function. A nitrate-rich diet may favor beneficial oral bacteria, potentially delaying cognitive decline.
Scientists from University of California San Diego use thermal release to extract water molecules from lunar rocks, revealing origin as either moon itself or comet impacts. The study provides valuable clues for NASA's Artemis program and future human settlements on the moon and Mars.
Dr. Laurence S. Sperling will lead programs focused on genetic causes of stroke in Americans, aiming to dramatically improve screening and diagnosis rates. The Family Heart Foundation appoints Dr. Sperling as Chief Medical Officer to drive this initiative.
A newly discovered papyrus from Israel provides direct insight into Roman jurisdiction and legal practice. The document details a spectacular criminal case involving forgery, tax evasion, and the fraudulent sale and manumission of slaves in the Roman provinces of Iudaea and Arabia.
A new trial will test whether taking HMB can improve patients' physical function and quality of life. The BOOST study aims to recruit 124 patients with cirrhosis and measure its effects on liver disease, mental wellbeing, and physical function over 24 weeks.
A review of cell death and aging in cancer research reveals the significance of cellular senescence in promoting cancer growth. The study highlights the potential of various types of programmed cell death, such as necroptosis and pyroptosis, as therapeutic targets against senescent cells.
Researchers develop BEND lipids to improve LNP mRNA delivery and gene editing by breaking through the endosomal membrane. The new lipids outperform existing LNPs used in COVID-19 vaccines, with improved efficacy rates up to tenfold.
Experiments found DNA accumulates differently depending on involvement in the process, aiding identification. The study also discovered DNA from capsules can be transferred to ziplock bags, providing a complete profile with minimal contact.
A Washington State University-led research team has developed a plant-based substitute for fossil fuels in polyurethane foams, which are used in various products. The bio-based foam is as strong and flexible as typical polyurethane foam, making it a promising sustainable alternative.
Researchers developed a novel coating material that captures the brilliance of structural colors using melanin particles, producing non-iridescent color even when viewed from different angles. The coatings displayed a contact angle of over 160 degrees, monochromatic hues, and a self-cleaning surface.
Adopting paywalls leads to a strategic shift in newspaper coverage, with a 5.1% decrease in local news and modest declines in soft news, according to a study of US newspapers between 2006-2022. Smaller cities and urban areas experiencing demographic changes exhibit notable declines in local news and increases in popular content.
A hybrid modeling approach predicts optimal nanofiltration membranes for chemical separations, reducing energy consumption by up to 40% and CO2 emissions by 90%. The AI-powered tool evaluates millions of potential separation options, enabling industries to make informed decisions.
A new study from the University of Exeter reveals that Kenyan smallholder farmers face barriers when trying to increase the diversity of trees and shrubs on their land. Factors such as past experiences, influence of other farmers, and perceived ability to grow different tree species play a crucial role in decision-making.
A recent University of Washington study found that a slower increase in atmospheric carbon dioxide levels has less impact on the Atlantic Ocean's circulation. The research, published in PNAS, suggests that this slowdown allows the ocean system more time to adapt to rising CO2 levels and mitigates its effects.
Astronomers detect a super-Earth in an eccentric orbit, oscillating between habitable and non-habitable zones. The discovery provides a laboratory for testing new hypotheses on the search for life beyond Earth.
A new optimization model improves microgrid operation by reducing computational burden and introducing replanning, ensuring stable power supply under uncertain conditions. This approach boosts energy efficiency, minimizes waste, and supports the transition to sustainable energy.
A University of Virginia study uses satellite data to show long-term air pollution inequalities tied to industrialized swine facilities in Eastern North Carolina. The research finds that these disparities extend multiple kilometers beyond the immediate vicinity of facilities, affecting communities of color disproportionately.
Researchers at Kyungpook National University have developed a new approach to map and engineer enzymes for enhanced plastic recycling. They employ landscape profiling to identify efficient biocatalysts for recycling polyethylene terephthalate (PET), producing high-purity monomers under mild conditions.
A new phase 2 clinical trial demonstrates the safety of fecal microbiota transplantation (FMT) in preventing acute graft-versus-host disease in patients undergoing allogeneic stem cell transplants. The study found that FMT helped restore microbial diversity and promote beneficial bacterial species, supporting a healthy immune system.
A team of scientists introduced a novel technique to refine prey size estimation from animal-borne camera footage, enhancing understanding of predator-prey interactions. The correction factors developed allow accurate measurements directly from video footage, providing unprecedented insight into wildlife feeding behavior.
Researchers have developed an injectable hydrogel that targets rapid localized increase in bone density. The results show a four- to five-fold increase in bone density in the legs of rats with bone loss. The study combines systemic osteoporosis drugs with local hydrogel injections, offering hope for future fracture prevention therapies.
Recent study finds that optimal reference heights provide better estimates of surface turbulent fluxes and thus better Earth system model predictions. The results show that computing momentum flux and heat flux are particularly improved with these new reference heights.
Research by scientists at the University of Cambridge found that young adults' physical activity increases when they start work, with a notable decrease seen among those working from home. Meanwhile, sleep levels drop immediately after starting work and remain stable over time, except for those without a university degree.
Researchers believe they have located Harold Godwinson's private power centre, a high-status house with latrine, at Bosham, West Sussex. The site is significant as it represents an Anglo-Saxon show-home and provides insight into the origins of aristocratic centres in England.
New research suggests that patients who see the same GP regularly need fewer follow-up appointments in practices and hospitals. This results in reduced workload for general practices and emergency departments, potentially freeing up NHS appointments.
The American Heart Association and Reese's Senior Bowl teamed up to teach Hands-Only CPR and AED use to NFL Draft prospects. Early recognition and action in cardiac emergencies can double a person's chance of survival, emphasizing the importance of having confident and capable individuals nearby.
A collaborative study investigates how advanced AI tools can make it easier to evaluate interventions for ageing, providing personalised recommendations. The researchers identified eight critical requirements for effective AI-based evaluations and found that following specific guidelines improved the quality of the recommendations.
Researchers develop a human-robot musical band featuring humanoid robots that perform alongside human musicians, achieving natural synchronization through advanced robotic systems. The project showcases the potential of humanoid robots in creative fields like music, highlighting real-time interaction, adaptability, and artistry.
A new Australian-developed technology has detected mysterious fast radio bursts and neutron stars, improving location data of pulsars. The system, CRACO, sifts through signals from space like sand on a beach to find anomalies.
The team's novel technique enables high-throughput screening of nanoparticle shapes, sizes, and modifications, reducing associated screening costs. The research demonstrates the distinct preferences of tumour cells for certain nanoparticle configurations, enabling personalized cancer treatments that are safer and more effective.
The American Academy of Family Physicians recommends guiding principles for AI use in research and publishing, emphasizing full disclosure, accountability, and understanding of AI limitations. AI can improve efficiency and accessibility but risks perpetuating bias and generating inaccurate information.
A peer health navigator pilot program in Saskatchewan improved access to affirming health care for transgender and gender-diverse individuals. The program reduced stress and positively impacted clients' mental health by providing tailored guidance and connecting them with affirming providers.
A support program increased rural primary care clinics' buprenorphine prescribing by fivefold, with clinic completion rates for treatment milestones also showing significant improvements.
The article proposes innovative strategies for preserving diversity in higher education and professional fields, including medicine. Institutions must expand STEM enrichment programs, strengthen K-16 recruitment efforts, and maintain holistic admissions processes to address declining enrollment of underrepresented minority students.
A tailored, toolkit-based intervention improved integrated behavioral health (IBH) integration in primary care practices. Practices that completed more intervention stages showed significant improvements in IBH, particularly in workflows and patient identification.
Despite financial incentives and small faculty sizes, family medicine departments struggle to produce scholarly work due to institutional budget constraints. Larger faculty sizes are linked to higher presentation rates, highlighting the importance of investing in research staff.
The AHRQ EvidenceNOW initiative reduces stigma by training primary care practices in universal screening, brief interventions, and medication-assisted therapy. Motivational interviewing techniques help clinicians address unhealthy alcohol use, promoting person-centered communication and empathetic interactions.